Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 57, Issue 1
Displaying 1-8 of 8 articles from this issue
Preface
Original articles
  • Shinya HORII, Takanori KOBAYASHI, Akihiko IIDA, Chikara SAITO, Takafum ...
    2011 Volume 57 Issue 1 Pages 2-7
    Published: January 20, 2011
    Released on J-STAGE: April 22, 2014
    JOURNAL FREE ACCESS
    Intravascular papillary endothelial hyperplasia (IPEH) is a reactive lesion histopathologically characterized by papillary proliferation of endothelial cells in organizing thrombi formed in dilated blood vascular spaces.We studied the clinicopathological features of 10 cases of IPEH treated at the Niigata University Hospital during the last 12 years from 1998 through 2009 and reviewed the literature. The patients were 5 men and 5 women.Their age mean was 51.2 years (range, 21 to 72). The lesions were most frequently located in the lower lip (5 cases), followed by the tongue (2 cases), and the buccal mucosa, gingivobuccal fold, and maxillary sinus (1 each). The lesions were all covered by mulberry-colored mucosae, measuring 8.6 mm in average diameter (range, 3 to 12 mm), while they were rather elastic on palpation and did not always fade on compression. Most ofthe clinical diagnoses were hemangioma (7 cases), while the diagnosis of hemangioma was ruled out in 2 cases arising in the lower lip and tongue by ultrasonography, which revealed high blood flow inside the lesion. All cases were surgically removed in accordance with the procedure for hemangioma, without recurrence. Thus, the application of ultrasonographic examination before surgery was suggested to be useful for the differential diagnosis of IPEH from hemangioma.
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  • Katsuhiro UZAWA, Masanobu YAMATOJI, Atsushi KASAMATSU, Yosuke SAKAMOTO ...
    2011 Volume 57 Issue 1 Pages 8-14
    Published: January 20, 2011
    Released on J-STAGE: April 22, 2014
    JOURNAL FREE ACCESS
    Although the status of surgical margins and regional lymph node metastases are relevant prognostic factors in oral squamous cell carcinoma (OSCC), local recurrences, distant metastases (r/m), or both have occurred in a subset of OSCC patients with histologically negative margins/lymph nodes.The principle objective of our study was to assess the possible monitoring of such OSCC cases by quantitative real-time PCR combined with high-resolution melting curve analysis (qPCR-HRMA) for circulating free mitochondrial DNA (mtDNA), which has copy numbers hundreds to thousands times higher than those of genomic DNA (gDNA) in each cell. mtDNA from normal and tumorous tissues and serum mtDNA obtained at two time points (pre-surgery, and 4 weeks post-surgery) from 43 patients (34 r/m-negative cases and 9 r/m-positive cases) were examined for the D-loop region at position 68 of human mtDNA genome. On qPCR-HRMA, we found that mutant mtDNA was identified in the samples from tumorous tissues at much higher concentrations than in samples from corresponding normal tissues. Furthermore, 67 % of r/m-positive cases showed higher amounts of mtDNA (>50 %) in their tumor tissues as compared with the r/m-negative group. On blood tests, all serum mtDNA samples obtained 4 weeks after surgery in r/m-positive cases, except for one case, maintained high amounts of mutant mtDNA.In conclusion, tumor-specific mitochondrial mutations in the sera of OSCC patients can be successfully identified using qPCR-HRMA, and this technique has potential application for the surveillance of patients after tumor resection.
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Case reports
  • Ryusuke TACHIBANA, Toru SATO, Yoko KAMIYA, Chika TERADA, Koichi ASADA, ...
    2011 Volume 57 Issue 1 Pages 15-19
    Published: January 20, 2011
    Released on J-STAGE: April 22, 2014
    JOURNAL FREE ACCESS
    We report the rare case of a central giant cell granuloma of the hard palate. A 30-year-old Japanese woman consulted our clinic because of a swelling of the hard palate. MRI examination showed a well-demarcated homogenous lesion of the hard palate with low signal intensity on T1-weighted images and high signal intensity on STIR. CT revealed a deep crater-like bone defect adjacent to the incisive foramen. Surgical excision was performed with the patient under general anesthesia. Histopathological examination revealed dense proliferation of spindle-shaped cells accompanied by blood capillaries ans multinucleated giant cells. The lesion was diagnosed to be a central giant cell granuloma. There has been no evidence of recurrence as of 17 months after the operation.
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  • Kazutada USAMI, Hirokazu MIZUNO, Yasuhiro OKAZAKI, Minoru UEDA
    2011 Volume 57 Issue 1 Pages 20-24
    Published: January 20, 2011
    Released on J-STAGE: April 22, 2014
    JOURNAL FREE ACCESS
    We describe a case of malignant lymphoma (stage I E) in the mandible that underwent Cyberknife therapy.The patient was a 71-year-old man who had pain of the lower gingiva. Intraoral examination revealed a slight swelling at the buccal gingiva in the left lower canine region. Radiographic examination showed a radiolucent lesion in the apical region. Under a clinical diagnosis of chronic apical periodontitis, extraction was performed for biopsy. The histopathological diagnosis was a diffuse large B-cell lymphoma (DLBCL). We performed Cyberknife therapy (30 Gy/5 sections) of the mandible. The patient has shown no signs of recurrence for 5 years 1 month after therapy.
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  • Hiroyuki TAKAFUJI, Kazuma FUJIMURA, Katu TAKAHASHI, Masasi YAMORI, Yas ...
    2011 Volume 57 Issue 1 Pages 25-29
    Published: January 20, 2011
    Released on J-STAGE: April 22, 2014
    JOURNAL FREE ACCESS
    Jacob disease is a rare condition that affects the coronoid process. In 1899, Jacob was the first to describe osteochondroma of the coronoid process, forming a pseudoarthrosis joint between the coronoid process and the zygomatic arch. A 21-year-old man with a 7-year history of progressive limitation of mouth opening was referred to our hospital by his dentist. The maximum interincisal opening was 20 mm. A radiographic examination showed a right enlarged fungiform coronoid process. Three-dimensional computed tomography clearly demonstrated the anatomic relation between the coronoid process and the surrounding bony structure. The coronoid process was bilaterally excised by an intraoral approach. Histopathological examinations revealed compact cortical bone surrounded by a thin band of cartilage tissue diagnosed as osteochondroma, which matched the characteristics of Jacob disease. After the operation, the maximum interincisal opening was 48 mm.
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  • Michiyo YAMAMURA, Kazuma NOGUCHI, Kuniyasu MORIDERA, Yukiyo TOYOHARA, ...
    2011 Volume 57 Issue 1 Pages 30-33
    Published: January 20, 2011
    Released on J-STAGE: April 22, 2014
    JOURNAL FREE ACCESS
    Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon osteolytic, pigmented neoplasm involving craniofacial sites, especially the maxilla of newborn infants. Since the first report by Krompecher in 1918, approximately 400 cases have been reported to date.We present a case of MNTI occurring in the maxilla of a 3-month-old girl. On initial examination, a grayish bony enlargement was noted at the left side of the anterior maxilla. Plain CT scanning demostrated two cyst-like radiolucent lesions measuring 15 mm and 10 mm in diameter and involving the central and lateral deciduous incisors.The clinical diagnosis was a maxillary tumor. Enucleation of the tumor was performed with the patient under general anesthesia. The tumor was lobulated and black and included two deciduous teeth. Histopathollogically, the tumor showed a nest-like proliferation of epithelial cells and small round cells with dense fibrous connective tissue. Most epithelial cells contained melanin pigments.On immunohistochemical staining of the excised tumor, NSE, synaptophysin, AE1/AE3, vimentin and HMB45were positive, and GFAP, NFP, MIC2, EMA, desmin, CEA, and S-100 protein were negative. On the basis of these findings, the tumor was finally diagnosed as MNTI. There has been no sign of recurrence as of 2 years after operation.
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  • Nobuhiro YAMAKAWA, Yuichiro IMAI, Kumiko AOKI, Takahiro YAGYUU, Kotaro ...
    2011 Volume 57 Issue 1 Pages 34-38
    Published: January 20, 2011
    Released on J-STAGE: April 22, 2014
    JOURNAL FREE ACCESS
    Lymphoepithelial carcinoma (LEC) is a very rare salivary gland neoplasm that is associated with Epstein-Barr virus (EBV) infection. The patient was a 31-year-old man who came to our hospital because of pain and swelling of the left floor of the mouth. CT, MRI, and US revealed a tumor of the sublingual gland. Resection of the tumor, neck dissection, and reconstructive surgery using a free forearm flap were performed with the patient under general anesthesia. Histologically, the tumor consisted of irregularly arranged solid nests. The surrounding tissue was infiltrated predominantly by tumor cells and lymphocytes. EBV-encoded small RNAs (EBER) were positive on in situ hybridization (ISH). Furthermore, EBV DNA was detected on 4PCR and Southern blot analysis.In addition, on serological verification, there were high values of anti-VCA-IgG (FA), anti-VCA-IgA (FA), anti-EADR-IgG (FA), and anti-EBNA (FA). The patient is alive with no evidence of recurrence 20 months after surgery.
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