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Volume 56, Issue 2
Displaying 1-9 of 9 articles from this issue
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Preface
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[in Japanese]2010 Volume 56 Issue 2 Pages 57
Published: 2010
Released on J-STAGE: October 19, 2013
JOURNAL FREE ACCESSDownload PDF (153K)
Secondary publication
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Chang-Hyen Kim, Cheol-Hun Park, Il-Kyu Lee, Sung-Woon Pyo2010 Volume 56 Issue 2 Pages 58-64
Published: 2010
Released on J-STAGE: October 19, 2013
JOURNAL FREE ACCESSBone morphogenetic proteins (BMPs) in combination with stem cells gain more significance for their use in bone tissue engineering. The mesenchymal stem cell can be differentiated into osteoblast by the treatment of BMP. The aim of this study is to characterize the osteogenic differentiation process of adult stem cells derived from buccal fat pad according to BMP-2 within culture media and decide the appropriate concentration of BMP-2 to facilitate osteogenesis.
The authors procured the stem cell from buccal fat pad and analyzed for presence of stem cell by flow cytomety against CD-34, CD-105 and STRO-1. The buccal fat derived stem cells (BFDC) were treated by application of the different concentration with BMP-2 of 0, 10, 50, 100 and 200 ng/ml, respectively. And their ability to differentiate into osteogenic pathway were checked by alkaline phosphatase (ALP) staining, Alizarin red staining and RT-PCR for osteocalcin (OC) gene expression at 7, 14 and 21day of culture. Flow cytometric analysis and biochemical assays demonstrated that BFDC might be a distinguished stem cells, and mineralization was accompanied in proportion to BMP-2 concentration. However, with 100ng/ml concentration of BMP-2, the BFDC demonstrated most efficent staining pattern of ALP and Alizarin red. The feasibilty of the osteogenic differentiation in the group of both 50 ng/ml and 200 ng/ml of BMP-2 showed similar activity and relatively weaker than that of 100 ng/ml.
These results suggest that the BMP-2 stimulate osteogenesis by BFDC effectively and that bone induction might be controlled through negative regulatory feedback in higher concentration.View full abstractDownload PDF (604K)
Case reports
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Tomohiro YAMADA, Norifumi MORITANI, Katsuaki MISHIMA, Tatsushi MATSUMU ...2010 Volume 56 Issue 2 Pages 65-69
Published: February 20, 2010
Released on J-STAGE: October 19, 2013
JOURNAL FREE ACCESSA case of multiple myeloma of the in mandible is reported. A 67-year-old man presented to our hospital with discomfort caused by a denture in October 2005. There was a bony edge at the left molar region of the mandible, and radiographs showed a 6-cm osteolytic lesion and a fracture line in the left side of the mandible. Osteolytic lesions were also observed in the right side of the mandible and right temporal bone. A computed tomographic scan of the chest and abdomen revealed diffuse osteolytic changes and fracture lines in the spinal bones. There was increased uptake in the 9th and 12th thoracic vertebrae and the mandible on bone scintigraphy. However, little uptake was found in the region of the tumor. Laboratory tests revealed elevations of protein and IgG levels, accompanied by anemia. Renal failure and Bence-Jones proteinurea were not apparent. M-protein was positive in the urine. Bone marrow aspiration revealed 30 % plasma cells, and immunoelectrophoresis showed that an IgG band with a κ light chain. IgG-κ type multiple myeloma was diagnosed. In the department of hematological medicine, 2 courses of VAD (vincristine, adriamycin, dexamethasone) chemotherapy were administered, followed 20 courses of MP (melphalan, prednisolone) chemotherapy in the outpatient clinic. After chemotherapy, a complete response was achieved in the hematological findings, the fractured mandible healed, and the osteolytic lesions decreased. Tumor recurrence has not occurred for 2 years after VAD therapy.View full abstractDownload PDF (708K) -
Satoko INOKUCHI, Makoto KOGA, Mayumi UENO, Haruki TSUYAMA, Osamu IWAMO ...2010 Volume 56 Issue 2 Pages 70-74
Published: February 20, 2010
Released on J-STAGE: October 19, 2013
JOURNAL FREE ACCESSWe present a rare case of epithelial-myoepithelial carcinoma (EMC) arising in right side of the soft palate that was accompanied by cervical lymph node tuberculosis.
A 72-year-old woman was referred to our hospital because of swelling of the right side of the soft palate. Intraoral examination revealed a submucosal mass lesion measuring 14 × 15mm in the soft palate. Contrast enhanced computed tomography showed a mass on the soft palate and cervical lymph node enlargement with ring enhancement. Magnetic resonance imaging and ultrasonography also revealed cervical lymphadenopathy. Fluorodeoxyglucose positron emission tomography (FDG-PET) showed intense focal FDG uptake in the enlarged lymph nodes, but not in the soft palate. Before surgery, the soft palate lesion underwent a biopsy, and the histopathological diagnosis was EMC. Thus, the enlarged cervical lymph nodes were diagnosed as EMC metastasis. Tumor resection of the soft palate and ipsilateral radical neck dissection were performed. Postoperative histopathological examination revealed EMC of the right soft palate and cervical lymph node tuberculosis. After surgery, antituberculous agents were administered to treat cervical lymph node tuberculosis.View full abstractDownload PDF (508K) -
Chizu FUJII, Yoshiaki NAKAMURA, Haruki TUYAMA, Hidenori SAKAINO, Tadam ...2010 Volume 56 Issue 2 Pages 75-79
Published: February 20, 2010
Released on J-STAGE: October 19, 2013
JOURNAL FREE ACCESSMucoepidermoid carcinoma is a relatively common salivary gland cancer in the oral cavity; however, it is extremely rare in infants. We report a case of mucoepidermoid carcinoma arising in the palate of an infant.
A 5-year-old girl had a painful, dome-like mass in the right side of the palate.
Although the tumor was covered with normal mucosa, it was mobile on palpation. There was no lymph node adenopathy in the neck. Radiographically, the lesion showed no defined area of osteolytic destruction. A biopsy was performed, and the histopathological diagnosis was a mucoepidermoid carcinoma.
The tumor was totally excised, including the palatal bone, with the patient under general anesthesia. Five years after surgery, the patient remains free of disease, and the postoperative development of the maxilla is good.View full abstractDownload PDF (485K) -
Takazumi YASUI, Katsuhiro ONIZAWA, Tomoko HYODO, Kimio UCHIYAMA, Yoich ...2010 Volume 56 Issue 2 Pages 80-84
Published: February 20, 2010
Released on J-STAGE: October 19, 2013
JOURNAL FREE ACCESSMyxoma is relatively rare in the stomatognathic region. The patient was a 16-year-old boy with an odontogenic myxoma occupying almost the entire right maxillary sinus. A panoramic radiograph showed clinically significant alveolar bone resorption in the right maxilla and a divergence between the right upper lateral incisor and canine. A computed tomographic scan revealed a neoplastic lesion extending throughout the right maxillary sinus. The lesion had caused thinning of the anterior, posterior, and inner walls of the maxillary sinus. The tumorlike mass was diagnosed as an odontogenic myxoma on biopsy and was surgically excised with the patient under general anesthesia. Follow-up 14 months after tumor resection indicated a good prognosis with no signs of recurrence to date.View full abstractDownload PDF (879K) -
Michihiro UEDA, Tetsuro YAMASHITA, Kazuyoshi YAJIMA, Shin RIN, Yoritos ...2010 Volume 56 Issue 2 Pages 85-89
Published: February 20, 2010
Released on J-STAGE: October 19, 2013
JOURNAL FREE ACCESSWe describe our experience with 4 patients who had squamous cell carcinoma of the soft palate treated by superselective intra-arterial chemoradiotherapy. Two patients had stage Ⅱ disease, and 2 had stage Ⅳ disease. Two of them presented regional lymph node metastatsis. All patients received cisplatin alone. The mean total dose of cisplatin was 461.3mg (300-600mg). Cisplatin was injected into the facial artery or the ascending palatal artery through the superficial temporal artery, with 200 mol times of sodium thiosulfate as the cisplatin neutralizer.
All patients received radiotherapy in a dose of 66 Gy and had a complete response. The primary tumor recurred in 1 patient, but was successfully resected by salvage surgery. All patients were alive at an average follow-up of 58.6 months.View full abstractDownload PDF (696K) -
Namiaki KO, Jinkyo SAKURAI, Ken OMURA2010 Volume 56 Issue 2 Pages 90-94
Published: February 20, 2010
Released on J-STAGE: October 19, 2013
JOURNAL FREE ACCESSWe report an unusual case of actinomycotic osteomyelitis with bone destruction. A 65-year-old man presented with swelling and induration on the right side of the mandible. Radiographic examination revealed bone destruction in a symphyseal lesion of the mandible. On the basis of these findings, the lesion was clinically diagnosed as osteomyelitis or a neoplasm of the mandible. Histopathological studies showed the presence of sulfur granules of the Actinomyces and granulation tissue. These findings led to the final diagnosis of actinomycotic osteomyelitis of the mandible. Surgical curettage was performed, together with the prolonged administration of antibiotics. Three months postoperatively, accumulation of 99mTc-MDP in the mandible had decreased, and computed tomography showed new bone formation at the lesion. There has been no relapse of disease during 1 year of follow-up.View full abstractDownload PDF (708K) -
Joh IWANAGA, Chihiro KOGA, Sinichiro KAKU, Chizu HUJII, Osamu IWAMOTO, ...2010 Volume 56 Issue 2 Pages 95-97
Published: February 20, 2010
Released on J-STAGE: October 19, 2013
JOURNAL FREE ACCESSA case of oral mucosal ulcer caused by the inappropriate use of nicotine gum is reported.
The patient was a 55-year-old man who was a heavy smoker. He had smoked 60 cigarettes a day for 36 years. He had been using nicotine gum as a "stop-smoking aid" for over 8 months. He was referred to our department because of an unhealed undermining ulcer at the mucogingival junction of the lower right anterior teeth. On exfoliative cytology, there were no atypical cells in a specimen of the ulcer. Therefore, we recommended him to stop using nicotine gum, which was inappropriately placed at the buccal vestibule of mouth. The tenderness then gradually improved, and the ulcer healed in the month. Long-term inappropriate use of nicotine gum can cause adverse effects to the oral mucosa.View full abstractDownload PDF (298K)
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