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Volume 51, Issue 8
Displaying 1-6 of 6 articles from this issue
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Yoshidou KAKIMOTO, Hideyuki NUMASAWA, Nobuharu YAMAMOTO, Eizou TAKEDA, ...2005 Volume 51 Issue 8 Pages 374-381
Published: August 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSFrequent allelic imbalances, including loss of heterozygosity (LOH) and microsatellite instability (MSI), have been found on the long arm of chromosome 2 (2q) in several types of human cancer. This study was designed to identify the tumor suppressor locus (or loci) associated with oral squamous cell carcinoma (SCC) on 2q. To better understand the details of genetic alterations on 2q, we performed polymerase chainreaction analysis of microsatellite polymorphisms corresponding to 10 loci on this chromosome. We identified a novel tumor suppressor locus in this region in primary oral SCCs. To further determine the role of 2q deletions in oral carcinogenesis, 19 oral SCCs (19 sets of primary and corresponding normal tissues) were examined for allelic imbalances (LOH or MSI) on 2q, using ten microsatellite markers. Among these 19 patients, 11 (57.9%) showed LOH at one or more loci. Deletion mapping of these tumors revealed four discrete, commonly deleted regions on the chromosome arm. Furthermore, we detected MSI in 4 of the patients (21.1 %).We compared our results with clinicopathologic features. A number of sites with LOH on 2q were detected in early stage lesions, and the frequency of LOH was slightly but not significantly higher in later clinical stages. Our results suggest that allelic imbalances on 2q are involved in the development of oral SCC and that one or more putative tumor suppressor genes contributing to the pathogenesis of this disease are present on 2q.View full abstractDownload PDF (1873K) -
Akiko KATSURAGI, Atsushi ABE, Fumi OHNO, Masahito MAEDA, Masaya NAKANO ...2005 Volume 51 Issue 8 Pages 382-385
Published: August 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESS7q deletion syndrome is an uncommon congenital anomaly caused by deficiency of the long arm of the seventh autosome. This syndrome is infrequently associated with cleft lip or palate and is rarely associated with median cleft of the upper lip. We report on a girl who had a median cleft of the upper lip with 7q deletion syndrome. Her gestational age and birth weight were 38weeks and 2, 646g, respectively. She had a median cleft of the upper lip with a flat nose; the premaxilla was missing. As she grew, mental retardation, growth disturbance, hypernatremia, and hypothyroidism became apparent. Chromosome examination showed aberration of 46, XX, del (7)(q35, 3). Lip plasty was performed under general anesthesia when the patient was 1 year old, and the postoperative course was uneventful. She is now 3years old, but cannot speak or drink. She can walk about 2m by herself. Further follow up is necessary for her development, including maxillofacial growth.View full abstractDownload PDF (1889K) -
A case of hemifacial microsomia due to Goldenhar syndromeHaruki SATO, Hitoshi MIYACHI, Shigeki OCHIAI, Naofumi OBAYASHI, Kazuo ...2005 Volume 51 Issue 8 Pages 386-389
Published: August 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSAcute upper airway constriction is the most critical of all respiratory disorders and its treatment demands prompt action. Acute upper airway constriction due to complications such as hemorrhage, pharyngeal edema, and upper airway narrowing can occur after maxillofacial surgery. We describe a case of acute upper airway constriction that occurred after bimaxillary distraction. The patient was a 12-year-old girl with hemifacial microsomia due to Goldenhar syndrome. The right mandibular body at the distal region of the first molar and maxillary alveolus underwent complete osteotomy. Intraoral-type distraction devices were set in place. There were no complications during surgery; however she complained of dyspnea and had signs of acute upper airway constriction, such as disturbed sleep and severe swelling from the submandibular to the cervical region, on the first postoperative day. X-ray CT scans showed obvious edema in the submandibular space and parapharyngeal space of the oropharynx. Emergency nasal airway intubation was performed, and a drainage route was placed at the site of mandibular osteotomy. Intravenous steroids were given. After drainage of the hematoma, her respiratory condition improved immediately, and X-ray CT scans showed decreased upper airway constriction the next day. We emphasized that postoperative evaluation of the airway and respiratory management have an important role in maxillofacial surgery.View full abstractDownload PDF (2104K) -
Tsutomu IWAMOTO, Takemitsu MATSUO, Souichi YANAMOTO, Goro KAWASAKI, Ak ...2005 Volume 51 Issue 8 Pages 390-393
Published: August 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSAmeloblastic fibrosarcoma (AFS) is a rare malignant tumor composed of benign odontogenic epithelial components and malignant ectomesenchymal components. We report a case of AFS occurring in the mandible of a 15-year-old boy. The patient was referred to our department for evaluation and treatment of gingival swelling. The lesion was diagnosed as a benign ameloblastic fibroma on examination of a biopsy specimen. The lesion was excised under general anesthesia, and the pathological diagnosis was AFS. At present, the postoperative course is good, with no recurrence as of about 4 years since the operation.View full abstractDownload PDF (1678K) -
Atsushi TAKIZAWA, Hideki MIYAZAWA, Hiroichi KOBAYASHI, Hiroshi KURITA, ...2005 Volume 51 Issue 8 Pages 394-397
Published: August 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSWe present a case of cervical lymph node metastasis from an unknown primary cancer in a 73-year-old woman. The patient was referred to our department for treatment of a submandibular swelling after extraction of a first molar. At the initial visit, a swelling measuring 22mm in diameter was detected in the left submandibular region. The mass was covered by normal skin and was elastic yet hard and immobile on palpation. The patient did not complain of pain or dysesthesia. Delayed healing was noted at the wound remaining after extraction of the first molar. The presence of a malignant disease such as malignant lymphoma or gingival carcinoma was suspected on the basis of the clinical findings and magnetic resonance and ultrasonographic images. Biopsy of the wound and resection of the cervical mass were performed under general anesthesia. Histopathological examination of the gingiva showed granulation tissue formation with inflammatory cell infiltration.The cervical mass proved to be a lymph node with metastasis from squamous cell carcinoma. Head, neck, and thoracic computed tomography, bronchoscopy, and other examinations were performed to locate the primary cancer, but its origin remained unknown. Left total neck dissection was combined with irradiation (total dose: 57.6Gy) of both sides of the neck and the upper, middle, and lower pharynx. The patient has been followed up for 1 year 5 months without any evidence of recurrence.View full abstractDownload PDF (2463K) -
Terumi SAITO, Yuji KAMIYA, Yosuke JINNO, Shin-ichiro KATO, Satoshi WAT ...2005 Volume 51 Issue 8 Pages 398-401
Published: August 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSFibrous dysplasia of bone is a benign disease characterized by the progressive replacement of normal bone elements by fibrous tissue. The disease can involve any bone in the body. However, involvement of the zygomatic arch is relatively rare. Moreover, depending on the site and extent, fibrous dysplasia may be accompanied by functional disorder. We report a case of fibrous dysplasia of the zygomatic arch that extended to the pterygoid fossa, producing trismus.
A 56-year-old woman was referred to our hospital because of a painless swelling in the left cheek and trismus. Computed tomography and simple X-ray examinations of lesion revealed a ground-glass appearance. Biopsy was performed, leading to a suspected diagnosis of osteoma. The lesion interfered with the movement of the mandible. The lesion was resected under general anesthesia. The histopathological diagnosis was fibrous dysplasia. The postoperative course was uneventful, and the lesion has not recurred for 6 years.View full abstractDownload PDF (2371K)
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