Benign fibrous histiocytoma commonly arises in the abdomen and sun-exposed skin and rarely occurs in the oral cavity. A case of benign fibrous histiocytoma arising around the mental foramen is reported. A 23-year-old woman was referred to our hospital because of a painless small mass on the right side of the subgingiva at the first premolar of the mandible, associated with hypoesthesia of the right mental region. The biopsy specimens were pathologically diagnosed to be a non-epithelial tumor, and the tumor was excised under general anesthesia. Microscopically, the tumor consisted of spindle-shaped cells and polygonal cells, and partly formed a storiform pattern. Immunohistochemically, the spindle-shaped cells were positive for vimentin, and the polygonal cells were positive for vimentin and CD68, but both types of cells were negative for NF, S-100, actin, EMA, factor VIII, and CD34. Based on these findings, the tumor was diagnosed to be a benign fibrous histiocytoma. Thirteen weeks after the operation, the hypoesthesia of mental region had completely disappeared. No evidence of recurrence has been noted as of 8 years after surgery.
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