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Tetsuro ISHIGAMI
1990 Volume 36 Issue 1 Pages
1-20
Published: January 20, 1990
Released on J-STAGE: July 25, 2011
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VX2 carcinoma cells were transplanted onto rabbit tongues to investigate the nature of tumor blood vessels and the effect of anticancer agents on VX2 carcinoma.
Ultrastructural observations, microangiography, and injection replica scanning electron microscopy were performed. Blcomycin (3 mg/kg/day) was given by intravenous injection daily for 15 days.
The results obtained were as follows:
1. The structure of the newly formed tumor blood vessels was different from that of normal vessels.
2. Ultrastructurally, normal blood vessels in the tongue were of a continuous type. On the other hand, fenestration and endothelial discontinuity (gaps) were observed in the tumor blood vessels. Investigation of the vascular resin cast showed that buds arose from host vessels, which then fused to form cross connections and ultimately intricate networks.
3. Application of Bleomycin had remarkable effects on the vessels. Ultratructurally, Bleomycin caused endothelial discontinuities to be enlarged markedly. Protrution of the cytoplasm, degenerative changes of the endothelium, multilayering of the basement membrane were also observed. Microangiographically, destruction and disappearance of vessels, fragmented vascularity, and narrowed vessels were found. Vascular resin casts revealed surface irregularity and intricate network decrease.
4. These results were interpreted to indicate that this anticancer agent damages the vascular system. This obstruction has harmful influence on the localized circulation within the carcinoma.
This harmful effect seemed to be an important factor for controling tumors in the clinical practice.
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Yoshihiro SAITO
1990 Volume 36 Issue 1 Pages
21-36
Published: January 20, 1990
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The effect of implant of single or composite materials on the back subcutaneous tissue and jaw bone defect was studied experimentally in rabbits. The materials used were autogenous bone marrow (BM), hydroxylapatite particles (HA), allogenic demineralized bone (DB), BM+HA, BM+DB and HA H-DB. After implantation of these materials, histologic findings were studied at various intervals, with particular attention to new bone formation and its remodeling. The results were as follows:
1. Subcutaneous implants: Ectopic ossification was induced in BM group, and the newly formed bone showed finally so-called ossicle. Bone formation was not seen in any HA group animals throughout the experimental period. Cartilage with ossification could be seen in and around DB fragments of DB group. Trabecular bone surrounding HA particles was formed in BM+HA group, but bone marrow-like spaces could not be found. Prominent bone and cartilage formations were induced in BM+DB group. In HA+DB group, multinucleate giant cells were observed in close contact with HA particles and DB fragments, however, no bone formation was seen in any animals.
2. Implants in jaw bone defect: Prominent bone formation and its remodeling were seen in BM group, showing finally repaired jaw bone defect by cortical bone and trabecular bone. Trabecular bone surrounding HA particles was formed near the margin of the jaw bone defect in HA group, but its complete remodeling was not seen. Ossification with fibrous bone formation and cartilage formation were seen and the jaw bone defect was finally replaced with new bone in DB group. The jaw bone defect was filled with trabecular bone surrounding HA particles but bone marrow-like structure was not formed in BM+HA group. In BM+DB group, prominent bone formation and its remodeling were seen and the jaw bone defect was finally repaired by cortical bone and trabecular bone. The jaw bone defect was finally filled with trabecular bone surrounding HA particles in HAH-DB group, though the remodeling of jaw bone defect was slower somewhat than that in BM+HA or BM+DB group. The results of the present study suggest that composite implant materials consisting of DB and other substances such as BM or HA are most suitable for reconstrtlcting jaw bone defects.
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Jen Li LAI
1990 Volume 36 Issue 1 Pages
37-49
Published: January 20, 1990
Released on J-STAGE: July 25, 2011
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The author attempted to elucidate the sensory recognition process in the oral and maxillofacial area through ERP during implementation of a 100% random stimulation, rightleft discriminatory response task and a strength discriminatory response task by using a painful electric stimulus applied on the upper lip. As a result, the following conclusions were obtained:
1. Irrespective of the strength of the stimulus and the nature of the task, five common major components consisting of N 65, p100, N 140, P 300 and N 400 were noted.
2. An ERP in the implementation of a discriminatory response task of painful stimulus revealed the presence of a positive component at 250 msec through 350 msec not only in the target stimulus input but also in the regular stimulus input, thereby showing a characteristic different from that ensuring a non-invasive stimulus. It was suggested that the current P 300 ensuring a painful stimulus reflects not only the renewal of recognition content appearing independent of the mode of stimulus as does conventional P 300 but also the evaluation of the situation including recognition of pain and empirical check of the past events.
3. The reaction time in the implementation of each task was proportional to the degree of difficulty of the task, and tended to be prolonged by a multiple of the radix of 60 msec.
4. p100 and N 140 represented electric potential changes occurring in the disposal process of selective attention, and were components corresponding to stimulus-set attention. Furthermore, they seemed to be components corresponding to response-set attention differentiating the target stimulus between N 2 and P 300, checking and differentiating OR from intrinsic memory, evaluating the task relevance and making a decision of the task to be carried out.
The intrinsic positive component near 700 msec noted in the waveform, obtained by subtracting the reference stimulus input ERP from the target stimulus input ERP during the strength discriminating task seemed to be a component corresponding to perceptomotor sequelae to reconfirm a response after implementation of the task.
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Tomoyuki ISHII, Takeshi HARADA, Yasuharu TAKENOSHITA, Masuichiro OKA
1990 Volume 36 Issue 1 Pages
50-55
Published: January 20, 1990
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Thirty adults diagnosed having oral lichen planus were studied in order to compare clinicopathological variants with the density and distribution of immunocompetent cells in oral lichen planus. It is generally accepted that the immunohistological findings of lichen planus are similar to those of lymphokine-generated inflammation. However, the oral lesions of lichen planus demonstrate rather marked variations in clinical appearance as well as in microscopic pathological staging.
In the present study, an attempt is made to subdivide all specimens into various clinicopathological categories (a. site of biopsy b. suffering period clinical type d. degree of epithelial atrophy e. degree of basal cell damage f. density of infiltrating mononuclear cells), and to analyze the correlation with the density and distribution of T cell subsets, ANAE+macrophages, and Langerhans cells.
1. There was no correlation of the density of any immunocompetent cells with both site of biopsy and age of the lesion.
2. In reticular lichen planus, Leu 2 a+ T cells (cytotoxic/suppressor T cells) were concentrated within and beneath the epithelium. On the other hand, the erosive forms of the lesion showed Leu 3 a/3 b + T cells (helper/inducer T cells) densely distributed throughout the stratum proprium.
3. There was no significant correlation between severity of basal cell damage and frequency of Leu 4+ T cell (pan T cell), but the density of Leu 2 a+ T cell infiltration was higher in “moderate/marked” than in “mild” basal cell damage.
4. This study revealed no correlation between the density of HLA-DR/DQ+ and T 6+cells and any clinicopathological variants. More data is needed before providing a solid conclusion.
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Yasuhiro SAKAMOTO
1990 Volume 36 Issue 1 Pages
56-71
Published: January 20, 1990
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The present study was designed to examine the antitumor effect of hyperthermia alone in relation to the histopathological changes. Rabbit VX2 carcinoma was used in this study. Microwave hyperthermia (2, 450 MHz) was carried out at 41°C, 43°Cand 45°Cfor a 30-minute period. Measurement of temperature was obtained by thermister at the tumor center. The antitumor effect was determined by comparing the growth curve of VX2 carcinoma which was obtained by tumor volume calculated from tumor width after heating. Tumor angiography was performed immediately and 3, 24 and 72 hours after heating and the same specimens were observed histopathologically using Hematoxilin-Eosin stained sections.
Consequently the antitumor effect was observed in the groups heated at 43°C and 45°C. In particular, the 45°C heated group showed a predominant antitumor effect. In the 41°C heated group, no antitumor effect was observed. With regard to tumor growth rate, it was relatively delayed in the 45°C heated group as compared to the 43°C heated group. In the 43°C and 45°C heated groups, tumor mitosis increased 72 hours after heating. Therefore, it was considered that recovery from damage tended to be later at higher temperatures. The histopathological changes of tumor cells after heating included pycnosis, karyorrhexis, karyolysis and eosinophilic degeneration and these changes tended to be remarkable in the tumor center rather than periphery. Tumor vessel damages showed thrombosis and dilatation of the vascular wall due to fibrin deposit. In the 45°C heated group, irreversible fibrinoid degeneration was additionaly observed. Though tumor vessel damage tended to continue as the temperature ascended, these changes were considered reversible because the contrast medium started flowing into these injured vessels with the passage of time. In the 45°C treated group, damage was observed in parts of normal vessels, therefore, the hyperthermic approach as considered to affect normal tissues at higher temperatures.
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Youichi SAITO
1990 Volume 36 Issue 1 Pages
72-87
Published: January 20, 1990
Released on J-STAGE: July 25, 2011
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In order to investigate the potential role of the cell-mediated immune system in jaw cysts, the presence and distribution of T-zone histiocytes (Langerhans cells and indeterminate cells) were studied immunohistochemically using antisera to S-100 protein in the walls of six different groups of jaw cysts in relation to the degree of inflammatory cell infiltration (macrophages, MT-1 positive lymphocytes, MB-1 positive lymphocytes, plasma cells and neutrophils) and the thickness and type of covering epithelium. Materials consisted of 42 radicular cysts, 19 odontogenic keratocysts, 9 dentigerous cysts, 8 postoperative maxillary cysts, 7 nasopalatine duct cysts and 7 cysts of unknown diagnosis. Twenty samples of oral mucosa served as control.
In contrast to 95% in the control oral mucosa, intraepithelial T-zone histiocytes were found in only 37% of 75 cysts having epithelial lining. The value in the supporting connective tissue was 74% and T-zone histiocytes were found more often in cysts with inflammatory cell infiltration. The mean numbers of T-zone histiocytes in a given field of the connective tissue for radicular cysts, odontogenic keratocysts, dentigerous cysts, postoperative maxillary cysts, nasopalatine duct cysts, cysts of unknown diagnosis and oral mucosa were 1.2, 1.2, 4.9, 0.2, 1.3, 2.6 and 2.5, respectively. A tendency to decreased T-zone histiocytes was observed in radicular cysts with little to very mild or severe inflammatory cell infiltration, but like in oral mucosa, the number in the odontogenic keratocyst-dentigerous cyst group was related to that of inflammatory cells, whereas there was no such correlation in the postoperative maxillary cyst-nasopalatine duct cyst group. A significant correlation was also observed between the number of T-zone histiocytes and the thickness of the covering epithelium in all cysts but those of unknown diagnosis. In addition to the thickness of covering epithelium, MT-1 and MB-1 positive lymphocytes were the factors related to the number of T-zone histiocytes in radicular cysts and odontogenic keratocyst-dentigerous cyst group in the multiple regression analysis.
In conclusion, T-zone histiocytes were found to be contributing in the induction of immune response in the presence of adequate inflammation except when it is too mild or too severe to cause extensive damage of cyst wall tissues. However, further study is needed to clarify their contribution in cysts with epithelial lining of respiratory origin.
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I. Comparison of the muscle-related proteins between the masticatory and tongue muscles to the fast and slow muscles in the leg
Hidenori MATSUSHITA, Moriyasu ADACHI, Kazuhisa NAKAYAMA, Yuuji KAMIYA, ...
1990 Volume 36 Issue 1 Pages
88-93
Published: January 20, 1990
Released on J-STAGE: July 25, 2011
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The concentrations of the muscle-related proteins (β-enolase, S-100 a
0 and creatine kinase of M and B type) were measured in the rat masticatory (masseter, temporalis, digastric) and tongue muscles and compared with those in the ext ensor digitorum longus (EDL) and soleus (SOL) muscle. Which proteins can be a useful marker of the muscles in the oral region was explored.
The results obtained were as follows:
1. The CKB concentration in the tongue muscles was markedly high compared to theother muscles. The β-enolase concentration was as low as in the SOL, a slow muscle.
2. The concentrations of the proteins in masseter, temporalis, digastric muscles were quite similar. The CKNI concentration was comparable to the EDL, a fast muscle. The S-100 a
0 concentration was lowest among the muscles studied. The concentration of β-enolase was intermediate between SOL and EDL muscles. The CKB concentration was comparable tothat of the EDL muscles.
It is concluded that the CKB and, 3-enolase are good markers for the tongue, while the CKNI and S-100 a
0 for the masticatory muscles.
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Mitsuhiro NAKAZAWA, Tomoji MORIYAMA, Motohiro TSUJINO, Masayoshi SAKUD ...
1990 Volume 36 Issue 1 Pages
94-100
Published: January 20, 1990
Released on J-STAGE: July 25, 2011
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The effectiveness and safety of UFT as adjuvant chemotherapy were examined in comparison with historical control group in which any kind of adjuvant chemotherapy was not carried. UFT therapy was carried out in 25 oral cancer patiets after primary treatment. UFT was administered orally at a daily dose of 300mg. The average period was 575. 3 days and average dose was 185. 2g.
The 3-year survival rate was 94.4% in the UFT group and 82.6% in the control group. The 3-year disease-free rate was 88.0% in the UFT group and 68.0% in the control group. When the object of analysis was restricted to stage II-IV, the 3-year disease-free rate was 90.5% in the UFT group and 61.9% in the control group (p<0.05, Cox-Mantel test).
Side effects were observed in 9 cases (36.0%), mainly digestive tract symptoms, liver dysfunction and bone marrow suppression. These were generally mild and only in 2 cases was administration of UFT stopped due to side effects.
It is suggested that UFT may be administered to oral cancer patients usefully and safely. However, a further randomized controlled study is necessary to confirm these findings.
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results of long-term observation
Keigo KUDO, Ryo KANOH, Kenichi SATOH, Hitoshi SATOH, Hidenori TAKAHASH ...
1990 Volume 36 Issue 1 Pages
101-105
Published: January 20, 1990
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Reconstruction using deltopectoral flaps was performed in 21 oromaxillo-facial defects after resection of 20 malignant tumors and 1 osteomyelitis of the mandible in the Dental Clinic of Iwate Medical University during the 12 year period from 1978 to 1989. The majority of reconstructions were immediately performed in the lower oro-facial defects and secondary achieved after delay in the upper cheek defects.
In 20 patients with malignant tumors an accumulative survival rate from 5 to 10 years was 47.8 percent. The survival rate was superior as 66.7 percent in 8 primary patients compared to 34.6 percent in 12 secondary ones. Among the 20 patiens with malignant tumors 3 cases died of local tumors and 5 cases of distal metastases. Coloring between the skin flap and the surrounding tissue became suitable during the 2 to 3 years period after reconstructions. Aged patients especially, were satisfied with results of their reconstructive surgery.
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Masaaki Tsuji, Michihiko ENOMOTO, Munetaka ARAO, Shuhei MATSUMOTO, Yuj ...
1990 Volume 36 Issue 1 Pages
106-111
Published: January 20, 1990
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A 1-year-old girl with trisomy 18 complicated with cleft lip and palate is reported. Trisomy 18 is the most common abnormal autosomal syndrome and has many clinical features. This syndrome has bad prognosis and 90% afflicted will die within one year of onset.
Deformity anomaly of the oral cavity encountered in this syndrome includes micrognathia, high archedpalate, cleft lip and cleft palate. The incidence of cleft lip and palate is said to be 10 to 50% of the patients. We performed a lip-palsty by Millard method for restoring bilateral cleft lip in this patient.
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Kazuhisa NAKAYAMA, Masahiko FUKAYA, Hiroyuki IWATA, Hiroshi INAMOTO, Y ...
1990 Volume 36 Issue 1 Pages
112-118
Published: January 20, 1990
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Acupuncture therapy was performed in patients with sensory paralysis of the lower lip following sagittal split osteotomy of the mandibular ramus.
The degree of improvement in relation to the kind of serception and the usefulness of acupuncture therapy were examined with the following results.
1) Sensory paralysis had various patterns of appearance according to the kind of perception.
2) Recovery from paralysis in relation to the kind of serception showed an almost similar tendency though, some difference was observed in its range (area). Diminution of the area was about 50 and 30% after 2 and 3 weeks, respectively.
3) Only slight paralytic sensation presisted with interview in 5 (41) and 3 patients (25%) of the treated group after 6 months and 1 year, respectively, while 8 (57) and 7 patients (50%) of the non-treated group (14 cases) had more or less residual paralytic sensation after 6 months and 1 year, respectively.
Acupuncture therapy was proved to be clinically useful for postoperative paralysis.
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Takahiro YAMAGATA, Masaharu MITSUGI, Motohiro KIMURA, Hiroshi ITO
1990 Volume 36 Issue 1 Pages
119-123
Published: January 20, 1990
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A case of myxofibroma involving the mandibular molar-ramus area in a 45-yearold male, under anti-coagulant therapy because of previous mitral valve replacement, is presented. Resection and reconstruction of the mandible were performed together with inferior alveolar nerve preservation. Regulation of the blood coagulation activiy was required through the period before and after surgery. The patient has been well and free of disease for more than 2. 5 years since the operation.
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Etsuko OKUMORI, Chinatsu IBUKI, Yuichi SASAKURA, Akira KOSE, Minoru KO ...
1990 Volume 36 Issue 1 Pages
124-129
Published: January 20, 1990
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This report includes a case of buccal tuberculosis on a 20 year-old male, who complained the swelling of the right cheek after mandibular molar tooth extraction.
At the first examination we diagnosed this case as purulent mandibular ostitis. Upon administration of ampicillin for ten days, the swelling impoved. Histopathological examination showed tuberculosis features, and then we found pulmonary tuberculosis lesion in the chest X-ray.
The patient was carried to the internal department of Yokohama Minami Hospital. After chemotherapies of rifampicin, INAH and ethanbutol for two months, the buccal lesion disappeared. However three months more was required for plumonary focus therapy.
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Hiroyasu TAMAKI, Takako KITAJIMA, Hiroki YAMADA, Makoto YAMBE, Kazuhis ...
1990 Volume 36 Issue 1 Pages
130-137
Published: January 20, 1990
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We encountered and reported a case of congenital tongue mass that developed on the dorsum of the tongue in a boy aged 1 and a half months. Histologically, it was a tissue malformation involving tissues such as smooth muscle, striated muscle, lymphatic vessels, blood vessels and salivary glands. So, diagnosis of heterotopic tissue was made. Congenital tongue mass has been reported as tongue anomaly, hamartoma, leiomyoma or benign mesenchymoma in literature, there being no unity in terminology. Many of the cases reported concern small pedunculated masses that developed on the dorsum of the tongue, and cases diagnosed as having hamartoma predominated. These tongue masses are diagnosed as tissue malformation histologically and somewhat different from true tumors in many cases. Hamartoma has a character intermediate between true tumors and malformations. Primarily it shows the structure deemed as overgrowth of tissue elements at the site of development, being applied to a relatively wide range of lesions. Accordingly, the term hamartoma is not appropriate for diagnosis of small masses of the tongue having heterotopic tissue. Benign mesenchymoma may fall under the category of hamartoma. However, it is one that stresses the concept of tumor and moreover, it is aimed at lesions which lack epithelial elements and in which several kinds mesenchymal elements are admixed. In contrast, congenital tongue masses contained epithelial elements such as salivary glands in many reported cases. Therefore, the term benign mesenchymoma is not preferable in the diagnosis of congenital tague mass. Leiomyoma is also tumor, and encapsulation is noted in many of the cases reported. However, the presence of capsules is not observed at all in the reported cases of congenital tongue mass, so far as the cases mentioned are concerned. So, dealing with congenital tongue mass regarded as tissue malformation as tumor is open to question. At present, there is no evidence that tissue malformation is of one stage of differentiation of tumor. So, tissue malformation needs to be strictly differentiated from tumor.
As to a mass that is histologically regarded as tissue malformation, therefore, it would be preferable to refrain from using such a term that may be confuses with “tumor”.
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Takafumi MURAYAMA, Shinji SARUTA, Shin-ichirou AYA, Reiko IWATSUBO
1990 Volume 36 Issue 1 Pages
138-142
Published: January 20, 1990
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According to the FAB classification, refractory anemia with excess of blasts (RAEB) is a subtype of myelodysplastic syndrome (MDS) and a preleukemic condition that is often transformed into acute myelogenous leukemia (AML).
We encountered a patient with RAEB who complained of oral symptoms. The patient, a 52-year-old male, visited our hospital due to swelling of the lower jaw on the right side. After treatment such as tooth extraction and incision, poor healing of the extraction cavity was observed. Based on the results of close examination, a diagnosis of RAEB was made. The condition progressed to AML after 9 months.
It seems to be important that oral symptoms were the initial symptoms that led to the diagnosis of RAEB in this patient.
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Toshirou KONDOH, Masaaki HORINAKA, Makoto NAKAMURA, Nobuyuki TANAKA, Y ...
1990 Volume 36 Issue 1 Pages
143-147
Published: January 20, 1990
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1) Motorized power instruments (Microdebrider-Small Joint Microelectric Arthroplasty System) were applied to arthroscopic lysis and lavage operation in 2 cases of temporomandibular joint internal derangement.
2) We evaluated the safety and efficiency of these instruments in temporomandibular joint arthroscopic surgery.
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Hitoshi KAMATA, Makoto SARAYA, Shin-ichro KOBAYASHI, Yuji OGAWA, Kirih ...
1990 Volume 36 Issue 1 Pages
148-153
Published: January 20, 1990
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May-Hegglin anomaly is a disease characterized by thrombopenia, giant bigarre blood platelets and Döhle like inclusion bodies in the polymorphonuclear leucocytes. We recently experienced a case of May-Hegglin anomaly for whom whole teeth extractions and gingivoectomy were performed. The patient, a 33-year-old female, visited our hospital with main complaint of gingival proliferation. Hematological examination on the peripheral blood performed before operation showed that her platelet count was 4.3×10
4/μ
l. Fresh frozen plasma was transfused under the diagnosis of I. T. P. and the operation was then performed with favorable prognosis.
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Akihiro KANEKAWA, Toshiaki KAMEI
1990 Volume 36 Issue 1 Pages
154-156
Published: January 20, 1990
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A 54 year-old-female came to the department, with complaints of rapid growing tumor of the anterior lower gingiva. The patient had a tumor in the right lower lobe of the lung, which was diagnosed as carcinoma by cytodiagnosis. Resection of the gingival tumor was performed. The lesion was diagnosed pathologically as a large cell carcinoma arising from lung tissue. This paper reported a case of gingival metastasis from lung carcinoma with a review of literature.
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Shigeru UENO, Akira MATSUO, Ryuichi KAJI, Kozo MUSHIMOTO, Rikiya SHIRA ...
1990 Volume 36 Issue 1 Pages
157-161
Published: January 20, 1990
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A histologically uncommon case of adenoid cystic carcinoma which arose in the maxillary sinus in a 43 year-old male was reported. The tumor mainly consisted of solid cell nests histologically resembling those of basal cell carcinoma. Neoplastic nests with cribriform or tubular pattern were also found adjacent to these solid nests. Marked squamous metaplasia with formation of many cancer pearls was often observed in these solid nests showing a basaloid pattern. Although the tumor had extended to the skull base, the patient survived for 4 years after surgery combined with intraarterial injection of ADR and CDDP and
60Co irradiation.
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Kojiro ONIZAWA, Hiroshi FUKUDA, Kazuo NEMOTO
1990 Volume 36 Issue 1 Pages
162-165
Published: January 20, 1990
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A case of a sagittal fracture of mandibular condylar head was reported and its causative mechanism and clinical management were discussed.
A 62 year old man was referred to our hospital because of limitation of mouth opening. He had been injured in a traffic accident 10 days previously. Radiographic examination revealed that left mandibular condyle was sagittally fractured and the medial part of the condylar head dislocated anteromedially. Because this medial part of condylar head was suspected to disturb the movement of the residual condyle at mouth opening, the dislocated medial part was surgically removed and arthroplasty was performed. Postoperative course was not eventful, but limitation of mouth opening in the morning continued until he acquired a stable occlusion with a new denture.
From these observations, it was strongly suggested that dental occlusion reconstruction was essential for treatment of this type of fracture.
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Yoshihiro ABIKO, Hironori HAMANO, Sadamitsu HASHIMOTO, Takashi INOUE, ...
1990 Volume 36 Issue 1 Pages
166-171
Published: January 20, 1990
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Carcinoma in pleomorphic adenoma is a relatively rare lesion, and a case of which is reported in this article.
A 52-year-old man had become aware of painless swelling in the right parotid gland about 15 years before. Because the swelling became larger, the patient was admitted to Tokyo Dental College Ichikawa Hospital. The Surgically removed tumor was examined using a light microscope and immunohistochemistry. Light microscopically, the tumor revealed that atypical epithelial cells infiltratively proliferated in the fibrous connective tissue, part of which had mucous degeneration. The immunohistochemical study suggested that EMA was useful as an diagnosis of carcinoma in pleomorphic adenoma.
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Ryoji MATSUURA, Yasuro YOSHIMURA, Kazunori UEKI, Shiro FUKUMOTO
1990 Volume 36 Issue 1 Pages
172-176
Published: January 20, 1990
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This paper described a case of drug induced colitis with maxillary sinus cancer in the follow-up period.
A 45-year-old male with left maxillary sinus cancer (T4N0M0) was treated by surgical interventions (extirpation of metastatic lymph nodes; radical neck dissection), cryotherapy, radiation therapy with and without 5-FU administration from superficial temporal artery, hyperthermia, and chemotherapy (Cisplatin, Peplomycin and Vincristine). Furthermore, oral administration of UFT and intradermal injection of OK-432 were also carried out.
He complained of fever and severe diarrhea in the follow-up period after the above treatments and was diagnosed as drug-induced colitis. OK-432 was suspected to be a causative of the drug induced colitis by lymphocyte stimulation test (LST) and tar stool appeared after accidental readministration of the ctrug.
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Masaru HATTORI, Yoshiki TAKAI, Toshiyasu YAMASHITA, Hidenori MATSUSHIT ...
1990 Volume 36 Issue 1 Pages
177-183
Published: January 20, 1990
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In this long term follow-up report, we presented a case of fibrous dysplasia of the left maxillo-facial region in a 4 year-old girl. The operation was performed 4 times (1st-Jun, 20, 1978. 2nd-Aug, 5, 1981. 3 rd-Jul, 28, 1986. 4 th-Aug, 3, 1988.) within the observation of 11 years follow-up.
In the peak of her school age growth, the elevation of serum alkaline phosphatase and remarkable transformation of maxillo-facial region were observed.
1 year has passed since the 4 th operation and the prognosis is favorable without any relapse tendency. However, from the nature of this disease we don't judge this case cured, it needs observation until adulthood is attained.
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Hiroyuki IWATA, Manabu MIHARA, Sanae MAEDA, Kazuhisa TANGE
1990 Volume 36 Issue 1 Pages
184-191
Published: January 20, 1990
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A clinical study of impenern/clastatin soditaum (IPM/CS Tienam
®, ) was performed in various infections in the field of oral and maxillofacial surgery. Tienam was adminstered by intravenous drip infusion at a daily dose of lg (0.5g×2 times) to 40 patients with various infections.
The subjects consisted of 34 maxillary ostitis, 2 phlegmon of the floor of the mouth, 2 parotitis, acute odontogenic maxillary sinusitis and 1 buccal abscess.
The following results were obtained. The subjective evaluation was excellent in 23 cases, good in 21 cases and poor in 1 case.
The scoring evaluation according to the scale proposed by Japanese Society of Oral Therapeutics and Pharmacology were excellent in 18 cases, good in 21 cases and poor in 1.
The effective rate was 97.5% is both subjective and scoring evaluations. We examined bacteriological MIC of IPM/CS, TAPC, CCL, BAPC, AMPC, PIPC and OFLX.
As a result, IPM/CS showed most favorable MIC data (90.3%) of all and there were no side effects.
The laboratory values shifted favorably with time elapsed.
The results indicated the usefulness of IPM/CS in the treatment of various infections in the field of oral surgery.
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Takafumi OGURA, Masahiro URADE, Kazuya WATATANI, Masaru SUGIYAMA, Hide ...
1990 Volume 36 Issue 1 Pages
192-198
Published: January 20, 1990
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In an attempt to prevent bad breath produced from the gauze tamponade applied to the postoperative defect of maxillary cancer, the effect of topically by used clindamycin (CLDM) was evaluated by olfactory judgement and microbiological analysis in eight patients with bad breath. When a gauze tamponade containing azulene ointment and CLDM (120μg/g azulene) was applied, the bad odor was markedly improved or disappearedin all cases one week later. Concomitant with the improvement of bad breath, anaerobic microorganisms such as Bacteroides and Peptostreptococcus, which are considered to be involved in bad odor, also became undetectable. In addition, other gauze tamponades containing azulene ointment only, povidone iodine gel and oxytetracycline hydrochloride ointment were examined for their preventive effect on bad odor in one or two patients. Azulene ointment only and oxytetracycline hydrochloride ointment were ineffective or less effective on both bad ordor and bacterial growth, and povidone iodine gel showed adverse reactions such as bitterness, dryness of the mouth and mucosal irritation though the bad odor and bacterial growth were both inhibited.
From these results, it was indicated that topical use of CLDM is very useful for prevention of bad odor of gauze tamponades in postoperative maxillary cancer patients.
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