We report a case of fixed drug eruption due to levofloxacin (LVFX) with multiple stomatitis localized in the oral cavity. In late October 2011, a 37-year-old woman was given LVFX for cystitis. The patient experienced discomfort in the oral cavity after 6 hours, and her condition rapidly worsened, with the appearance of multiple stomatitis and erosion on the oral mucosa. On consultation with an otolaryngologist 6 days after starting treatment, she was instructed to discontinue LVFX. However, the condition of the oral cavity did not improve, and she was therefore referred to our section 2 days after discontinuing LVFX.
At presentation, the patient’s lips were red, swollen, and blood-encrusted and bled effortlessly on scratching. Multiple stomatitis was apparent with sharp pain on the buccal mucosa, together with a large mucosal erosion on the right dorsal surface of the tongue. However, symptoms involving the skin and mucosa, including the vulva and eyes, were not evident. Furthermore, 2 months previously the patient had a history of similar stomatitis after treatment with LVFX. We gave the patient a diagnosis of a fixed drug eruption due to LVFX. She was hospitalized, and methylprednisolone sodium succinate 750 mg per day was administered for 3 days. Her condition immediately improved, and she was discharged from the hospital after 9 days.
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