White sponge nevus is a rare disease that develops in the oral mucosa, which becomes edematous and spongy.
We report two cases of white sponge nevus of the oral mucosa.
Patient 1 was a 25-year-old woman. Her chief complaint was a bilateral sense of incongruity of the buccal mucosa and upper and lower lips. Her father and older brother had similar lesions. She also had a similar lesion on the perineum. The symptoms improved in response to treatment with a cephem antimicrobial agent, which had been prescribed after the biopsy.
Patient 2 was a 44-year-old man. He requested a detailed examination of bilateral white lesions of the buccal mucosa. A biopsy yielded a diagnosis of a white sponge nevus. In this patient, lesions were present in only the oral cavity.
His symptoms responded to treatment with macrolide antibiotics, which had been prescribed after the biopsy.
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