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Volume 32, Issue 1
Displaying 1-14 of 14 articles from this issue
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I. Localization of keratin in carcinomas of cheek pouch mucosaTohru KAKU, Osamu NAKADE, Minoru EDO, Miki TATEYAMA, Tomizo OKUYAMA1986 Volume 32 Issue 1 Pages 1-7
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThe distribution of intracellular keratin was studied in dysplasia and squamous cell carcinomas of the cheek pouch mucosa of the hamster induced by the application of a 0.5% DMBA mineral oil. The hamster cheek pouchs were excised, and placed in a cold aqueous solution of 1% acetic acid for 1 hour while stirring. The pouches were rinsed and placed in a shallow pan of distilled water. The epithelium was then gently freed from the underlying connective tissue with the use of wooden chopsticks. With this technique the epithelium was easily separated from the connective tissue. anti-keratin antibody was induced in rabbits against total keratin extracts from the squamous epithelium of the cheek pouch mucosa. The serum was tested by the indirect immunoperoxidase method (PAP method). Chilled acetonefixed, paraffin-embedded tissues were employed.
Anti-keratin antibody against total keratin was directed toward cytoplasmic antigen of keratinocytes of spinous and granular layers of the hamster cheek pouch epithelium. No labeling could be detected in the basal cell layer. In the dysplastic lesions and squamous cell carcinomas the expression of keratin antigens was markedly diminished or not detected.
The present study suggests that the difference of the staining intensities of keratin among the normal epithelium, dysplasia and squamous cell carcinoma is a valuable indicator of the malignant transformation in the cheek pouch mucosa.View full abstractDownload PDF (8546K) -
(2) Radiosensitive effect of Dinitroimidazole ethanol for Ehrlich solid carcinomaKazuo SAKAIZUMI, Shigeru SENUMA, Kazuhito SATO, Tetsuo NAGAI, Masami F ...1986 Volume 32 Issue 1 Pages 8-14
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSDinitroimidazole ethanol is a new radiosensitizer of hypoxic tumor cells.
The purpose of our study is to compare the sensitizer enhancement of misonidazole and dinitroimidazole ethanol.
Methods and evaluation: Battelle Columbus Laboratories Protocol.
Radiation: 60Co 15 Gy local radiation. These radiosensitizers were administered into the mice's abdomen before 30 minutes of local irradiation 60Co 15 Gy.
Tumor: Ehrlich solid carcinoma. On the first day of the experiment, 2-3 pieces of 1-3mm tumor blocks in Eagle's MEM medium were transplanted to subcutaneous region of the right thigh of each mouse.
Subjects: Male conventional DDY mice, conventional ICR mice and nude ICR mice.(10 weeks, about 20g) Results: The most effective case was DNIE 10 mg+60Co 15 Gy in DDY mice and second case was DNIE 10mg+60Co 15 Gy in conventional ICR mice. There was no significant differences in tumor growth among the control group, 60Co 15 Gy group and DNIE 2mg+60Co 15 Gy group with regard to Ehrlich solid carcinoma.View full abstractDownload PDF (928K) -
Hiromichi AKIZUKI, Hiroshi YOSHIDA, Ken-ichi SAITO, Yukihiro MICHIWAKI ...1986 Volume 32 Issue 1 Pages 15-27
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSAs gray-scale ultrasonographic examination has the advantages of being noninvasive, rapid and easily repeated, this method can be a valuable diagnostic aid for oral lesions. Generally, ultrasonographic examination of oral lesions has been carried out by placing a transducer on the subjects' facial skin, since the oral cavity is too small to insert the transducer. Using this extraoral approach, it is difficult to obtain data from the tongue edge, palate and gingiva because the air space in the oral cavity is a deterrent to acoustic transmission.
To resolve these problems, an intraoral transducer has been newly developed and employed clinically in the examination of oral lesions. This transducer is characterized by a pulsed 2-9MHz ultrasonic beam and a 3cm long linear array of 26 piezoelectric crystals. Phantom examination revealed that this system has capability of 3cm focus, 1mm axial resolution and 2mm lateral resolution.
It can be inserted into the oral cavity with a water bag or agar used as a coupling agent, and placed securely against the oral mucosa, allowing ultrasound images of many areas in the oral cavity to be easily observed.
Clinical application of this technique to oral lesions can distinguish between cystic, solid and complex characteristics of the lesions, and also yield size, shape, location and relationship to adjacent structures. To a cleft palate, the width of bony cleft is measured. These ultrasonic patterns are similar to the findings of excised materials and surgical exploration.
These results suggest that intraoral ultrasound scanning can be useful for the diagnosis of the oral lesions.View full abstractDownload PDF (20273K) -
Ultrastructural and immuno-histochemical investigationsHiroshi OKUI, Ryoichi YASUI, Masazumi MIYAKE, Mikimasa YAMAHARA, Taken ...1986 Volume 32 Issue 1 Pages 28-34
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA malignant fibrous histiocytoma (MFH) arising from the left maxilla of a 55-year-old woman is reported.
According to Weiss and Enzinger, this tumor was a pleomorphic-striform type of MFH. At present, it seems to be difficult to make a differential diagnosis, although the diagnostic criteria for MFH have been proposed. To make further investigation, electronmicroscopy, histochemistry and immuno-histochemistry were utilized. The ultrastructure revealed the presence of histiocyte-like cells as composing cells. The positive immuno-histochemical reactions with anti-α1 lysozyme, anti-arantitrypsin, anti-α1-antichymotrypsin antibodies suggested histiocytic character of tumor cells.
It is emphasized that these immuno-histochemical and electron microscopic studies are available for differential diagnosis of this tumor.View full abstractDownload PDF (9220K) -
Mamoru MACHINO, Kenichi NAKANO, Tamuro MASUDA, Kojin NAKATA, Eitoku KY ...1986 Volume 32 Issue 1 Pages 35-41
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA 20-year-old student with epidermolysis bullosa was referred for the examination of teeth and oral mucosa in June, 1983.
During the physical examination, extensive erosion and blistering were recognized over the limbs and arms. The fingernails and toenails were absent, but scarring and milia were not seen. By the oral examination, enamel hypoplasia of all teeth was seen. Panoramic radiography showed eight impacted teeth. Biopsies were performed on the gingiva and skin of blistering and clinically intacted areas. Histological findings showed junctional blister formation.
Upon ultrastructual examination of the gingiva and skin, the number of hemidesmosomes was found to be less than in normal individuals.
Diagnosis was made as the Disentis type of epidermolysis bullosa hereditaria with junctional blistering. Our report represents a second case in Japan and the first case in the dental province.
We think that it is vital to have a thorough understanding of the oral manifestations of epidermolysis bullosa.View full abstractDownload PDF (8137K) -
Hiroshi NIKI, Shinichiro HIRAKI, Yoshio MATSUMOTO, Hakuro OKANO1986 Volume 32 Issue 1 Pages 42-46
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThe nodular fasciitis is a nodular tumor of the reactive fibroblast developed from fascia. Because the tumor increases rapidly in a short period, the adhesion with fascia is rarely observed, and because it reveals a pattern similar to that of a malignant tumor due to the proliferation of fibroblast in the pathohistological pattern, this disease is worthy of note based on its characteristic clinical and pathohistological patterns.
This time, one case was studied and reported as follows. The patient was a 31-year-old woman, who recognized swelling on the right side of the cheek region from approximately 1 month ago, and received medical examination at our hospital due to the increasing swelling.This tumor was extirpated under the general anesthesia. The tumor partially adhered with superficial fascia. The proliferation of irregular fibroblast, erythrocytic emigration of extra-blood vessel, etc. were noted in the pathohistological finding, and she was diagosed as nodular fasciitis. The progress after extirpation of tumor was favorable, and continued for 3 years and 8 months with no recurrence noted.View full abstractDownload PDF (4242K) -
Miyo YOSHINARI, Yukiko YOSHIDA, Masaru NAGAYAMA, Yoshiaki TANI, Akira ...1986 Volume 32 Issue 1 Pages 47-53
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSDermoid (or epidermoid) cysts of the head and neck are rare. They are generally found in the bottom of the mouth, but also occassionally ocurr in unusual locations such as the cheek, lip, tongue and uvula.
In this paper, we made clinical observations on 15 cases of dermoid (or epidermoid) cysts, diagnosed histopathologically, in the oral region.
The results were as follows:
1. Of 15 cysts seen in the oral region, 8 were in the bottom of the mouth, 3 in the cheek, 2 in the tongue, 1 in the lip and in the uvula.
2. A total of 15 cases received an operation, 73.3% of which were epidermoid cysts.
3. The period of time between the appearance of noticeable symptoms caused by the cysts and first medical examination ranged from 2 months to ten years.
4. Although the majority of the cysts had no symptoms, the cyst in the bottom of the mouth of a seven-month-old baby had markedly obstructed nursing.View full abstractDownload PDF (5748K) -
Kenji MOGI, Koichi SAITO, Yasuyuki YOKOYAMA, Mamoru YOKOBORI, Takashi ...1986 Volume 32 Issue 1 Pages 54-60
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSPrimary malignant melanoma of the oral cavity is rare, and few reports of this type of tumor have dealt with a large number of cases. Eight patients with oral malignant melanoma treated in the Department of Oral Surgery, School of Medicine, Gunma University, during the past 12 years have been studied clinico-pathologically. The results are as follows:
1. Malignant melanoma constituted about 4.8% of all the cases of oral malignancy during the same period.
2. The age ranged from 30 to 67 years with a mean age of 52.6 years. Three cases occurred in the seventh decade, two in sixth, one in fifth and one in fourth. There were two males and six females.
3. As for the areas involved, six cases were afflicted in upper gum or hard palate, one in lower gum and one in submaxillary area.
4. As for clinical features, three cases were characterizedby just flat spot, and five by tumor-like masses. All of the cases were black in color with one exception, which occurred in the submaxillary area. Four cases were ulcerated and four nonulcerated.
5. Microscopically, six cases were of spindle cell type, one of round cell type and another of intermediate type.
6. All cases were treated by irradiation and five of them were additionally treated by surgery. All cases were treated with chemotherapy and immunotherapy or cryosurgery. The metastatic lymphonodes were treated by irradiation.
7. The prognosis of seven of the cases was grave and the prognosis of one was excellent. At present, the latter has survived two years and five months after the initial visit.View full abstractDownload PDF (6309K) -
Masayoshi SAKUDA, Hisanori HARADA, Teruaki OGAWA, Toshio SUGAHARA, Tak ...1986 Volume 32 Issue 1 Pages 61-67
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSOsteochondroma or osteocartilageous exostosis is a common disease in the osseoustissue.
However, osteochondroma occurring in the coronoid process is relatively rare, and is interesting in differential diagnosis when resulting from trauma, developmental malformation, temporomandibular dysfunction syndrome and others, and causality of this disease.
This paper described a female patient, 54 years old, whose presenting problem was a chronic limitation of mandibular movement caused by the osteochondroma of coronoid process, and she was treated surgicaly. The problem disappeared following the operation, and the prognosis is favorable.View full abstractDownload PDF (4986K) -
Motoo YOKOI, Yasuhiko INOUE, Takuzo JINNO, Yoichiro KAMEYAMA, Junji SU ...1986 Volume 32 Issue 1 Pages 68-74
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSYolk sac tumor is extremely rare in the oral region. This report presents a case of Yolk sac tumor in the sublingual region of an 5-month-old boy. The patient received surgical resection of the primary lesion and later VAC chemotherapy for pulmonary metastasis. The prognosis is favorable, and there is no evidence of recurrence.View full abstractDownload PDF (10071K) -
Hideo KUROKAWA, Minoru KAJIYAMA, Isao AKAMA, Kajin RIN, Masanobu SAKO, ...1986 Volume 32 Issue 1 Pages 75-80
Published: January 20, 1986
Released on J-STAGE: September 13, 2011
JOURNAL FREE ACCESSCongenital lower lip fistulas are considered to be relatively rare developmental anomalies. These fistulas are usually symmetrically situated on the vermilion portion of the lower lip as a well-marked, circular depression. Frequently, these lesions are associated with bilateral or unilateral cleft of the lip-jaw-palate.
We have experienced a case (2.7-year-old boy) of bilateral congenital fistulas on the vermilion of the lower lip. There was associated with the left cleft of lip and upper jaw. In the treatment, surgical excision was performed.
The clinical and histopathological findings of these lesions were reported and the literature was reviewed.View full abstractDownload PDF (4850K) -
Yuuichi SASAKURA, Mari SASAKURA, Kazuhiro KUMEGAWA, Junichi SHINDO1986 Volume 32 Issue 1 Pages 81-86
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThis report presents two cases of globulomaxillary cyst at our hospital.
Case 1. This case was a 22 year old Japanese female who visited our hospital on February 18, 1982. She complained of unusual sensitivity in upper left side lateral incisor area. The upper left side lateral incisor with resin filling showed non-vital pulp, the upper left side canine was vital. Labial and palatal mucosa of their apical part showed no abnormal swelling nor redness, though the area was severely painful. The root distance between the upper left side lateral incisor and canine was expanded, as seen in radiograph. Using a local anesthesia, the cyst was surgically removed; part of the cyst wall contacted with the sinus mucosa. The cyst contained a light, yellow colored serous fluid.
Microscopic examination revealed cystic lining with stratified columner and cuboidal epithelium with scattered squamous epithelium. The wall of the cyst was infiltrated with chronic inflamatory cells. Case 2. A 50 year old Japanese male visited our hospital on October, 16, 1975. He complained of labial gingival swelling of upper left side, central and lateral incisor apical part. The upper left side central, lateral incisor and canine were vital. The cyst was the tip of thumb size, recognized clearly under the upper left side central and lateral incisor apical part in radiograph. Using a local anesthesia, the cyst was surgically removeed. The cyst contained yellow colored serous fluid. Microscopic examination revealed cystic lining with cuboidal epithelium. The loose connective tissue with few infiltrated cells was seen in subepithelial region. In addition to these two cases, we analyzed 62 cases in the existing Japanese literatures (1939-1983).View full abstractDownload PDF (4323K) -
Hiroshi YAMASAKI, Haruhiko MIYAKO1986 Volume 32 Issue 1 Pages 87-91
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSAngiomyomas are commonly observed in the skin, especially in the subcutaneous region of the lower extremities. But in the oral cavity, these tumors are rare due to the paucity of smooth muscle. Most oral angiomyomas are believed to be derived from vascular smooth muscle.
In this paper, a rare case of angiomyoma of the buccal mucosa is presented and the literature reviewed.View full abstractDownload PDF (6912K) -
A multi-clinic studyShojiro TAKAHASHI, Chikara SATTO, Hitoshi OHHATA, Noboru SONOYAMA, Hit ...1986 Volume 32 Issue 1 Pages 92-107
Published: January 20, 1986
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSClinical evaluation of ceramic hydroxylapatite (Alveograf ®) in oral and maxillofacial region was investigated by multi-clinic, with the results as follows
1. In this investigation, 176 patients with resorbed alveolar ridges (36 cases), cysts in maxillary and mandibular bone (104 cases), and tooth extraction socket (36 cases) were treated with this matrial, and were recorded on protocol.
2. Inflamation was of the same degree as universal wound after operation.
3. Following the operation, no immune reaction was noted.
4. The secondary surgical treatment (27 cases, 15.7%) showed good progress.
5. Prosthodontic treatment after operation was 15 cases (Resorbed alveolar ridges; 13 cases, Cyst; 1 case, Tooth extraction socket; 1 case), especially resorbed alveolar ridges was very useful.
6. As a result, the following evaluations were obtained; markedly useful and moderately useful 156 cases (90. 3%).
7. In conclusion, (Alveograf) is considered one of the most useful implants insist of bone, in oral and maxillofacial region.View full abstractDownload PDF (9961K)
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