Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 43, Issue 8
Displaying 1-12 of 12 articles from this issue
  • Mayumi FUKUDA
    1997 Volume 43 Issue 8 Pages 581-589
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    In cartilage, β 1 integrins are considered to be adhesion molecules of extracellular matrix (ECM) components, such as type II collagen and fibronectin (FN). However, which β 1 integrin (s) is present in cartilaginous tissue and acts as a receptor of chondrocytes for type II collagen or FN has not been fully clarified. This study was designed to examine the localization of β 1 integrins (α 2 β 1, α 3 β 1, α 4 β 1, and α 5 β 1 integrin) in a transplanted cartilaginous tumor derived from a human osteogenic sarcoma of the mandible. The transplanted tumor grows in a multilobular manner and shows chondrogenic differentiation 3 months after transplantation into the nude mouse. Type II collagen, a specific marker of cartilage, and FN appear in the tumor lobules. Thus, the tumor serves as a useful model for study.
    The localization of β 1 integrins, type I collagen, type II collagen, and FN was studied immunohistochemically using frozen sections of the tumor. The results revealed that all β 1 integrins were expressed in this tumor. Strong staining for each integrin was observed in the marginal region of the tumor lobules, where type I collagen was predominantly localized. In the middle region, where type II collagen was chiefly found along with chondrocytic cells, these integrins were also expressed, but to a lesser extent. In the central region, where hypertrophic chondrocytic cells and calcification were found, the localization of these integrins, except for α 5 β 1 integrin, could not be confirmed because of the presence of nonspecific positive staining. The staining pattern was not so different for each integrin. The distribution of α 5 β 1 integrin was similar to that of FN.
    The results indicate that β 1 integrins may participate in ECM formation with type I collagen, type II collagen, and FN, and that the expression of β 1 integrins may be reduced as the transplanted tumor undergoes chondrogenic differentiation. The β 1 integrin (s) responsible for type II collagen receptor was not clarified in this study.
    Download PDF (13020K)
  • Yukoh MURAKI, Chihiro YOSHIOKA, Akira TATEISHI, Jin-ichi FUKUDA, Tatsu ...
    1997 Volume 43 Issue 8 Pages 590-595
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Fas antigen is a cell surface glycoprotein that mediates apoptosis from the cell surface into the cytoplasm. A monospecific and high titer polyclonal antibody, designated as Fas D, raised against a synthetic polypeptide selected from a part of the human Fas antigen (aa 104-114) was used to detect the Fas antigen in human oral squamous cell carcinoma (SCC). Biopsy specimens of oral SCCs obtained from 38 patients were prepared, and paraffin sections were stained with the FasD antibody using an indirect immunohistochemical method.
    Expression of Fas antigen was observed in 68% of the SCC cases examined. The mean age of the Fas-positive group (65.8 years old) was significantly higher than that of the Fasnegative group (55.8 years old). The specimens were also divided into well, moderately, and poorly differentiated grades according to histopathological criteria. Although the number of specimens examined was limited (24 cases) in the present study, 92% of the well differentiated SCCs stained for Fas antigen. In moderately differentiated SCCs, only 37% of the SCCs (4 out of 11) showed Fas-positive staining. No Fas-positive cells were detected in poorly differentiated SCCs although only three specimens were examined. It was found that the production of Fas antigen was related to the degree of tumor differentiation. No relationship was noted between Fas antigen expression and tumor location, T categories of the TNM classification of the UICC (1987), and cervical lymph node metastasis.
    Furthermore, the clinical and pathological effects of chemotherapy in each case were evaluated with respect to the correlation with Fas antigen expression. There was a significant positive correlation between Fas antigen expression and the clinicopathological course after chemotherapy.
    Download PDF (4723K)
  • Akira TANAKA
    1997 Volume 43 Issue 8 Pages 596-609
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A trend toward an increased incidence of multiple primary cancers has been reported. This report is consistent with this trend and describes the results of an investigation of patients registered at our hospital. Seventy-two patients with multiple primary cancers (7.8% incidence) were identified among 927 patients with oral and maxillofacial cancers from January 1975 through December 1992.
    In the former period (1975 to 1983) and the latter period (1984 to 1992), multiple primary cancers accounted for 5.4% and 10.2% of all oral and maxillofacial cancers, respectively. As for tumor site, the socalled multicentric zone, which includes the oral cavity, pharynx, larynx, esophagus, and lung, accounted for 68.3%. Among 20 cases of synchronous occurrence, 9 subsequent cancers were detected in an early stage. However, among 26 cases of metachronous occurrence, 16 cases were in an advanced stage.
    Smoking tobacco, alcohol intake, and familial history were also investigated as risk factors for malignancy. A family history was present in 23 patients (31.9%), a smoking history in 47 patients (65.3%), and a drinking history in 37 patients (51.4%). The degrees of smoking and drinking were evaluated on the basis of Brinkman index and Sake index respectively. The mean Brinkman in the 72 patients was 486.7, and the Sake index was 56.4. The mean average of Brinkman index in the smokers was 745.5, and the Sake index was 109.7. A high Brinkman index score was related to cancers of the oral floor and, soft palate, and a high Sake index score to cancers of the soft palate and esophagus.
    Histologically, the incidence of squamous cell carcinoma was 65.2%, and coincident squamous cell carcinomas were found in 31 patients (43.1%).
    Download PDF (1732K)
  • Akihiko IIDA, Hideyuki HOSHINA, Hiroshi TSURUMAKI, Tatsuaki KOBAYASHI, ...
    1997 Volume 43 Issue 8 Pages 610-612
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A patient with advanced carcinoma of the mandible, extending to the tongue and oral floor, was treated by radio frequency (RF) capacitive hyperthermia using needle-type applicators in combination with irradiation and chemotherapy. Needle-type applicators (1 mm in diameter) made of stainless steel coated with gold were used. Multiple (6-8) applicators were inserted into the tumor in a parallel fashion at intervals of about 10 mm. An electric current was applied to the applicators and concentrated at the diffusion electrode. The tumor temperature was monitored with thermocouple sensors at three or four points. The power was controlled automatically to achieve a tumor temperature of 43°C. The tumor temperature was increased to about 43°C immediately after heating and remained at this level for about 40 minutes. Heat treatment in combination with 60Co irradiation (2 Gy/day, total 70Gy) was repeated six times. Chemotherapy (CDDP, 10mg) was given five of these times. After treatment, the tumor decreased in size, and oral dysfunction present before treatment, such as eating disorders and speech difficulty, resolved. Our results suggest that RF hyperthermia using needle-type applicators is effective in the treatment of oral cancers and does not produce heating spots on the surface of bone.
    Download PDF (3389K)
  • Mitsuru YAMA, Hiroyasu NOMA, Kiyohiro KASAHARA, Masaaki Kou, Gen-yuki ...
    1997 Volume 43 Issue 8 Pages 613-615
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A 49-year-old man was admitted to the First Department of oral and Maxillofacial Surgery, Tokyo Dental College Hospital, because of a painless swelling (19 × 22 × 10 mm) of the left side of the upper lip. Cytopathologically, the lesion was suspected to be a benigh salivary gland tumor. Under local anesthesia, the tumor, including the surrounding normal tissue, was resected. The histopathological diagnosis was carcinoma in pleomorphic adenoma, because most of the lesion showed a structure typical of pleomorphic adenoma and consisted of several sizes of duct-like cells. However, malignant epithelial cells were also found. There has been no evidence of recurrence as of 6 months after the operation.
    In this patient, the diagnosis of a salivary gland tumor was difficult, especially before the operation. The outcome suggested that resection including the surrounding normal tissue should be performed, even the lesion is suspected to be a benign tumor.
    Download PDF (3404K)
  • Norihiko NISHIMURA, Munehiro HAMAGUCHI, Munehiro TAKEDA, Takayosi SAKA ...
    1997 Volume 43 Issue 8 Pages 616-618
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We describe a 14-year-old boy with a mucoepidermoid carcinoma arising in the hard palate.
    He visited our clinic because of a swelling in the left side of the hard palate on May 16, 1995. A hard palate tumor was diagnosed because of a 25×30mm diffuse, painless swelling in the left side of the hard palate. A biopsy was performed, and the histopathological diagnosis was a mucoepidermoid carcinoma (well differentiated type). With the patient under general anesthesia, a partial maxillectomy was performed. There has been no evidence of recurrence or metastasis after the operation.
    In this patient, we performed immunohistochemical studies using MIB-1 antibody, which detects Ki-67 antigen. The MIB-1 positive index was 2% to 3%. The results indicated that the lesion was a low-grade malignancy.
    Download PDF (3317K)
  • Masato HAMADA, Ryoji ARIMA, Mitsuhiro KOMURA, Koji KASHIMA, SUMIO SAKO ...
    1997 Volume 43 Issue 8 Pages 619-621
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A rare case of carcinoembryonic antigen (CEA)-producing branchiogenic carcinoma is reported. A 56-year-old man was referred to our clinic, because of a painless swelling in the right side of the neck. A branchial cyst was diagnosed from the clinical and radiological findings. The serum CEA level at presentation was above the normal range. The cyst was removed surgically. Histological findings showed a well differentiated squamous cell carcinoma arising from the branchiogenic cyst wall. Radiotherapy and chemotherapy were given, followed by surgical treatment. A squamous cell carcinoma was recognized in the right platoglossal arch 10 months after the cystectomy. The tumor was resected surgically, and supurahyoid neck dissection was performed bilaterally. The patient has been well without recurrence for 6 years since the second operation. The serum CEA level fluctuated parallel to development of the tumors. Immunohistochemical findings showed that the branchial tumor cells exhibited CEA in the cytoplasm.
    Download PDF (6225K)
  • Kimio UCHIYAMA, Kazuyuki TSUNODA, Tomohiro OHWADA, Hiroshi IWABUCHI, K ...
    1997 Volume 43 Issue 8 Pages 622-624
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The KTP laser was developed for medical use in 1986. The wavelength is 532nm. The laser is a pure green light in the visible portion of the electromagnetic spectrum. This wavelength has unique characteristics when interacting with tissue, i. e., negligible absorption by water, high absorption by hemoglobin, and a relatively shallow depth of penetration. These characteristics make this laser wavelength ideal for hemostatic cutting and photo-coagulation.
    This paper describes 11 patients with 12 superficial hemangiomas at various sites. Five males and six females aged 13 to 85 years were treated with the KTP laser. The treated lesions were located at sites such as the lips, cheeks, gums, tongue, and floor of mouth. All lesions were superficial and ranged in size from 5 mm to 30mm.
    Treatment with the KTP laser resulted in significantly less bleeding and postoperative scarring than other treatment methods, such as surgical excision. Our experience shows that the KTP laser is a safe and effective tool for the treatment of superficial hemangioma.
    Download PDF (3390K)
  • Yasuaki SAKATA, Yasuhiro SAKAMOTO, Makoto NAKATSURU, Tsuyoshi TAKATO
    1997 Volume 43 Issue 8 Pages 625-627
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Most previous reports on neurilemmoma of the head and neck region describe a solitary tumor. Although most reports on multiple neurilemmoma considered these lesions to belong to von Recklinghausen disease, atypical cases of von Recklinghausen disease were also included in some reports. Recently, these multiple neurogenic tumors have been classfied into neurofibromatosis type 1 and 2 (NF 1, 2). NF 1 is considered as original von Recklinghausen disease, whereas NF 2 refers to atypical von Recklinghausen disease, which has been reported along with multiple neurilemmoma, including other neurogenic tumors. It is well known that NF 2 is distinguished from NF 1 both clinically and genetically. The clinical criteria for NF 1 and NF 2 have also been described. NF 2 is often associated with meningioma and neurilemmoma. The present case had both meningioma and neurilemmoma, which occurred at multiple sites, such as the tongue, mediastinum, and brain. Considering recent reports that the gene of atypical multiple neurilemmoma may be identical to that of NF 2, we regarded the present case to be NF 2.
    Download PDF (6813K)
  • Madoka INUI, Toshiro TAGAWA, Toshiyuki NAKAGAWA, Akira GOTO, Yuki KURI ...
    1997 Volume 43 Issue 8 Pages 628-630
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A case of mandibular myofibroma in a 11-month-old boy is described. Forty-six patients with maxillofacial myofibroma, including our case, have been reported since 1981. Among 42 patients, excluding 4 patients for whom age was not stated, 67% of the tumors occurred in those younger than 16 years old. We classified the patients into a pediatric patient group and an adult patient group, divided at 16 years old. Tumors arose in bone, including the mandible and temporal bone, in 71% of the pediatric patients, but in none of the adult patients. The mean tumor size in the pediatric patients was greater than that in the adult patients. Immunohistochemical staining was useful for establishing the diagnosis. Of the 32 cases for whom immunohistochemical findings were described, all were positive for α-smooth-muscle-actin and vimentin. However, all cases were negative for desmin and S-100 protein. No recurrence was reported among 20 patients for whom the outcome was described.
    Download PDF (4084K)
  • Kazuyuki OHASHI, Yoko AKASAKA, Kouichi MATSUMOTO, Yoshinori JINBU
    1997 Volume 43 Issue 8 Pages 631-633
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Epidermoid cysts are considered developmental anomalies, and the floor of the mouth is the most common site of these cysts in the head and neck region. We encountered two unusual cases of epidermoid cysts in the upper lip. One case was in a 27-year-old man who complained of a painless mass, which had developed slowly in the left portion of the upper lip. The mass was diagnosed to be a benign tumor and was surgically removed. Another case was in a 9-year-old girl who also complained of a painless mass in the right portion of the upper lip. The mass was also surgically removed. In both cases, epidermoid cysts were diagnosed on the basis of microscopic findings. A short review of the literature is included in this report.
    Download PDF (3939K)
  • Yoshihumi KOBAYASHI, Tadamitsu KAMEYAMA, Yoshiaki NAKAMURA, Shisei TOY ...
    1997 Volume 43 Issue 8 Pages 634-636
    Published: August 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A case of gas gangrene caused by Clostridium septicum in the neck is reported. The patient was a 62-year-old man who was repeatedly treated by excision and surgical debridment. Computed tomography (CT) was useful in monitoring the location and extension of gas bubbles.
    Download PDF (3267K)
feedback
Top