Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 53, Issue 9
Displaying 1-7 of 7 articles from this issue
  • Miwa AKUTSU, Naomi OGURA, Hiroyuki SAKAMAKI, Makiko TOBE, Ko ITO, Yosh ...
    2007 Volume 53 Issue 9 Pages 538-544
    Published: September 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    Tumor necrosis factor-α(TNF-α) plays a key role in pathological conditions of the temporomandibular joint (TMJ). However, the molecular mechanisms by which TNF-α contributes to synovial inflammation remain unclear. In this study, the gene expression profile of synovial fibroblasts stimulated by TNF-α was studied by Gene Chip analysis. Synovial fibroblasts were prepared from the tissues of three patients with internal derangement of the TMJ, using the outgrowth method. The synovial cells were stimulated by TNF-α for 4 hours, after which total RNA was extracted with TRlzol. Gene expression profiling was performed using the Affymetrix Gene Chip (Human Genome Focus Array, 8500 genes). Hybridization data were analyzed with Gene Spring software.
    Two hundred forty-five genes were found to be TNF-α responsive, showing a greater than two-fold difference in average intensity between the stimulated and control samples. The gene ontology classification was the “transregulator”, “catalytic activity”, “transcription regulator”, and “chaperone activity” categories. Among the top 25 up-regulated genes, 8 were found to be chemokines. The expression of chemokines in TNF-α responsive genes measured by Gene Chip was confirmed by real time-PCR. Chemokine gene expression was found to be increased by TNF-α.
    These results suggest that TNF-α may contribute to inflammation in internal derangement of the TMJ by producing chemokines.
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  • Eisaku UETA, Seiji OHNO, Yukiko HIBI, Eri SASABE, Takaaki KAMATANI, Te ...
    2007 Volume 53 Issue 9 Pages 545-548
    Published: September 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    Osteoma, a benign proliferative bony lesion, is an uncommon lesion in the maxillary sinus. We report a case of ring-shaped osteoma with stratified squamous epithelium in the left maxillary sinus. A 55-year-old man was referred to our clinic because of a radiopaque lesion in the sinus. Computed tomography disclosed a bulky highdensity mass with a cavity. The mass was pedunculated and extended from the inferior to the posterior walls of the left maxillary sinus. The mass was extirpated by opening the maxillary sinus from the canine fossa under general anesthesia. The histopathological diagnosis was osteoma consisting mainly of spongeous bone, partially overlaid with pseudostratified ciliated epithelium and containing granulation tissue covered by stratified squamous epithelium. The clinical features, histopathology, and pathogenesis of osteoma in the maxillary sinus are discussed.
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  • Yutaka MARUOKA, Hiroyuki HARADA, Ken OMURA
    2007 Volume 53 Issue 9 Pages 549-552
    Published: September 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    We report a rare case of Warthin tumor accompanied by bone formation. A 57-year-old woman with pus discharge in the right mandibular gingiva visited our hospital in August 1995. Several fistulas in the right mandibular gingiva and a rough-surfaced tumor 1.5 cm in diameter on the right side of the tongue were found. The clinical diagnosis was osteomyelitis of the mandible and tongue cancer. Sequestrotomy of the mandible and partial glossectomy were performed in October 1995. At that time, a computed tomographic (CT) scan showed 1-cm-diameter lesion in the right parotid gland; however, she hesitated to undergo surgery. In April 2001, a CT scan revealed a bilateral mass 1.2 cm in diameter near the parotid glands, and the mass in the right parotid gland increased to 2 cm in diameter and possessed a small calcified granule inside. 99mTc scintigraphy of the salivary glands showed a hot spot in the both parotid glands, consistent with the tumor. In March 2002, she underwent extirpation of the tumors arising in the both parotid glands. Histopathological examination showed a typical Warthin tumor appearance, with bone formation in the hyalinized structure of the tumor. At present, the patient has no evidence of disease.
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  • Hiroyuki KITAJO, Hiroki NAGAYASU, Takanori SHIBATA, Makoto ARISUE, Yas ...
    2007 Volume 53 Issue 9 Pages 553-557
    Published: September 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    Ameloblastic carcinoma rarely arises in the oral cavity and is classified into primary type and secondary type. No report, however, has proposed the malignant transformation of a benign tumor into an ameloblastic carcinoma. We report the case of a secondary ameloblastic carcinoma that showed pathological evidence of transformation from a benign to a malignant tumor in the right mandible of a 73-year-old man.
    The patient was referred to a dental clinic because of swelling of the right side of the mandible. Biopsy yielded a diagnosis of ameloblastoma, plexiform type. A partial resection of the right side of the mandible was performed under general anesthesia in April 2003. The postoperative pathological diagnosis was ameloblastic carcinoma. The patient was given a definitive diagnosis of secondary ameloblastic carcinoma, because evidence of malignant transformation was observed. No recurrence and no metastasis have occurred for 3 years.
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  • Katsuhito NAKASHIMA, Kenichi KURITA, Makoto TAKAISHI, Tetsuya YAJIMA, ...
    2007 Volume 53 Issue 9 Pages 558-562
    Published: September 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    We report a case of ankylosis in childhood treated by TMJ mobilization with preservation of the condyle and disc. The patient was a 9-year-old boy with a history of a right condylar fracture at the age of 7 years. As the maximal mouth opening had markedly decreased, TMJ mobilization was performed at the age of 13 years. We resected the bony adhesion, retaining the fractured condyle and disc in their displaced position.
    Five years after surgery, the patient had a maximal mouth opening of 45mm, as well as better contralateral and protrusive movements without any recurrence. Mandibular deviation has gradually improved.
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  • Arisa SEKINE, Yoshiko FUJITA, Maya KUWAYAMA, Yoshitsugu AKIMOTO, Masay ...
    2007 Volume 53 Issue 9 Pages 563-567
    Published: September 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    Marfan's syndrome is a congenital disorder that affects connective tissue. It is characterized by arachnodactyly, aortic incompetence, mitral valve prolapse, and dissecting aneurysm throughout the body. Patients with this syndrome show craniofacial abnormalities such as a high palatal vault, cleft palate, mandibular prognathism, malalignment, and morphological abnormalities of the teeth.
    We report a case of jaw deformity associated with Marfan's syndrome that was treated by Le Fort I osteotomy and sagittal splitting ramus osteotomy.
    The patient was a 29-year-old man with complications throughout his entire body, including hardness of hearing, pneumothorax, aortic valve enhancing syndrome, and aortic regurgitation. We therefore closely consulted with his heart surgeon and anesthesiologist before the operation. We performed surgery, taking the following precautions:(1) Antibiotics were administered preoperatively to prevent bacterial endocarditis.(2) Anticoagulants were discontinued to reduce the risk of hemorrhage.(3) An appropriate circulatory volume was maintained to reduce the burden on the circulatory organs.(4) An excessive rise in airway pressure was avoided to prevent pneumothorax. An excellent result was obtained, with no complications.
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  • Katsuhiro MINAMI, Yoshihide MORI, Miyuki OTANI, Hiroyuki NAKANO, Nagat ...
    2007 Volume 53 Issue 9 Pages 568-571
    Published: September 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    May-Hegglin anomaly is a rare autosomal dominant inherited disorder characterized by thrombocytopenia, giant platelets, and inclusion bodies in granulocytes. Because of thrombocytopenia, a mild hemorrhagic diathesis occurs. We extracted a mandibular wisdom tooth in a patient with May-Hegglin anomaly. By applying cotton-type oxidized cellulose to the extraction cavity and compression hemostasis with a tie-over, complete hemostasis was obtained without platelet transfusion.
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