This study was designed to clarify the neural interaction between the two physiological mechanisms which induced velar movement. One is the deglutition evoked by repetitive pulse stimulation (RS) of internal branch of the superior laryngeal nerve (In-SLN). Another is the reflex from the levator veli palatini evoked by the afferent nerve stimulation of pharyngeal branches of glossopharyngeal nerve (Ph-GPN). Five adult dogs were used as experimental animals under an intraperitoneum anesthesia by thiopental sodium.
Results were summarized as follows:
1. RS applied to In-SLN, induced deglutition many times in one minute in 10 to 100 msec of stimulus interval (SI). The frequency of deglutition reached maximum at 30 msec of SI.
2. RS was applied to the afferent fibers of Ph-GPN which evoked levator reflexes under a condition of RS of In-SLN to induce deglutition. RS in 10 to 100 msec of SI to the afferent fibers of Ph-GPN decrease the frequency of deglutition.

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In this study the relationship between sisterchromatid exchange (SCE) frequency and cell survival was examined in 3 neoplastic epithelial cell lines originating in salivary glands and maxillary sinus of the human, which were exposed to 4 antineoplastic drugs, cis-diaminedichloroplatinum (cis-DDP), mitomycin C (MMC), 5-fluorouracil (5-Fu) and bleomycin (BLM).
These cells included 2 salivary gland adenocarcinoma cell lines (HSG and HSY) and 1 maxillary sinus squamous carcinoma cell line (OKK). All of the cells were grown in Eagle's minimal essential medium (MEM) supplemented with 10% newborn calf serum and 2mM L-glutamine in the presence of 5% CO₂ in an incubator at 37°C. Search for SCE of cells was performed according to the modification of fluorescent plus Giemsa method described by Perry and Wolff.
The respective doubling times for HSG and HSY cells were 21.4±2.5 and 39.1±8.0 hours, while the doubling time for OKK cells was 30.2±6.5 hours. To make permanent cytological preparations of SCE, the cells were cultured in the growth medium containing 1μg/ml bromodeoxyuridine (BUdR) in a 5% CO₂ incubator at 37°C for 62 hours during which time 2 rounds of replication occurred.After further cultivation for 1 hour in the presence of 10^-5M colcemid, the cells were subjected to SCE analysis.
The mean number of spontaneous SCEs per chromosome of HSG cells (0.18±0.05; mean±SD, n=40, P<0.05), HSY cells (0.19±0.07, n=42, P<0.05) and OKK cells (0.15±0.06, n=31, P<0.05) was significantly increased as compared with that of human peripheral lymphocytes from normal controls subjects (0.10±0.06, n=20). When the cells were cultured for 62 hours in growth medium containing 1μg/ml BUdR and various concentrations of antineoplastic drugs, both cis-DDP and MMC induced high frequencies of SCEs in all of the examined cells.
Although treatment of these cells with 5-Fu resulted in an induction of moderate frequency of SCEs, BLM did not increase frequency of SCEs. Especially, the frequency of cis-DDPinduced SCEs was higher in OKK cells than in HSG and HSY cells, whereas an increase in the frequency of MMC-induced SCEs in HSG and HSY cells as compared with that in OKK cells was observed.
Moreover, the frequecy of SCEs induced by cis-DDP or MMC was intimately associated with reduced cell survival.

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Various diagnostic methods are employed for salivary gland diseases. Among these, salivary gland scintigraphy employing ^99mTc-pertechnetate is widely used in determining both morphological and functional statuses. In this paper, we evaluated the diagnostic value of this method.
Fifty nine cases were examined in this study: 2 cases of acute sialoadenitis, 12 cases of chronic submandibular sialoadenitis, 14 cases of chronic parotitis, 4 cases of benign submandibular gland tumor, 7 cases of benign parotid tumor, 2 cases of malignant tumor, 3 cases of cyst, 3 cases of Sjögren's syndrome, 8 cases of xerostomia, and 4 cases of sialolithiasis.
^99mTc-pertechnetate was administered i.v. at a dose of 5-10mCi. After about 10 minutes, antero-posterior, right lateral, and left lateral views of the face were obtained. Bilateral parotid and/or submandibular glands were selected as R.O.I.and time activity curves were obtained. As a stimulation test, lemon juice was administered after another 10 minutes, and anteroposterior views of the face were obtained.
An analysis was carried out with three parameters: accumulation patterns (AP), the secretory patterns after the stimulation test (SP) and the stimulatory sacretion ratio (SSR) expressed as the ratio of post-to pre-stimulation counts on the salivary glands.AP were subclassified into five images: defective, decreased, normal, increased and enlarged. SP were also subclassified into five patterns (A-E).
The following results were obtained:
1) “Defective” images were an aid to differentiation between tumors except Warthin's tumor and other diseases.
2) “Increased” image with tumorous swelling were strongly indicative of Warthin's tumor, but more detailed examinations were required.
3) Differences in accumulations in Sjögren's syndrome and xerostomia were useful in distinguishing between the two diseases.
4) SP was helpful in differentiating between Sjögren's disease and xerostomia.
5) The SSR was more effective than SP for evaluation of minuter secretory functions.
6) Salivary gland scintigraphy employing ^99mTc-pertechnetate therefore appears to be an extremely useful diagnostic method for salivary gland diseases.

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Angular and dimensional linear analysis were performed on 100 patients with mandibular prognathism. The results were classified to show the relationship between maxilla and mandibule. Details are given below:
Sanborn's classification was followed for angular classification.
Group A: Maxilla within the normal range, mandibule beyond the normal range.
Group B: Mandibule within the normal range, maxilla below the normal range.
Group C: Maxilla and mandibule within the normal range.
Group D: Maxilla below the normal range, mandibule beyond the normal range.
Group E: Maxilla and mandibule beyond the normal range.
The linearly measured classification was performed according to the distance from a line perpendicular to SN plane through S to Point A and Pogonion.
typea-type e has the same relationship as Group A-Group E.
type f: Maxilla and mandibule below the normal range.
There were considerable differences between the angular and the linearly measured analyses. Which seems to have a close relationship to the distance of S-N.
It seems to be useful to display both classifications together in order to grasp precisely the form of mandibular prognathism and also to be useful clinically.

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Fractures of the mandibular condylar processes are classified into intracapsular and extracapsular groups according to the location of the fracture lines. However, the mechanism underlying the difference between them has not been studied in the laboratory or at least not described in any publications.
To clarify this mechanism, we measured the stress and strain distributions and the deformation patterns under a static load applied from several directions to human mandibles and their replica models to which strain gauges were adhered. Furthermore, the cross-sectional characteristics of the test specimen and the internal strain of the condylar neck region were measured.
Consequently, the following conclusions were made:
1) The directions of principal stresses and the orders of their magnitude were very similar between the mandible and replica model and proved to be correlated. So, by using replica models we could determine the positions where the stresses were apt to concentrate and their directions.
2) The stress and strain distributions of the mandibles could be classified according to the direction of loading into two types. One was the type with longitudinal force to the mandibular body, with the stress being concentrated in the subcondylar region primarily and in the anterior region secondarily. The other was the type with the force lateral to the mandible; here the stress was concentrated at the loading point and anterior region primarily and in the subcondylar region secondarily.
3) With the loading londitudinal to the mandibular body, the stress behavior and the deformation pattern of the condylar neck could be divided into two types:(1) the bending stress type, observed when the condylar heads were fixed and the necks were bent buccolingually, so the neck projected inwardly, and (2) the longitudinal type, observed when the condyles were supported freely and the neck transferred the force to the condylar head such that the head rotated inwardly.
4) The cross-sectional area was largest in the mandibular angle section and smallest in the condylar neck section. The moment of inertia in all sections was larger about the horizontal than about the vertical axis. Among the evaluated data about the horizontal axis, in the condylar neck region the moment of inertia was smallest and at the angle region it was largest. About the vertical axis, in the condylar neck section it was smallest. The radius of gyration about both the horizontal and vertical axes was smallest in the condylar neck section.
5) The above experimental results revealed that the conditions in which the condylar head was most prone to fracture was with free end fixation and a mento-condylar direction of loading. Under these conditions, fifteen mandibles were subjected to the fracture test, and all the specimens fractured sagittaly or obliquely and only along the internal side of the condylar head under a mean static load of 92kg.

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Measurements of the blood flow kinetics in healed wounds which had been sutured by nylon thread were carried out in the group of mice receiving aspirin (300mg/kg) and the control group, using the laser doppler flowmeter (LDF) and the results were histopathologically compared. The following interesting results were obtained.
1) Blood flow kinetics in wound areas in the group sutured by nylon thread increased from the 1st postoperative day till the 14th day.
2) When aspirin was administered at doses of 300mg/kg, the blood flow decreased from the 1st postoperative day till the 4th day and then gradually returned to normal level. But there was a significant difference between the group receiving aspirin and the control group.
3) On histopathological studies wound healing process was normal in the group sutured by nylon thread. In aspirin administered group, however, gaping of the wound was seen on the 3rd postoperative day and the wound showed healing tendency from the 5th postoperative day and the wound showed healing tendency from the 5th postoperative day. Therefore, wound healing process was more delayed than that in the control group.
These results indicate that the measurements of blood flow using LDF can reflect the peripheral blood flow kinetics and show a good coincidence with the change in histopathological findings. Therefore, LDF can sensitively measure a delicate change in the tissue blood flow. In addition the administration of aspirin was found to delay the healing process in incised wound of mouse-skin.
Consequently, it is necessary to determine the time to take out the stiches in consideration of the fact that the administration of non-steroidal antiinflamatric analgesics may delay wound healing process, although extractin of the stiches has been generally carried out on the 7th postoperative day.

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A case of osteosarcoma occurring in the mandible of 48-year-Dld man was presented. At first visit, clinical diagnosis was osteomyelitis, and the diagnosis of osteosarcoma was done by biopsy.He underwent radical operation (hemimandibulectomy and reconstruction with D-P flap), before and after which high-dose methotrexate therapy (100mg-300mg/kg) was carried out.There is no evidence of recurrence till now.

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Two cases of immediate reconstruction using palatal flap for defect following excision of the soft palatal tumor were reported.
A reconstruction for palatal defect of the soft palate using palatal island flap was very useful in following advantages. The flap was able to transfer from adjacent hard palate. There were no functional disturbances in the hard palate and no necrosis of the flap because of excellent blood supply. The flap was very movable so that it could transfer even to posterior border of the soft palate. This procedure which could achieve in only one stage without delay was easier than in other flaps.
On the other hand, in a reconstruction for defect of the entier soft palate, atrophy of the flap was remarkable after 2 or 3 months so that it should be simultaneously used with pharyngeal flap.

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A 79-year-old female patient was placed with diagnosis of idiopathic trigeminal neuralgia. On oral carbamazepine and right mental nerve block with lidocaine and alcohol were given for about 8 years from July 1975, and as the result the pain was abolished. But in September 1983, the pain recurred, and subsequently eating became difficult. During the attack of the pain, right facial clonic muscle spasm was observed, and dysacousia was shown by audiogram. Intracranial tumor was suspected, and CT scanner disclosed the presence of tumor in the right cerebellopontile angle. In October, the tumor was removed at the Department of Cerebral Surgery of our University Hospitad and pathological examination gave the diagnosis of psammoma meningioma. After the operation, the pain disappeared, and now at 2 1/4 postoperative years, she shows favorable prognosis.
Since trigeminal neuralgia of unknown cause may sometimes be ascribable, like in the present case, to tumor near semilunar ganglion, it will be necessary to examine by CT scan and symptoms derived from the 7th and 8th cerebral nerves which are adjacent to trigeminal nerve.

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Vascular lesion in the jaws are rare diseases, but oral surgeons must mind the dangers that causes a sudden fatal bleeding. We have experienced a case of very rare arteriovenous fistula with a large quantity of bleeding.
A 15-year-old boy was referred from a dentist. About a year ago, he was conscious of gingival swelling and a slight bleeding at the lower right molar region, so he had been treated by the dentist. On the first visit, he had a diffuse swelling at the right mandibular region and a diffuse swelling, redness and hot feeling at MP gingival region, without fluctuation nor pulsation. A panoramic radiograph showed a diffuse radiolucent area from 7 to 5 and the honeycomb shadow from 5 to 1 in the mandible. Severe hemorrhage occurred during diagnotic puncture, so this disease was clinically diagnosed as the aneurysmal bone cyst. The emergency operation was performed under general anesthesia. The operative procedure included partial resection of the mandible and reconstruction with the autogeneous bone graft using iliac crest. The histopathological diagnosis after the operation was an arteriovenous shunt.
A year and three months after the initial operation, reconstructive operation was performed with a ceramic artificial bone. The recurrent sign of this disease, facial deformity and functional disorder had been noticed a year and four months after the final operation.

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Since Hajdu et al in 1948 and Cheney et al in 1965 reported that Hajdu-Cheney syndrome is a disease showing acro-osteolysis, cranial deformity, Wormian bone, malformation of frontal sinus, basilar impression, osteoporosis, etc., only 29 cases have been reported including the personal case (J. Kawamura et al.: J. Neuroradiology 21: 295-301 1981) so far. This time, we studied about the findings of jaw and face of patients who were diagnosed as Hajdu-Cheney syndrome in the Department of Neurology and Internal Medicine of our hospital, and report its outlines as follows.
Patient: A 25-year-old male. Chief complaint: Trembling of the teeth and difficulty of chewing in 3+3/5+5. Date of the initial examination: October 3, 1983.
The finding of oral cavity noted the trembling of the teeth in 35-4;35 The cleaning of oral cavity was extremely unfavorable, and odontolithiasis with high degree was noted in 7+7/7+7 in 3+3/5+5. The cleaning of oral cavity was extremely unfavorable, and odontolithiasis with high degree was noted in 7+7/7+7 Anterior ejected disease of lower jaw was noted in overjet-4 mm and overbite-2mm. X-rays finding: By panorama X-rays, absorption picture of bone, taurodontia and impacted teeth were observed in 7+7/7+7, and, respectively. No characteristic findings were noted in X-rays of head region, vertebral column, upper limb and lower limb, and CT scan.

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The mucoepidermoid carcinoma is a neoplasm originating from both major and minor salivary glands, and its incidence is the highest concerning the parotid gland in major salivary glands and at the palate in minor salivary glands.Its incidence is said to be comparatively low in the mandible.
We have recently experienced one case of mucoepidermoid carcinoma considered to have occurred in the mandible in a 48-year-old woman, and reported on it with some comments based on the literature.

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The ameloblastoma has been subjected to definition ranging from a benign odontogenic epithelial tumors.
Ameloblastoma of mandible has been discussed extensively in the literature.
Most often, it occurs usually in the mandible and tewer of thew in the maxilla.
Since then we experienced a case of ameloblastoma which appeared in the maxilla in a 54-year-old man.

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This study is based on an analysis of biopsy specimens that were diagnosed histopathologically in the Department of Oral Pathology, Tokushima University School of Dentistry from 1979 to 1983. This paper reported with special reference to the cystic lesion in this series.
1. The total number of the specimens related to cystic lesions during these five years were 520 and it corresponded to 467 cases. Of the 467 cases, 266 cases (57.0%) were the cysts of jaw bones, 73 cases (15.6%) were the cysts associated with the maxillary antrum, 107 cases (22.9%) were cysts in the soft tissues, one case was calcifying odontogenic cyst and 20 cases were unclassified.
2. The most common cyst of jaw bones was radicular (residular) cyst (62%) and followed by dentigerous cyst and primordial cyst.
3. The age distribution of the radicular cyst in this series tend to be found at a somewhat older age than the other reports. About 61% of the radicular cysts was found in the maxilla. The most common site of the radicular cyst was in the maxillary lateral incisor and followed by the mandibular first molar and the maxillary central incisor, etc.
4. The age distribution of the dentigerous cyst in this series also tend to be found at a somewhat older age than the other reports. The most common site of the dentigerous cyst was in the mandibular third molar and followed by the maxillary anterior teeth.
5. The most common cyst in the soft tissue was mucous retention cyst. They were 89 cases in this series and 59 cases (66%) of them occurred in the lower lip.
All mucous retention cysts in this series were extravasation cyst.

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A case of cementoblastoma which occured in the mandibleof a 50-year-old woman was reported.
The tumor was extripated and pathologically examined. The pathological finding showed hard tissue, which contained entrapped cells with many reversal-lines, and uncalcified cementoid at the periphery sheets.
After the operation, there has been no recurrence of the tumor and prognosis is good.

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Secondary bone grafting of alveolar clefts has been performed in 109 cleft palate patients, 55 boys and 54 girls, using the autogenous particulate cancellous bone and marrow of the iliac bone. The patients age range was 8 years 2 months to 28 years 8 months, with a mean age of 12 years 11 months.
Before the bone grafting, any malocculusion of the maxillary segments were corrected with orthodontic treatment. Operation was done with simultaneous correction of alveolar clefts and oral-nasal fistulas.
The incision made along the clefts margin of the labial site, mucoperiosteal flap was developed.
Mucoperiosteum of the fistula was dissected and separated the palatal and nasal portion with scissors. The mucoperiosteum were closed with stiches in each.
At this point, nasal and palatal layers of mucoperiosteum had been created. Cancellous bone and marrow were packed into any spaces, and placed in the area of the alar base. After an adequate osseous form was obtained, the labial mucoperiosteum was undermined and relaxed, and closed with stiches. But, the cases of great oral-nasal fistulas, labial sulcus flap used closure of the labial and palatal portion of oral-nasal fistula.
Secondary bone grafting of alveolar clefts has following benefits to cleft palate patients.
1) Stabilization of the maxillary segment.
2) Closure of oral-nasal fistulas.
3) Support of the slumping alar base of the nose.
4) Restoration of alveolar process and dental arch.
5) Provision of bone support for unerupted canine.
These advantages of secondary bone grafting were results of short term observation, but, in the future, long term observation is necessary.

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As well known, schwannoma is thought a tumor derived from the Schwann cell of the neurilemmal sheath. It is a relatively rare disease especially in the oral region. Mostly it emerges from the tongue, the buccal mucous membrane and the palate. Recently authors experienced a case which developed from the pterygopalatine fossa. This case is reported below, together with its clinical and documentary discussion.
The patient is a female aged 14. She had a chief complaint of swelling of left buccal region. The familial and past history was unremarkable. In July 1985 her mother had noticed the swelling of left buccal region, the patient was referred to a certain orthopedic hospital firstly. And then she was introduced to our department on July 25, 1985. Clinical observation revealed bony swelling of indistinct boundary sized about 50 ×30mm from the left zygomatical arch to the front of auricula. Neither tenderness pain nor trisms was observed. Treatment and clinical course are followed;biopsy was carried out under local anesthesia August 7, 1985. The disease was diagnosed as schwannoma. An enucleation was performed under general anesthesia August 21, 1985. The results of the surgery is excellent. And careful attention will be paid to the prognosis of this patient.

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A case of malignant lymphoma of the maxillary gingiva-alveolar region is documented. This case presented difficulty in histopathological differential diagnosis from squamous cell carcinoma.
The patient was a 46 year-old man.He had a lesion from the upper gingiva of the molar region on the left side to the paranasal sinuses. On first biopsy examination, the lesion was diagnosed as poorly differentiated squamous cell carcinoma. He was treated with radiation and chemotherapy. After this treatment, a rapid growth of the left supramandibular lymph node was seen.
The histopathological diagnosis of the extirpated tumor was non-Hodgkin's lymphoma, pleomorphic type. Retrospectively, the lesion of the gingiva-alveolar region, which was diagnosed previously as poorly differentiated squamous cell carcinoma, was considered to be malignant lymphoma. Special attention should be paid to the fact that the figure of malignant lymphoma's cells can be similar to that of poorly differentiated squamous cell carcinoma's cells.

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Calcifying odontogenic cyst is a relatively rare disease reported first by Gorlin et al.in 1962.
Recently, we encountered a 25-year-old woman with this disease bilaterally in the region of the lower wisdom teeth.
Orthopantomography revealed relatively well-defined, periodontal cyst-like radiolucencies of the size of a thumb ball bilaterally in the region of the lower wisdom teeth. Under local anesthesia with 2% Xylocaine, extraction of the left lower wisdom tooth and excision of the cyst were performed. The lesion on the right side was also managed by extraction of the wisdom tooth and cystectomy. The wounds on both sides were treated with gauze tamponage.
Histopathologically, the cyst walls in both locations were composed of markedly degenerated stratified squamous epithelium containing ghost cells which were partly calcified.
The postoperative course was uneventful without evidence of recurrence.

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The Fuji Computed Radiography (FCR) developed recently involves the following procedures;photography in the same way as the hitherto radiography, printing auto imaging plate of photostimulable phospher, conversion to electric signals, and recording reproduced images by computerization.
Highly valuable images for diagnoses in the medical field have already been obtained by the FCR.Then, we attempted to study FCR images panoramically radiographed for jaw lesions in the field of oral surgery.
Method for study: As the samples to be studied, the selected subjects were cases of periodontal diseases, fracture of the jaw, odontogenic cyst and tumor, etc.
In the present study the FCR images of panoramic radiography were compared with hitherto panoramic flat radiograms.
Result of study: Although the images of the FCR vary depending on the methods of treatment, that is, on how gradient processing and spatial frequency enhancement are, the method of purpose-fitting treatment provided diagnostically significant images for grasping bone lesions.
The images obtained from this FCR permitted us to grasp more distinctly condition of alveolar bone resorption in periodontal diseases, running of minute fracture lines in fracture of the jaw, and characteristic images of bone resorption in odontogenic cysts and tumor, etc.
Thus the images of the FCR are highly useful in diagnosing bone lesions, but granularity of the images themselves have still been questioned, and additionally the images vary depending on the methods of gradient processing and spatial frequency enhancement. Therefore further repeat studies are probably needed for these questions.

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The patient was a 38-year-old woman who complained of an irritating sound at the left TMJ while chewing. The symptom disappeared within a few months after beginning treatment. However, the patient returned complaining about trismus and had severe anxiety about not being able to open her mouth ever again.
We decided to take a psychological approach and suggest to her the close relationship between the psychological factors and the aggravation of symptoms.
By using this psychological approach, we were able to resolve the problematic relationship between the patient's anxiety and symptoms. We then proceeded with physical treatment to remove all symptoms.
In this case, it was considered that the use of a small amount of psychotherapy enabled a better relationship between the doctor and patient that was important to the success of the treatment.

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Actinomyces is micro flora which usually exist in human oral cavity, dental plaque, and tonsil. Essentially, actinomycosis occurs due to weakness of general and local resistance in spite of frail disease germ.
Recently we experenced a case of actinomycotic sulfur granule following the remaining of nylon suture which was used for stitching low lip lacerations.
This time, we reported the above-mentioned case added to another report and studied a part of foreign materials which are related to formation of actinomycotic sulfur granule.

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It is well known that myxoma is observed in the jaws, but it does not occur with great frequency.
This report described a 35-year-old female suffering from large myxoma of the mandible. She was offered to the clinic with a chief complaint of apainless swelling in 8-2 region. Under general anesthesia removal of the tumor was performed surgically and the postoperative course was good.
Radiographs revealed a multiocular lesion with delicate trabeculations in 7+2 region.
Pathological findings showed myxoma of the mandible. It was impossible to clarify if the origin was odontogenic and it seemed that the tumor had originated from differentiation of fibroblasts.

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A 51-year-old female noted the tumor, arising from the 167 region of alveolar ridge around November 1982.
The tumor gradually increased in size, and the patient was referred to our department in November 1983. Two epulises bad elastic hard, smooth, surfaces.
In the orall cavity, two large tumors, pyorrhoer alveolaire, dental calculus were found.
Radiographic examination revealed a horizontally absorption over the alveolus dentalis. Tomographic examination revealed lower radiolucency in the left maxillary sinus than in the right.
Under local anethsethia, these epulises were extirpated and extracted3/2-8 8543/8.
Pathologically, the surface of the epulis is covered by squamous epithelium with frequent and irregular elongation of rete ridges. Subepithelial tissue is loosely or densely fibrous and rich in vasculatures.
Postoperative, inflammation in the maxillary sinus disappeared.

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A case of primary extranodal malignant lymphoma was reported, which manifested on the gingiva of left maxilla and arose on the gingiva of the mandible after seven years as another histological type.
A 59-year-old man visited the Department of Maxillofacial and Oral Surgery, Nagasaki University, Hospital of Medicine with the chief complaint of ulcer involving from the gingiva of left maxilla to left soft palate on 12 Sep.1975.
A biopsy confirmed malignant lymphoma, medium-sized cell type (L.S.G. classification), of the gingiva of left maxilla. Chemotherapy and irradiation (Tele ⁶⁰Co) were performed, and significant improvement of the lesion was observed.
Following up for five years after the therapy, clinical investigation revealed complete remission of the lesion because of no recurrence and metastasis.
On 20 Dec.1982 the patient visited the Department of Maxillofacial and Oral Surgery, Nagasaki University, Hospital of Dentistry complaining of ulcer of the anterior mandibular gingiva. As malignat lymphoma was intensely suspected, a gingival biopsy was performed.
Histological diagnosis was malignant lymphoma, pleomorphic type (L.S.G. classification), of the gingiva. Chemotherapy and irradiation (Linac X-ray) were carried out, which caused disappearance of the gingival ulcer. Further chemotherapy was continued after transfer to the Department of Hematology, Atomic Disease Institute, Nagasaki University, Hospital of Medicine.
On 30 Mar.1983 malgnant lymphoma was found in the stomach, and the patient died of the advanced lymphoma on 23 May 1983.
Autopsy showed invasion of malignant lymphoma into bilateral lungs, stomach, spleen, pancreas, and lymph nodes of the lungs and abdomen. Lymphoma cell in pleural effusion had 67% of E-rosette forming cells, which suggested T-cell type malignant lymphoma.

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Adenolymphoma is a fairly rare benign epithelial tumor of the salivary glands and it occurs most frequently in the region of the parotid gland.
Adenolymphoma associated with other tumors is extremely rare.
Recently, we had a case of adenolymphoma of the parotid gland associated with the squamous cell carcinoma of the floor of the mouth. The patient, a 63 year-old man, visited our hospital with a chief complaint of an ulcer on the left floor of the mouth. The biopsy of the region was his topathologically diagnosed as squamous cell carcinoma.Then he was received radiation therapy and radical surgery. Clinically, d small finger tip sized tumor mass was found adjacent to the left parotid gland and was removed surgically.
The tumor mass measured 0.8×0.7×0.5cm in size, encapsulated by fibrous connective tissues.
Histologically, the tumor had epithelial and lymphoid component. The epithelium consisted of cells arranged in double layers around cystic or duct-like spaces. In a part of the tumor denudation of the epithelial cells and leakage of the mucous material into the lymphoid stroma were also seen.
In this case, clinically the tumor mass adjacent to the left parotid gland was suspected to be the metastasis of the squamous cell carcinoma. But histopathological examination revealed that the tumor was adenolymphoma.

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A case of nodular fasciitis occured in the mandible is discribed in a 7-year-old male. Reports concerning nodular fasciitis are scarce. This leision is presented in which the condition clinically resembled malignancy and histopathologically resembled fibrous tumor. Because of them, it is difficult to make exact diagnosis of this lesion. In this case, a complete excisional biopsy was performed in four years ago, and there has not been recurrence up to the date. Electron microscopy shows that the myofibroblasts which had together with the features of fibroblasts and smooth muscle cells were mainly in this tissue.

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A rare case of oral tuberculosis seen in a 47 year-old female is described. The slightly hard mass occured in the mucobuccal fold corresponding to the upper left molar and premolar region was found by intraoral examinations.
Histological examination revealed tuberculous granuloma.
The patient was given antituberculous drugs and the mass was resected. The patient is well without recurrence 33 months after operation.

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The most effective treatment for adenoid cystic carcinomas arising from minor salivary glands is surgical removal of primary lesion including the wide safety margin. However, it is well known that the salivary gland tumors have poor prognosis and high frequency of metastasis. Therefore, the multidisciplinary therapy that prevents effectively recurrence and metastasis is needed.
Two cases of adenoid cystic carcinoma of the maxillary sinus were treated according to the follwing multidisciplinary method. Case 1 (T3NOMO by JJC proposal): The patient had surgical removal of the affected maxilla and then radiation therapy. Four weeks later, adjuvant chemotherapy (Adriamycin and Cisplatin) was performed. In addition, UFT and OK-432 were administered continuously up to date from the onset of the treatment. Consequently, the patient remains be disease-free 24 months postoperation. Case 2 (T4NOMO by JJC proposeal): The patient was treated with the multidisciplinary methods such as surgical reduction of a tumor-burden, radiation therapy, intraarterial infusion of cisplatin and 5-FU into a superficial temporal artery and intradermal administration of OK-432. Thereafter, complete regression of the primary tumor was observed. However, metastasis was detected in the regional lymph nodes, which were subjected to radical neck dissection. The patient remains be disease free 8 months postoperation. These findings indicate that the multidisciplinary therapy may improve the prognosis of adenoid cystic carcinoma of the maxillary sinus.

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Lingual lymph node metastasis was confirmed clinico-pathologically in a 77-yearold male patient with tongue cancer. The two lingual lymph nodes were considered to correspond anatomically to the lateral lingual lymph nodes. It was indicated that the median of the tongue and the floor of the mouth where lingual lymph nodes are present must be palpated carefully for diagnosis and treatment of cancer of the tongue and the floor of the mouth.

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So far, hemangioma has been difficult to treat. This paper describes our use of a Nd-YAG laser to successfully cauterize a giant hemangioma of the tongue.
The subject was a 62-year-old female with a tumor measuring 67×35×20 mm on the left side of the tongue which contained more than a dozen phleboliths.
In this patient, the tumor was successfully cauterized with a Nd-YAG laser (Model 8000, Molectron Inc.). No hemorrhage occurred during the surgical procedure, which was of very short duration, about 15 minutes, and postoperative healing was excellent.
As morphology, sensory nerve, and taste were retained intact in this patient, results were considered satisfactory.

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