The Japanese Journal of Antibiotics
Online ISSN : 2186-5477
Print ISSN : 0368-2781
ISSN-L : 0368-2781
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Volume 52, Issue 3
Displaying 1-4 of 4 articles from this issue
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  • COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIALAGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM PATIENTS WITH URINARY TRACT INFECTIONS (1997)
    III. SECULAR CHANGES IN SUSCEPTIBILITY
    YOSHIAKI KUMAMOTO, TAIJI TSUKAMOTO, TAKAOKI HIROSE, AKIFUMI YOKOO, SHI ...
    1999 Volume 52 Issue 3 Pages 177-267
    Published: March 25, 1999
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.52.177
    JOURNAL FREE ACCESS
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    Susceptibilities to various antimicrobial agents were examined for Enterococcus faecalis, Staphylococcusaureus, Echerichia coli, Klebsiella spp., and Pseudomonas aeruginosa that were isolated from patients withurinary tract infections (UTIs) in 9 hospitals during June 1997 to May 1998, and the results were comparedwith those obtained during the same period in earlier years.
    1.E. faecalis
    The MIC90s of quinolones forE. faecalis isolated from uncomplicated UTIs have changed better state duringthe latest period. AmongE. faecalis strains, those with high susceptibilities to ampicillin (ABPC) andminocycline (MINO) appeared to had decreased during period of 1995-1997, which recovered during the latestperiod.
    2.S. aureus
    The sensitive strains ofS. aureus to imipenem (IPM) and clindamycin (CLDM) had increased during theperiod of 1996-1997, but those have decreased again during the latest period.
    3.E. coli
    The susceptibilities ofE. coli to MINO have been better in the latest period with the MIC90 was ranged from2 to 4 μg/ml. The susceptibilities to quinolones of E. coli isolated from complicated UTIs had decreased duringthe period of 1995-1997, but those have recovered during the latest period.
    4.Klebsiella spp.
    AmongKlebsiella spp. strains isolated from uncomplicated UTIs, those with low susceptibilities to almostcephems have increased in the latest period. To other antimicrobial agents, the susceptibilities ofKlebsiella spp.did not show any changes during the latest period.
    5.P. aeruginosa
    The susceptibilities to most agents ofP. aeruginosa did not show any changes, the decreased susceptibilitiesto cefozopran (CZOP), carbapenems and monobactams ofP. aeruginosa observed in 1996 appeared to have beenretrieved in 1997.
    These susceptibility changes should be utilized in determining clinical treatments.
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  • COMBINATION EFFECT OF TEICOPLANIN AND PANIPENEM ON HIGHLY RESISTANT STRAINS OF MRSA
    YUKIO UTSUI, CHIKA ISHII, TOMOMI ABE, MASAYO KAKUTA, SATOSHI OHYA
    1999 Volume 52 Issue 3 Pages 268-277
    Published: March 25, 1999
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.52.268
    JOURNAL FREE ACCESS
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    We investigated the in vitro combination effect of teicoplanin (TEIC) and panipenem (PAPM) on highlyoxacillin-resistant strains of Staphylococcus aureus (MRSA) isolated from various clinical specimens.Combination of TEIC and PAPM using checkerboard titration technique by agar dilution exhibited an excellenteffect with mean fractional inhibitory concentration index of 0.18±0.07 on 47 MRSA strains, and the effectswere judged as synergistic against all of the strains tested. In the combination of TEIC and PAPM at 1/4 MICeach against exponentially growing cells of MRSA, good bactericidal activity was found when TEIC and PAPMwere added simultaneously, and PAPM was added at 1 or 2hours prior to addition of TEIC, although the bactericidalactivity was scarcely demonstrated when TEIC was added at 1 or 2hours prior to addition of PAPM. Bactericidalactivity against MRSA was enhanced in the combination of TEIC and PAPM at 1/4 MIC each for MRSAthan the bactericidal activity of TEIC at 1 MIC alone. TEIC alone showed no bactericidal avctivity againstP. aeruginosa in the mixed cultures with MRSA, while strong bactericidal activity against P. aeruginosa wasinduced by PAPM. in vitro bactericidal activities against mixed cultures of MRSA with P. aeruginosa wereevaluated under conditions of concentrations of TEIC and PAPM, alone and in combination, whose plasmaconcentrations in human were simulated by a pharmacokinetic simulation model. Bactericidal activity againstMRSA was enhanced by the combination of TEIC at 200mg twice or once daily with PAPM at 500mg twicedaily in comparison with the bactericidal activity of each antibiotic alone, and P. aeruginosa was killed by the antibacterial activity of PAPM.
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  • [title in Japanese]
    1999 Volume 52 Issue 3 Pages C1-
    Published: 1999
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.52.C1
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1999 Volume 52 Issue 3 Pages C1a-
    Published: 1999
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.52.C1a
    JOURNAL FREE ACCESS
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