Granulocytic sarcoma (GS) is a localized infiltrate of immature granulocytes in an extramedullary site. This lesion is most frequently associated with leukemia, but can occur with other myeloproliferative disorders. We report an unusual case of GS of the gingiva and skin associated with acute myelogenous leukemia.
A 32-year-old man was referred to our department because of bilateral swelling of the cervical lymph nodes and gingiva accompanied by general fatigue and body weight loss. He also had a rash on the right side of the neck and right lower leg.
Blood tests showed a high leukocyte count (21,370/μL), and bone marrow examination revealed acute myelogenous leukemia (French-American-British classification, M5b). We performed biopsies of the gingiva and skin lesion, and histological examination of the surgical specimen demonstrated GS.
Systemic chemotherapy was initiated, and complete remission was successfully induced. The lesions of the cervical lymph nodes, gingiva, and skin disappeared after chemotherapy.
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