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Volume 46, Issue 8
Displaying 1-10 of 10 articles from this issue
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Relationship between loss of heterozygosity on 3 p25-pter region and clinical and histological featuresNarikazu UZAWA, Daisuke AKANUMA, Akihide NEGISHI, Teruo AMAGASA, Mitsu ...2000 Volume 46 Issue 8 Pages 455-461
Published: August 20, 2000
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSCytogenetic and molecular studies have indicated that a putative tumor suppresor gene (s), which may play an important role in oral squamous cell carcinogenesis, is located on the short arm of chromosome 3 (3 p). We analyzed loss of heterozygosity (LOH) on 3 p, especially the 3 p25-pter region, in 17 oral squamous cell carcinomas (OSCCs) with the use of 5 microsatellite markers and constructed a deletion map for this chromosome arm. LOH at one or more loci was detected in 9 of 17 (53%) tumors. LOH on these region was more common in advanced OSCCs and may be associated with tumor progression. Our data support the notion that one of tumor suppressor gene (s) contributing to the progression of oral squamous cell carcinoma resides on 3 p25-pter.View full abstractDownload PDF (3580K) -
Hiroshi NAKAJIMA, Masaro MATUURA, Toshie OKADA, Kanichi SETO2000 Volume 46 Issue 8 Pages 462-471
Published: August 20, 2000
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThis study was designed to evaluate a new method for assessing masticatory disturbances in patients with occupational maxillofacial injuries From November 1993 through March 1998, 70 patients (60 men and 10 women, mean age, 43.8 years, range 21 to 69) were examined on the basis of (1) dental findings, (2) number of maxillofacial injures, (3) maximum rate of jaw tapping in a 10-second period, and (4) occlusional findings by DENTAL PRESCALE (Fuji Photo Film Co.). In addition, the masticatory efficiency rate was calculated from the results of a questionnaire assessing the ability to chew 50 different foods. Multiple regression analysis was used to examine the relationship between masticatory efficiency rate and variables (1) to (4).
The following results were obtained:
The correlation coefficient was 0.725 between masticatory efficiency rate and the maximum rate of jaw tapping in a 10-second period. At a 90% masticatory efficiency rate, the jaw tapping rate was about 46/10-second period, (70%, about 31, 50%, about 17). On multiple regression analysis, the multiple correlation coefficient was 0.799, and the coefficient of determination was 0.615. A new test to evaluate masticatory disturbances duc to occupational maxillofacial injuries was designed on the basis of the masticatory efficiency rate, assessing the ability to chew 50 different foods.
The grade of masticatory disturbance was classified from 1 to 6 (grade 1, eating soup only; grade 2, chewing four kinds of soft foods, including soup; grade 3, 10% to less than 50%; grade 4, 50% to less than 70%; grade 5, 70% to less than 90% grade 6, 90% to 100%) on the basis of the masticatory efficiency rate.View full abstractDownload PDF (1314K) -
Tamami DAICHO, Ichiro YAMADA, Kazuma MASUMOTO, Kazue YAMAGUCHI, Hirosh ...2000 Volume 46 Issue 8 Pages 472-474
Published: August 20, 2000
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSPhotodynamic therapy is a new therapeutic technique that utilizes a photosensitizer selectively localized in tumors and activated by exposure to laser light, resulting in tumor necrosis. Photodynamic therapy has proved to be effective in the treatment of early cancers of the lung, esophagus, stomach, and uterine cervix, and was approved by the Japanese goverment. We consider early oral cancers to be good candidates for photodynamic therapy. This report describes two cases of tongue carcinoma treated by photodynamic therapy.View full abstractDownload PDF (7619K) -
Hiroshi SUETSUGU, Tsutomu INOUE, Masanori TAKEKAWA, Mitsuyoshi MATSUDA ...2000 Volume 46 Issue 8 Pages 475-477
Published: August 20, 2000
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA rare case of synchronous multiple cancers involving mandibular osteosarcoma and breast cancer is reported. A 49-year-old woman was referred to our department because of a swelling at the left mandibular angle. Extended radical mastectomy had been performed 6 months previously, and the histopathological diagnosis was papillotubular carcinoma. One month after the mastectomy, the patient experienced discomfort of the left mandibular angle and hypalgesia of the left side of the lower lip. Intraoral examination revealed a hard mass, measuling 6×4 cm and covered normal mucosa, in the left lower molar region. Occlusal radiography showed a sun-ray-like appearance at the focus. Bone scintigraphic scans showed an area of increased intake of radiolabeled technetium in the left side of the mandible. Preoperative chemotherapy with a high dose of methotrexate had been given in accordance with Rosen's T-12 protocol, but the tumor grew rapidly. Radical resection of the tumor was performed. Postoperatively, she was given chemotherapy with CDDP and ADM. There have been no clinical or radiological signs of recurrence or distant metastasis as of 9 years after operation.View full abstractDownload PDF (6919K) -
Aya KOIZUMI, Hiroki BUKAWA, Nobuyuki MIZUKI, Ryoichi KAWABE, SUSUMU OM ...2000 Volume 46 Issue 8 Pages 478-480
Published: August 20, 2000
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe report a case of pulmonary embolism that occurred after mandibulectomy. A 59-year-old woman underwent mandibulectomy for a keratocyst arising in the left side of the mandible. After being moved for treatment on the morning of the first postoperative day, vomiting, transient uncousciousness, chest pain, and dyspnea suddenly occurred. Pulmonary embolism (PE) was diagnosed on the basis of hypoxia, overload of the right ventricle, and RI scintigraphy of pulmonary blood flow. Heparin was administered intravenously as anticoagulant therapy immediately after the episode. She successfully recorvered from PE and was discharged on the 35th postoperative day.View full abstractDownload PDF (3867K) -
Kouji NITTA, Eiji HAYASHI, Kenji FUJISAWA, Nobuyuki KAMATA, Masaru NAG ...2000 Volume 46 Issue 8 Pages 481-483
Published: August 20, 2000
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe report two cases of ameloblastic fibro-odontoma, a rare odontogenic tumor. Patient 1 was a 12-year-old boy with a tumor in the right side of the mandible, and patient 2 was a 13-year-old boy with a tumor in the right side of the maxilla. The clinical diagnosis was a benign tumor of the mandible and an odontogenic tumor of the maxilla, respectively. The lesions were removed with the patients under general anesthesia. Histopathologically, the tumors showed proliferation of fibrous tissue and ameloblast-like epithelial cells. In addition, dentin-like and bone-like hard tissues were observed in the matrices of the tumors. On the basis of these findings, the tumors were diagnosed as ameloblastic fibro-odontomas. The courses of both patients were favorable with no sign of recurrence.View full abstractDownload PDF (4202K) -
Yasuhiro OZAWA, Gen-yuki YAMANE, Morio TONOGI, Yutaka WATANABE, Ienaka ...2000 Volume 46 Issue 8 Pages 484-486
Published: August 20, 2000
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe describe a tumoral calcinosis-like lesion arising in the maxillary anterior alveolus. The patient was 63-year-old woman who presented with a painless swelling of the maxilla. A benign tumor was suspected, and excision was performed. However, the postoperative histopathological diagnosis was a tumoral calcinosis-like lesion. The patient had been undergoing hemodialysis three times a week for chronic renal failure. Blood chemical analysis revealed that the parathyroid hormone was high (2220pg/ml) and the serum calcium-to-phosphorus product exceeded 70mg/dl before hemodialysis. These results suggested that ectopic calcification had occurred.
To our knowledge, only 2 tumoral calcinosis-like lesions arising in the oral cavity have been reported.View full abstractDownload PDF (4174K) -
Tabito KITAMURA, Takao IMAI, Takamasa MATSUO, Atsushi ABE, Takahisa TS ...2000 Volume 46 Issue 8 Pages 487-489
Published: August 20, 2000
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSAmong 90 cases of partial Monosomy of the short arm of chromosome 9 that have been described in the literature, only 4 cases have been reported in Japan. We describe a new case associated with cleft palate. The patient was a 1-month-old girl. She came to our hospital for treatment of cleft palate in 1994. Because of her peculiar facial appearance, including slanted eyes, flat nasal bridge, and prominent forehead, we conducted a chromosome analysis, which revealed a partial monosomy of the short arm of chromosome 9 (9p-syndrome). At the age of 2.5 years, her physical development was favorable, and we performed palatoplasty with the patient under general anesthesia. She is being observed at the department of pediatrics and our department since the operation.View full abstractDownload PDF (3784K) -
Hisashi HATTORI, Hideki MIZUTANI, Michio KAWAI, Minoru UEDA2000 Volume 46 Issue 8 Pages 490-492
Published: August 20, 2000
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe report an unusual case of calcium pyrophosphate dihydrate (CPPD) crystal deposition involving the temporomandibular joint (TMJ) of a 51-year-old woman. The patient presented with a 20-year history of right TMJ clicking sounds without pain and had a locking duration of 6 months with pain. The medical history was unremarkable, and there was no history of disease involving any other joints. There was moderately limited translation of the right condyle and a slight deviation of the mandible to the right during mouth opening. Radiological examination revealed mild bony changes of right condyle, but showed no calcified mass. MRI disclosed anterior disc displacement without reduction. We performed arthrocentesis of the right TMJ and discovered CPPD crystals in the patient's irrigation solution after centrifugation. The crystals were examined by compensated polarized light microscopy and by light microscopy with alizarin red staining. These observations led to a diagnosis of CPPD arthritis of the TMJ. After a 5 years of follow-up, no signs or symptoms of recurrence have been observed.View full abstractDownload PDF (4021K) -
Yoshikuni SANGU, Kenji FUKADA, Keika HOSHI, Takashi YAMAZAKI, Makoto S ...2000 Volume 46 Issue 8 Pages 493-495
Published: August 20, 2000
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSIn diabetic patients, the microcirculation is impaired in oral mucosal capillaries as well as in the retina. Consequently, the concentration of drug transferred to the oral mucosa is expected to be lower than in healthy persons. Therefore, we orally administered an antimicrobial drug before oral surgery and evaluated its transfer to oral tissue. The study group comprised 30 diabetic patients who visited our department and underwent tooth extraction. Differences between the diabetic patients and a control group were statistically analyzed. Before tooth extraction, an antimicrobial drug was orally administered. Immediately after operation, we obtained samples of peripheral blood, blood retained in the extraction cavity, and gingival tissue of the surrounding area. The concentrations of antimicrobial drug in the serum and gingiva were determined by bioassay. There was no significant difference between the diabetic patients and the control group. Therefore, more detailed studies of additional patients are necessary. Our results suggest that an increase in the dose of antimicrobial drugs is not necessary in patients with relatively well controlled diabetic mellitus.View full abstractDownload PDF (431K)
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