Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 53, Issue 1
Displaying 1-9 of 9 articles from this issue
  • Functional evaluation ofets-1 gene
    Mitsunori AKANE, Yuichi OHNISHI, Kenji KAKUDO
    2007 Volume 53 Issue 1 Pages 2-7
    Published: January 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    Metastasis in invasive carcinoma is closely associated with the production of extracellular matrix catabolic enzymes, such as matrix metalloproteinases (MMPs). It is known thatetsproto-oncogenes exist in transcriptional regulation refions of the MMP gene and enhance or inhibit MMP transcription. In this study, we restrained theets-1 gene expression of an oral squamous carcinoma cell line by means of RNA interference (RNAi) and examined the change in invasion ability from a molecular biological perspective. An oral squamous carcinoma cell line (HSC-3) was transfected with short interfering RNA (siRNA) ofets-1. The invasive ability of the transfected cells was determined by a matrigel invasion assay, and MMP-9 production was measured by gelatin zymography. These data were compared with those of normal cultured cells. Matrigel invasion assay demonstrated that the transfected cells had a lower invasive ability than HSC-3, and gelatin zymography demonstrated that the MMP-9 production in these cells had decreased. These results suggested that transfection of siRNAets-1 would inhibit tumor invasion through down-regulation of MMP-9.
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  • Takashi YAMAMOTO, Akihiro MIYAZAKI, Makoto NOGUCHI, Yasushi HARIYA, Ke ...
    2007 Volume 53 Issue 1 Pages 8-12
    Published: January 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    Malignant lymphoma occurs fairly frequently in the oral cavity, but is relatively rare in the mandible. We report a case of malignant lymphoma arising from the middle of the alveolar bone of the mandible. The patient was a 38-year-old man who had a swelling on the middle of the lower alveolus. Histopathological examination of a resected specimen was performed several times, but failed to prove malignant lymphoma. Southern-blot analysis disclosed the clonality of B-cells. We assessed the patient's overall clinical progress and decided to reexamine the surgical specimen. This led to a diagnosis of diffuse large B-cell lymphoma, Stage I E according to the Ann Arbor classification. The patient received combination treatment consisting of chemotherapy with CHOP (R-CHOP) and radiotherapy. There have been no signs of recurrence during the 27 months since treatment.
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  • Hideto SAIJO, Yoshiyuki MORI, Daichi CHIKAZU, Hisako FUJIHARA, Yoshiyu ...
    2007 Volume 53 Issue 1 Pages 13-17
    Published: January 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    A 20-year-old man was referred to our department because of severe pain while eating. Physical examination revealed an erosion and ulcer in the oral cavity. He had been treated for aplastic anemia on an outpatient basis at the Department of Cell Therapy and Transplantation Medicine of our hospital. He had received bone marrow transplants twice. Subsequently, graft-versus-host disease (GVHD) developed, and treatment with cyclosporine was started. Biopsy ruled out the possibility that the lesion in the oral cavity was caused by GVHD. Gingival hyperplasia was noted 8 months later, and granulomatous epulis was diagnosed. The patient's general condition subsequently deteriorated, and mucosal proliferation spread throughout the oral cavity. Biopsy yielded a diagnosis of post-transplantation lymphoproliferative disorder (PTLD). We describe our experience with this rare case of PTLD.
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  • Noriyuki TAKASHI, Makoto MATSUOKA, Yusuke MATSUZAWA, Makiko ABUCHI, Ka ...
    2007 Volume 53 Issue 1 Pages 18-22
    Published: January 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    Inability to recognize one or two taste qualities of the four primary tastes is termed dissociated taste disturbance. We report two cases of dissociated taste disturbance. A 46-year-old woman complained of a sweet taste disorder after tonsillectomy. A 76-year-old woman complained of a sweet taste disorder after herpes zoster infection of the mandibular nerve tract. The causes of this rare complication are speculated to be (1) direct or indirect damage to nerves, (2) lack of dietary zinc, and (3) habitual drug intake.
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  • Motokatsu TSUYUKI, Kazuhiko YAMAMOTO, Yuichiro IMAI, Tsutomu SUGIURA, ...
    2007 Volume 53 Issue 1 Pages 23-27
    Published: January 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    Zinc deficiency is known to be one cause of taste disorders.
    We report our clinical experience with the administration of polaprezinc to two patients with zinc-deficient taste disorders. The patients had serum zinc deficiency and were given a diagnosis of zinc-deficient taste disorder. In response to 75 mg of polaprezinc twice daily, taste disorder improved parallel to an increase in the serum zinc concentration.
    Polaprezinc is effective for patients with zinc-deficient taste disorders.
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  • Naoko KISHI, Tadafumi ADACHI, Hidehiko KOIZUMI, Seiji IIDA, Mikihiko K ...
    2007 Volume 53 Issue 1 Pages 28-32
    Published: January 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    Bisphosphonates (BPs) are widely used for the management of hypercalcemia related to malignancy and bone metastases from breast cancer in Japan. We report a case of osteonecrosis of the jaw (ONJ) associated with a history of BPs therapy forthe management of bone metastases from breast cancer. A 69-year-old woman was referred to our department becaused of unhealed extraction sockets of the lower left premolar and first molar, which were removed at a dental clinic. CT scans of the mandible showed regions of mottled bone and sequestra, and a clinical diagnosis of ONJ was made. After conservative treatment with antibiotics and local minor curettage, the inflammatory symptoms almost completely disappeared. Dentists should be aware of this potentially serious complication in patients receiving long-term treatment with BPs.
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  • Yasufumi MYOISHI, Ryouji TANI, Yoshiharu TANAKA, Yasutaka ISHIDA, Shig ...
    2007 Volume 53 Issue 1 Pages 33-37
    Published: January 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    Rhabdomyolysis results from the release of skeletal muscle contents (myogloblin, creatinine kinase) and causes renal damage.
    We report a case of rhabdomyolysis that developed after a by mandibular fracture operation under general anesthesia.
    The patient was an 18-year-old man who underwent operation for surgical repositioning and fixation of the mandible, preformed under general anesthesia with sevoflurane. The course of anesthesia was uneventful, and the patient recovered uneventfully. Two hours postoperatively, dark red urine was voided. On the 1st postoperative day, the creatinine kinase (CK) was 38700 IU/I and increased further to 73900 IU/I at reexamination. He had tenderness of the right brachial muscle, and dark red urine presisted. Rhabdomyolysis caused by general anesthesia was diagnosed. The patient received an infusion of extracellular fluid, and CK normalized on the 11th postoperative day. As postoperative malignant hyperthermia (MH) was suspected, the Ca2 +-induced Ca2 +release (CICR) rate was examined. CICR was unaccelerated, ruling out a predisposition to MH. Seven months later, the fixation plates were removed with the patient under local anesthesia. There were no complications.
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  • Yoshiko WATANABE, Fuminori KATOU, Takehiro OURA, Hideo TANAKA, Fumihik ...
    2007 Volume 53 Issue 1 Pages 38-41
    Published: January 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
    Hereditary angioneurotic edema (HANE) is a rare disease caused by functional disorder or reduction of Cl inhibitor. The disease is characterized by episodic localized edema of subcutaneous tissues or gastrointestinal or laryngeal mucosa caused by physical or mental stress. Fatal laryngeal edemamay be caused by dental treatment.
    We report the case of a patient with HANE who required teeth extraction.
    A female patient had edema of unknown origin of the extremities and face, and abdominal colic since she was in junior high school. In addition, she hadhad laryngeal edema after tooth extraction. Her son also manifested the symptoms. HANE was diagnosed on further examination.
    To prevent angioedema, we injected tranexamic acid and a C1 esterase inhibitor before teeth extraction. Treatment was done after endotracheal intubation and tracheostomy. No angioedema was caused by teeth extraction.
    Teeth extraction was safely performed in a patient with HANE who was given tranexamic acid and a C1 esterase inhibitor to prevent angioedema.
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  • Takae ABE, Toshikatsu FUJIWARA
    2007 Volume 53 Issue 1 Pages 42
    Published: January 20, 2007
    Released on J-STAGE: April 22, 2011
    JOURNAL FREE ACCESS
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