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Volume 51, Issue 7
Displaying 1-10 of 10 articles from this issue
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Masayoshi MIURA, Keitaro HIDAKA, Teruaki IWAHASHI, Ryuji UCHIDA, Kazuh ...2005 Volume 51 Issue 7 Pages 324-331
Published: July 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSTelomerase reverse transcriptase (TERT) is acknowledged to be the rate-limiting determinant of telomerase, and transcriptional regulation of the TERT gene plays a key role in the activation of telomerase. Hamster and human TERT promoters share common protein binding sites, such as E-boxes or GC-boxes, which are for Myc and Spl, respectively. Recent studies have demonstrated that expression of human TERT (hTERT) is usually affected by Spl, but not by c-Myc.
To study the effect of transcriptional factor Spl on the transactivation of TERT, we investigated the expression of Spl and TERT mRNAs by RT PCR during carcinogenesis of the hamster tongue induced by DMBA. We attempted to gain insight into the relation between the expression of these factors.
The expression of hamster TERT mRNA strongly correlated with telomerase activity. Coincidentally, we found that the expression of Spl and hamster TERT were upregulated in dysplasia and squamous cell carcinoma tissues and were closely linked to each other. These results suggest that Spl is a crucial regulatory factor for hamster TERT transactivation during carcinogenesis of the tongue.View full abstractDownload PDF (4726K) -
Emiko ISOMURA, Hiroshi KOHARA, Yasuhiro MIURA, Taiji KITAGAWA, Mutsumi ...2005 Volume 51 Issue 7 Pages 332-339
Published: July 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSGrafting of autogenous particulate cancellous bone and marrow to residual alveolar clefts in patients with cleft lip and palate is a well-established procedure for non-prosthetic rehabilitation with canine eruption into the grafted bone or for maintenance treatment after achieving arch alignment. Various analyses of the effect of grafting have been reported, but nearly all previous studies focused on non-prosthetic rehabilitation. The reconstruction of alveolar bone has been evaluated on only intraoral radiographs.
We consider the purposes of bone grafting to the alveolar cleft to be not only non-prosthetic rehabilitation, but also correction of anomalies around the nasal cavity. We evaluated the status of bone bridge formation and bone resorption in 146 unilateral clefts of the prepalate and palate, which underwent bone grafting between 1996 and 2000. We also examined factors related to bone anomalies around both the alveolar ridge and the piriform aperture.
Our results showed that age at bone grafting had a signifcant influence on resorption. Thus, we consider the time of bone grafting to be very important. Grafting should be done before 11 years of age and eruption of the canines. In addition, orthodontic space closure, which includes tooth root guidance to the grafted bone after alveolar bone grafting, is necessary for bone bridge formation on the piriform aperture side.View full abstractDownload PDF (2174K) -
Akio TANAKA, Tadashi MATSUMOTO, Chitoshi TERAMURA, Toshiaki NAKATA, Yo ...2005 Volume 51 Issue 7 Pages 340-343
Published: July 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSIn patients receiving dialysis for chronic renal failure, various biochemical abnormalities are often associated with kidney dysfunction. Such abnormalities can promote degradation and deformation of bones. The use of dental implants in such patients therefore requires careful consideration. A patient receiving chronic dialysis in whom maxillary sinusitis developed after a fixture was accidentally inserted into the sinus is reported. The patient was a 65-year-old man with a 21-year history of chronic dialysis. Before surgery, antibiotics were administered at decreased dosage, and dialysis was performed with an anticoagulant, nafamostat mesilate, which has a short halflife. After the patient was anesthetized with isofluorane, which is not nephrotoxic, the aberrant fixture in the sinus as well as two other loose fixtures were removed, and radical surgery was performed on the right maxillary sinus. The postoperative course was good, and the patient has not had any further problems during a 3-month follow-up. This case emphasizes the importance of preoperative bone evaluation when dental implants are placed in patients receiving chronic dialysis.View full abstractDownload PDF (2408K) -
Hajime TURUTA, Takefumi OGASAWARA, Fumio ATA, Yutaka TERAO, Kazuo IORO ...2005 Volume 51 Issue 7 Pages 344-347
Published: July 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSNodular fasciitis is a benign pseudosarcomatous proliferative lesion of soft tissue. It usually develops in the subcutaneous fascia of the extremities and trunk. Nodular fasciitis rarely occurs in the oral cavity. It was described for the first time by Konwaler et al. in 1955, and in Japan it was reported in 1963 by Imai. This paper reports a case of nodular fasciitis arising from the buccal mucosa.
A 45-year-old woman presented with a slightly painful swelling in the right buccal mucosa. Intraoral examination revealed an elastic hard nodule, measuring 20×20mm in diameter. The overlying mucosa was normal in appearance. Because the tumor rapidly grew within 10 days, it was surgically excised intraorally. Histopathological examination showed a nodular lesion proliferating contiguously from the fascia, with fibroblast proliferation and some mitotic figures, accompanied by inflammatory cell infiltration. There were no signs of recurrence for 5 years 5 months after operation.View full abstractDownload PDF (2944K) -
Hirotaka KURABAYASHI, Hiroshi YAMAZAKI, Mitsunobu OTSURU, Masashi SASA ...2005 Volume 51 Issue 7 Pages 348-351
Published: July 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSA case of nodular type lipomatosis arising from both borders of the tongue is reported. The patient was a 72-year-old man who presented with multiple nodules arising bilaterally from the margin of the tongue. The nodules were elastic and soft, and the mucosa of the tongue surface was normal. Excisional biopsy was performed on the right-side nodules. The left-side nodules were extirpated 9 months after the excisional biopsy on the right side. The histopathological diagnosis was lipomatosis. There has been no sign of recurrence as of 1 year after surgery. The patient had a history of alcoholic hepatitis, hypertension, hyperlipidemia, and hyperuricemia. Lipomatosis of both borders of the tongue was suggested to be associated with local factors (e. g., teeth, bite occlusion, trauma) and systemic disorders (e. g., alcoholism, liver dysfunction, hyperlipidemia).View full abstractDownload PDF (1763K) -
Hiroko SHIDA, Akio TANAKA, Masakatsu FUKUDA, Hisao SHIGEMATSU, Kaoru K ...2005 Volume 51 Issue 7 Pages 352-355
Published: July 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSA 30-year-old man was referred to our department because of pain in the right pre-auricular region on mouth opening. Physical examination revealed a round, hard mass, about 25mm in diameter, in the parotid gland. Computed tomography (CT) showed a round, well-circumscribed mass. An oval mass measuring about 5×10mm was detected inside the tumor on CT. The clinical diagnosis was a benign tumor of the right parotid gland, and superficial parotid lobectomy was performed. Histopathologically, the tumor was characterized by multiple duct-like structures or solid and trabecular masses composed of small isomorphic cells with hyperchronic, round nuclei and eosinophilic cytoplasm. A basal cell adenoma was diagnosed on the basis of these findings. The inner small mass of the tumor showed lymphadenopathy. Immunohistochemical examination showed that the inner epithelial cells of the tubular tumor nests were positive for keratin, and the outer cells were positive for a-smooth muscle actin and vimentin. The stromal cells stained positively for S-100 protein, α-smooth muscle actin, and vimentin, and stained negatively for keratin. The positive ratio of Ki-67 was 6.1%, which indicated relatively low rate of Ki-67 positive cells, supported the diagnosis of a basal cell adenoma.View full abstractDownload PDF (2875K) -
Shinsuke OHTA, Susumu OMURA, Yoshiharu TSUYUKI, Kei WATANUKI, Ryoichi ...2005 Volume 51 Issue 7 Pages 356-359
Published: July 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSAlthough hemangioma is a common soft tissue tumor in the oral and maxillofacial region, hemangioma of bone is very rare, especially in the maxilla. A 47-year-old woman was referred to our hospital because of a painless mass at the base of the right ala nasi. Panorama X-ray films showed a well-defined round radiopaque region, characterized by well-marked spoke-wheel trabeculation diverging from the center of the mass. Computed tomography (CT) revealed a mixed density mass at the base of the right ala nasi. The mass was characterized by a spoke-wheel or honeycomb pattern. We performed surgical excision, and fortunately there was no excessive hemorrhage during the operation. The lesion was diagnosed as a cavernous hemangioma with osteogenesis on pathological examination. The macroscopic and microscopic findings were characterized by a radial pattern of osteogenesis, consistent with the findings on X-ray film.View full abstractDownload PDF (2505K) -
Chigusa MOCHIDA, Kaname SUMITANI, Toshiyuki NEMOTO, Yukiko MAEDA, Tets ...2005 Volume 51 Issue 7 Pages 360-363
Published: July 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSAngiolipoma usually develops in the trunk and extremities and rarely arises in the head and neck region, especially in the oral cavity. A case of angiolipoma of the cheek is reported. A 12-year-old girl was referred to our hospital because of swelling of the left cheek. Clinical examination revealed a rather ill-defined soft mass in the left cheek. Magnetic resonance (MR) imaging and MR angiography (MRA) suggested the mass to be a hemangioma. The mass was extirpated transorally with the patient under general anesthesia. Microscopically, the mass consisted of mature fat tissue intermixed with abundant vascular elements. A pathologic diagnosis of angiolipoma was made.View full abstractDownload PDF (2505K) -
Nobuaki TAMURA, Minoru MIYAKE, Takaaki OGAWA, Yumiko OHBAYASHI, Shun-i ...2005 Volume 51 Issue 7 Pages 364-367
Published: July 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSMalignant tumors rarely arise from jaws cyst. We report a case of squamous cell carcinoma arising from a nasopalatine duct cyst. A 70-year-old man presented with a swelling in the palatal gingiva at the middle of the maxilla. Oral examination showed a 28×25mm swelling with a puncture mark, asmooth surface, and normal color. Radiographic examination revealed a round translucent image measuring 15×12mm in diameter in the middle of maxilla. The image was clearly demarcated. Under general anesthesia, extirpation of the cyst was performed for a diagnosis of nasopalatine canal cyst. Histopathological examination of the resected specimens showed transition of histologically normal cystic epithelium to squamous cell carcinoma. After the first operation, partial resection of the maxilla was performed. Three months after the partial resection, left jugular lymph node metastasis was detected. Partial neck dissection, chemotherapy, and irradiation were performed. Twelve months after partial resection of the maxilla, right jugular lymph node metastasis was found. Radical neck dissection was performed.
For 2 years 4 months, there was no disease recurrence. However, the patient died due of pneumonia on April 13, 2002.View full abstractDownload PDF (2363K) -
Satoru SHINTANI, Tohru ISHIKAWA, Tomohide YOSHIMURA, Koh-ichi NAKASHIR ...2005 Volume 51 Issue 7 Pages 368-371
Published: July 20, 2005
Released on J-STAGE: April 22, 2011
JOURNAL FREE ACCESSWe report on a patient who had tongue cancer with neck metastasis. The left common carotid artery was resected and replaced with an artificial vessel. A 49-year-old man was referred to our hospital because of an ulcer arising at the left side of the tongue. After 4 years of observation, the patient underwent a partial glossectomy because of malignant transformation. One year 6 months subsequently, the patient was readmitted because of metastasis to the left middle internal jugular lymph nodes. The neck metastasis surrounded the carotid artery and invaded its wall. In collaboration with vascular surgeons, an extended neck dissection was performed, and a segment of the common carotid artery was resected. A vascular prosthesis was used for reconstruction.
Although this radical operation might not markedly increase the long-term cure rate, it may improve the quality of life and achieve loco-regional control of disease. This procedure should therefore be positively considered in selected patients with advanced neck metastasis.View full abstractDownload PDF (2964K)
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