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Volume 50, Issue 11
Displaying 1-12 of 12 articles from this issue
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Toshiaki TAKEMI, Kunio TAKIZAWA, Masayasu IWASE, Masao NAGUMO2004 Volume 50 Issue 11 Pages 629-635
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSFas is widely expressed on the cell surface of many normal and neoplastic cells and induces apoptotic cell death in the presence of Fas ligand (FasL) or Fas-agonistic antibody CH11 (Fas-mediated apoptosis) Cancer cells constitutively expressing Fas are generally resistant to Fas-mediatedapoptosis. Recently, it has been reported that interferon-γ(IFN-γ) enhances Fas-mediated apoptosis. An oral squamous cell carcinoma cell line, NA, also constitutively expresses Fas on the plasma membrane and shows low susceptibility to Fas-agonistic antibody-induced apoptosis. This study was conducted to examine the effects of IFN-γ on Fas-mediated apoptosis, the expression of Fas and FasL, and the production of soluble Fas (sFas) in NA cells. The results revealed that a Fas-agonistic antibody, CH11, induced apoptosis of NA cells and IFN-γ enhanced susceptibility of NA cells to CH11-induced apoptosis. Further more, IFN-γ up-regulated Fas expression on NA cells without affecting the expression of FasL. A slight decrease in sFas expression was induced by treatment with IFN-γ. These results suggest that IFN-γ may enhance the susceptibility of NA cells to Fas-mediated apoptosis through the up-regulation of Fas.View full abstractDownload PDF (2024K) -
Atsuhisa KAJIHARA, Kazuhiko YAMAMOTO, Masayoshi KAWAKAMI, Masaki FUJIM ...2004 Volume 50 Issue 11 Pages 636-642
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSWe clinically analyzed autogenous bone grafts placed in the alveolar clefts of patients with cleft lip and palate. The subjects were 26 patients, 18 males and 8 females. At the time of bone grafting most patients ranged in age from 10 to 16 years. Twenty patients had cleft lip and palate, and 6 had cleft lip and alveolus. Fifteen cases were unilateral, and 11 were bilateral. The width of the alveolar clefts ranged from 3 to 15mm at the alveolar crest and from 6 to 18mm at the nasal floor. Maxillary expansion had been carried out before bone grafting in 9 patients. Cortico-cancellous bone harvested from the chin in 15 patients and from the iliac crest in 11 patients was grafted as a block in all patients and fixed with microplates. Clinically significant bone bridge formation was observed in 25 patients, but the alveolar bone height of the grafted portion was not satisfactory in all patients. Dental implants were placed into the grafted region in 4 patients.View full abstractDownload PDF (1910K) -
Kei-ichi MORITA, Akemi GUNJI, Masatoshi ISHII, Takashi MORIYAMA, Fumik ...2004 Volume 50 Issue 11 Pages 643-648
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSConsiderable progress has recently been made in nose correction techniques in the field of cleft lip surgery. However, surgical repair alone cannot solve the multiple problems associated with wide clefts of the lip and severe deformity of the nose. Presurgical nasoalveolar molding (PNAM) technique for patients with clefts was described by Grayson et al.(1999). This treatment's objectives are non-surgical correction of the nose and alveolar processes, including repositioning the deformed alar cartilages, lengthening of deficient columella, and reduction of the alveolar cleft gap by using Hotz-type palatal molding plates with acrylic nasal stents and surgical adhesive tapes that are applied to the cheeks during the neonatal period. In this paper, we describe our experience with primary management using PNAM in 12 infants with unilateral cleft lip and palate. All cases showed elongation of the columella and reduction of the alveolar cleft gap before primary surgical repair of the lip and nose, which suggested that PNAM is useful for promoting presurgical morphological improvement.View full abstractDownload PDF (3278K) -
Yasuhiro MIURA, Masahide NAGATA, Taiji KITAGAWA, Emiko TANAKA, Mikihik ...2004 Volume 50 Issue 11 Pages 649-651
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSCongenital lip pits usually occur in the lower lip or the angle of mouth, but those in the upper lip are extremely rare. We report a case of bilateral upper lip pits with bilateral cleft lip. The patient was a 1-month-old girl with bilateral cleft lip. Two congenital lip pits were symmetrically located on the upper lip. Excision of these lip pits was performed at the time of cheiloplasty. Histological examination showed that the lip pit tract was lined by squamous epithelium. Surgical excision provided a good outcome without recurrence of lip pits. However, the etiology of congenital upper lip pits remains obscure.View full abstractDownload PDF (1574K) -
Ayumu MORISAKI, Kazuhiko YAMAMOTO, Wakashi KITAYAMA, Masamitu HYOUMOTO ...2004 Volume 50 Issue 11 Pages 652-655
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSA case of ameloblastoma with a trend toward rapid growth in an elderly patient is reported. The patient, a 71-year-old woman, was referred to our clinic for swelling of the right premolar region of the mandible. At presentation, a well-circumscribed bony hard swelling (22×15mm) was observed at the right premolar gingiva. On X-ray examination, a radiolucent lesion was found between the right lateral incisor and the first premolar, accompanied by a honeycomb-like lesion at the alveolar process of the right premolar region of the mandible. Under the diagnosis of an odontogenic tumor, tissue biopsy was performed, and the lesion was histologically diagnosed as an ameloblastoma. Before surgery, the radiolucent lesion had extended between the left central incisor and the right second premolar region. Therefore, marginal resection from the left lateral incisor to the right first molar of the mandible was performed under general anesthesia. Histopathological examination revealed a follicular type of ameloblastoma with no evidence of malignancy. No recurrence was observed for 2 years 10 months after surgery, but the patient died of hepatocellular carcinoma.View full abstractDownload PDF (2683K) -
Shu ISHIBASHI, Kazuo OBATA, Yoshiki SUGIYAMA, Yoichi TSUTSUMI, Koichi ...2004 Volume 50 Issue 11 Pages 656-659
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSOsteoma is non-odontogenic tumor consisting of hyperplasia of compact or cancellous bone. It occurs more frequently in the maxilla than in the mandible, and it often arises unilaterally in the molar or canine region of the maxilla. This article presents a case of peripheral cancellous osteoma occurring bilaterally in the molar region of the maxilla.
A 64-year-old woman visited our hospital because of a swelling on the palatal side of the alveolus in the bilateral maxillary molar regions. Bone-like hard tumors were observed bilaterally on the palatal side of the alveolus in the upper wisdom tooth regions. On panoramic X-ray film, radiopaque tumors were observed in the regions. We excised the tumors under local anesthesia. The tumors were diagnosed pathologically as peripheral cancellous osteomas. The patient is making satisfactory progress without any recurrence in either region of the maxilla.View full abstractDownload PDF (2425K) -
Hidemi ISHIDA, Masahiro UMEDA, Tsutomu MINAMIKAWA, Yasuyuki SHIBUYA, S ...2004 Volume 50 Issue 11 Pages 660-663
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSA case of mucoepidermoid carcinoma occurring in the parotid gland of a child is presented. A 12-yearold girl visited our hospital because of a painless swelling of the left cheek. Hypertrophy of the masseter was initially suspected. She did not undergo a further examination by MRI because of mental retardation. She had been followed up clinically for 1 year, until the swelling of the cheek grew rapidly. Then, she was examined by CT and MM under intraveneous sedation, and a parotid tumor was diagnosed.
A biopsy specimen revealed mucoepidermoid carcinoma of the parotid gland. She underwent total resection of the left parotid gland, functional neck dissection, and reconstruction of the facial nerve by transplantation of the sural nerve. She has been well for 18 months postoperatively, without recurrence or metastasis, although a moderate degree of facial nerve paralysis remains.
We review 16 children with mucoepidermoid carcinoma of the parotid gland, previously reported in the Japanese literature.View full abstractDownload PDF (2297K) -
Kazuko TAKUBO, Kazuhiko TANIO, Hirofumi SAKAMOTO2004 Volume 50 Issue 11 Pages 664-667
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSFibrosarcoma, a malignant tumor of fibroblasts, occurs rarely in the head and neck. This report describes a case of fibrosarcoma in the left side of the mandible in a 54-year-old man. He was referred to our department because of occlusal pain in the molar region of the left side of the mandible. Panoramic tomography showed a poorly defined radiolucent area extending from the second premolar of the left side of the mandible to the mandibular angle. Under the clinical diagnosis of a malignant tumor of the left side of the mandible, an incisional biopsy was performed. A mesenchymal malignant tumor was suspected. Surgical treatment comprising radical neck dissection, segmental resection of the left side of the mandible, and reconstruction of the mandible was performed under general anesthesia. Histopathological examinations of multiple sections and specially stained sections, as well as immunohistochemical studies, were performed. The final tissue analysis revealed a fibrosarcoma. After surgery, one course of combination chemotherapy with cyclophosphamide, vincristine, epirubicin and dacarbazine, (CYVADIC therapy) was administered. A 30-month follow-up showed no evidence of local recurrence or distant metastasis.View full abstractDownload PDF (3058K) -
Yusuke MORI, Takayuki AOKI, Hiroyuki NAITO, Ryou SEKIYA, Keiichi TSUKI ...2004 Volume 50 Issue 11 Pages 668-671
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSAcinic cell carcinoma of the minor salivary glands is relatively rare. A case of acinic cell carcinoma with a microcystic pattern arising in the buccal mucosa is reported. A 55-year-old man presented with a painless swelling in the left buccal mucosa. The tumor measured 18×18mm. No swelling of the cervical lymph nodes was found. Only surgical excision was performed. Sections taken from the buccal mucosa showed proliferation of atypical cells characterized by strong immunoexpression of Lact-F. These cells were arranged in a microcystic pattern. The histopathological diagnosis was acinic cell carcinoma. Sixteen months after surgical exision, there has been no evidence of recurrence or metastasis.View full abstractDownload PDF (2615K) -
Kazuki TAKAOKA, Yukiyo MANNO, Osamu ODANAKA, Chouken FUTENMA, Kazunari ...2004 Volume 50 Issue 11 Pages 672-675
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSWe report a case of bullous pemphigoid occurring in the palatal mucosa. A 72-year-old woman complained of herpetiforms of the palate. Multiple red herpetiform lesions were noted on the palatal mucosa. A biopsy of the lesion showed submucosal bullae. Immunohistochemical examination with antibodies against C3 and IgG exhibited positive staining of the basement membrane. On the basis of these findings, bullous pemphigoid was diagnosed. Treatment with oral prednisolone (20mg/day) resulted in a fair response. The dose of prednisolone was gradually decreased. After 5 months of prednisolone treatment, the herpetiform lesions completely disappeared, and there has been no relapse.View full abstractDownload PDF (2327K) -
Particular focus on the development of an impacted supernumerary toothYoko NAKAYAMA, Kouichi YASUDA, Masaaki NAKAMURA, Ryota MORI, Takashi M ...2004 Volume 50 Issue 11 Pages 676-679
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSWe report a rare case of an embedded supernumerary tooth in the left pterygoid process region of a patient with first and second branchial syndrome. A 3-month-old Japanese boy was referred to our clinic for treatment of a lateral facial cleft. The patient, birth weight 2960g, was born to a 29-year-old mother following an uncomplicated full-term pregnancy. He had a left lateral facial cleft, a left lateral cleft palate, a midline mandibular cleft, and absence of the left coronoid process. The surgical procedures were directed at repairing the anatomic defects of the left lateral facial cleft and the lower lip cleft at the age of 5 months. Then, a block iliac bone was used to repair the median cleft at the age of 6 years 2 months. In a panoramic radiograph at 2 years 8 months of age, an embedded supernumerary tooth was recognized near the left pterygoid process. We regularly observed the supernumerary tooth on panoramic radiographs until he was 21 years old. We have no reliable information on its origin because there is no cleft at the upper alveolar arch of the maxilla of this patient. Perhaps the supernumerary tooth originated from the dental germ in the coronoid process and wandered into the pterygoid process because of the first and second branchial syndrome.View full abstractDownload PDF (2497K) -
Shigehiro TAMAKI, Masayoshi KAWAKAMI, Toshimitsu NOSHI, Atsuhisa KAJIH ...2004 Volume 50 Issue 11 Pages 680-683
Published: November 20, 2004
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSProtein S deficiency is associated with multiple thrombosis resulted from a decrease in vitamin-K dependent protein S. Surgical treatment of patients with this condition requires anticoagulant control with heparin and warfarin potassium.
We report a case of protein S deficiency who received anticoagulant control with heparin and warfarin potassium during multiple teeth extraction. A 27-year-old woman was referred to our hospital because of dental caries and malocclusion. Her medical history did not include venous thromboembolism, but her mother and sister had protein S defficiency.
Protein S deficiency was diagnosed because free-PS antigen was 50.0%(normal range, 65-135 %) and total-PS antigen was 22.0 %(normal range, 60-150%).
Before extraction of the lower left second premolar and both lower third molars, 10, 000units/day of intravenous heparin and 2.0mg/day of warfarin potassium was administered orally when the activated clotting time (ACT) ranged from 130-150 seconds.
Both upper first premolars and the third molar were also extracted affer oral administration of 2.0mg/day of warfarin potassium.
Our experience suggested that anticoagulant therapy with heparin and warfarin potassium for surgical treatment of patients with protein S deficiency provides an excellent perioperative condition without inducing excessive hemorrhage or thromboembolism.View full abstractDownload PDF (1522K)
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