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Volume 52, Issue 12
Displaying 1-14 of 14 articles from this issue
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Kunihiro MYO, Narikazu UZAWA, Ryozo MIYAMOTO, Tetsuo SUZUKI, Teruo AMA ...2006 Volume 52 Issue 12 Pages 684-688
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSOverexpression and amplification of the epidermal growth factor receptor (EGFR) frequently occur in many malignant tumors, including oral squamous cell carcinomas (SCCs). Several studies have reported that abnormalities of this gene may be a valuable biologic marker of a poor prognosis. To investigate numerical aberration of the EGFR gene, we performed fluorescence in situ hybridization (FISH) with specimens obtained by fineneedle aspiration (FNA) biopsies of 57 primary oral SCCs. The EGFR numerical aberrations were identified in 24 (42.1 %) of the 57 patients with primary oral SCCs. Twenty-one (36.8 %) were polysomic for the EGFR gene, and amplification of this gene was found in 3 (5.3 %) of the tumors. The EGFR numerical aberrations were associated significantly with histopathologic grade (p=0.001), the mode of invasion (p=0.001), disease recurrence (p=0.001), and survival (p=0.002). Moreover, disease-free survival rate and overall survival rate in the patients with EGFR numerical aberrations were significantly lower than those in the patients without EGFR numerical aberrations (p=0.0020 and p=0.0021). Therefore, analysis of numerical aberrations of the EGFR gene by FISH with tissues derived from fine-needle biopsy may be a rapid and useful method for predicting poor outcomes in patients with oral SCCs.View full abstractDownload PDF (1478K) -
Yuichiro SAWA, Akihisa MANO, Akira TAKIMOTO, Toshiya HIGO, Dai KAWANO2006 Volume 52 Issue 12 Pages 689-699
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSThis study evaluated the usefulness of vertical distraction osteogenesis (VDOG) using a non-vascularized bone fragment prepared by an osteotomy with preservation of the lingual cortical bone in the posterior mandible. Thirteen surgical sites in 9 patients with insufficient vertical bone height were treated by means of a track-type distractor. After a two week latency period, distraction was started, and after 8 weeks of consolidation the distractor was removed. Four weeks later, fixtures were placed in the distracted regions. Radiological evaluation was carried out with CT images, taken before implant surgery and after removal of the distractor. Vertical bone height and CT values were analyzed. Distraction effect and bone formation were evaluated on cross-sectional dental CT images. Bone formation was clinically evaluated at each surgical point. Distraction ranged from 2.7 to 9.2 (mean 5.03+/-1.66) mm, and CT value ranged from 102.5 to 160.3 (mean 127.4+/-21.1). As for the surgical findings of bone formation, fixtures could be placed in almost all distraction regions, except for two cases of immature bone formation that required minor secondary bone grafts with simultaneous fixture placement. Bone formation promoted by VDOG with a free bone fragment was similar to that with conventional methods despite the temporary arrest of blood supply. We concluded that VDOG with preservation of the lingual cortical bone plate reliably augmented vertical bone for implant treatment in the posterior mandible.View full abstractDownload PDF (5851K) -
Naoko KISE, Takehiro OURA, Hideyuki KATSUTA, Akiyoshi GOTOU, Fuminori ...2006 Volume 52 Issue 12 Pages 700-702
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSAsplenia syndrome is characterized by complex congenital heart defects, asplenia, and abdominal heterotaxy. We report a case of asplenia syndrome associated with cleft lip and alveolus. The patient underwent cheiloplasty while in good condition after cardiac surgery, i. e., Blalock-Taussing shunt operation. Prophylaxis against infective endocarditis is important, and the operation was performed successfully without any infection. There were no circulatory problems, and the patient had an uneventful hospital stay.View full abstractDownload PDF (1423K) -
Hiroshi IWABUCHI, Emi IWABUCHI, Kimio UCHIYAMA, Koji TAKAMORI, Tetsuo ...2006 Volume 52 Issue 12 Pages 703-707
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSGlandular odontogenic cyst (GOC) was first proposed by Gardner et al in 1988 as an infrequent developmental epithelial cyst occurring in jaw bones. We describe our experience with a case of GOC arising in the mandible and report the clinical course. The patient was 52-year-old woman with clearly bordered multilocular radiolucent lesions in bothsides of the mandibular premolar region. These cysts were extirpated, and the specimens were studied by routine pathological examination and immunohistochemical staining with cytokeratins. The diagnosis was established to be GOC. The cyst recurred 3.5 years after surgery, and reoperation was performed.View full abstractDownload PDF (3701K) -
Masayuki MAEJIMA, Yasunori SATO, Kazuma MASUMOTO2006 Volume 52 Issue 12 Pages 708-711
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSWe encountered a bilateral case of verruca vulgaris that developed at different times at the angle of the mouth.
A 55-year-old man complained of a tumor at the angle of the mouth. The tumor had a clear margin and was elastic hard. Histological examination of a hematoxylin-eosin-stained section showed hyperkeratosis, parakeratosis, acanthosis, papillomatosis, and the presence of koilocytes in upper spinous cells and granular layers. Verruca vulgaris was diagnosed. Polymerase chain reaction performed with HPV consensus primers showed amplification for HPV DNA.
The postoperative course has been uneventful for 20 months.View full abstractDownload PDF (2957K) -
Yoshiyuki OKAMOTO, Shihomi SHOJI, Yukio HASEGAWA, Shinsuke OHTA, Satos ...2006 Volume 52 Issue 12 Pages 712-715
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSParotid gland tumors are almost invariably epithelial tumors such as pleomorphic adenoma. Nonepithelial tumors such as lipoma are rare. According to previous reports, lipomas account for about 1% of all parotid gland tumors. This tumor produces strong signals on Tl and T2 weighted MR images and weak signals on fat suppression images, which confirms the clinical diagnosis.
We report a case of lipoma arising in the parotid gland. The patient was a 53-year-old man. Surgical excision was performed. Sixteen months after the operation, there was no sign of recurrence.View full abstractDownload PDF (2608K) -
Kenzo OISHI, Takashi KURODA, Nobuyoshi AOYAGI, Toshitaka MURAJI, Toshi ...2006 Volume 52 Issue 12 Pages 716-719
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSIntramuscular lipoma is characterized by muscular fibers in mature adipose tissue and is extremely rare in oral tissues. A 69-year-old man had noticed a painless swelling of the right buccal submucosa 20 years previously. The patient was referred to us for evaluation and treatment of the mass, which had significantly grown over the last year. The bulbous mass measured 35×20×25mm and was elastic soft in consistency. The mass was movable, but partially adhered to the surface of the buccal mucosa. We diagnosed it as lipoma on computed tomography.
The tumor was removed surgically under general anesthesia. Even though the mass did not have a capsule, it was easily removed, except for the part of the buccinator muscle infiltrated by the tumor. Histopathological examination of the surgical specimen showed intramuscular lipoma. There has been no recurrence of the tumor for eighteen months since the operation.View full abstractDownload PDF (2654K) -
Kyou IIJIMA, Hiroshi KURITA, Hiromi KANEKO, Hiroki OKUBO, Hideki MIYAZ ...2006 Volume 52 Issue 12 Pages 720-723
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSA case of schwannoma extending from the parotid gland to the parapharyngeal space is presented. The patient was a 53-year-old woman. She was referred to us because of a swelling under the left auricle. CT scanning and MRI revealed a tumor extending from the deep lobe of the parotid gland into the parapharyngeal space, compressing the stylomandibular tunnel. This tumor was referred to as a “dumbbell tumor” because of its special shape. Such tumors are rare. The tumor was removed by an extraoral and mandibular swing approach. The histopathological diagnosis was schwannoma with a mixture of Antoni type A and B components. After sugery, no evidence of recurrence has been observed to date.View full abstractDownload PDF (2949K) -
Satoshi TAKADA, Tomohiro HAMADA, Tsutomu KOITABASHI, Hideki KON, Jiro ...2006 Volume 52 Issue 12 Pages 724-727
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSOral cancer in childhood is extremely rare. We report a case of squamous cell carcinoma arising from a cyst that occurred in a child.
A 13-year-old boy was referred to the Department of Oral Surgery, Ohu University School of Dentistry because of slight pain and swelling in the left upper jaw. Radiologically, the lesion showed a well-defined, pear-shaped radiolucent area between the roots of the lateral incisor and cuspid, producing divergence of the roots of these teeth. A tentative clinical diagnosis of maxillary cyst was made, and the lesion was enucleated. Histopathological examination of the cyst wall revealed atypical growth of the lining epithelium, and squamous cell carcinoma was diagnosed. After chemotherapy and radiotherapy, the patient underwent partial maxillectomy. There has been no evidence of recurrence as of about 10 years after surgery.View full abstractDownload PDF (2630K) -
Masahiro ATSUZAWA, Hisao SHIGEMATSU, Hizuru MIYAMOTO, Seiji SUZUKI, Ka ...2006 Volume 52 Issue 12 Pages 728-732
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSWe describe a rare case of Warthin's tumor with formation of a large cyst. This case was classified as Seifert's metaplastic type (Type IV) histopathologically. A brief discussion is included. A 61-year-old woman was referred to our hospital because of a swelling on the left side of the neck on August 26, 2003. She had noticed the mass for 2 years, and a fine-needle aspiration biopsy was performed at another hospital on August 12, 2003. However, a definitive histopathological diagnosis was not obtained, and her dentist referred her to our hospital. Physical examination revealed a painless, elastic hard, mobile mass measuring 40mm in diameter, in the inferior pole of the parotid gland, anterior to the sternocleidomastoid muscle. There was no evidence of associated lymphadenopathy. No uptake of99mTcO4-was detected in the lesion. MRI revealed a mass with medium T1signal intensity and low T2signal intensity in the left side of the neck, involving the superficial lobe of the parotid gland. Clinically, a benign parotid gland tumor was diagnosed, and a superficial parotidectomy was performed under general anesthesia on October 14, 2003. The excised tumor was diagnosed as Warthin's tumor with formation of a large cyst. The postoperative course was uneventful.View full abstractDownload PDF (3650K) -
Takayuki OHSAWA, Satoshi SHIMIZU, Hiroyuki MIYAZAKI, Eiro KUBOTA2006 Volume 52 Issue 12 Pages 733-737
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSAcquired hemophilia is a rare disease, diagnosed in individuals without any prior bleeding history. The incidence rate is reported to be 1 to 4 patients per million population. We report a case of acquired hemophilia diagnosed incidentally on postoperative bleeding after tooth extraction. A 71-year-old man was referred to our department because of postoperative bleeding after extraction of the lower anterior teeth. The patient had no previous episodes of bleeding tendency. Initial laboratory evaluation revealed a prolonged activated partial thromboplastin time (APTT) and decreased coagulant activity of factor VIII. Further examination revealed the presence of factor VIII inhibitors at the value of 3 Bethesda units. In our patient, the use of activated factor VII concentrates, effective for severe bleeding tendency in patients with acquired factor VII inhibitors, was unnecessary. He successfully responded to treatment with factor VIII concentrates and corticosteroids to control hemorrhage and inhibit the formation of autoantibodies against factor VIII (factor VIII inhibitors).View full abstractDownload PDF (2111K) -
Tsubura SUZUKI, Hideaki SAKASHITA, Akira EDA, Noriyuki SUKA, Seiji SUZ ...2006 Volume 52 Issue 12 Pages 738-742
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSWe report a rare case of an ectopic thyroid gland located from the base of the tongue to the submandibular region. A 69-year-old man was referred to the department of dentistry and oral surgery of a general hospital because of swelling of the left submandibular region. He had elastic hard masses in the submandibular region (63×50mm) and the base of the tongue (15×15mm). Magnetic resonance imaging showed the presence of solid masses. An open biopsy revealed that the tumor in the left submandibular region consisted of normal thyroid tissue. Continuity of the mass at the base of the tongue with that in the submandibular region was confimled by ultrasonography.The lack of anormal thyroid was also confirmed.The diagnosis was an ectopic thyroid gland. Tumor size decreased gradually in response to treatment with thyroid hormone.View full abstractDownload PDF (2764K) -
Ryusaku HORIUCHI, Tadashi YAMAMOTO, Hideo FUKANO, Atsuo KAETSU, Tomoyo ...2006 Volume 52 Issue 12 Pages 743-747
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSAcute intermittent porphyria (AIP) is a hereditary metabolic disease with a mortality rate of still 25% when clinical symptoms develop.
We described our experience with extraction of an upper impacted wisdom tooth in a patient with AIP.
The patient was a 35-year-old woman in whom AIP developed after celiotomy. Her condition deteriorated, and she became bedridden and was receiving rehabilitation. She had trismus due to pericoronitis of an upper wisdom tooth. We used safe antibiotics and performed an operation. To avoid stress, the patient was sedated with morphine and nitrous oxide and was sufficiently desensitized to pain with propitocaine. The prognosis was good.
Clinical symptoms of AIP are often caused by agents such as carbamazepine, sulfa drugs, and lidocaine, which are used in clinical oral surgery. When surgery for treatment is done in patients with AIP, it is necessary to avoid stress, use safe drugs, sufficiently desensitize the patient to pain, and cooperate closely with other medical departments.View full abstractDownload PDF (1707K) -
Toshinori IWAI, Yoshiro MATSUI, Jiro MAEGAWA, Kazunori YASUMURA, Shinj ...2006 Volume 52 Issue 12 Pages 748-751
Published: December 20, 2006
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSFacial artery musculomucosal (FAMM) flaps are musculomucosal flaps based on the facial artery. These flaps consist of mucosa, submucosa, a small amount of buccinator muscle, the deeper plane of the orbicularis oris muscle, the facial artery, and the venous plexus. We describe the use of a FAMM flap for the repair of a vermilion defect after resection of a lower lip carcinoma.
A 62-year-old man with an ulcer and mass of the lower lip was referred to our hospital. The pathological diagnosis was squamous cell carcinoma. He underwent tumor resection and vermilion reconstruction using an FAMM flap. We identified the facial artery by Doppler ultrasound. The FAMM flap was designed superiorly to Stensen's duct. The flap was elevated and rotated inferiorly. Then, the defect of the vermilion was covered. The donor site was closed primarily. Although the tip of the FAMM flap underwent partial necrosis postoperatively, the flap survived after conservative treatment.
An FAMM flap is useful for repairing defects in the vermilion, although only a flap of limited size can be harvested.View full abstractDownload PDF (3825K)
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