Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 61, Issue 12
Displaying 1-10 of 10 articles from this issue
Preface
Original article
  • Taku KOJIMA, Michiko YOSHIZAWA, Chikara SAITO, Tadaharu KOBAYASHI
    2015 Volume 61 Issue 12 Pages 642-649
    Published: December 20, 2015
    Released on J-STAGE: March 14, 2016
    JOURNAL FREE ACCESS
    We used the combination of a thermoplastic bioresorbable plate and a beta-tricalcium phosphate (β -TCP) grafting substitute for bone defects to induce three-dimensional bone regeneration and evaluated the regenerated bone by histological, ultrastructual, and elemental mapping analyses. Standardized bone defects surgically formed in rat calvariae were filled with β -TCP particles (OSferion®) and covered with a domeshaped plate (LactoSorb®). In the control group, bone defects were covered with a plate without grafting β -TCP particles. In the experimental group, newly formed woven bone extended from the bottom of the defects at 2 weeks. Osteopontin immunopositivity was seen throughout the β -TCP particles grafted in the bone cavity. At the bottom of the cavity, alkaline phosphatase (ALP)-positive cells and tartrate-resistant acid phosphatase (TRAP)-positive cells were localized on the β -TCP particles. At 4 weeks, the new bone had reached half of the height of the cavity, and at 8 weeks, it was close to the plate. At 24 weeks, the new bone had reached the height of the plate and showed histological characteristics of compact bone. The volume of β -TCP particles had decreased and was replaced by new bone. Analyses using a transmission electron microscope and electron probe microanalyzer also revealed that the new bone showed the properties of compact bone. In the control group, the new bone encapsulated with fibrous tissue did not have sufficient height to reach the dome-shaped plate. The results indicate that new bone established by the combination of a thermoplastic bioresorbable plate and a β -TCP grafting substitute might be an alternative material for mandible reconstruction.
    Download PDF (1009K)
Case reports
  • Sayaka YOSHIBA, Kenji SEKI, Setsu YOSHIMURA, Tatsuo SHIROTA
    2015 Volume 61 Issue 12 Pages 650-655
    Published: December 20, 2015
    Released on J-STAGE: March 14, 2016
    JOURNAL FREE ACCESS
    Progressive hemifacial atrophy is a rare degenerative condition characterized by progressive atrophy of facial tissues. Atrophy involves the skin, subcutaneous fat, muscle, and bone. Because of the prolonged therapeutic process, it is important to evaluate temporal maxillofacial changes based on an objective approach. We report a case of progressive hemifacial atrophy in which we performed stellate ganglion block therapy and evaluated the clinical course by MRI and electromyography (EMG) analysis.
    A 47-year-old man was given a diagnosis of progressive hemifacial atrophy at our department and received stellate ganglion block therapy. We evaluated the progression of the atrophy by comparing the muscle volume by MRI analysis before and after treatment. In addition, we measured the muscle activity of masticatory muscles by EMG. We conclude that MRI and EMG analysis can be useful for evaluating changes in maxillofacial tissues and thereby make an objective diagnosis, as well as for assessing therapeutic effects and disease progression.
    Download PDF (804K)
  • Ayumi SHIBUTANI, Yoshisato MACHIDA, Shinya KOSHINUMA, Tomoki HIGO, Syo ...
    2015 Volume 61 Issue 12 Pages 656-661
    Published: December 20, 2015
    Released on J-STAGE: March 14, 2016
    JOURNAL FREE ACCESS
    A brown tumor is a giant cell bone lesion that occurs as a complication of hyperparathyroidism. We report a case of mandibular brown tumor associated with primary hyperparathyroidism in a 27-year-old man. Computed tomography (CT) showed a large bilateral tumor in the mandibular region, and biopsy of the mandibular tumor showed a giant cell lesion.
    The laboratory data showed hypercalcemia and hyperparathyroidism. Contrast-enhanced CT revealed a cystic lesion on the right parathyroid gland. On the basis of these findings, the mandibular tumor was diagnosed to be a brown tumor. Three years 5 months have passed since right parathyroidectomy was performed, and the mandibular bone brown tumors have disappeared bilaterally. Moreover, the progress of the patient has been good.
    Download PDF (746K)
  • Keita TODOROKI, Hajime MATSUMOTO, Nanae KUSHINO, Takahiro HARAGUCHI, O ...
    2015 Volume 61 Issue 12 Pages 662-666
    Published: December 20, 2015
    Released on J-STAGE: March 14, 2016
    JOURNAL FREE ACCESS
    Spindle cell carcinoma (SpCC) is a subtype of squamous cell carcinoma (SCC) and has a poor prognosis. We report a case of SpCC of the tongue with multiple ipsilateral neck recurrence and contralateral lymph node metastasis successfully treated by radiotherapy followed by S-1 administration. A 72-year-old woman consulted our center in August 2010 because of a mass in the right margin of the tongue. The mass was an exophytic granulomatous tumor measuring 25×20×17mm. She had received a partial glossectomy for SCC (T1N0M0) of the right side of the tongue in 1999. Based on the clinical diagnosis of recurrence of SCC (rT2N0M0), a partial glossectomy was done in October 2010. Histopathological examinations revealed SpCC. One month after surgery, radical neck dissection was done for ipsilateral metastasis. Three months after the second procedure, she had multiple ipsilateral neck recurrence involving the retropharyngeal lymph nodes, with contralateral lymph-node metastasis. Because radical surgery was considered extremely difficult, the patient underwent palliative radiotherapy (total 36 Gy). After the radiotherapy, S-1 was administered. After 1 course of treatment, the lesion of the cervical region markedly shrank. Currently, she has been receiving S-1 and remains free of disease as of 44 months after surgery.
    Download PDF (573K)
  • Masaki SAITO, Takashi HATANAKA, Takuro KAWAGUCHI, Takahito KYUMA, Kenj ...
    2015 Volume 61 Issue 12 Pages 667-672
    Published: December 20, 2015
    Released on J-STAGE: March 14, 2016
    JOURNAL FREE ACCESS
    Recently, methotrexate-associated lymphoproliferative disorders (MTX-LPD) in patients with rheumatoid arthritis (RA) have frequently been reported as a lymphoproliferative disorder developing in immunosuppressed patients. Many reports have indicated a relation between MTX-LPD and Epstein-Barr virus (EBV). We report 4 cases of EBV-positive MTX-LPD arising in the oral cavity. After consulting a hematologist, methotrexate (MTX) was discontinued in three patients, and one patient moved to another medical facility. Three lesions regressed after MTX withdrawal. However, one patient who resumed treatment with MTX had a relapse of LPD. A literature search on MTX-LPD in the oral cavity revealed a high positive rate of EBV, a good response to MTX withdrawal, a higher prevalence in women, and a high frequency of maxillary gum involvement.
    Download PDF (681K)
  • Toshiya OKUMURA, Shigehiro ONO, Takayuki NAKAGAWA, Mutsumi MIYAUCHI, I ...
    2015 Volume 61 Issue 12 Pages 673-677
    Published: December 20, 2015
    Released on J-STAGE: March 14, 2016
    JOURNAL FREE ACCESS
    Generally, intraoral osteoma frequently arises on the lingual side of the mandibular molar and maxillary hard palate. As for the radiopacity in the maxillary sinus of affected patients, aspergillosis-derived calculus, root insertion, and osteoma have been suggested. We report a case of osteoma arising in the maxillary sinus. The patient was a 55-year-old man referred to our department for detailed examination and treatment because radiopacity was noted in the left sinus on a panoramic radiograph obtained during a visit to a local dentist for dental treatment. Computed tomography revealed a walnut-sized oval radiopaque mass in the left maxillary sinus. The lesion had arisen in a pedunculated manner from the floor of the left maxillary sinus to form a cup shape. On the basis of our clinical diagnosis of osteoma in the maxillary sinus, the lesion was resected with the patient under general anesthesia. The excised specimen was a hard bone-like mass, measuring 45×40×20mm and containing maxillary sinus mucosa. Histopathological findings led to the diagnosis of osteoma with invagination of the maxillary sinus mucosa. One year after surgery, the course was favorable without recurrence. In this paper, we report our experience with this case of massive osteoma containing maxillary mucosa in the left maxillary sinus and the positive outcome, along with a discussion of related studies.
    Download PDF (624K)
  • Takeshi TAKAYAMA, Akihiro IKAI, Hiroyuki AKIYAMA, Teruhisa YONEZAWA, K ...
    2015 Volume 61 Issue 12 Pages 678-681
    Published: December 20, 2015
    Released on J-STAGE: March 14, 2016
    JOURNAL FREE ACCESS
    Most patients with trigeminal nerve disorder caused by a brain tumor have trigeminal neuralgia. In this case report, we describe impaired opening and closing of the mouth caused by trigeminal motor paralysis. The patient was a 17-year-old boy with a history of a brain tumor, which remitted in response to chemotherapy and radiotherapy and was being followed up. He complained of difficulty in opening and closing the mouth and was hospitalized because of deafness and unsteadiness. However, there were no symptoms of temporomandibular disorder. After detailed examination of the intracranial lesion, the cause was found to be metastasis of the brain tumor to the trigeminal nerve. Chemotherapy and radiotherapy were performed. Subsequently, the difficulty in opening and closing the mouth improved. Our findings suggest that trigeminal nerve disorder caused by a brain tumor can lead to trigeminal motor paralysis. Examinations for intracranial lesions might be of value for the diagnosis of impaired opening and closing of the mouth in patients lacking symptoms of temporomandibular disorder.
    Download PDF (497K)
  • Ryosuke ABE, Masaatsu YAGI, Daishi SAITO, aki ABE, Harumi MIZUKI, Yasu ...
    2015 Volume 61 Issue 12 Pages 682-686
    Published: December 20, 2015
    Released on J-STAGE: March 14, 2016
    JOURNAL FREE ACCESS
    A case of primary ameloblastic carcinoma of the mandible is reported. The patient was a 15-year-old boy with a complaint of swelling of the gingiva adjacent to the lower left canine. He visited our department to receive further examination of the lesion. A bone-like hard swelling was detected in the area from the buccal gingiva adjacent to the lower left canine to the mucobuccal fold. On the basis of the results of biopsy, an ameloblastic carcinoma was diagnosed. After confirming the absence of systemic metastasis, we performed a segmental mandibulectomy with metal plate reconstruction with the patient under general anesthesia in May 2013. The diagnosis of primary ameloblastic carcinoma was confirmed on examination of the excised specimen. After 1-year follow-up, titanium mesh-assisted autogenous iliac bone grafting was performed to reconstruct the mandible in March 2014. One year 8 months have elapsed since the initial surgery. The patient has made satisfactory progress, with no signs of recurrence or metastasis.
    Download PDF (671K)
  • Atsushi LEE, Takashi MIMA, Yasunari MORIMOTO, Yoko TAKIGAWA, Mitsunobu ...
    2015 Volume 61 Issue 12 Pages 687-689
    Published: December 20, 2015
    Released on J-STAGE: March 14, 2016
    JOURNAL FREE ACCESS
    Bee stings of the skin are common injuries. However, bee stings in oral cavity are extremely rare. This article describes a foreign body granuloma of the buccal mucosa induced by a retained bee sting. A 62-year-old woman was referred to our hospital because of swelling of the buccal mucosa. A bee had stung her buccal mucosa while she was eating a whole honeycomb 2 weeks previously. After that, swelling of buccal mucosa developed progressively. She was therefore referred by her family dentist.
    At initial presentation, a solid mass about 8 mm in diameter was found in the right buccal mucosa. It was tentatively diagnosed as a benign tumor of the buccal mucosa clinically. The mass was resected with the patient under local anesthesia. There was granulation tissue around the bee sting, with inflammatory cell infiltration in the pathological specimen. The histopathological diagnosis was a foreign body granuloma. The postoperative course was uneventful, and the patient has remained asymptomatic during the follow-up period.
    Download PDF (537K)
feedback
Top