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Volume 25 (1972)
- Issue 6 Pages 329-
- Issue 5 Pages 283-
- Issue 4 Pages 223-
- Issue 3 Pages 157-
- Issue 2 Pages 61-
- Issue 1 Pages 1-
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Volume 25, Issue 3
Displaying 1-9 of 9 articles from this issue
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MASAO YAMANAKA1972 Volume 25 Issue 3 Pages 157-162
Published: June 25, 1972
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
1972 Volume 25 Issue 3 Pages 162-162,168
Published: June 25, 1972
Released on J-STAGE: May 17, 2013
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MASAAKI OHKOSHI, YORIO NAIDE, ICHIRO NAGAKUBO, AKIRA HASEGAWA, KEIZO S ...1972 Volume 25 Issue 3 Pages 163-168
Published: June 25, 1972
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSCarbenicillin has been used for several years in complicated infections and shown to be effective in urinary tract infections. The antibacterial activity of this drug was shown against most E. coli and Enterobacter (Cloaca) strains. Most indole-positive Proteus species were susceptible to carbenicillin. The MIC for Pseudomonas strains was much higher than that for Proteus species and carbenicillin. However as is known urinary excretion of carbenicillin is quite rapid and the concentration in urine easily attains several hundreds micrograms per ml. This phenomenon might explain the good clinical response in urinary tract infections. Therefore, we have administered rather large dose of carbenicillin against complicated urinary tract infections,most of which were due to Pseudomonas strains to see dose related response.In this paper the results of management of urinary tract infections by 8g per day of carbenicillin is presented in comparison with that by 4g per day.Of 30 patients 18 were chronic Pseudomonas infections.From other 6 chronic infections, 2 E. coli,2 Klebsiella, 1 Cloaca and 1 Proteus mirabilis strains were isolated.In the remaining 6 acute pyelonephritis cases, 5 E. coli and 1 Klebsiella bacteriuria were revealed. Among 18 Pseudomonas infections 11 were cured by carbenicillin 3 showed temporary eradication of bacteriuria and 4 no response (resulted in failure). The MIC for Pseudomonas isolates were mostly 12.5 or 25mcg/ml excepting two 250mcg/ml, and no clear dose related response was shown in this study.The efficacy rate in other 6 chronic cases was 50%. In acute cases carbenicillin medication was fully effective.Being compared with previous case in which 4g of carbenicillin was the daily dose (5cure,4 relapse and 3 failure in 12 chronic Pseudomonas infections),8g course is shown to be effective in diminishing relapse rate.View full abstractDownload PDF (898K) -
MICHIYO YAMAZAKI, KYOKO TANABE, YASUKO ARIMA, YUKAKO MATSUMOTO, KENJIR ...1972 Volume 25 Issue 3 Pages 169-174
Published: June 25, 1972
Released on J-STAGE: May 17, 2013
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KATSUYOSHI KONDO, MASAMICHI AMANO, TADAO NIIJIMA1972 Volume 25 Issue 3 Pages 175-180
Published: June 25, 1972
Released on J-STAGE: May 17, 2013
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TAKEMI KOEDA, UICHI SHIBATA, HIROYASU ASAOKA, YUKIO KABATA1972 Volume 25 Issue 3 Pages 181-186
Published: June 25, 1972
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSCentral Research Laboratories, Meiji Seika Kaisha,Ltd.
Pharmacological effects of SF-837, a new macrolide antibiotic, were studied and following results were obtained.
1) In urethane (1g/kg, s. c.) anesthetized rabbit, 20mg/kg (i. p.) SF-837 showed depressor effect, but no effect on respiration and ECG. When 100mg/kg SF-837 was administered orally, almost the same effects were observed. These cardiovascular effects were retained after the administration of atropine and diphenhydramine, vagotomy,and spinal resection.
2) The movements of isolated rat uterus and rabbit intestine by MAGNUS' method were inhibited by 0.01% SF-837 and 0.1% SF-837 caused relaxation on isolated guinea-pig trachea muscle in MAGNUS' method.These effects on isolated smooth muscle were antagonized by ACh and BaCl2.
3) No effect was observed by the administration of 0.2% SF-837 on the plate of diaphragm nervemuscle preparation in rat.
4) For the examination of formation of antibody in rabbit, MATSUHACHI's method was used. SF-873 was administered bcutaneously twice a week 50mg/animal for 4 weeks and the blood was taken on 8th week. SF-837 did not form any antibody in rabbit.
5) SF-837 at 10% caused a slight irritation to the subcutaneous tissue and muscle of rabbit and 500mg/kg caused slight irritation to the gastric mucosa of rat.
6) No effect was observed on body temperature when 200mg/kg of SF-837 was administered orally.View full abstractDownload PDF (9024K) -
MASAHIDE MORIGUCHI, MASATAKA FUJITA, TAKEMI KOEDA1972 Volume 25 Issue 3 Pages 187-192
Published: June 25, 1972
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSTeratological effects of SF-837,a new macrolide antibiotic,on Donryu rats were studied and followingresultswere obtained.
The dosages,0.5, 1, 2 and 3g/kg/day of SF-837, were administered orally for 6 days from 10th to 15th day of gestation.
1) About 67% of mothers in 3g-medicated group died but no mortal mother was found in other groups treated.
2) In pregnant rats, no significant difference was observed between the control and the medicated groups in changes of mean body weight.
3) In fetal mortality, no significant difference was observed between the control and the medicated groups, except in 3g-group.
4) No deformity was observed in 2g-group, except in one case out of 186 fetuses edema and malformed limbs was observed.
5) A few skeltal malformations,usually found in our experience of the studies, were observed in every group. It is unlikely that these malformations have no relation with this drug.
6) During the course of suckling period of 2g-group, one cystic kidney out of 143 fetuses was observed.View full abstractDownload PDF (6666K) -
MASAHIDE MORIGUCHI, MASATAKA FUJITA, TAKEMI KOEDA1972 Volume 25 Issue 3 Pages 193-198
Published: June 25, 1972
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSTeratological effects of SF-837, a new macrolide antibiotic,on dd-strain mice were studied and following results were obtained.
The dosages, 0.5, 1, 2 and 3g/kg/day of SF-837 were administered orally for 6 days from 8th to 13th day of gestation.
1) About 43% of mothers in 2g-medicated group and 82% in 3g-group died.
2) In pregnant mice, decrease in mean body weight by the medication was observed compared with that of the control.
3) In fetal mortality, no significant difference was observed between the control and the medicated group.
4) A few skeltal malformations,usually found in our exprience of the past studies, were observed in every group. It is unlikely that these malformations have no relation with this drug.
5) One cephalomyelorachisiasis in control group, one excencephalia and cleft lip in 0.5g-group and one excencephalia and facial cleft in 2g-group were observed.
During the course of suckling period of 0.5g-group, two polydactylia were observed.View full abstractDownload PDF (9978K) -
1972 Volume 25 Issue 3 Pages e1-
Published: 1972
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS
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