Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 38, Issue 12
Displaying 1-49 of 49 articles from this issue
  • Yoshihiro SUNAGA, Nobuo YOSHIZAWA, Satoshi ASANO, Kenji ERA, Kazuo YAS ...
    1992 Volume 38 Issue 12 Pages 1709-1717
    Published: December 20, 1992
    Released on J-STAGE: September 13, 2011
    JOURNAL FREE ACCESS
    Palatal vault osteotomy is performed in the clinic as a preprosthetic procedure designed to increase the depth of the palate and thus attain better retention of maxillary dentures in edentulous patients. However, in some cases relapse occurs. To investigate factors potentially affecting the outcome of this procedure, we performed palatal vault osteotomy in 25 adult dogs. After surgery the morphological changes of the palate were determined by plaster models and Moire topograms.
    One month postoperatively, palate depth had increased by an average of 4.1mm, palate surface was 1.14 times that of control and palate volume was 1.4 times that of control. However, two mcnth after surgery each of these parameters tended to decrease. As for the width and anteroposterior length of the palate, no changes were detected one or two months postoperatively.
    The results of this study indicate that the relapse observed two months after surgery was due to the suction pressure exerted when taking the impressions for plaster models. This pressure most likely contributed to the downward movement of the palate. Sincebone segments can be easily moved during procedures that require negative pressure, it is of great importance tc carefully take impressions and to insert dentures as soon as possible.
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  • strength to bone of zirconia dispersed hydroxyapatite ceramics
    Masayuki FUKUDA
    1992 Volume 38 Issue 12 Pages 1718-1737
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    To evaluate the effect of zirconia concentration on the characteristics of candidate bioceramic materials, the mechanical properties and biocompatibility of zirconia dispersed hydroxyapatite ceramics (Zr-HAs) containing 1.6, 50 and 65vol% of zirconia were examined and compared with those of hydroxyapatite ceramic (HA), partially-stabilized zirconia ceramic (PSZ), titanium (Ti), and cobalt-chrome alloy (Co-Cr).
    The bending strength and fracture toughness of all Zr-HAs were higher than those of HA, and these variables increased parallel to the zirconia concentration.On the other hand, Young's modulus of all Zr-HAs was lower than that of HA.
    In order to examine the affinity for bone, the materials were implanted into die femurs of rats and specimens were taken periodically.Histological examination, contact microradiography, scanning electron microscopy (SEM) and energy dispersion X-ray microanalysis (EDXA) revealed that the patterns of bone formation around the implanted Zr-HAs and Ti were similar to that of HA, showing direct contact with the newly formed bone.
    To evaluate bonding strength to bone, Zr-HAs, HA, PSZ and Ti were implanted into tibias of adult mongrel dogs.Three months after implantation, bonding strength was examined by a push-out test.The values for the bonding strength of Zr-HAs were significantly higher than those of PSZ or Ti (p<0.01).Bonding strength decreased when higher concentrations of zirconia were contained in the ceramics.SEM and EDXA analyses of the implanted Zr-HAs after the push-out test revealed fracture sites beneath the surface of newly formed bone or at the interface between the materials and bone.For implanted HA, fractures sites were situated within the implant, within the bone, or at the interface between implant and bone.On the other hand, in the case of PSZ and Ti, fracture sites were noted in the connective tissue layer or at the interface between the implant and bone.
    In conclusion, although the mechanical properties of Zr-HAs were dependent on the concentration of zirconia, each Zr-HA evaluated in this study showed excellent mechanical strength, bone affinity and bonding strength.The results suggest that Zr-HAs are desirable ceramics for clinical use.
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  • Takeshi HARADA, Masanori SHINOHARA, Seiji NAKAMURA, Makoto SHIMADA, Ma ...
    1992 Volume 38 Issue 12 Pages 1738-1744
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    An immunohistochemical study of human lung cancer antigen and gastric cancer antigen in oral squamous cell carcinoma was performed to elucidate the clinical usefulness of these antigens by investigating their relationship to clinical and histopathological features.
    Significantly increased expression of human lung cancer antigen was noted in highly differentiated tumors according to the WHO classification criteria. On the other hand, human gastric cancer antigen was significantly more abundant in the peritumoral epithelia of the tongue and lower gingiva than in other sites. However, no discernible relationship was detected between the distribution of these antigens and the mode of tumor invasion, or the presence of cervical lymph node metastasis.
    These results suggested that immunohistochemical evaluation of human lung cancer antigen is useful in assessing tumor differentiation, and that of human gastric cancer antigen can facilitate identification of the primary site in oral squamous cell carcinoma.
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  • Kenichi HATADA
    1992 Volume 38 Issue 12 Pages 1745-1763
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We examined the antitumor effect of peplomycin morphologically using a rat model of tongue carcinoma induced by the carcinogenic agent, 4-nitroquinoline 1-oxide. We also studied the survival status of reproliferative tumor cells and the reproliferative movement of the tumor after the completion of peplomycin treatment.
    The effective rate of peplomycin was 25.5% if tumors showing a reduction of 1/2 or greater are designated as a positive response or 5.9% if histological evidence of Grade III or above is regarded as a positive response.
    We noted a correlation between clinical macroscopic type and the mode of invasion. The frequency of ingrowing growth patterns such as ulcer type was statistically hingher in types 4 C and 4 D, while outgrowing growth patterns were more commonly noted in types 1 to 3.
    We also noted that the higher the tumor invasion, the lesser was the antitumor effect both macroscopically and histologically. Therefore, when carrying out neo-adjuvant chemotherapy with peplomycin, the mode of tumor invasion can be an important factor in forecasting the effect of treatment.
    Even after the macroscopic eradication of the lesion by peplomycin treatment, we sporadically noted some sections with histological evidence of surviving tumor cells. Although the antitumor effect of peplomycin remained up to 20 days after completing treatment, it was most remarkable 10 days after treatment histologically.
    Macroscopically, tumors of ulcer type showing A type 4 C or 4 D mode of invasion were characterized by rapid reproliferation of surviving tumor cells and strongly tended to be heteromorphic.
    It was concluded that peplomycin preoperative chemotherapy is most effective when treatment is planned so that surgery can be carried out within 10 days after completing chemotherapy.
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  • Postural change of the hyoid bone and skeletal relapse
    Toshio SUGAHARA, Yoshihide MORI, Katsuhiro MINAMI, Tomoaki KAWAMOTO, K ...
    1992 Volume 38 Issue 12 Pages 1764-1770
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The present investigation studied the relation ship of hyoid bone position to skeletal relapse in mandibular prognathism patients who underwent mandibular sagittal split osteotomy. The study material consisted of presurgical and 6-months postsurgical profile cephalograms of 43 patients.
    At point Gn, 1.4% horizontal and 7.7% vertical skeletal relapse was found following mandibular osteotomy in mandibular prognathism without anterior open-bite. In mandibular prognathism with anterior open-bite, the horizontal relapse was 4.7% and the vertical relapse 24.5%.
    Postoperatively, the hyoid bone moved posterosuperiorly or posteroinferiorly. This change in hyoid bone position indicates that some physiologic mechanisms operate to maintain pharyngeal airway patency. The group of patients with posteroinferior displacement of the hyoid bone after surgery was found to have a large relapse. This relapse was suggested to be related to increased geniohyoid contracting force of mandibular opening components by vector analysis, because the interplay of forces in the suporting structure of the hyoid bone has important effects on mandibular form and function. It therefore appeared that the stability of the surgical outcone could be associated in some way with the change in hyoid position.
    Distance H-G continued to show a large reduction effected by posterior repositioning of the mandible by surgery. However, distance Sp-H remained only slightly reduced. This may indicate that the stylohyoid muscle surporting the hyoid bone and the mandible plays an important role in vertical skeletal relapse.
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  • Masato KOIE
    1992 Volume 38 Issue 12 Pages 1771-1784
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    To investigate new biomaterial possessing active osteogenetic competence in hard tissue, half-purified bone morphogenetic protein (BMP) was combined with sintered titanium dioxide (titania). BMP-titania complex was implanted in bone marrow cavities and bone defects.
    In this experiment titania was used as a carrier of BMP, therefore the mechanical properties of titania were investigated initially, and then the effects of titania on BMP activity were studied in vitro. The biaxial flexure strength of titania was 133.8±9.33MPa, diametral tensile strength was 29.9±7.48MPa, compressive strength was 262.7±33.04MPa, and Vicker's hardness was 628.1±45.13Hv. Titania neither enhanced BMP activity, nor suppressed it. This may indicate possible use as a carrier of BMP.
    For the implantation of BMP-titania complex, three mg of BMP bound into a hollow titania cylinder with an external diameter of 4mm, an internal diameter of 2mm, and a length of 5mm, was deeply implanted into the marrow cavities and bone defects of the femur of Japanese white rabbits. Four weeks after implantation, all animals were sacrificed, and the tissue in the hollow part of the titania cylinder was observed histologically using H-E., toluidine blue, and tetrachrome staining.
    The results showed BMP-titania complex to have osteogenetic competence in both bone marrow cavities and bone defects. As a result of the histologic observation of the ossification process, it is suggested that ossification by BMP in marrow cavities is not via chondrogenesis. In conclusion, the BMP-titania complex can act as a bone substitute.
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  • 2. Age-related structural differences in the rabbit ulnar periosteum
    Ken TSUYAMA, Shin-ichi KITA, Mitsuyoshi MATSUDA, Thoru ICHIKAWA
    1992 Volume 38 Issue 12 Pages 1785-1790
    Published: December 20, 1992
    Released on J-STAGE: September 13, 2011
    JOURNAL FREE ACCESS
    The periosteum in a long bone is apparently a thick layer of specialized dense connective tissue covering the entire bone surface, except for the articular cartilage and insertion site of the tendon or ligament.
    In case of the ulna, its periosteum exists in the area between the bone and muscule tissue. It is composed of two or three parts. The cellular layer with its numerous cell components exists in contact with the bone aurface. This cellular layer has been generally regarded to have osteogenic capacity.
    Most research indicates that the cellular layer is almost impossible to recognize upon reaching adulthood; therefore, the periosteum at this stage is considered to lack osteogenic capacity. However, the opposing view exists that the periosteum an adult maintains its osteogenic capacity, albeit accompanied by some time lag. To date, there are various opinions concerning the relationship between periosteal structure and its osteogenic capacity.
    Research on the adult periosteal structure is especially insufficient, and many unanswered questions remain.
    The present study was designed to obtain fundamental knowledge on structural differences of the periosteum in young and adult stages. We studied the ulnar periosteum of rabbits by light microscopy.
    The results are summarized as follows:
    The young periosteum can be divided into two parts: cellular and fibrous layers. The cellular layer with rich cell components was observed on the inner surface in contact with bone, indicating that this layer has osteogenic capacity. The fibrous layer, in contact with muscular tissue, consists of fibrous tissue containing few cells.
    In the periosteum of adults, the existence of two layers cannot be discerned. The adult periosteum was devoid of a cellular layer rich in cells, and consisted mostly of fibrous tissue with a few spindle-shaped cells.
    The thickness of the periosteum in young rabbits was nearly three times wider than that of adults.
    Our observations agree with many previous reports and support then, except for a few minor differences. The adult periosteum therefore dose not have a cellular component and lacks osteogenic capacity or its is osteogenic potential is markedly inferior to that of the young periosteum.
    However, it is interesting to observe structual changes of the adult periosteum induced by certain stimuli. The mechanisms of periosteal bone repair will be the subject of further studies.
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  • Using the cecerebral evoked potential as an indicator
    Toshiya MATSUZAKI
    1992 Volume 38 Issue 12 Pages 1791-1808
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Unstable pain in the oral and maxillofacial region has often been treated with imipramine, a tricyclic antidepressant. Trigeminal neuralgia has been treated with carbamazepine. Although these drugs have been effective in a number of cases, their mechanism of analgesic effect has not been thoroughly clarified. In the present study, visual analogue pain scale (VAS) was used to evaluate subjective pain. To evaluate objective pain, the somatosensory evoked potential (SEP) of the cerebral evoked potential (CEP), which was induced by electric dental stimulation, was enployed. In this way, the analgesic effect of the study drugs was analyzed.
    Moreover, to study the effect of drugs on the CNS and information processing, auditory evoked potential was assessed by the right-left discriminatory response task. Event related potential (ERP) representing the wave of target stimuli was studied. Reaction time (RT) was also determined stimultaneously with SEP and ERP. For comparison, diclofenac sodium (an analgesic) and placebo were similarly evaluated. In the SEP wave, peak latency of the late component was prolonged by the administration of imipramine and carbamazepine. The N2-P2 amplitude involved in algesthesia was reduced by the administration of imipramine (p<0.05), carbamazepine (p<0.025), and diclofenac sodium (p<0.01). Values determined with the VAS declined after the administration of imipramine, carbamazepine (for both, p<0.01) and diclofenac sodium (p<0.05).
    In the ERP wave, P3-peak latency alone was prolonged by the administration of imipramine and carbamazepine (p<0.05). N2-P3 amplitude was reduced by imipramine (p<0.05) and carbamazepine (p<0.001).
    No significant change was seen after administering placebo, and no significant difference in the mode of ERP was observed after the administration of diclofenac sodium.
    The results of this study of CEP suggest that imipramine and carbamazepine suppress the high CNS, secondarily inducing an analgesic effect.
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  • Kinuko TANAKA, Eiro KUBOTA, Takeshi KATSUKI, Hiroyuki KUROKAWA, Hideo ...
    1992 Volume 38 Issue 12 Pages 1809-1814
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We applied the in vitro colorimetric dye reduction technique described by Mosmann to carry out chemosensitivity tests of human squamous cell carcinomas.
    The assay is based on the selective reduction of the tetrazolium salt, MTT, by cells which remain viable after exposure to drugs. Mitochondrial dehydrogenases at the sites of coenzyme Q as well as cytochromes b and c in viable cells convert the yellow form of the salt to an insoluble intracellular purple formazan. Solubilized formazan can then be quantitated spectorophotometrically.
    Squamous cell carcinoma cell lines which we established from oral cancer patients were used throughout the experiments. A linear relationship between the number of viable tumor cells, 0.625×104-1×104 cells/well, and absorbance at 590nm was established. With cell numbers over 2×104 cells/well, this relationship no longer existed, and this necessitated adjusting the number of target tumor cells to 1×104 in the assay. The formazan formation reached plateau by 2h of culture period. The assay was so sensitive that it could distinguish the fine sensitivities of various SCC sublines to an anti-cancer drug. By using a multititer plate, the assay can be used to readily test a large number of samples with much easier and less expensive technique. It also exhibits high sensitivity and reproducibility.
    All of these results indicate that chemosensitivity tests by MTT assay are useful for screening oral cancers.
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  • Eiro KUBOTA, Hideo IMAMURA, Mitsuo KATANO, Hiroyuki KUROKAWA, Kinuko T ...
    1992 Volume 38 Issue 12 Pages 1815-1822
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Antitumor activities of OK-432-stimulated peripheral blood mononuclear cells (PBMC) were examined. Killer activity against natural killer (NK) cell-sensitive K562 as well as lymphokine activated killer (LAK) cell-sensitive Daudi and PC3 target cells were detected among PBMC cultured with a low dose (0.0125-0.05 KE/ml) of OK-432. Kinetic analysis of killer activity showed that it reached a plateau level by 48 h of culture. Various freshly isolated tumor cells from oral cancer patients were also lysed by both the autologous and allogeneic OK-432-stimulated PBMC (OK-MC), suggesting that the specificity of the killer was not restricted by HLA and was thus non-specific. Fluorescence activated cell sortor (FACS) analyses showed that CD57+/CD25+ and CD16+/CD25+ cells were increased in PBMC after 48-h stimulation with OK-432. The killer activity was further augmented by the addition of rIL-2 at the time of killer assay.
    Tumor growth inhibitory factor (TGIF) activity, which we previously reported, was found in the culture supernatant (CSN) of OK-MC from various cancer patients. The titer of TGIF from these patients was high enough, 16-64 × of the reciprocal dilution of the CSN, which was almost equivalent to the activity from normal healthy controls.
    These results suggest that two kinds of antitumor activities were induced in the OK-432-stimulated PBMC in vitro, the one being cell-mediated and the other lymphokine-mediated (TGIF). OK-MC is thus supposed to be effective for adoptive immunotherapy (AIT) in oral cancer patients.
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  • JUSUI HIROTA, Tokio OSAKI, Kazunori YONEDA, Tetsuya YAMAMOTO, Eisaku U ...
    1992 Volume 38 Issue 12 Pages 1823-1831
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    This article dealt with extremely aged (about 90 years old) patients (2 males and 8 females) with oral or salivary gland malignancies which were treated in our clinic during the last 10 years. The following results were obtained in clinico-immunologic studies comparing these patients with younger cancer patients and healthy individuals.
    1. Histologically, 7 tumors were squamous cell carcinoma which originated from the gingiva except for one case, 2 were of salivary gland origin, and one was malignant lymphoma. Out of the 9 carcinomas, 5 were in stage W.
    2. Most patients originally had multiple complications and disabilities.
    3. Compared to younger patients and healthy controls, significant decreases of Leu 8+ T cells, lymphocyte blastogenesis, NK activity, and a significant increase of CD 16+ CD 57+ cells were observed, while LAK activity and O-2 generation of neutrophils were not suppressed.
    4. Six patients received radical treatment, and four received non-radical treatment. All tumors were locally controlled, while metastatic lymph nodes became uncontrollable in one of the 3 N (+) cases.
    5. Except for one case, adverse effects such as bone marrow suppression and stomatitis were observed. Among these effects, decreases is white blood cells and cholinesterase persisted even after discharge.
    These results indicate the importance of considering both psychological and physiological conditions unique to highly aged patients when deciding therapy principles for them. Moreover, local treatment such as radiation and surgical excision avoiding impairment of the patient's quality of life is advantageous for extremely aged patients
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  • Kohjiroh MATSUMOTO, Yutaka HASHIMOTO, Manabu TAKARADA, Masafumi YAMADA ...
    1992 Volume 38 Issue 12 Pages 1832-1838
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    During the last 8 years between 1983 and 1991, we experienced 46 cases of vascular lesions of the oral and maxillofacial region at the Department of Oral and Maxillofacial Surgery, Ehime University Hospital. Thirty-six cases, which were easily diagnosed as capillary or cavernous hemangioma from clinical findings, were treated by vaporization or excisional surgery by CO2 laser without digital subtraction angiography (DSA) and intravenous radionuclide arteriography (IRA).
    The remaining 10 cases were examined by DSA, 8 of these cases also underwent IRA. In DSA, as compared with the conventional film screeen methods, stress was less and resolution of the vascular system higher. Hemodynamics were assessed in detail by IRA. Therefore, diagnostic accuracy was improved. Five cases were treated by transcatheter arterial embolization (TAE) after examination by DSA and/or IRA. Treatment was successful in every case without severe complications. DSA, IRA and TAE were evaluated to be useful and safe for the management of oral and maxillofacial vascular lesions.
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  • Keisuke TAKAHASHI, Kazuhiko TANIO, Masami YAO, Yasuyuki YOSHINO, Syuuz ...
    1992 Volume 38 Issue 12 Pages 1839-1844
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Recently, cyclosporin-A (Cy-A) induced gingival hyperplasia has been reported. We examined the oral condition of 8 patients with kidney transplants who were administered Cy-A at Tottori Prefectural Central Hospital, and found gingival hyperplasia in 3 patients. We studied the total dose and duration of Cy-A treatment in the 8 patients. In the group with gingival hyperplasia, the mean total dose given until gingival hyperplasia appeared was 2, 433.2 mg/kg, and the mean period until gingival hyperplasia appeared was 744.3 days. In the group without gingival hyperplasia, the mean total dose was 5, 462.7 mg/kg, and the mean period of treatment was 1, 278.6 days at the time of the study. Oral hygiene was evaluated by the Oral Hygiene Index-Simplified (OHI-S). In the group with gingival hyperplasia, the mean OHI-S score was 3.66, while in the group without gingival hyperplasia, the mean OHI-S score was 1.65. No correlation was found between gingival hyperplasia and either the total dose or the duration of Cy-A treatment. A significant correlation was found between gingival hyperplasia and oral hygiene.
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  • Kenji MITSUDO, Masao ITO, Iwai TOHNAI, Takashi WAKAYAMA, Kengo UMEDA, ...
    1992 Volume 38 Issue 12 Pages 1845-1850
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    In general, cancer treatment is evaluated based on the parameters of tumor reduction rate, remission period, and survival rate. Recently, the quality of life (QOL) in cancer patients has become increasingly important in medical treatment. The patients with head and neck cancer usualy suffer from symptoms of oral dysfunction such as dysgeusia, dysmasesis, dysphagia and allolalia after cancer treatment. In addition cosmetic disturbances are caused by surgical treatment. In advanced cases, severe pain is involved. We devised a QOL questionnaire for head and neck cancer patients. In this study, we analysed changes in QOL scores and oral function scores caused by chemotherapy and surgery. Furthermore, the relationships between pain and QOL, oral function and QOL, ingestive function and QOL, appetite and QOL, and speech and QOL were analysed through the questionnaire.
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  • Toshiyuki OGASAWARA, Yasuo ISHII, Kaihei HAYASHI, Syunsuke ITO, Naoto ...
    1992 Volume 38 Issue 12 Pages 1851-1858
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Computed tomography (CT), CT-sialography and ultrasonography (US) were performed in 3 cases of static bone cavity.
    1. Axial CT sections clearly demonstrated defects of the lingual cortex of the mandible.
    2. In all three cases, CT-sialography clearly showed a lobulated submandibular gland which occupied the bone defect.
    3. US performed in two of the patients, clearly detected the bone defect. The contents in the bone defect were also clearly detected; the internal echo of the contents was hyperechoic and heterogeneous. US was thereby confirmed to be a useful examination for this disease.
    Both CT-sialography and convertional sialography were performed in one case to compare differences in the resulting images. Convertional sialography did not clearly demonstrate the spatial relationship between the submandibular gland and bone defect in contrast to CT-sialography. We attributed this difference to mandibular position during the X-ray.
    One case in which the buccal cortex at the lesion was thin and distended underwent surgery. The intraoperative and histopathological findings were found to match the diagnostic imagings.
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  • Yasuo HANAZAWA, Kohsuke ITOH, Toshinori MABASHI, Kazuki AKIZUKI, Satos ...
    1992 Volume 38 Issue 12 Pages 1859-1866
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Ten patients with malignant lymphomas in the oral and maxillofacialregion who were treated at our department during the period from 1986 to 1991 underwent clinical biometric analysis. The results were as follows:
    1. The subjects consisted of 4 males and 6 females aged from 39-82 years (mean age 62.6 years).
    2. In all cases, the chief complaints or initial symptoms were swelling or tumor formation in the affected areas and pain was present in 3 cases.
    3. The presumed primary site of the tumor was the submaxillar or cervical lymphnodes in 5 cases, the gingivae or alveoli of the mandible in 3, the hard palate in 1 and the tongue in 1.
    4. According to the Ann Arbor staging classification, four cases were in stage I, two stage II, one stage III and three stage IV, respectively.
    5. The histopathological diagnosis, defined by the Rye (Hodkin's disease) and LSG (non-Hodgkin's lymphoma) classification, was lymphocytic predominance type of Hodgkin'sdisease in 1 case and non-Hodgkin's lymphoma in the other 9 cases. The tumor cell types were diffuse small in 1 case, diffuse medium in 1, diffuse mixed in 1 and diffuse large in 6, respectively.
    6. Immunophenotypic analysis of surface markers, preformed in 7 cases, revealed that one case was T-cell type and the others were B-cell type.
    7. For treatment, radiotherapy alone was applied in stage I (4 cases) and stage II (1), chemotherapy alone in stage IV (3), and combined treatment in stage II (1), and III (1), respectively. Eight patient were alive and 2 cases have died as of May 1992. The overall 3-year survival rate was 73%.
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  • Norihiko TAKADA, Hisamichi GOHKE, Kan-ichi SETO
    1992 Volume 38 Issue 12 Pages 1867-1868
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Takeo NAKAMURA, Kenji KANEKO, Tatsuo ISHII, Keiji NAKAYAMA, Fumihisa A ...
    1992 Volume 38 Issue 12 Pages 1869-1870
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Shisei TOYOFUKU, Yoshiaki NAKAMURA, Miho OHUCHIDA, Hiroshi MURASE, Tad ...
    1992 Volume 38 Issue 12 Pages 1871-1872
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Clinical conclusions about a fractures of the condyloid process
    Norimasa SHIMAMURA, Kuniteru NAGAHARA, Toshi-ichiro TANABE, Shuji KURE ...
    1992 Volume 38 Issue 12 Pages 1873-1874
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Yoshihiro SAWAKI, Mitsuyuki YAMADA, Minoru UEDA, Toshio KANEDA
    1992 Volume 38 Issue 12 Pages 1875-1876
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Masayuki IKEDA, Fumihiko MATSUSHITA, Kazue YAMAGUCHI, Taichiro SAZUKA, ...
    1992 Volume 38 Issue 12 Pages 1877-1878
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Takumi MIZUI, Hideki ICHIHARA, Makoto TOIDA, Hiroyoshi SAKI, Takashi O ...
    1992 Volume 38 Issue 12 Pages 1879-1880
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Akio YASUI, Youji TOMIDA, Yasuo KINOSHITA
    1992 Volume 38 Issue 12 Pages 1881-1882
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Tetsuji KAWAKAMI, Masashi TSUZUKI, Etsuo SHOHARA, Kenji MISHIMA, Masum ...
    1992 Volume 38 Issue 12 Pages 1883-1884
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Shigehito WADA, Masataka KIDA, Yutaka YAMAZAKI, Tohru SAITOH, Ken-ichi ...
    1992 Volume 38 Issue 12 Pages 1885-1886
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Yoshiaki YURA, Hiroki IGA, Yasuo KONDO, Kouji HARADA, Hitoshi TSUJIMOT ...
    1992 Volume 38 Issue 12 Pages 1887-1888
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Kuniteru NAGAHARA, Kenzou MOURI, Akihide KAMEGAI, Yoshiaki TAKAI, Taka ...
    1992 Volume 38 Issue 12 Pages 1889-1890
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Seishi KAWANO, Takatoshi ITOH, Kenji NISHIMURA, Kazumasa SUGIHARA, Yas ...
    1992 Volume 38 Issue 12 Pages 1891-1892
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Makoto FUJISAKI, Hiroshi MUKAI, Tetsurou ISHIGAMI, Yasushi IWASIGE, Ry ...
    1992 Volume 38 Issue 12 Pages 1893-1894
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Mitsuyoshi IINO, Shiteku SONG, Mitsuru EDAMATSU, Masaru SASAKI, Kiyosh ...
    1992 Volume 38 Issue 12 Pages 1895-1896
    Published: December 20, 1992
    Released on J-STAGE: July 25, 2011
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  • Yasuyuki YAMAZAKI, Jun SHIMADA, Yasuo FURUICHI, Mitsuhisa OKITSU, Hiro ...
    1992 Volume 38 Issue 12 Pages 1897-1898
    Published: December 20, 1992
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  • Junko NAKAJIMA, Takenori FUKUYA, Tetsuo YAMADA, Satoshi NAKAJIMA, Yuta ...
    1992 Volume 38 Issue 12 Pages 1899-1900
    Published: December 20, 1992
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  • Yuji NAGUMO, Kenji ONO, Shoritsu YASUDA, Takafumi SATOMI, Hiroyuki WAT ...
    1992 Volume 38 Issue 12 Pages 1901-1902
    Published: December 20, 1992
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  • Kazuhisa OHTSUKA, Yasuhiro ARAKI, Masato OKUDA, Narisato KANAMURA, Kou ...
    1992 Volume 38 Issue 12 Pages 1903-1904
    Published: December 20, 1992
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  • Susumu MIZUNO, Makoto TAKAISHI, Masaru HATTORI, Hiroyuki IWATA, Kazuo ...
    1992 Volume 38 Issue 12 Pages 1905-1906
    Published: December 20, 1992
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  • Yasuaki OKUMURA, Tadashi YASUOKA, Takanori INOUE, Takashi OKUDA, Noric ...
    1992 Volume 38 Issue 12 Pages 1907-1908
    Published: December 20, 1992
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  • Kouichiro NAGAMINE, Mitsuhisa OKITSU, Jun SHIMADA, Yoshiro YAMAMOTO, Y ...
    1992 Volume 38 Issue 12 Pages 1909-1910
    Published: December 20, 1992
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  • Mitsunobu ONO, Satoshi NISHIKATA, Nobuo INOUE, Masaaki KAWAMURA, Takao ...
    1992 Volume 38 Issue 12 Pages 1911-1912
    Published: December 20, 1992
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  • Keishi KITAMURA, Gaku YAMAMOTO, Shintaro SAWATARI, Mitsunobu MORI, Yos ...
    1992 Volume 38 Issue 12 Pages 1913-1914
    Published: December 20, 1992
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  • Seiji YAMAGIWA, Ken-ichi NOTANI, Yasunori TOTSUKA, Shin OHRUI, Shin-ya ...
    1992 Volume 38 Issue 12 Pages 1915-1916
    Published: December 20, 1992
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  • Seiji OBARA, Takahiro MIKAMI, Shuji MATSUDA, Yasuro YOSHIMURA
    1992 Volume 38 Issue 12 Pages 1917-1918
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  • Takashi TSUDA, Junji MACHIDA, Seiji IIDA, Yoshiyasu UCHIDA, Tokuzo MAT ...
    1992 Volume 38 Issue 12 Pages 1919-1920
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  • Hideki Kizu, Yoshiaki KOMIYA, Ikuhiro UCHIDA, Masahisa FUKAYAMA
    1992 Volume 38 Issue 12 Pages 1921-1922
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  • A clinical experience with conservative therapy
    Noriaki Aoki, Tomokatsu SAITO, Chika MIYAZAKI, Seiichi HAYASHI, Shiger ...
    1992 Volume 38 Issue 12 Pages 1923-1924
    Published: December 20, 1992
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  • Noriko TACHIKAWA, Norio SAKURAI, Tetsuya YODA, Kiyoshi HARADA, Norihik ...
    1992 Volume 38 Issue 12 Pages 1925-1926
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  • Tomohiko OGAWA, Mitsunobu MORI, Shintaro SAWATARI, Gaku YAMAMOTO, Yosh ...
    1992 Volume 38 Issue 12 Pages 1927-1928
    Published: December 20, 1992
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  • Michio FUKUDA, Sumihisa KOWAKA, Masaru HOSODA, Tsuyoshi HATA
    1992 Volume 38 Issue 12 Pages 1929-1930
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  • Etsurou KAJIMURA, Masayuki IWAI, Makoto YONEMORI, Isao FURUTA
    1992 Volume 38 Issue 12 Pages 1931-1932
    Published: December 20, 1992
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