Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 32 , Issue 12
Showing 1-33 articles out of 33 articles from the selected issue
  • Natsuki SEGAMI
    1986 Volume 32 Issue 12 Pages 2185-2194
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Extraction wounds of dogs were examined chronologically with a scanning electron microscope in order to clarify the epithelial repair process.
    On postextraction day 1, dome-like elevated cells had proliferated in the clot at the residual inner epithelium surface. By day 4, as ascertened by transmission electron microscopy, thin epithelial layers had moved horizontally and were attached over multinucleated leukocytes.
    Both the above proliferative patterns were observed until days 21-30, when extraction sockets were closed by newly formed epithelial. Then the newly formed hypertrophic epithelium had turned into stratified squamous epithelium, thereby completing epithelial repair of the extraction socket.
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  • Keiichi KAWAI, Hideharu SUZUKI, Toshio KANEDA, Keizou SATO, Yoshinao K ...
    1986 Volume 32 Issue 12 Pages 2195-2200
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Since 1966, the cyanmethemoglobin method has been the internationally standardized method for determination of hemoglobin in blood.
    However this method is not suitable for determination of low concentrations of hemoglobin in saliva. Recently we devised a modified cyanmethemoglobin method for determination of low concentrations of hemoglobin. In this method, absorption maximum at 420nm having high molecular extinction coefficient was chosen, and sample volume was increased ten-fold.
    In the present study, sensitivity was further incresed by a 100-fold increase in sample volume. Thus, hemoglobin concentration could be correctly determined even in 10, 000-fold diluted blood with saline. The use of half-diluted saliva as a diluent showed very little effect on the values of hemoglobin concentration.
    For quantitative analysis of intraoral hemorrhage, we adopted a gargling method; after letting a patient gargle with 3 ml of physiological saline for 15 sec, and the saliva mixed with the saline was obtained for hemoglobin assay. Patiens easily understood the method after brief explanations, and approximately the same volumes of the sample as the initial saline were recovered after gargling. The sample could be stored for 12 hours at 5°C or 24 hours at-30°C without significant changes in hemoglobin concentration. The present method seems a good quantitaive analysis for intraoral hemorrhage.
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  • Kyoko SATO, Saburo KAKUTA, Kimitoshi YAGAMI, Toshikazu TOKUOKA, Masao ...
    1986 Volume 32 Issue 12 Pages 2201-2204
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    It is well known that macrophages play a key role at the healing phase of acute inflammation as scavengers through phagocytosis and digestion of tissue-degradated products. In order to perform this key role, macrophages must accumulate at inflammatory sites. Some chemotactic factors on macrophages were isolated and identified from inflammatory sites.
    Since pus is often produced with acute bacterial infection, it is considered that macrophages accumulation at the disease sites is significant for repair We examined whether the macrophages chemotactic factors on existed in the pus.
    The results revealed that there were several kinds of chemotactic factors in the pus according to partial decrease of chemotactic activity with dialysis or heat treatment at 56°C for 30min. It was also shown that the pus chemotactic activity was completely inhibited by trypsin treatment.
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  • Tadaharu KOBAYASHI
    1986 Volume 32 Issue 12 Pages 2205-2219
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A new method for quantitative analysis of face morphology in three-dimensions was described and its clinical use efficacy discussed. The method consisted of calculating threedimensional values of reference points on the face by perspective transformation from twodimensional values of these and other nine standard points in two pairs of photographs taken simultaneously from both sides of the face with the head in a metal frame reference on which the standard points of known three-dimensional values were set and displaying a three-dimensional image of the face seen from any direction as a wire-frame model as well as its contour at any plane of section on a CRT and an X-Y plotter. All calculations were done with a personal computer.
    The variation in the reconstructed three-dimensional coordinate values of nine reference points on a test plane in 20 trials was 0.36 mm at 1 SD at maximum and the mean error in each direction was within a 0.75 %range. The effect of angle in taking a pair of photographs on the error of reconstructed coordinate values which was highly correlated to the reciprocal of the angle (r=0.9996) was also found to be minimal when it was set at 20 degrees or more by a computer simulation analysis.
    Clinical application of this analysis to six patients who underwent orthognathic surgery for mandibular prognathism showed that the characteristics of facial deformity and the postoperative change in facial appearance could be well visualized by superimposing pre-and post-operative images. In addition, quantitative evaluation of volume change in various areas of the face was also available. Thus, the method was found to be quite useful for diagnosis and analysis of postoperative changes in face morphology in jaw deformities.
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  • Akihide KAMEGAI
    1986 Volume 32 Issue 12 Pages 2220-2233
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Since Nordin et al. and Schmid (1955) reported bone grafting in the defects of cleft alveolus and palate, negative views of early bone grafting have arisen because maxillary bone growth inhibition, malocclusion and so on. In secondary cases of the cleft palates of the adolescents, however, good cosmetic and functional results came from bone or periosteal grafting. It has been reported that electrical stimulation to the periosteum was characterized by the existence of the defined bone formation. Transplantation of electrically stimulated periosteum (ESP) was useful as augmentation in bone defects.
    In the present study, adult Japanese monkies were used. The tibial periosteum was electrically stimulated by direct current of 20 μA for 2 weeks and the ESP consisting of large ammounts of osteoid with proliferating osteoblasts was transplanted into the artificially defected region of the palatal bone. At the same time, the ESP was transplanted into the muscle tissue of the same animals. As a control, non-electrically stimulated periosteum was transplanted into the palatal bone defect region and the muscle.
    The X-ray findings showed that new bone formation was identified in the ESP transplanted area of all cases after 1 and 2 month treatments. In the control side, however bone defect without ESP, showed no bone formation. Histologically, transplanted ESP into the palatal bone defect was differentiated to more calcified, matured bone and not proliferated in situ, excluding bone absorption, and that the ESP transplanted into the muscle has formed a defined bone. The ESP showed that osteogenesis was included Cambium layer in periosteum, proliferated undifferentiated mesenchymal cells, osteoblasts, osteocytes and osteoid. The proliferated undifferentiated mesenchymal cells in the ESP were directly differentiated into osteoblasts and formed bone. As new bone is definitely formed in this method, this is a clinically useful one as a boneless bone graft.
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  • Kenji HASHIMOTO, Shigetoshi SHIODA
    1986 Volume 32 Issue 12 Pages 2234-2238
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    The procedure involved in the three dimensional classification (description) of diagnosis is outlined with regard to the asymmetry in the maxillo-facial deformities, citing examples of typical cases. The relationship of the ideal facial medial sagittal plane and occlusal plane is expressed as the basic planes of the three dimensional description.
    Maxillo-facial symmetry (A0) or asymmetry (A1, A2) are estimated by mirror images of right and left sides of the face at the facial median line.
    The diagnosis and/or the symptom of the genesis of the deformity was additionally described in [] at the end of this description formula.
    The thus-obtained description formula for maxillo-facial asymmetry according to this procedure is:
    A(UML) W(UML)CXOY [disease]
    It seems that this three-dimensional description gives the standard of diagnosis in any institutions and has a utility value not only in the diagnosis but also in the planning of treatment and the evaluation of after-operation for the morphological classification of the maxillofacial deformities.
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  • Yoshiaki KANAI
    1986 Volume 32 Issue 12 Pages 2239-2257
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    There are many studies in the literature of temporomandibular joint (TMJ) roentgenography which reported various methods. Schuller's method is one of the routine techniques in TMJ roentgenography, but it was designed for otological diseases rather than for TMJ. The purpose of my study is the determination of a suitable angle of X-ray incidence in lateral oblique transcranial projection (LOTP) that indicates the normal rest position in between the codyle and articular fossa. Thirty five dry skulls were examined in various angles of X-ray incidence in LOTP and the film images were analysed by computer and visual evaluation. The results showed that an angulation of 15 degrees with LOTP of TMJ was more suitable than the 25 degree angle which is ordinarily used. This method produced the obvious images of the shapes of articular condyle and condylar fossa, and also the reproducibility of TMJ position was improved when head supports were used. The coincidence was recognized in images of both tomography and LOTP for the relationship of condyle and fossa, but the method was unable to exhibit obviously the internal surface of condylar head, which should be given particular attention. I believe that this method is useful as the bases of TMJ roentgenography on the screening of the clinical diagnosis of TMJ disorders, since the disease of TMJ disorders is usually recognized on the external surface of the temporomandibular joint.
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  • Akihide KAMEGAI, Nobutake KANEMATSU, Kazuto TSUGE, Syuji KURENUMA, Shi ...
    1986 Volume 32 Issue 12 Pages 2258-2264
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Oral florid papillomatosis located on the tongue and palate, was diagnosed in a 42 year-old-man. Clinical evidence suggested that disease spread or transmission was through contact.
    The concept of oral florid papilomatosis was first introduced by Rock and Fisher, in which they described clinical features of the lesion as a chronic, hypertrophic, pseudoneoplastic change in oral and pharyngeal mucosa. Little is known regarding the causative agent (s), so only assumptions can be made regarding the precipitating factor (s) responsible for this neoplastic lesion. However, some causative factors such as viruses, chornic persistent irritation, and cigarette smoking are suspected.
    Therefore, an investigation was initiated using the PAP immunohistochemical method for papilloma viruses in an attempt to establish a viral etiology for this disease process.
    Structural antigens of papilloma viruses were identified in a case of oral florid papillomatosis from both lingual and palatal biopsies using the PAP immunohistochemical method.
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  • Hirofumi KISHIMOTO, Toshio HARADA, Masahiko TANAKA, Eri SANTOH, Masafu ...
    1986 Volume 32 Issue 12 Pages 2265-2273
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Parenteral alimentation was undertaken to examine nutritional level of patients with malignant tumors (10 cases) and with ameloblastoma (one case). Procedure was carried out at the pre-and postoperative periods, during cancer chemotherapy or radiotherapy. Cases which it was impossible to continue peroral feeding were also undertaken. Among catheter complications, catheter cracking at the external-body portion (6), abnormal Position (4), thrombi formation (2) and bending in the vessel (1) were observed.
    As metabolic complications, there existed slight electrolyte unbalance (7 cases), slight elevation of liver enzymes such as GOT or GPT (5 cases), LDR (2 cases), and ALP (3 cases).
    In the comparison of 5 operated cases of parenjteial nutritional feeding with 5 gastric tube feeding cases, the reduction rate of body weight on the 16 th postoperative day against the preoperative one was less in the parenteral nutritional group than irr the gastric feeding group.
    Changes of serum albumin and total protein from the preoperative period to the postoperative three weeks were not constant. However the reduction value.on the third week of postoperation was equivalent in the group of parenteral nutrition and in the group of gastric tube feeding.
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  • Yoshihiro SUNAGA, Kenji ERA, Yoshihiro KIMIHIRA, Kazuo YASUKAWA, Hajim ...
    1986 Volume 32 Issue 12 Pages 2274-2283
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Cockayne syndrome is a rare autosomal recessive disorder first described by Cockayne in 1936 as a syndrome of “dwarfism with retinal atrophy and deafness”.
    We reported a typical case of this syndrome in a 12-year-old boy, with a review of the world literature.
    The oral and maxillo-facial examinations revealed well-developed frontal sinus and mastoid air cells, and abnormality of roots of first molars.
    These findings seemd to be previously described in the literature.
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  • Hiroshi FUKUDA, Shigeaki TADOKORO, Eiichi TAKASAKA, Toshiyuki HAGIWARA ...
    1986 Volume 32 Issue 12 Pages 2284-2288
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Restriction of mandibular movement is one of the main reasons for seeing a dentist. In this article, two patients were reported in whom torus-like morphological changes at posterior aspect of articular eminence of temporal bone considered to be playing the main role in the trismus, and the anatomical bases influencing the mandibular movement especially the translation of mandibular condyle was briefly reviewed.
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  • Yusuke TAKEUCHI, IWAI TOUNAI, Akimasa YANASE, Susumu UKAI, Kenji NAKAT ...
    1986 Volume 32 Issue 12 Pages 2289-2293
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Hemangiomas in the perioral region are not uncommonly encountered by oral surgeons. Managements of these lesions and the modes of therapy employed depend on factors such as the age of the patients, size and extent of the lesions, as well as on the clinical characteristics. Surgery of these benign lesions can at times be disfiguring, especially when lips, muscles, maxilla and/or mandible are involved.
    We report a case of large hemangiomas in oral and perioral region managed with a technique of transarterial embolization. The patient was a 29-year-old man with a multiple hemangiomas in his left buccal-temporalis region. The embolization was performed via the femoral artery using the Seldinger technique. Geratin sponge, polyvinyl alcohol foam and stainless steel coil with wool were used as the embolic materials. After 17 months study of this patient, we observed a significant decrease in the size of the hemangiomas. We consider that this treatment is one of the best choices for the richly vascularized benign tumors such as hemangiomas.
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  • Michiya OSADA, Yoshimi ISHIKAWA, Seiichi HAYASHI, Shigeru ONO, Kiyohid ...
    1986 Volume 32 Issue 12 Pages 2294-2300
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Von Willebrand's disease is a coagulation disorder caused by the insufficient activity of von Willebrand factor. The hemostatic management for tooth extraction in the patient with von Willebrand's disease is described.
    The patient, a 28 year old female was referred to our clinic to have a tooth extracted. Ten units of commercially obtained cryoprecipitates preraration (AHF) per kg body weight was given preoperatively, additionally 10 units per kg was administered after 24 hours just at bleeding and no further bleeding was detected. The blood level of VIII R: WF was 20% at the beginning and VIII R: WF was elevated to 60% at 60 minutes after infusion and returned to preinfusion level after 24 hours. However the patient developed serum hepatitis about a month later.
    On the other hand, in addition to von Willebrand's disease the patient had membranous lipodystrophy for 8 years, which is apparently a new disease of symmetrically degenerative changes in the bones of the extremities, which seems to progress slowly with age. The etiology of this disease is unknown and a hereditary factor is suggested.
    Relations between von Willebrand's disease and membranous lipodystrophy have not been studied enough and are yet to be clarified.
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  • Takao MASUDA, Kenji MOGI, Masahiko SAKASITA, Hiroshi TSUCHIYA, Tsutomu ...
    1986 Volume 32 Issue 12 Pages 2301-2310
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Two cases with basal cell nevus syndrome and a review of literature are presented. Multiple jaw cysts, hypertelorism, palmer and planter pits, and a calcification of falx cerebri and of tentorium were observed in both cases.
    Beside this syndrome, a 22-year-old female (case 1) had a cleft lip-alveolus, and another 31-year-old woman (case 2) had a basal cell epithelioma in the occipital skin and bridging of sella turcica radiographically.
    Frequency of the cleft lip, alveolus, and/or palate with this syndome, including one casc of ours, was 12.8% and the incidence was far more frequent compared with the national avarage.
    Considering a high recurrence of odontogenic keratocysts, it was suggested that a sufficient curattage of the bony walls after the removal of cysts might be useful for the treatment of odontogenic keratocysts.
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  • Masahiro NISHI, Hiroshi TAKASHIMA, Kazuhiro MARUTANI, Etsuro NOZOE, Na ...
    1986 Volume 32 Issue 12 Pages 2311-2318
    Published: December 20, 1986
    Released: September 13, 2011
    JOURNALS FREE ACCESS
    Controversy continued as to surgical treatment of a sialolith located close to the submandibular gland, the opinions being excision of the submandibular gland and transoral removal of the stone.
    To determine the extent of grandular recovery, we examined the submandibular gland function with 99mTc-pertechnetate sialo-scintigraphy following sailolithectomy or spontaneous excretion in four cases of sialolithiasis in which the stone was located on the posterior submandibular duct. An intraindividual comparison of the function of the treated gland with that of the contralateral normal gland was made by time-activity curve from regions of interest over both submadibular glands.
    In two cases the function of surgically treated submandibuar gland was restored to the same condition as that of the contralateral normal gland at more than two months later after the removal of the stone. In the other two cases submandibular gland was firm on palpation and extensive inflammation was noted showing pus secretion from the orifice of Wharton's duct at first visit. Salivary excrete function on the sialo-scintigraphy was not seen soon after removal of the stone. More than three months later, however, it recovered to about 60% of contralateral normal gland associated with a production of clear saliva from treated submandibular gland.
    These results suggested that functional recovery may be expectd to some extent in a submandibular gland strikingly damaged by sialolithiasis, and that transoral removal is a valid treatment for a stone located close to the submandibular gland.
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  • Yoshiaki KAYATA, Takeshi KIRIYAMA, Shigeyuki KOYAMA, Shunsuke NISHIUCH ...
    1986 Volume 32 Issue 12 Pages 2319-2324
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A rare lesion, osteosarcoma of the jaw with a good prognosis, from high dose therapy in the post operative period, is presented.
    Male patient diagnosed as osteosarcoma of the mandible (right side) was treated with a high dose of methotrexate along with VEPA therapy as post-operative adjuvant chemotherapy. This combined therapy was significantly effective without any local recurrence or distant metastasis observed in the 2-years follow-up studies. A review of the past literature was discussed.
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  • Shin-ichi UEDA, Kasuke NAKASHIMA, Hitoshi TANABE, Yasuyuki UENO, Masam ...
    1986 Volume 32 Issue 12 Pages 2325-2335
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    The calcifying odontogenic cyst first reported by Gorlin et al. in 1962 has been considered to be a comparatively rare disease.
    The histo-pathological findings were characterized by appearance of ghost cell and calcareous deposits on the cyst wall epithelial layer.
    Recently, we treated a large cyst which developed on the right maxillary bone of a 25-year-old male. At the first diagnosis with X-ray, it was suspected to be globulomaxillary or maxillary cyst, but the histo-pathological diagnosis indicated it was calcifying odontogenic cyst.
    Now, 85 cases of this lesion have been reported in Japan and their literatures have been considered. The fact that complications with odontogenic tumor as odontoma or ameloblastoma were found in 29 cases suggests that this lesion has a relation to these odontogenic tumors. Generally, this lesion has various foci structures, such as tooth-like hard tissues formations, mono or multilocular cysts, impacted teeth, and granular X-ray lucency, therefore clinical diagnosis is very difficult. Some cases which have apparent tumorous characteristics in histopathological findings such as recurrence or malignancy have been reported in the literature. Therefore, it seems to be necessary to discuss a new classificational position.
    This patient has a good prognosis after the extirpating operation, so we reported the details of this case.
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  • Hideaki SAKASHITA, Junya HIGASHINO, Eisuke FUJIMOTO, Kiyomasa NAKAGAWA ...
    1986 Volume 32 Issue 12 Pages 2336-2353
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Arteriovenous malformation (AVM) of the jaws are considered to be rare lesions. A 26-year-old woman was referred to our hospital because of right mandibule profuse swelling. Radiography showed the irregular radiolucency extending from the right first premolar region to the right condyle. In angiography, wide AVM was founded. Embolization of right external carotid artery and lingual artery was performed to decrease the hemorrhage during operation on Cyanoacryrate. At 2 weeks after the embolization, the operation was performed under nasoendtracheal general anesthesia. Hemimandibulectomy and enucleation of the tumor was by extraoral approach. The hemorrhage was uncontroled and reached 3, 035 ml. Postoperatively anaerobic infection occurred, and controlled by antibiotics and removal of the reconstructed plate. The pathological diagnosis was AVM.
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  • Toshio SAITO, Keisuke MACHIDA, Koichi SAITO, Shoichi FUSEJIMA, Akihiro ...
    1986 Volume 32 Issue 12 Pages 2354-2361
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Three cases of pemphigus vulgaris with lesion confined to oral mucosa and one case manifesting stomatitis with mild dermatitis were treated. The diagnosis was based on the oral pathohistological picture and the circulating antipemphigus antibody (hereafter referred to as I.C. antibody). The patients were given adrenocortical hormone at the Department of Dermatology, and the relation between stomatitis and I.C. antibody was observed there in cooperation with our Department.
    Case 1, a female aged 49 with 40 fold LC. antibody titre, but 30 mg of Predonine mitigated the symptom, lowering the titre to 0.
    Case 2, a female aged 58 with I.C. antibody titre as high as 160 to 640 fold. Predonine administration in doses of 10 to 20 mg for about 18 months markedly improved the oral symptom, and the I.C. antibody titre level returned to normal
    Case 3, a female aged 34 with 160 fold I.C. antibody titre. Administration of 30 mg Predonine resulted in remission of the symptom, then the dose was reduced to 5 mg. In 4 months, the I.C. antibody titre reached 0, and the symptom almost vanished.
    Case 4, a male aged 80 with I.C. antibody titre as high as 640 fold. Oral administration of Predonine for 3 months brought about improvement of the oral symptom, the I.C. antibody titre falling to normal.
    As mentioned above, I.C. antibody titre, which was higher in the 4 cases during the development of the oral symptom, was restored to the normal level by administration of Predonine. It was consequently assumed that there might be an intimate relation between the oral symptom and I.C. antibody titre.
    Direct and indirect fluorescent antibody methods revealed the topical presence of IgG and C3 complement among epidermic cells in lesional oral mucosa.
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  • Takahide SUGIHARA, Eri SANTO, Masahiko TANAKA, Hirofumi KISHIMOTO, Tos ...
    1986 Volume 32 Issue 12 Pages 2362-2370
    Published: December 20, 1986
    Released: September 13, 2011
    JOURNALS FREE ACCESS
    Three cases with so-called Mikulicz's disease were studied clinically.
    Case 1 A 35-year-old woman was suffering from bilateral lacrimal and submandibular gland swelling. Biopsy of the submandibular gland and lacrimal gland showed severe atrophy of the glandular tissue and extensive lympoid infiltration accompanied by germinal center. It is five years since she first came to our clinic and has remained generally well without any treatment. The swelling of the gland is naturally decreasing.
    Case 2 A 62-year-old man was suffering from bilateral lacrimal and submandibular gland diffuse swelling. Histological examination revealed extensive infiltration with lymphocytes and plasma cells. Five months after his first visit, he showed significant changes in clinical and laboratory findings, that is to say, general lymphnode swelling, total protein 9.8 g/dl, hyper gamma globulinemia 50.1%, elevated ESR 119 mm/hr, etc. Steroid treatment resulted in gradual disappearance of the swelling.
    Case 3 A 69-year-old woman was referred to our clinic for evaluation regarding the enlargement of bilateral parotid gland, submandibular gland, right orbital region and submental lymphnode. This is a case of 45 years' duration and for a long time was treated as sarcoma. Steroid treatment resulted in gradual disappearance of the swelling.
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  • Arifumi MIKAMI, Takaaki OGAWA, Kazuo RYOKE, Hikoemon INAMURA, Hitomi K ...
    1986 Volume 32 Issue 12 Pages 2371-2376
    Published: December 20, 1986
    Released: September 13, 2011
    JOURNALS FREE ACCESS
    Amyloidosis is a disease characterized by progressive intercellular deposition of amyloid fibrilis in various tissues. It was termed like this by Virchow in the nineteenth century, because the typical tissue deposits resembled starch in iodine staining reaction.
    Amyloid deposits have been little known, but recently its substance has proved to be a group of highly organized fibrillar proteins by biochemical, immunological and morphological procedures. However, the pathogenesis of amyloidosis is still indefinite. We experienced a case of amyloidosis associated with multiple myeloma. The patient was a 55 year old woman who complained of tumor formation at submental region with 10-month history of dysphagia. Tumor was also seen at forearms, but macroglossia was not seen initially. About a month later, tongue was markedly swelled and indurated, and amyloid deposition was revealed by biopsy of optical and electromicroscopy specimen. Amyloid deposition was also seen in sub mental and forearm tumors.
    Bence-Jones protein was seen in her urine. Bence-Jones & IgA κ type monoclonal protein appeared in immunologic test. The plasma cell proliteration rate in bone marrow study showed 23.6 % with mild dysplasia.
    This case was diagnosed as amyloidosis associated with multiple myeloma and now treated with prodonin® and melphalan®.
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  • Yasufumi HORINOUCHI, Masanori SHINOHARA, Syuro KUBO, Masuichiro OKA
    1986 Volume 32 Issue 12 Pages 2377-2383
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Pleomorphic adenoma is statistically the most common salivary gland neoplasm, but multiple case of the tumor is extremely rare.
    According to the literature, multiple pleomorphic adenoma is less than 0.8% of all salivary gland tumors.
    We have recently experienced a case of benign multiple pleomorphic adenoma occurring simultaneously, involving both parotid and palatal glands.
    The patient, 76-year-old woman was referred to our clinic complaining of swelling of the right parotid region and the palate.
    The tumors were surgically removed.
    They were entirely encapsulated by fibrous connective tissue and were completely separated.
    Histological findings showed that they were benign pleomorphic adenoma with no evidence of metastasizing pleomorphic adenoma.
    The postoperative course is favorable with no sign of recurrence, but observation will have to be continued.
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  • Kazuyuki MIYATA, Nobuo MORITA, Takeshi WADA, Yoshinobu IWAGAMI, Kazuhi ...
    1986 Volume 32 Issue 12 Pages 2384-2389
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Two cases of large pleomorphic adenoma in the parapharyngeal space were presented.
    One case of a 69-year-old woman was considered a tumor originating from the deep lobe of parotid gland and advancing to the parapharyngeal space through a “stylomandibular tunnel”.
    Another case of a 74-year-old woman was considered a primary tumor in the parapharyngeal space, extending to the submandibular region.
    Each tumor was operatively removed, and no evidence of recurrence was observed to date.
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  • Ryuichi NEMOTO, Masami MISHINA, Takashi OHNO, Kazuo TAKADA, Tomoya OHN ...
    1986 Volume 32 Issue 12 Pages 2390-2395
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    The lipoma is a relatively rare tumor of this month. It has been reported in various sites, including the buccal mucosa, mucobuccal fold, tongue, and gingiva. We recently experienced a case of lipoma arising from the tongue, clinical presentation and histologic observation described in this paper.
    A 62-year-old man was admitted Oct. 26, 1983 with tongue progressive swelling. The tumor was removed under local aneshesia. Histologic observation revealed mature fat cells belowfibrous connective tissue.
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  • Hisanari KOTANI, Nozomu TAGUCHI, Tsuguhisa ASAI, Yasuyosi FUKUOKA, Tak ...
    1986 Volume 32 Issue 12 Pages 2396-2400
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    During this study, 38 patients (all females under 20 years old) with TMJ arthrosis who visited the Department of Oral Surgery at Nagoya University Hospital, the Department of Dent-Oral Surgery at Nagoya University Branch Hospital and Lion Foundation for Dental Health were studied.
    A comparison was done on 28 females under 20 years who did not have TMJ arthrosis. The following results were obtained.
    1. There were no significance differences between normal and TMJ patients in the mean value of condyle and glenoid fossa.
    2. But we observed that cases had definite symptoms of smaller condyle and glenoid fossa in the troubled side.
    3. In the ratio between condyle and glenoid fossa, there was no significance difference between T and N groups.
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  • Yoshitaka SHIBATA, Seiji KITAYAMA, Tohru NAGAO, Kazuhiko KONDOH, Tetsu ...
    1986 Volume 32 Issue 12 Pages 2401-2406
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Now, a combination chemotherapy with Peplomycin, Cisplatin and Mitomycin C (PPM therapy) has been used for head and neck cancer. Between August, 1982 and July, 1985, we treated seven advanced and recurrent cancers with PPM therapy. All cases were treated previously with surgery and radiation therapy. These cases consisted of six males and one female. The age of the patients ranged from 43 to 74 years (mean age 57.7 years). Included were five cases of squamous cell carcinoma and one of epidermoid carcinoma and mucoepidermoid carcinoma. Among these cases, one was a complete response (CR), three were no change (NC), one was a progress disease (PD) and two were impossible to assess. Though we can not assess a response of the PPM therapy objectively, we were under the impression that the PPM therapy will prevent head and neck cancer progression. Regarding side effects, four cases of nausea and vomiting, one of marrow dysfunction, and one of acute kidney dysfunction were observed. We thought, the infusion of cortical steroid and domperidon may be useful for improvement of nausea and vomiting.
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  • Noboru AKAZAWA, Masumi FUJIMORI, Eisaku SANO, Masahiro UMEDA, Katsuhik ...
    1986 Volume 32 Issue 12 Pages 2407-2412
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Amyloidosis is a disease characterized by progressive irreversible deposition ofamyloid in the body.
    A case of oral amyloidosis as initial symptom of systemic primary amyloidosis is described. A 67 year old man, who complained of multiple hard nodules on the dorsal surface of the tongue, was first seen in the Oral Surgery clinic May, 1986, and the biopsy was carried out.
    Histology showed extensive deposition of pale eosinophilic amorphous material. Congo red stains were positive for amyloid and the typical apple green birefringences were noted on polarisation.
    Routine laboratory tests were initiated and Bence Jones protein (κ) was positive in urine. Bone marrow aspiration from sternum revealed plasmacytosis. Amyloid depositions were noted later on the face skin, hands and hard palate. Amyloid tumor of the hard palate as vaporized by CO2 LASER. Chemotherapy (Melphalan, predonine and DMSO) was carried out, but the effect was poor and the patient died of cerebral infarction Feb, 1985.
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  • Shigeru YOSHIDA, Tsuyoshi KAWAI, Masanobu OHNISHI, Yoshiyuki HATTORI, ...
    1986 Volume 32 Issue 12 Pages 2413-2424
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A open trial study was performed to ascertain clinical efficacy and safety of Emorfazone for the treatment of inflammatory diseases in dental and oral surgery.
    The following results were obtained:
    1) The study was analysed in 44 patients.
    2) The local symptoms of the specified 10 items impoved significantly both on the third and fifth day after the administration.
    3) Rates of overall clinical effectiveness showing “excellent” and “good” were 39.5% on the first day, 67.6% on the third day and 80.6% on the fifth day after administration.
    4) The rates of final overall effectiveness showed good and excellent were 65.9%.
    5) Although side effects effects were found in 13.6% of 44 patients, most cases were not severe.
    6) The overall usefulness showing “excellent” and “good” was 54.5%.
    7) From the above rsults, Emorfazone was confirmed to be useful for treatment of inflammatory diseases in dental and oral surgery.
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  • Kazuo RYOKE, Takeshi HAMADA, Tomoji SAKAMOTO, Kazuaki TAKADA, Masahisa ...
    1986 Volume 32 Issue 12 Pages 2425-2436
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    The effect and safety of Cefmetazole was evaluated in 86 cases treated prophilactically after surgery. Furthermore, 45 cases with oral infections were treated with the drug. Bacteria were isolated from the infectious lesions and their sensitivities to antibiotics were tested. The results could be summarized as follows:
    1. Clinicl effects of Cefmetazole in 45 cases of infectious group were excellent in 7 cases, good in 28 and poor in 10, the effectiveness rate being 77. 8 %. No occurrence of infection was noted in the 86 cases prophilactically treated with Cefmetazole after surgery.
    2. Bacteriological examinations were carried out for 23 cases with infectious disease and isolated in 18 cases (78 %). There were 29 isolated strains, 55.6 % of which were anaerobic. Antibiotic-susceptibility test showed that all isolated aerobic and anaerobic bacteria except Enterococcus faecalis were highly sensitive to Cefmetazole.
    3. Side effects noted were mild eruption in 3 cases, slight stomach discomfort in 1 case and diarrhea in 1 case, but no other abnormality was observed.
    4. In laboratory findings, the slight elevation of GOT and eosinophilia were observed, although these values returned to normal immediately after therapy.
    According to these result, Cefmetazole was evaluated to be a useful antibiotics on prevention of infection after surgery and various infections in the field of oral surgery.
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  • Masanori SEKIDO, Yoshikuni SANGU, Mitsuko AOKI, Toshiharu FUJII, Nobuy ...
    1986 Volume 32 Issue 12 Pages 2437-2442
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    In past years, IVH has been the main method of nutritional management. However, as the management and surgical operation are complicated, recently Elemental Diet (ED) as a method of oral feeding has received great interest. In 1977, ED-AC (Elental) was developed for Japanese patients.
    We examined the clinical symptoms and observations of 20 cases of ED-AC application. As a result, the clinical observations during the period of its application, showed a slight decrease in weight, serum proteins and serum albumine, but no significant changes in other tests.
    Besides, among the 20 cases, 7 patients complained of diarrhea as side effect, but there was not a single case in which the application was suspended.
    The clinical results in the application of ED-AC in the area of oral surgery showed in general an effective diet without causing serious side effects and with possibility of long-term application. It is concluded as being a valuable method.
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  • Masanobu OHNISHI, Tsuyoshi KAWAI, Yoshiyuki HATTORI, Shigeru YOSHIDA, ...
    1986 Volume 32 Issue 12 Pages 2443-2460
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Emorfazone, a non-steroidal analgesic and anti-inflammatory drug, was clinicallyevaluated by the double-blind controlled study.
    The clinical usefulness of Emorfazone on oral inflammatory disease at a daily dose of 600 mg was compared with that of aspirin at a daily dose of 1, 500 mg according to the preliminary study.
    The results were as follows:
    1. Out of the total 192 cases, 186 were needed on safeness study and 178 on usefulness study.
    2. The rate of subjective improvement and the efficacy rate judged by the doctor were not significantly different between the drugs at any phases.
    3. The frequency of side effects was 11.1%(10 cases) in Emorfazone and 10.4%(10 cases) in aspirin. Almost all cases were accompanied with slight gastrointestinal disorder.
    4. The rates of final over-all improvement and usefulness were 67.1%, 62.4% respectively in the E group and 63.7%, 55.9% respectively in the A group. There was no significantdifference between the two drugs.
    These results suggest that Emorfazone is a useful drug for the treatment of oral inflammatory diseases.
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  • Yoshiaki KAZAOKA, Kazuhisa TANGE, Akira SUZUKI, Yuji KAMIYA, Kazuo MIZ ...
    1986 Volume 32 Issue 12 Pages 2461-2468
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    For the study of the clinical application of Cefbuperazone (CBPZ, keiperazone) in the oral field, fundamental studies on CBPZ were carried out and the following results were obtained.
    1) In vitro antibiotic activity of CBPZ agaist 57 clinical isolated organisms from oral infection cases were examined. The peak of the minimum inhibitory concentraion was 12.5 μg/ml.
    2) Doses of 1 g CBPZ were administrered to 45 patients by one shot intravenous injection, and pharmacokinate analysis was performed. The half life of CBPZ in serum was thus estimated to be 114 minutes.
    3) The hightest concentratins of CBPZ were 32.1 μg/mlin the gum and 31.8 μg/ml in the cyst wall. These concentraions were noted to show good distribution.
    The above results suggested the usefulness of CBPZ for the treatment of any oral surgery infections.
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  • Kazuhisa TANGE, Yoshiaki KAZAOKA, Yuji KAMIYA, Kazuo MIZUNO, Yoshiki T ...
    1986 Volume 32 Issue 12 Pages 2469-2477
    Published: December 20, 1986
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Clinical evaluation of cefbuperazon (CBPZ, Keiperazon) in various infections in the field of oral surgery were carried out.
    Cefbuperazon was administered by intravenous injection at a daily dose of 2g (1g×2 times) to 60 patients with various infections.
    The following results were obtained:
    Cases consisted of 39 with maxillary ostitis, 7 phlegmon of the floor of the mouth, 5 buccal abscess, 4 odontgenic maxillary sinuitis, 3 post operative maxillary cyst, 1 peritonsillitis and 1 sialoadenitis submandibularis. The evaluation was made with 59 cases.
    The clinical effects obtained in subjective judgement were excellent in 26 cases, good in 26 cases, fair in 5 and poor in 2. The clinical effects obtained in judgement by point were classified as excellent in 16 cases, good in 36 and poor in 7.
    Effective rate in subjective was 88.2%. Effective rate in judgement by point was 88.2%.
    As side effects, eruption and itching appeared in one case, diarrhea in two and nausea in one.
    The elevation of s-GOT and s-GPT was observed after cefbuperazon administration in 4 cases in the laboratory examiations.
    The results indicated the usefulness of cefbuperazon in the treatment of various infections in the field of oral surgery.
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