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Volume 61, Issue 2
Displaying 1-6 of 6 articles from this issue
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Preface
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[in Japanese]2015 Volume 61 Issue 2 Pages 85
Published: February 20, 2015
Released on J-STAGE: September 16, 2015
JOURNAL FREE ACCESSDownload PDF (855K)
Invited review article
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Superselctive intra-arterial chemotherapy for oral cancer -Toward the therapy of organ preservation-Iwai TOHNAI2015 Volume 61 Issue 2 Pages 86-101
Published: February 20, 2015
Released on J-STAGE: September 16, 2015
JOURNAL FREE ACCESSIntra-arterial infusion for oral cancer exists in 3 methods, historically. The conventional method is catheterization into the external carotid artery via a superficial temporal artery or a superior thyroid artery. The catheterization of the conventional method is relatively easily, however, the concentration of the anticancer drug in the tumor is uncertain. Superselective intra-arterial chemoradiotherapy using Seldinger method of the catheterization into the tumor-feeding artery via a femoral artery contributed considerably to treatment for head and neck cancer, however, have a problem with safety. On the other hand, retrograde superselective intra-arterial chemotherapy using HFT method of the catheterizations into the tumor-feeding artery via a superficial temporal artery and an occipital artery has safety and the concentration of the anticancer drug using this method is certain. One hundred and twelve patients with stage III and IV oral squamous cell carcinoma underwent intra-arterial chemoradiotherapy using HFT method. Treatment consisted of superselective intra-arterial chemotherapy (DOC: total 60 mg/m2, CDDP: total 150mg/m2) and daily concurrent radiotherapy (total 60Gy) for 6 weeks. Primary site complete response was achieved in 98 (87.5%) of 112 cases. Five-year survival and local control rates were 71.3% and 79.3%, respectively. This treatment method will be promising to noninvasive therapy for advanced oral cancer.View full abstractDownload PDF (1576K)
Original article
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Takeshi KOIKE, Hiroshi KURITA, Takahiro KAMATA, Yuji TERAMOTO, Shinobu ...2015 Volume 61 Issue 2 Pages 102-109
Published: February 20, 2015
Released on J-STAGE: September 16, 2015
JOURNAL FREE ACCESSThe purpose of this retrospective study was to assess the surgical success and survival of implants placed with maxillary sinus floor elevation and to estimate the factors that influenced implant survival. A total of 131 implants were placed in 74 sinuses of 67 patients. Fifteen sinuses (18 implants) were augmented by the transalveolar osteotome technique (OT), 42 sinuses (75 implants) by the one-stage lateral window technique (1-stage LW), and 17 sinuses (38 implants) by the two-stage lateral window technique (2-stage LW). The Kaplan-Meier estimate of the 5-year success/survival rate of all implants was 93.8%. The estimated success/ survival rate was 100% for OT, 98.6% for 1-stage LW, and 81.2% for 2-stage LW. The results of multivariate analysis using a Cox proportional-hazards model revealed that either residual bone height or the presence of perforation of the sinus membrane was a statistically significant independent predictor of success/ survival. In this study, the residual bone height was closely related to the applied surgical technique. Moreover, perforation of the sinus membrane was associated with infection and bone graft loss in the patients treated by the 2-stage LW. The results of this study suggested that OT was a reliable technique if a long implant ( ≥ 12 mm) was placed with sinus floor elevation of up to 5 mm. Our results also suggested that if the LW is performed, simultaneous implant placement would have a favorable outcome if primary implant stability was obtained.View full abstractDownload PDF (956K)
Case reports
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Miwako SASE, Hiroto ITOH, Naoyuki MATSUMOTO, Kazuo KOMIYAMA, Yoshinori ...2015 Volume 61 Issue 2 Pages 110-114
Published: February 20, 2015
Released on J-STAGE: September 16, 2015
JOURNAL FREE ACCESSDentinogenic ghost cell tumor (DGCT) is a rare tumor that often shows an aggressive growth pattern. DGCT has a high recurrence rate after tumor resection. We describe a case of DGCT of the maxilla that recurred after local resection. A 65-year-old man was referred to our hospital because of painful swelling of the left side of the maxilla. Computed tomography (CT) showed a bone defect in the left upper jaw and a mass lesion with invasion of the surrounding soft tissue. A calcifying cystic odontogenic tumor (CCOT) was diagnosed on biopsy, and the tumor was resected with the patient under general anesthesia. The histopathological diagnosis was DGCT. Ten months postoperatively, CT showed tumor recurrence in the same area, associated with a highly invasive pattern of growth. Partial resection of the maxilla was performed. The postoperative course was uneventful, and there was no sign of recurrence during 12 months of follow-up.View full abstractDownload PDF (966K) -
Masaya NISHIKAWA, Daiki MIZUNO, Noriyuki YAMAMOTO, Kazutada USAMI, Hi ...2015 Volume 61 Issue 2 Pages 115-119
Published: February 20, 2015
Released on J-STAGE: September 16, 2015
JOURNAL FREE ACCESSWe report a rare case of mycosis fungoides arising in the right upper gingiva. A 58-year-old woman with a history of lumbar mycosis fungoides visited our clinic because of a reddish swelling in the right upper molar gingiva. A gingival biopsy was performed with the patient under local anesthesia. Histopathologically, the lesion showed dense infiltration of T cells with cellular atypia in the epithelial layer. Immunohistochemical studies for CD3, CD4, and CD5 showed positive staining, indicating that the phenotype was identical to that of the lumbar mycosis fungoides lesion. The final diagnosis was therefore mycosis fungoides of the right upper gingiva. There has been no evidence of stage progression as of 4 years after diagnosis.View full abstractDownload PDF (1036K) -
Hayato HAMADA, Yoko KAWASE-KOGA, Harutsugi ABUKAWA, Michihide KONO, Ko ...2015 Volume 61 Issue 2 Pages 120-124
Published: February 20, 2015
Released on J-STAGE: September 16, 2015
JOURNAL FREE ACCESSNevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome or basal cell nevus syndrome (BCNS), is an autosomal dominant disorder that causes multiple basal cell carcinoma (BCC), keratocystic odontogenic tumor (KCOT), calcification of the falx cerebri, bifid rib, and palmar or plantar pits. The human patched-1 (PTCH-1) gene has been identified as the causative gene of NBCCS; however, its relation to clinical findings remains to be well defined. A 22-year-old woman was referred to our hospital in October 2011. We gave her a diagnosis of NBCCS based on clinical findings and diagnostic criteria. The surgical excision of 4 tumors was performed with the patient under general anesthesia. The pathologic findings indicated that the tumors were KCOTs. We subsequently identified a PTCH1 germline mutation of c .478C > T, which was a nonsense mutation in PTCH1. This nonsense mutation was considered the cause of the NBCCS manifestations seen in this patient. The aim of this study was to evaluate the relations of mutation types on the PTCH1 gene to clinical findings in NBCCS patients, including our case.View full abstractDownload PDF (1005K)
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