Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 43, Issue 7
Displaying 1-12 of 12 articles from this issue
  • Shyuji MATSUZAWA
    1997 Volume 43 Issue 7 Pages 521-531
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We studied the in vivo antitumor effects of interleukin-2 (IL-2) and interferon-β(IFN-β) in combination with chemotherapy on murine syngeneic transplantable squamous cell carcinoma, NR-S 1.
    Tumors were inoculated subcutaneously by injecting NR-S 1 cells into the back of 5-weekold female C 3 H/He mice. The tumor-bearing mice were divided into eight groups, and the following agents and anticancer drugs were administered:(1) control (saline), (2) IL-2+IFN-β, (3) bleomycin (BLM), (4) cyclophosphamide (CY), (5) cisplatinum (CDDP), (6) BLM+IL-2+IFN-β, (7) CY+IL-2+IFN-β, and (8) CDDP+IL-2+IFN-β.
    Intratumoral injections of saline or IL-2 +IFN-β and intraperitoneal injections of anticancer drugs were continued daily for 14 days. Treatment effects were estimated by measuring the tumor diameter and calculating the survival rate. Fourteen days after treatment, cytotoxic activities (against YAC-1, P815 and NR-S 1 cells) and their splenocyte phenotypes (Thy1.2, L 3 T 4, Lyt-2, and asialo-GM 1) were determined. The excised tumor tissues were also examined histologically.
    Although tumor size decreased slightly in the IL-2+IFN-β group, the reductions in size were significantly greater in each of the chemotherapy groups (p<0.05). Furthermore, the combination of chemotherapy and IL-2+IFN-β was much more effective in tumor reduction than the corresponding chemotherapy alone. Survival rate was significantly longer in all experimental groups except for the IL-2+IFN-β group. Tumors disappeared completely in two mice in the BLM+IL-2+IFN-β treatment group, which survived for more than 100 days. NK activity was significantly enhanced in mice treated with CDDP, BLM, or CDDP+IL-2+IFN-β. Although low LAK activity and cytotoxic activity against syngeneic NR-S 1 tumor cells were observed in the IL-2+IFN-β grove or the chemotherapy alone group, both of these activities were enhanced when these treatments were combined. Histological examinations disclosed remarkable infiltration of mononuclear cells and tumor necroses in the chemotherapy +IL-2+IFN-β groups. The infiltrated mononuclear cells predominantly expressed Mac-1 or asialo-GM 1 phenotype.
    These results suggest that the combination of systemic chemotherapy with local administration of IL-2+IFN-β is feasible for cancer therapy. Furthermore, NK cells may play an important role in both antitumor effect and the prolongation of survival.
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  • Yutaka IMAI, Tadaaki SASAKI, Hirotate IWASE, Setsuko ASAKURA, Takashi ...
    1997 Volume 43 Issue 7 Pages 532-540
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Twenty-seven primary oral and soft palate squamous cell carcinomas were examinedto classify the degree of malignancy according to the volume corrected mitotic (M/V) index, and the relationship between the degree of malignancy and outcome was studied. The following results were obtained:
    1.In terms of the relationship of the M/V index to the 5-year cumulative survival rate, group I (<10 mitoses/mm 2), group II (≥10 to <20), and group In (≥ 20) had a survival rate of 100.0%(P<0.001), 77.8%(P<0.05), and 25.0%, respectively. There was a significant negative correlation between survival rate and degree of malignancy.
    2.Tumor size (T) and regional lymph node metastasis (N) showed no significant correlation with M/V index.
    3.In terms of the relationship of M/V index to the degree of histological malignancy, there was a significant positive relation between M/V index and the degree of malignancy. With respect to tumor control, group M, with a high M/V index and a high histological malignancy grade, had a significantly higher recurrence rate than did group I, with a low M/V index and a low histological malignancy grade.
    4.The mode of invasion showed no significant correlation with the M/V index.
    5.Multivariate analysis with quantification method II, revealed that a combination of M/V index, histological malignancy grade, and N classification showed the highest predictive accuracy, and the M/V index was the most powerful factor among them for the prediction of outcome.
    The results indicate that the M/V index is very important in the prediction of outcome in patients with oral and soft palate squamous cell carcinomas.
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  • Tomoyuki OHUCHI, Yoshihiro ABIKO, Masato SAITOH, Jun KURAGUCHI, Michik ...
    1997 Volume 43 Issue 7 Pages 541-548
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Adenomatoid hyperplasia is an uncommon clinicopathological entity, which is a non-neoplastic, non-inflammatory enlargement of the minor mucous salivary glands. This lesion presents clinically as an asymptomatic tumor-like nodule that is characterized microscopically by a proliferation of minor salivary gland tissue. Very few reports of this lesion have appeared in the literature, and the proliferative activity of adenomatoid hyperplasias has not been studied previously.
    The number of argyrophilic nucleolar organizer regions (AgNOR) can be used to study the degree of cell proliferative activity. The mean number of AgNOR increased in a stepwise fashion from normal salivary glands (1.47±0.05) to adenomatoid hyperplasia (1.58±0.05) and pleomorphic adenomas (1.73±0.07). The clinical features also were discussed with a review of the literature.
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  • Styloid process
    Toshio SHIGETOMI, Sawako KUWAHARA, Tsunetoshi HAYASHI, Hiroaki NISHIGU ...
    1997 Volume 43 Issue 7 Pages 549-554
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Burning mouth syndrome (BMS) is a chronic oro-facial pain disorder that is usually unaccompanied by mucosal lesions or other clinical signs. Glossodynia is defined as a burning sensation in the tongue from any cause. However, different studies have indicated that in about half of patients with glossodynia other intraoral locations are involved in complaints of pain. Therefore, BMS has been used to encompass a broader range of symptoms. Although many etiologic factors of BMS have been reported, the pathogenesis of this cordition is not fully understood. On the other hand, studies have documented an association between an elongated styloid process and cervicopharyngeal pain. This condition has been referred to as Eagle's syndrome or, stylohyoid syndrome.
    To evaluate the association between the length of the syloid process and symptoms of BMS, we measured the length of styloid processes on panoramic radiographs taken from patients with BMS and control patients. Fifty women with BMS 40 to 75 years of age were enrolled from among patients with BMS who were being followed up at the Department of Oral Surgery, Nagoya University Hospital between 1995 and 1996. Fifty control patients were enrolled from among outpatients without symptoms of BMS who were matched for age. Patients were excluded if they had symptoms of temporomandibular disorder. The mean age in the control and BMS patients was 57.8 ± 8.9 and 59.3±9.8 years, respectively.
    The following results were obtained:
    1) The length of the styloid process increased with age in BMS patients, but there was no relationshipto age in control patients.
    2) The number of teeth was significantly lower in control patients.
    3) When intraoral pain affected three or more regions, the length of the styloid process was significantly greater in BMS patients. These patients had pain in the tongue and other regions. However, they had no symptoms(throat discomfort, otalgia, dysphagia)of Eagle's syndrome.
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  • Chie YANAI, Ken OMURA, Shigehito WADA, Kazuhiko OKUMURA, Tomomi YAMASH ...
    1997 Volume 43 Issue 7 Pages 555-557
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We describe a 46-year-old man with T 4 N 2 bM 0 squamous cell cancer of the floor of the mouth. After concomitant radiotherapy (51.2Gy) and chemotherapy (CBDCA 480mg), he underwent total glossolaryngectomy, bilateral neck dissection, and reconstruction using a free rectus abdominis flap. Postoperatively, an IVH catheter was placed, and antibiotics (CEZ) were given prophylactically. Candida albicans sepsis developed 3 weeks after the operation. Administration of FCZ 200 mg daily for 17 days improved sepsis; however, candida osteomyelitis developed in the ribs and lumbar vertebrae 4 months after the operation. Persistent osteomyelitis of the ribs required partial costectomy. Postoperatively, the patient received FCZ 200 mg daily for 1 month, followed by FCZ 100mg daily. Osteomyelitis of the ribs completely healed, but the lesions of the lumbar vertebrae were not controlled.
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  • Tetsuo SHIMOYAMA, Norio HORIE, Tsubura SUZUKI, Kaoru KUSAMA
    1997 Volume 43 Issue 7 Pages 558-560
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The authors describe four cases of granular cell tumor of the tongue. The patients ranged from 22 to 46 years of age; two were women and two men. Both S-100 protein and neuron-specific enolase were positive in granular cells, but myoglobin was negative in all cases. Granular cells were filled with numerous lysozomal granules and myelin figures and were encompassed by a basal lamina. These findings suggests that granular cell tumor may be derived from peripheral nerve Schwann cells.
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  • Tsuguo SANO, Hideto KATAOKA, Tisei SHINODA, Kohichiroh TOMORI, Masashi ...
    1997 Volume 43 Issue 7 Pages 561-563
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Recently, we encountered a rare case of leiomyoma that developed in the hard palate of a 3-year-old girl, which we report below together with a review of the literature.
    The patient was a 3-year-old girl who presented on December 10, 1988, because of a swelling on the right side of the palate.
    On examination, a tumor was found in the area corresponding to ED of the right palate. The surface was partially ulcerated but its color was generally normal. When palpated, the tumor felt hard, lacked elasticity and mobility, and was not tender. An X-ray film showed evidence of a mass at the site corresponding to the E Dlapical region. The clinical diagnosis was a benign tumor of the right palatal region. The tumor was totally extirpated under general anesthesia. The tumor measured 35×28×20mm and was bounded by a fibrous film. Histopathological examination showed that elongated cells with spindle-shaped nuclei formed bundles that intersected with each other. A diagnosis of leiomyoma was made.
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  • Yoshihiro SAWAKI, Hiroko HAGINO, Hiroki YAMAMOTO, Toshio SHIGETOMI, Hi ...
    1997 Volume 43 Issue 7 Pages 564-566
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The authors report on a patient whose mandibular defect was reconstructed by distraction osteogenesis. The patient was a 45-year-old man who had been treated for cancer of the oral floor. After preoperative irradiation therapy, the mandible had been resected from the second right incisor to the first left molar, and had been reconstructed with a titanium plate and a vascularized rectus-abdominis compound flap 8 months previously. However, an infection developed and the titanium plate had to be removed. Therefore, trifocal distraction using a three-dimensional distractor of an original design was performed at the rate of 1 mm per day (0.5 mm in the morning and 0.5 mm in the evening). During the distraction period, the skin flap was pushed out from the bone defect. Consequently, the segmental bone defect of about 60 mm was filled by the regenerated bone and the lengthened gingiva. Radiographic examination showed successful new bone formation at the lengthened region.
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  • Yoko KUGA, Chihiro KOGA, Shun-ichi TANAKA, Hidenori SAKAINO, Jingo KUS ...
    1997 Volume 43 Issue 7 Pages 567-569
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Here we report a case of bilateral coronoid process hyperplasia. A 37-year-old man was referred because of limited mouth opening. Panoramic tomography revealed bilaterally elongated coronoid processes protruding over the zygomatic arch. The coronoid processes were resected extraorally, and the maximum voluntary mouth opening was improved from 22mm to 40 mm.
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  • Koji SATOH, Goroh HIBI, Sigeo OHNO, Takako AIZAWA, Miho NAKAMURA, Taka ...
    1997 Volume 43 Issue 7 Pages 570-572
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A rare case of a 2-year-old girl with encephalocele is reported. She was admitted at birth to the department of pediatric surgery because of a hydrocele and a left buccal tumor. The buccal tumor was irradiated up to 30 Gy under a tentative diagnosis of a low malignant neurogenic tumor. A V-P shunt operation was performed for the hydrocele. The tumor gradually enlarged postoperatively, resulting in facial asymmetry. An ulcer formed in the buccal mucosa because of close contact with ID. The patient was referred to our department because of the buccal ulcer and facial deformity. The buccal tumor was of the size of a hen's egg and had an irregular surface. Intraorally, it was multilobulated and extended to the palate and pharyngeal space. Before surgery, an encephalocele was suspected on the basis of imaging findings, including 3 D-CT and MRI. ID extraction and partial resection of the lesion were performed. Degenerated brain tissue with calcification was identified pathologically. For six years postoperatively, the patient has been free from severe complications and can lead normal life.
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  • Yoshinori KANOH, Tadashi YAMAMOTO
    1997 Volume 43 Issue 7 Pages 573-575
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Salmonella enteritidis (S. enteritidis) often causes bacterial food poisoning. However, infection, with the exception of gastroenteritis, caused by S. enteritidis is very rare. This report describes a case of submandibular abscess caused by S. enteritidis, which we encountered recently. We believe that this is the first reported case of S. enteritidis infection in the oral and maxillofacial region.
    A 42-year-old man visited our hospital because of right submandibular swelling after the extraction of his right wisdom tooth. His general condition was good, except that he had discontinued treatment for diabetes mellitus. Surgical drainage was perfomed, and S. enteritidis was detected from the pus but not from feces. Therefore, he was given tosufloxacin for 2 weeks.
    The route of infection in this case was thought to be poisoned food. Furthermore, S. enteritidis directly invaded an extracted dental socket.
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  • Naoki SAITOH, Nagato NATSUME, Hiroo MASUDA, Masanori HONDA, Teruyuki N ...
    1997 Volume 43 Issue 7 Pages 576-578
    Published: July 20, 1997
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A case of translocation 21 trisomy with atrial septal defect in a patient undergoing surgery for cleft lip and palate is reported. The patient was born as a second child when his father and mother were 33 years old. The parents had no intermarriage and denied having heredodiathetic disorders. She took a drug for uterine bleeding in the 2nd month of pregnancy for about 2 months. After that, she took a drug for anemia from 5 th to 7 th months of pregnancy. The baby was born with cleft lip and palate at 35 weeks and 3 days of gestation and weighed 2440g at birth. Examination revealed a flat face, epicanthus, flat nose bridge, flat occiput, and simian line. Besides these findings, complications of atrial septal defact were recognized. Assessment of chromosomal analysis was Robertsonian translocation 21 trisomy, that is 46, XY, -21, +t (21q21q).
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