Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 42, Issue 4
Displaying 1-23 of 23 articles from this issue
  • Association with metastasis to regional lymph nodes and the influence of cancer chemotherapy on E-cadherin expression
    Atsushi SATO
    1996 Volume 42 Issue 4 Pages 331-346
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    To test whether the expression of E-cadherin in oral squamous cell carcinoma (SCC) might influence metastatic potential, we utilized an anti-E-cadherin monoclonal antibody, HECD-1, to immunohistochemically study SCCs obtained from 59 patients who had no history of treatment for carcinoma. E-cadherin of the SCCs were expressed on the cell surface in the following patterns: 1) all cells were strongly positive for the staining (“positive”); 2) some cells were positive but the remaining cells were negative or weakly positive (“weakly positive”); 3) all cells were almost or completely negative (“negative”). Statistical analyses revealed that the incidence of metastasis to regional lymph nodes in the “negative” and “weakly positive” cases (59.1%) was significantly higher than that in the “positive” cases (0%)(p=0.0002). In addition, metastases in multiple lymph nodes were detected in all of the “negative” cases with metastasis (p=0.0471). Moreover, the actuarial survival rate after 4 years in the “positive” cases (93.3%) was significantly higher than that after 5 years in the “negative” and “weakly positive” cases (74.5%)(p<0.05). The determination of E-cadherin expression in oral SCC is therefore expected to provide useful information with regard to prognosis. In this study, we also examined the influence of the anti-cancer agents, including cisplatin, carboplatin, peplomycin, pirarubicin, and/or doxorubicin, on the expression of E-cadherin in oral SCCs obtained from 36 patients. The patterns of HECD-1-staining differed between specimens obtained before and after chemotherapy in 14 of the 36 cases (38.9%). Moreover, increased expression of E-cadherin on the SCC cells was seen in 12 of the 14 cases (85.7%) that showed a different staining pattern after treatment. Consequently, the increased E-cadherin expression on the SCC cells may have been mediated by the anti-cancer agents.
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  • Yutaka YAMAZAKI
    1996 Volume 42 Issue 4 Pages 347-362
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A chronological study of genetic alterations during progression of DMBA-induced squamous cell carcinomas (SCCs) of the cheek pouch in golden hamsters was performed to clarify multistep carcinogenesis in experimental oral cancer.
    No genetic alterations were observed in c-K-ras and c-myc genes. c-erbB-2 gene amplification was found only in 1 out of 15 cases in the 20-week group, suggesting that these genetic alterations may not be involved in progression in this experimental model. Mutations in the c-H-ras gene were frequent, and 36%(4/11) of samples in the 18-week group and 33%(5/15) in the 20-week group were positive for c-H-ras gene mutations. All mutations were A→T transversion in the second position of codon 61. Mutations in the p53 gene were consistently detected in samples from the 14 to 18-week groups (less than 20% in each group). The rate of mutations increased to 40% in samples of the 20-week group. These data indicate that mutations in the c-H-ras and p53 genes may play important roles in late events in the pathogenesis of oral cancer progression. However, both p53 and c-H-ras mutations were found in only one case, suggesting independent genetic events that have different roles in the pathogenesis of oral cancer.
    Further studies of other genetic alterations will assist in understanding the processes involved in multistep carcinogenesis in this experimental model.
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  • Masayuki IWAI, Toshiharu SAWADA, ISAO FURUTA, Tadashi SADO, Ryuichi TE ...
    1996 Volume 42 Issue 4 Pages 363-369
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We retrospectively analyzed the effectiveness of preoperative treatment with combined chemotherapy, including cisplatin (CDDP) and carboplatin (CBDCA), and radiotherapy. Among 19 patients with oral squamous cell carcinoma, the primary site was the tongue in 13, the oral floor in 3, and the maxilla, lip, and gingiva in 1 case each. The clinical stage was 7 cases Stage II, 5 cases Stage III, and 7 cases Stage IV.
    Chemotherapy was administered intravenously using CDDP 50-80mg (1 time) or CBDCA 150mg once a week in a total dose of 300-750mg, PEP 5 mg twice a week in a total dose of 40-60mg, and 5-FU or Tegaful 300-600mg in a total dose of 9.0-18.0g. Radiotherapy was carried out with Liniac (5 times a week) in a total dose of 20-40Gy/10-20 f/10-20 days.
    Results: The clinical response to treatment was evaluated as CR 3 cases, PR 9 cases, and NC 6 cases. The response rate was 12/18 (66.7%) cases. Histologic effectiveness, evaluated according to the classification of Oohoshi and Shimosato, was Grade N 11 cases, Grade III 3 cases, and Grade II 5 cases. The following adverse reactions were reported: stomatitis 19 cases, fever 13 cases, leukopenia 12 cases, loss of apetite 12 cases, and neutropenia 10 cases. Fourteen of the 19 patients (73.7%) have a good prognosis, without any signs of recurrence or metastasis.
    The results indicate that multidrug chemotherapy combined with radiotherapy is effective even for highly malignant carcinoma in the oral cavity.
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  • Shigeru YAMABE
    1996 Volume 42 Issue 4 Pages 370-380
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Silver-stained nucleolar organizer regions (AgNORs) in malignant lymphoma of the oral mucosa were studied using a computer-assisted system for image analysis. Sixtytwo cases of oral lymphoma, including 1 follicular mixed type, 3 follicular large cell types, 8 diffuse medium-sized cell types (DMC), 7 diffuse mixed types, 19 diffuse large cell types (DLC), 16 diffuse pleomorphic types (DPM), and 8 diffuse lymphoblastic & Burkitt types (DLB-DBK), were investigated. AgNOR dots were counted at the light microscope level and 5 morphometric variables (AgNOR clusters, area, perimeter, round-factor, and unevenfactor) were assessed on paraffin sections. The results were compared according to histopathological subtype and immunological phenotype.
    The major findings were as follows: 1) Statistically significant differences were found between DMC and DLC, and between DMC and DPM with respect to AgNOR dots, area, and perimeter. 2) A significant difference was found between DMC and DLB-DBK with regard to AgNOR perimeter. 3) A significant difference was found between DLC and DPM with respect to AgNOR uneven-factor. 4) A significant difference was found between B cell lymphoma and T cell lymphoma with regard to AgNOR area.
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  • Hironori MIGIYAMA, Mari TAKEUCHI, Mikiko KADOHISA, Takehisa OHBAYASI, ...
    1996 Volume 42 Issue 4 Pages 381-386
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Acute respiratory distress syndrome (ARDS) is defined as non-cardiogenic pulmonary edema that develops in individuals with no underlying lung disease. The initial symptoms vary among individuals, but they are followed by common clinical symptoms such as severe dyspnea, tachypnea, and cyanosis. Patients with ARDS show severe hypoxemia, which resists conventional oxygen therapy. They also show reduced pulmonary compliance and the sudden appearance of diffuse shadows on X-ray films of both lungs. The prognosis of this condition is quite poor. We recently encountered a case of ARDS which developed, triggered by aspiration pneumonia, after resection of metastatic tumors of the neck.
    The patient was a 52-year-old man. On November 28, 1994, he underwent tumor resection and vessel grafting for the treatment of neck tumors that had metastasized from the upper gingiva. On the 4 th postoperative day (December 2), severe dyspnea developed, and diffuse shadows suddenly appeared on radiograms of both lungs. Although routine oxygen therapy was provided after tracheotomy, the patient's ventilation did not improve. He was therefore admitted to the ICU, where the administration of antibiotics to treat and prevent infection and mechanical ventilation were started immediately. The patient's condition deteriorated gradually despite these measures. On December 9, pulsed steroid therapy was started, leading to marked improvement in ventilation and in radiolucency of both lung fields. On December 15, he was weaned from mechanical ventilation and returned to the standard care ward.
    In the case presented in this paper, ARDS seems to have been induced by misswallowing.
    The medical staff must be alert when attending patients after oral surgery to note and respond immediately to misswallowing, because the risk of misswallowing is very high after oral surgery.
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  • Masakuni Aso
    1996 Volume 42 Issue 4 Pages 387-395
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We examined 50 unilateral cleft lip and palate patients among many others who underwent plastic surgery at the Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University. The time course of the dental arch was observed and the following results were obtained.
    1. Before operation, the width of the alveolar arch was larger than control, but the sagittal length was smaller than control. The larger width may reflect apparent broadening of the jaw due to the presence of a cleft, and the smaller sagittal length may be caused by congenital malformation of the jaw.
    2. Soon after plastic surgery for cleft lip and palate, both the width and sagittal length of the alveolar arch rapidly decreased. The effect of cleft palate plasty on narrowing the width of the alveolar arch was more marked than that of cleft lip plasty.
    3. Retarded jaw development after cleft palate operation persisted, even in patients undergoing surgery at the age of 3 years.
    4. To improve jaw growth after cleft palate surgery, appropriate pre- and post-operative patient management and better operative techniques are necessary.
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  • Correlation with clinical symptoms of TMJ disorders
    Nagataka TOYODA, Koichi ASADA, Hiroaki NAOHARA, Masato JIBIKI, Katsuno ...
    1996 Volume 42 Issue 4 Pages 396-404
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    MR imaging is useful in the diagnosis of bilateral internal derangement of the temporomandibular joint. This study was performed to investigate the correlation between clinical symptoms and displacement of the bilateral articular disk in patients with temporomandibular joint disorders (TMJD). A series of 170 patients who had signs and symptoms of TMJDs (TMJ pain, TMJ sound, trismus) were examined bilaterally by MR imaging. One hundred twenty-six patients had only unilateral symptoms, but 55 (44%) of them showed bilateral disk displacement. Among 93 patients with unilateral TMJ pain, 89% showed disk displacement (22 TMJs with reduction, 61 TMJs without reduction) on the symptomatic side, and 44% showed disk displacement on the asymptomatic side. Among 53 patients with unilateral TMJ sound, 96% showed disk displacement (28 TMJs with reduction, 23 TMJs without reduction) on the symptomatic side, and 53% showed disk displacement on the asymptomatic side. In patients with severe trismus (interincisal opening distance <39mm), unilateral or bilateral disk displacement without reduction was frequently found. The results indicate that examinations by MR imaging are important for the diagnosis of internal derangement of the temporomandibular joint.
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  • Masatoshi CHIBA, Masahiro KUMAGAI, Tetsu TAKAHASHI, Hirokazu NAGAI, Sh ...
    1996 Volume 42 Issue 4 Pages 405-412
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The posterior disc attachment (PA) of the temporomandibular joint (TMJ) has relatively high signal intensity on T 1 -weighted or proton density-weighted magnetic resonance imaging (MRI). Sometimes, however, low signal intensity of the PA is observed in patients with chronic disc displacement. On the basis of previous histopathological studies, the areas of low signal intensity in the PA may be consistent with pseudodisc formation associated with fibrous metaplasia of the PA.
    The purpose of this study was to evaluate the relations between MR signal intensity of the PA and MRI findings, including the degree of disc displacement, disc reduction, disc shape, bone change, and condylar translation, as well as clinical findings, including the duration of symptoms, joint pain, and range of motion. The study was based on MRI of 216 TMJ in 184 patients with anterior disc displacement. The sagittal closed-mouth T 1 -weighted SE images were used to determine the presence or absence of low signal intensity in the PA.
    Low signal intensity in the PA was seen in 33 joints in 32 patients (15.3%). The incidence of low signal intensity was significantly higher in males (27.8%) than in females (12.8%).
    No statistical difference was found between anterior disc displacement with reduction (10.5%), anterior disc displacement without reduction (21.5%), and anterior disc displacement without reduction with osteoarthrosis (14.3%).
    Low signal intensity in the PA was seen only in moderate or severe disc displacement. Low signal intensity in the PA was not associated with specific clinical or MRI findings except for the degree of disc displacement.
    In conclusion, low signal intensity in the PA is directly correlated with disc displacement, and there was no apparent correlation with clinical findings. Low signal intensity of the PA is not necessarily related to adaptation of the joint in disc displacement.
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  • Yoshiki ISHIGAKI, Tazuko SATOH
    1996 Volume 42 Issue 4 Pages 413-423
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We used Streptococcus milleri NCTC 7331 (S. milleri) and Bacteroides fragilis NCTC 9343 (B. fragilis) to prepare rabbit mandibular infection models. We studied their usefulness and obtained the following results:
    The post-inoculation rubefaction at the infection site disappeared within 7 to 10 days. Swelling of the infection site, which was noted on the 2nd day, did not disappear even by the 28th day. Elastic hardening was quite palpable from the 21st day.
    In hematological examinations, the white blood cell count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum sialic acid reached their peak levels within 3 days after inoculation. The levels of these variables on the 28th day were just slightly higher than those before inoculation, and equilibrium was maintained.
    In bacteriological examinations we counted the numbers of living bacteria in the pus. Living S. milleri reached peak levels 7 days after inoculation and thereafter showed a downward trend. Although living B. fragilis showed only a slight decreasing tendency after reaching its peak on the 14th day, a high level persisted subsequently.
    Roentgenologic and histopathological examinations disclosed that the changes were due to acute inflammation during the first half of the post-inoculation period and chronic osteomyelitis-like conditions during the latter half of the post-inoculation period.
    The time course of serum antibody titers of inoculated bacteria was similar to that of the numbers of living bacteria in the pus. S. milleri and B. fragilis had maximum antibody titers of 1: 400 and 1: 1600, respectively.
    These models showed pathological evidence of acute inflammation for the 1st week after inoculation. After 4 weeks, they can be used as a model of chronic infection.
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  • Hideki ICHIHARA, Yukihiro KATO, Hiroyoshi SAKI, Norichika TATEMATSU, M ...
    1996 Volume 42 Issue 4 Pages 424-426
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A case of recurrent pleomorphic adenoma with multicentric satellites is reported in this paper. The tumor occurred in a minor salivary gland in the right buccal mucosa in a 67-year-old man. It was diagnosed on the basis of histopathological examinations of the mass and a swollen cervical lymph node. The diagnosis was recurrent pleomorphic adenoma with malignant transformation 36 years after primary surgery. In this report, the clinical course and histopathological findings are described and discussed.
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  • Yutaka SHINODA, Toshitaka MURAJI, Shinjiro SUZUKI, Yasutoshi OSUGI, Sh ...
    1996 Volume 42 Issue 4 Pages 427-429
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We report a case of malignant myoepithelioma arising in the minor salivary gland of the palate in a 70-year-old man. The tumor consisted of a solid growth of rounded cells with some spindle-shaped cells showing frequent signs of mitoses. At the periphery of the tumor, the tumor cells were infiltrated by a hyaline-like stroma. Immunohistochemically, the tumor cells were positive for S-100 protein, cytokeratin, and sometimes glial fibrillary acid protein, which is typical of myoepithelial cells. Electron microscopic examination showed cytoplasmic filaments with dense bodies and a basal lamina around the tumor cells. These findings also supported the myoepithelial features of the tumor.
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  • Yasutaka KUBOTA, Yasuharu TAKENOSHITA, Tomohiro NINOMIYA, Masanori SHI ...
    1996 Volume 42 Issue 4 Pages 430-432
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Eighteen primary cases of non-Hodgkin's lymphoma were examined clinically and histophathologically at our department from 1985 to 1994. The results were as follows:
    1) There were 7 cases of nodal lymphoma, 9 cases of extranodal lymphoma, and 2 cases of lymphoma in Waldeyer ring. According to the LSG classification, 72%(13 of 18 cases) were diffuse large cell type or diffuse mixed cell type. Immunophenotypic analysis of surface markers revealed that 86%(12 of 14 cases) were B cell type.
    2) The combination of CT with ultrasound examinations, and cytological examinations were valuable in the diagnosis of malignant lymphoma.
    3) Ten cases followed up for over 3 years were in stage I or II, and 6 of them were treated with irradiation and chemotherapy. The prognosis of T cell type was poor.
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  • Masahide TSUJI, Kayoko OHTSUKI, Masatoshi OHNISHI
    1996 Volume 42 Issue 4 Pages 433-435
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We report a very rare case of Castleman's lymphoma arising in the left submandibular region. A 12-year-old girl complained of swelling of the left submandibular region. The swelling was a sharply defined, elastic hard, elliptic mass measuring 30×30 mm. However, there was no tenderness. Tuberculin reaction test, Paul-Bunnel test, and virus antibody reaction test were negative. As this lesion was clinically suspected to be a benign tumor of the submandibular region, enucleation of the tumor was performed. The histopathological diagnosis was Castleman's lymphoma of a hyaline-vascular type. There was no evidence of recurrence in the patient 2 years 6 months after operation.
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  • Yukihiro YOKOKURA, Mizue FUKUDA, Hirotate IWASE, Makoto SHINOHARA, Har ...
    1996 Volume 42 Issue 4 Pages 436-438
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    An angiomyoma is a benign tumor of the smooth muscle that originates in the blood vessels and is usually located in the extremities. Here, we report out experience with an extremely rare case of an angiomyoma that arose from the lower lip in a 29-year-old man. He had first noticed symptoms a few years ago. He was referred to our department with a complaint of incongruity with the tumor. It was a 1-cm, painless, non-tender mass on the labial mucosa of the left lower lip. Thus, enucleation of the tumor was performed. Microscopically, the tumor consisted of masses of leiomyoma and endothelial cells. The histopathological diagnosis was angiomyoma. Postoperative observation has revealed no recurrence, as of 3.9 years after surgery.
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  • Report of a case with 23 years, follow-up
    Yukiko HOSHINA, Mamoru NAGASE, Tamio NAKAJIMA
    1996 Volume 42 Issue 4 Pages 439-441
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A case of Hand-Schüller-Christian disease with 3 recurrences during 23 years is reported.
    The patient was a 4-year-old girl with bone lesions of the skull and maxilla. The lesions were diagnosed histologically as histiocytosis X on biopsy and were treated successfully with steroid therapy. The disease recurred with diabetes insipidus, exophthalmos, bone lesions of the skull, and growth retardation at the age of 14. At the age of 20, bone lesions of the maxilla and femur were noted. In addition, a bone lesion appeared in the mandible 5 years later. Steroid therapy was effective, but the cessation of therapy or reduction of the dose resulted in recurrence of bone lesions. Thus, maintenance steroid therapy may be needed to control the disease.
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  • Yasuomi OHTOMO, Toshitaka MUTO, Jun MAEDA, Johji KAWAKAMI, Hiroyuki MI ...
    1996 Volume 42 Issue 4 Pages 442-444
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We report our experience with a rare case of bilateral simple bone cysts in the mandible. The patient was a 14-year-old girl referred to our clinic for further examination of radiolucent areas in the mandible, which were pointed out by her dentist. These cysts were treated by aspiration of the contents through a small drill hole in the cortical bone. Postoperatively, excellent new bone formation was demonstrated on radiographs.
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  • Satoshi TAKADA, Jiro NAKAE, Hisashi MIYAJIMA, Kazuo WADA, Tomoya OHNO, ...
    1996 Volume 42 Issue 4 Pages 445-447
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    This case report describes a mucous cyst in the uvula of an infant. The cyst was considered to be congenital.
    The patient was a 3-month-old boy who was referred to our department for a tumor in the uvula. The tumor was semitransparent, spherical, and measured 7 mm in diameter. The clinical diagnosis was an epidermoid cyst, and it was surgically enucleated under general anesthesia. Histopathologically, the cyst was lined by pseudostratified columnar epithelium or ciliated columnar epithelium, and mucus was observed in the cyst on PAS, alcian blue, and mucicarmine staining. The minor salivary glands were close to the cyst wall on keratin wide immunostaining. The diagnosis was, therefore, a mucous cyst.
    There has been no recurrence as of 2 years after operation.
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  • Takashi IDE, Akira MIYAKAWA, Chikao KATAOKA, Makoto NOGUCHI, Hiroyoshi ...
    1996 Volume 42 Issue 4 Pages 448-450
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A case is reported of a patient who fainted and dislocated the left mandibular condyle into the middle cranial fossa. The diagnosis was made by neurological surgeons, and the patient was treated at our department. A resin pivot was placed between the left upper and lower molars and continuous elastic intermaxillary traction was applied. The condylar head remained in the middle cranial fossa after reduction, but no neurological complications occurred. After 6 years' follow up, radiographs demonstrated satisfactory occlusion and jaw movement, except for slight deviation to the left on maximum opening.
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  • Yasuyuki KANO, Junichiro NUKATA, Minoru ADACHI, Riki MATUMOTO, Hiromi ...
    1996 Volume 42 Issue 4 Pages 451-453
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Ninety-seven patients who had undergone internal fixation for maxillofacial fractures were examined with respect to the removal of osteosynthetic materials. All patients were scheduled to undergo removal of implant materials, but 16 patients refused. Among these patients, 64 % refused because they did not wont to undergo a second operation, 18% because they feared facial nerve palsy, 18 % because they feared an operation scar.
    Osteosynthetic materials were removed in 67 % of patients more than 40 years of ago and 87% of patients less than 40 years. Midface osteosynthetic materials were removed in 92% of male patients and 71% of female patients. Mandibular osteosynthetic materials were removed in 97% of patients treated with an intraoral approach and 63% of patients treated with an extraoral approach.
    To facilitate the removal of midface osteosynthetic materials, operation should be done with an unmarked skin incision.
    To increase the removal rate of mandibular osteosynthetic Materials, operation should be done with an intraoral approach, if possible.
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  • Masaki HONDA, Atushi NIIMI, Yasuhiro NOSAKA, Minoru UEDA, Kouji KASHIW ...
    1996 Volume 42 Issue 4 Pages 454-456
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A maxillofacial prosthesis is one useful method to restore defects after orbital exenteration. A conventional orbital epithesis would satisfy cosmetic requirements if there were no movement, such as facial expression. However, the orbital region has many kinds of movement, and there is no prosthesis that can mimic such movement, expect for a few experimental ones.
    Unnatural facial expressions that are not linked with the normal side adversely affect the patient's social rehabilitation.
    We developed a “Blinking-eyelid orbital epithesis” by adding blinking movement to a conventional epithesis, as the first step to overcome this problem. With conventional methods for epithesis support, it was impossible to support a blinking-eyelid orbital epithesis because the weight of the epithesis increased when the blinking function was added. However, we solved this problem by using osseointegrated implants to support the epithesis.
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  • Yoshiyasu UCHIDA, Seiji IIDA, Mikihiko KOGO, Gen OKADA, Takashi TACHIM ...
    1996 Volume 42 Issue 4 Pages 457-459
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Hemifacial microsomia is defined as a condition affecting primarily aural, oral, and mandibular development and its clinical features may vary. In this paper we report a case of hemifacial microsomia with cleft palate. A Japanese girl 8 months of age was referred to our clinic for the treatment of cleft palate. Clinically, she had hypoplasia and inferior displacement of the left auricle, stenosis of the external auditory canal, a hypoplastic mandible, and facial palsy at the left side of the lower lip. There was no significant asymmetry of the maxillary dental arch or soft palate, and the left side of the soft palate showed mild hypokinesia. Palatoplasty with a push-back method was performed under general anesthesis at the age of 1 year 5 months. A few reports have shown a trend toward velopharyngeal insufficiency in hemifacial microsomia due to hypoplastic palatal muscles and poor neural control of these muscles. In the future, comprehensive speech therapy will be required in this patient.
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  • Tomohiro HAYASE, Youji TOMIDA, Yasuo KINOSHITA, Akio YASUI
    1996 Volume 42 Issue 4 Pages 460-462
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Phocomeliais characterized by hypoplasty of the upper limbs and is known to be a complication of thalidomide embryopathy. Robert's syndrome may also be associated with phocomelia but is often accompanied by other serious malformations.
    We report a patient with bilateral cleftlip, cleft palate, and phocomelia that were idiopathic and could not be classified into any known category of malformations.
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  • Masashi TANAKA, Takahisa YAMADA, Akihiko ARATA, Hiroko HOSHINO, Yasuyu ...
    1996 Volume 42 Issue 4 Pages 463-465
    Published: April 20, 1996
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The sialolithiasis most commonly occurs in the submandibular salivary gland. We have recently encountered a rare case of bilateral sialolithiasis of the submandibular gland. The patient, a 61-year-old woman, was referred to our hospital, for pain in the left side of the oral floor caused by the lower denture.
    After clinical examination the salivary stones were removed and examined with an X-ray microanalyzer. The stones were composed of Ca, P, F, Na, Mg, Al, Si, S, Cl, K, Fe, Cu, and Zn.
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