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Volume 44, Issue 5
Displaying 1-16 of 16 articles from this issue
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Hirotaka UENO1998 Volume 44 Issue 5 Pages 455-465
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSActivation of antigen specific T cells requires not only antigen-recognizing signals obtained via T-cell receptors (TCR) but also co-stimulatory signals produced by contact with antigen-presenting cells. Furthermore, without costimulatory signals, clonal anergy develops even if T cells make contact with TCR. Recent studies have shown that these signals are induced by fibronectin (FN), which comprises one type of extracellular matrix. We therefore evaluated the use of FN for immunotherapy in the rabbit VX 2 tongue cancer model. FN was administered concomitantly with OK-432 (OK), a biological response modifier, to the area around the cancer.
Enhancement of the anticancer effect of OK by FN was investigated with respect to invasion by the transplanted cancer, deep cervical lymph node metastasis, and number of T cells infiltrating into the cancer.
1) The OK+FN group showed significantly better suppression of the cancer growth rate than did the control group (P<0.05) and the OK group (P<0.05).
2) The OK group and the OK+FN group showed significantly better suppression of deep cervical lymph node metastasis than did the control group (P<0.025, P<0.025), but there was no significant difference between the OK group and the OK +FN group.
3) The OK+FN group showed a significantly higher number of T-cells infiltrating into the cancer than did the control group (P<0.001) and the OK group (P<0.01).
4) Fibrosis of the cancer stroma and increasing number of infiltrating T-cells apparently enhanced the anticancer effect of OK with FN.
These results suggest that FN enhances the anticancer effect of OK and therefore may be useful for immunotherapy in the future.View full abstractDownload PDF (9272K) -
Serum PTHrP levelsYasuo OKADA, Makoto TSUCHIMOCHI, Tohru ONO, Shuji TOYA, Atsuo OKANO, K ...1998 Volume 44 Issue 5 Pages 466-476
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSMalignancy-associated hypercalcemia (MAH) often occurs in patients with squamous cell carcinoma of the lung, esophagus, oral cavity, and pharynx as well as those with other histopathologic malignancies, such as breast cancer, renal cell carcinoma and adult T-cell leukemia. We often encounter MAH in patients with terminal oral cancer. Parathyroid hormone related peptide (PTHrP) is considered the most likely cause of MAH. The aim of our study was to investigate whether the serum concentration of PTHrP rises in patients with oral cancer. We measured serum PTHrP (C-terminal) in 84 serum samples obtained from 70 patients with oral squamous cell carcinoma and 7 serum samples from 7 patients with hepatocellular carcinoma (HCC). Serum Ca, alkaline phosphatase, and PTHrP (C-terminal) were higher in patients with terminal oral squamous cell carcinoma than in those with oral squamous cell carcinoma before treatment. The incidence of patients who had high levels of serum Ca, alkaline phosphatase, and PTHrP (C-terminal) was higher in patients with oral squamous cell carcinoma patients than in those with HCC. Among patients with oral squamous cell carcinoma before treatment, some had high PTHrP (Cterminal) concentrations and others did not. All patients with T 1 and stage I oral squamous cell carcinoma had normal serum PTHrP (C-terminal) levels. In patients with oral squamous cell carcinoma, the serum PTHrP (C-terminal) level correlated with the serum Ca and alkaline phosphatase levels. These results indicate that PTHrP is responsible for humoral hypercalcemia of malignancy in oral squamous cell carcinoma. We conclude that assessment of serum PTHrP concentrations may facilitate the early diagnosis of hypercalcemia of malignancy in oral squamous cell carcinoma.View full abstractDownload PDF (5574K) -
Relationship of ultrasonographic and computed tomographic findings withclinicopathologic malignancy gradingManabu KISHABA, Hajime SUNAKAWA, Hiroyoshi HIRATSUKA, Wakatsu TSUHAKO1998 Volume 44 Issue 5 Pages 477-488
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThis study was designed to evaluate the relationship among clinicopathologic findings, preoperative computed tomographic (CT) and ultrasonographic (US) findings, and cervical lymph node metastasis in squamous cell carcinoma of the oral cavity. The subjects consisted of 209 patients with oral cancer who underwent primary therapy during the 12-year period from 1985 through 1997. A total of 117 cervical lymph nodes suspected to have metastasis on preoperative CT and 56 suspected to have metastasis on preoperative US were studied retrospectively. The largest and the shortest diameters of each node was measured on axial CT scans, and the absence or presence of rim enhancement was confirmed. Analysis of the relations among short-axis diameter, rim enhancement on CT, and pathological findings indicated that lymph nodes that show rim enhancement tend to be metastatic lymph nodes. Therefore, on US the shortest diameter of each node was measured, and border findings were observed. Metastatic lymph nodes less than 10mm in shortest axis diameter tended to have a score higher than 12 points in the clinicopathologic malignancy grading. US findings showed a similar tendency. The accuracy of CT alone increased from 81.4% to 84.6% with the addition of clinicopathologic malignancy grading. The accuracy of US alone increased from 87.5% to 89.3% with the addition of clinicopathologic malignancy grading. When CT and US findings were combined with clinicopathologic malignantcy grading to evaluate the same lymph nodes, the accuracy increased to 93.9%.View full abstractDownload PDF (4321K) -
Naoko MURATA, Yoshiki SUGIYAMA, Hiro OSANAI, Masaru SASAMORI, Chika SA ...1998 Volume 44 Issue 5 Pages 489-494
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSRadicular cysts arising from deciduous teeth are rare, although they are the most common cysts of the jaws. During the 20-year period between 1976 and 1995, we studied four cases (three boys, one girl) of radicular cysts arising from deciduous teeth at our hospital. These cases were diagnosed clinically and histologically. The patients' ages ranged from 9 years to 12 years, with a mean age of 11 years 4 months, and they were all in Hellman's Dental Age III B. Three patients had gingival swelling as a primary symptom, and the other had no symptoms. All lesions were located in the second premolar area of the mandible. Three cases were unilateral, and one was bilateral. All lesions showed swelling on the buccal side of the mandibular bone in the areas of the cysts. In all the lesions, X-ray examination showed cyst-like radiolucency at the apex of the second deciduous molars. Extirpation or mar supialization of the cysts was the treatment of choice for all lesions. There has been no recurrence, and all permanent teeth erupted at their normal positions in all patients.View full abstractDownload PDF (10948K) -
Yoshihiro KIMURA1998 Volume 44 Issue 5 Pages 495-504
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSTo evaluate the osteoinductive activity and the biocompatibility of BMP-agarose composite, three kinds of experimental samples (BMP pellet samples, agarose samples, and BMP-agarose composite samples) were implanted into the hindquarter muscle pouch of ddy conventional mice.
The mice were killed 21 days after implantation, and the hind limbs were examined by roentgenographic and histologic methods. The osteoinductive activity of the samples was confirmed by computer assisted analysis of soft X-ray photographs to determine the volume of induced new bone.
BMP pellet samples induced stable heterotopic new bone formation.
Three weight-percent agarose samples induced no bone formation. Histologically, the implant was surrounded by a thin fibrous layer, but did not cause inflammatory cell aggregation. Therefore, agarose has excellent biocompatibility and is very stable in living tissue.
BMP-agarose composite samples induced stable heterotopic new bone formation. Histologically the induced bone region was surrounded by a thin fibrous tissue layer and consisted of bone-like calcified tissue with osteocyte-like cells, cartilaginous cells, and bone marrow. However, the bone induced by BMP-agarose composite samples seemed to be less mature than that induced by BMP pellet samples. This suggested that the initial effects of BMP remained because of slow release from the composite, and that the BMP continuously formed bone, which contained less mature tissue during the initial period of bone formation.
A comparison of the volume of induced bone showed a trend toward an increase in bone with higher concentrations of agarose in the composite. The BMP-agarose composite, made with 2 and 3 weight-percent agarose solution, induced significantly greater bone formation than did BMP pellet samples.
These results show that BMP-agarose composite has the advantage of acting as an osteoinductive implant material in vivo.View full abstractDownload PDF (12920K) -
Kazue YAMAGUCHI, Takashi KOYAMA, Ayako MORI, Takayuki OHSAWA, Kenji HA ...1998 Volume 44 Issue 5 Pages 505-507
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSProliferative verrucous leukoplakia (PVL) is a particular form of leukoplakia with a very high risk of malignant transformation. Therefore, this lesion may provide clues to understanding malignant transformation of the precancerous lesion “leukoplakia”.
To define the process of the malignant transformation of PVL, serial sections of a rare case of tongue PVL were examined pathologically, ultrastructurally, and immunohistochemically with the use of nuclear protein “Ki-67”, a widely accepted marker of cell proliferation.
The patient was a 55-year-old man. The lesion was white and verrucous. The tissue showed various pathologic characteristics, such as those of simple hyperplasia, severe dysplasia, verrucous hyperplasia, and squamous cell carcinoma. Ki-67 positive nuclei increased parallel to the degree of malignancy. Ultrastructurally, the tumor cells extended cytoplasmic processes to stromal tissue, indicating a highly invasive nature.
The data are presented in detail here. Moreover, based on this case, methods for treatment are discussed. We concluded that cases of PVL, such as the presented one, that were suspected clinically should be treated similarly to malignant tumors.View full abstractDownload PDF (3104K) -
Hiroyuki HARADA, Kanchu TEI, Shujirou MAKINO, Akira SATOH, Motoaki HAN ...1998 Volume 44 Issue 5 Pages 508-510
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe analyzed 44 cases of secondary cervical lymph node metastasis in patients with squamous cell carcinoma of the oral cavity and lip from 1974 through 1993. Secondary cervical lymph node metastases were found in 16.3% of N O cases. Metastasis was histologically confirmed at 47 sites. The average number of lymph node metastases was 2.2/site, and the pathological spread of metastatic nodes (level M or more) was found at 20 sites (42.6%). Extracapsular spread was seen at 22 sites (46.8%). Of the 47 sites of metastasis, 39 (83.0%) were controlled, and the overall 5-year survival rate was 61.7%.View full abstractDownload PDF (405K) -
Takaaki UENO, Hiromitsu YAMAMOTO, Shin TAKAGI, Toshio SUGAHARA1998 Volume 44 Issue 5 Pages 511-513
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe report a case of malignant lymphoma presenting with multiple ulceration of the palate, maxillary gingiva, and mandibular gingiva in a 79-year-old woman. This case of malignant lymphoma was immunohistochemically diagnosed as diffuse large angiocentric NK/T cell lymphoma, which has very unique clinical features. In the oral and maxillofacial region, there have been few reports of this disease, and its concept is not generally recognized.View full abstractDownload PDF (3405K) -
Manabu SHIMADA, Yoshihito ISHIKAWA, Hiroki MIYATE, Yoshiyasu FUKUTA, Y ...1998 Volume 44 Issue 5 Pages 514-516
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSAngioleiomyoma is a benign tumor in smooth muscles, which often occurs in the limbs, especially in the subcutaneous part of the inferior limbs. Angioleiomyoma in the oral cavity is rare and therefore has been rarely reported. We report a case of angioleiomyoma arising in the alveolar mucosa of the mandible. Among cases of angioleiomyoma in the oral cavity, lesions occurring in this region are particularly rare. The patient was a 49-year-old woman with a 10mm×7mm×5mm hemispherical tumor. The tumor border was seen in the alveolar mucosa of the mandible. Clinically, it was diagnosed as a mandibular benign tumor. The lesion was resected with the patient under local anesthesia. Histopathologically, the tumor was diagnosed as angioleiomyoma and was classified as venous type according to Morimoto's classification. The patient's postoperative course has been good, with no evidence of recurrence as of 1 year 10 months after the operation.View full abstractDownload PDF (2654K) -
Yuko FUJIMORI, Akira SATOH, Ken-ichi NOTANI, Hiroshi FUKUDA, Masanobu ...1998 Volume 44 Issue 5 Pages 517-519
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA case of mononuclear phagocyte system (MPS) histiocytosis in the mandible of a 26-year-old woman is reported. Although she had no complaints, orthopantomography showed a honeycomb appearance in the right mandible.
A diagnosis of histiocytosis was made on biopsy. The tissue was consisted of large numbers of histiocytes rich in foamy cytoplasm. Immunohistochemical examinations revealed that these cells were S-100 protein (-), α 1-antitrypsin (+), α 1-antichymotrypsin (+), and CD68 (+). The lesion was considered to represent histiocytosis derived from MPS histiocytes. Enucleation was done, and there have been no radiographic signs of remodeling and no clinical evidence of progression as 7 years after the operation.View full abstractDownload PDF (4766K) -
Yasunori ARIYOSHI, Masashi SHIMAHARA, Yasuko TAKEUCHI, Toshiyuki KONDA ...1998 Volume 44 Issue 5 Pages 520-522
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe describe a 10-year-old girl with juvenile ossifying fibroma arising at the right side of the mandible. The lesion had recurred about 2 years after tumor extirpation and bone currettage. Segmental mandibulectomy was performed. For secondary reconstruction of the mandible, a vascularized calvarial bone graft was planned, because this bone graft has an appropriate shape and outline and because the surgical wound is covered by hair.
During the operation, a full-thickness calvarial bone flap, measured 3×7cm, with the temporal muscle, temporal fascia, innominate fascia, and superficial temporal artery as a pedicle was designed.
The postoperative course was uneventful. Three days after the operation, Tc bone scintigraphy was performed and demonstrated good uptake of Tc by the bone graft. One month after the operation, intermaxillary fixation was removed, and the patient was discharged.
Seven years 3 months after reconstructive surgery, the patient is disease free and is satisfied with both appearance and function, including mastication.View full abstractDownload PDF (5130K) -
Eiko MARUKAWA, Hiromasa KAWANA, Taisuke MORI, Atsuko SUZUKI, Hiromasa ...1998 Volume 44 Issue 5 Pages 523-525
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThis paper describes a case of microtia treated with an auricular episthesis using bone-anchored titanium implants. Special emphasis is placed on the surgical procedure. A 58-year-old woman with presbyopia and conjunctivitis is described. The placement of implants and the wearing of glasses improved the patient's quality of life. Our findings suggest that longer implants can be placed in the temporal bone if computed tomographic analysis is done preoperatively in patients with microtia, because they often have a thickened cortex of the temporal bone.View full abstractDownload PDF (2984K) -
Yoshinori JINBU, Yoko AKASAKA, Akihiro NUMAO, Yutaka KIMURA, Hiromi NA ...1998 Volume 44 Issue 5 Pages 526-528
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSArteriovenous malformation (AVM) is a rare disease in the oral and maxillofacial region. We encountered two cases of AVM in the maxillofacial region. The first case was diagnosed in a 26-year-old woman. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a hypervascular lesion in the right buccal region, and a large AVM was demonstrated on angiography. After embolization of the feeding arteries, the lesion decreased in size. The second case was diagnosed in a 15-year-old girl. Panoramic radiography showed a radiolucent lesion surrounded by an indistinct margin in the right side of the mandibule. A large AVM extending from the right buccal region to the mandibule was suspected on CT and MRI scans, and AVM was diagnosed on angiography. After 1 year 6 months, the lesion has decreased in size spontaneously, without any treatment.View full abstractDownload PDF (5588K) -
Jun KUNO, Nagato NATSUME, Teruyuki NIIMI, Hiroo FURUKAWA, Motoo YOKOI, ...1998 Volume 44 Issue 5 Pages 529-531
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSPeters anomaly involves a major error in the embryonic development of the eye, associated with corneal clouding and variable iridolenticulocorneal adhesions. Short limb dwarfism and a pathognomonic face (thin upper lip, hypoplastic columella, round face, and micrognathia) occur as complications of Peters anomaly. Cleft lip and palate have also been reported as a complication of Peters anomaly.
Here, we describe a case of Peters anomaly with cleft palate.View full abstractDownload PDF (2332K) -
Hirokazu NAKAHARA, Atsuyuki MORI, Tomie NAKAYAMA, Takafumi OGURA, Masa ...1998 Volume 44 Issue 5 Pages 532-534
Published: May 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe report a case of first and second branchial arch syndrome with complete cleft lip and palate. A Japanese newborn baby was referred to our clinic for the treatment of the cleft lip and palate and a transverse facial cleft. Cheiloplasty was performed under general anesthesia at the age of 4 months. Plastic surgery of the transverse facial cleft was performed under general anesthesia at the age of 9 months. The patient has atrial septal defect with malformation of the auricles and the right thumb, which should be treated at another department. At our clinic, palatoplasty with a pushback method will be performed in near future, and comprehensive speech therapy will be required.View full abstractDownload PDF (5143K) -
1998 Volume 44 Issue 5 Pages e1
Published: 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSDownload PDF (37K)
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