Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 47 , Issue 1
Showing 1-17 articles out of 17 articles from the selected issue
  • Saisei Fu, Yoshitaka HIBINO, Yoichi YAMADA, Atsushi NIIMI, Masaki HOND ...
    2001 Volume 47 Issue 1 Pages 1-7
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Recently, tissue engineering has received considerable attention for regeneration. The present study was undertaken to evaluate whether porous β-tricalcium phosphate (β-TCP) can be used as a scaffold for cultured bone marrow cells.
    Bone marrow cells were obtained from the shaft of the rat femur cultured in a standard medium for 10days, and trypsinized to combine the cells with ceramics. An additional subculture was done for cells/ceramics composite in a standard medium with the addition of β-glycerophosphate, ascorbic acid, and dexamethasone. After 20 days, the subcultured composites were implanted into the subcutaneous sites of syngenic rats. These implants were harvested 4 and 8 weeks after implantation, and prepared for biochemical and histological analyses.
    Histological analysis showed active bone formation in the composites. Bone formation was confirmed by the presence of an active osteoblast lining on the bone surface. Substantial alkaline phosphatase activity in the composites was detected at both 4 and 8 weeks. Osteocalcin was also detected at 4 weeks, and increased significantly at 8 weeks. In contrast, there was no significant bone formation in the control groups.
    These results suggest that β-TCP may act as a scaffold for cultured bone derived from marrow cells and there by promote the regeneration of bone tissue.
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  • Shin-ichiro OHISHI
    2001 Volume 47 Issue 1 Pages 8-18
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    To evaluate prognostic factors affecting surgically treated osteoradionecrosis (ORN) of the mandible, 13 patients with mandibular bone necrosis caused by irradiation for head and neck cancer were examined clinicopathologically. The subjects were included 12 men and 1 woman, with a mean age of 65.3 years at surgery. The mean total dose of irradiation was 61.6Gy. The clinical stage according to Epstein et al.(1987) was II B in 1 patient, III A in 4, and III B in 8. The mandible was resected 10mm or more from the lesion. Delayed healing was found in two patients, and three had recurrence of necrosis of the remaining bone. Patients whose mandibular periosteum had been resected previously who received mandibular reconstruction had a poor outcome. Pathological changes, such as stenosis of the inferior alveolar artery, fibrosis of bone marrow, and low osteocyte density in cortical bone, were found in all resected mandibles. Among them, mandibles lacking sequestra and bone remodeling had poor viability. Therefore, the periosteal blood supply should be conserved and surgical interventions, particularly heat, must be minimized to avoid recurrence of ORN.
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  • Yoshikazu KAMINO, Hiroyuki OKADA, Hitoshi NISHIMURA, Yoshiaki AKIMOTO, ...
    2001 Volume 47 Issue 1 Pages 19-21
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A case of hepatocellular carcinoma in a 67-year-old man with initial symptoms arising in the maxillary sinus.
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  • Seiji OBARA, Yasuro YOSHIMURA
    2001 Volume 47 Issue 1 Pages 22-24
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    We describe a case of tongue carcinoma associated with leukocytosis and hypercalcemia after lung metastasis. The leukocytosis and hypercalcemia were accompanied by a high concentration of G-CSF (285pg/ml) in the pleural effusion and a high serum level of PTHrP (3, 109pg/ml).
    Squamous cell carcinoma (SCC) tissue samples obtained by biopsy and neck dissection underwent immunohistochemical staining with G-CSF and PTHrP polyclonal antibodies by the streptoavidin-biotin peroxidase complex method. Although staining by G-CSF antibody was negative in the primary carcinomatous tissue, it was positive in the metastatic cervical lymph nodes. As for PTHrP, both the primary and metastatic SCCs were positive. In the primary lesion, small clusters of SCC cells detached from main SCC tissue appeared to be stained more intensively by PTHrP than did the main SCC tissue.
    These findings indicate the following:
    1) G-CSF-and PTHrP-producing SCC cells induced leukocytosis and hypercalcemia.
    2) Clones of G-CSF-and PTHrP-producing SCC cells probably had a high potential for metastasis.
    The production of cytokines and hormones such as G-CSF and PTHrP may affect the invasiveness of carcinoma cells as well as outcome.
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  • Toshiko YAMASHITA, Nobuo MORITA, Jun MATSUHIRA, Sachiko HATA, Hisaharu ...
    2001 Volume 47 Issue 1 Pages 25-27
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    An extremely rare case of an eccrine porocarcinoma that metastasized to the buccal mucosa in an 80-year-old man is presented. The patient was referred to our department 1 week after surgery for a tumor of the left palm, because of tenderness of the left buccal mucosa. Examination revealed a 2.2×2.2cm firm, well demarcated mass with a bank-like margin, located from the left upper labial mucosa to the left buccal mucosa. Biopsy showed features similar to an eccrine porocarcinoma of the left palm. The lesion of the buccal mucosa was diagnosed to be an eccrine porocarcinoma that had metastasized to the buccal mucosa. The buccal tumor was excised, and the defect was reconstructed with nasolabial and the buccal mucosal flaps. Tenderness disappeared and the quality of life of the patient improved.
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  • Masayuki SUZUKI, Yasuo KINOSHITA, Tetsuya YAJIMA, Hiroaki YATA
    2001 Volume 47 Issue 1 Pages 28-30
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Neurinoma is a benign tumor arising from Schwann cells. In the oral and maxillofacial region, tumors usually arise in the tongue and rarely occur in the mandible. We present a case of neurinoma originating in the inferior alveolar nerve. A 39-year-old man was referred to our hospital because of discomfort in the right side of the mandible. The clinical diagnosis was a mandiblar tumor. The tumor was extirpated with the inferior alveolar nerve. The histopathological diagnosis was neurinoma. The tumor was confirmed to have originated in the inferior alveolar nerve.
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  • Hirofumi INODA, Masanori NISHIKAWA, Gaku YAMAMOTO, Yoshinori YAMAGUCHI ...
    2001 Volume 47 Issue 1 Pages 31-33
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Pleomorphic adenoma usually occurs in the parotid gland or submandibular gland and rarely occurs in the sublingual gland. We describe a pleomorphic adenoma of sublingual gland in a 58-year-old man. The patient's chief complaint was a painless mass in the oral floor. The mass was elastic hard and mobile. The patient underwent excision of tumor, including the capsule, under general anesthesia. On histopathological examination, the solid lesions were found to consist of plasma cells or myoepithelial cells. Interstitial components showed myxomatous degeneration or hyalinization.
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  • Haruhiko TERAI, Masashi SHIMAHARA, Yoshiaki SAKINAKA, Isao SAKINAKA, H ...
    2001 Volume 47 Issue 1 Pages 34-36
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A case of hemangiopericytoma of the palate is presented. The patient was a 47-year-old woman. She came to our department because of swelling (2×2cm) of the left side of the hard palate, present for 1 year. MR imaging showed an isointense tumor on T 1- and T 2-weighted images, and a dynamic study showed a short time to peak with a rapid washout pattern. The tumor was resected under general anesthesia, and the histopathologic diagnosis was a hemangiopericytoma with no malignant findings. There have been no signs of recurrence or metastasis as of 2 years 2 months after operation.
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  • Akira HARA, Ken'ichi SAITO, Takashi FUJIBAYASHI
    2001 Volume 47 Issue 1 Pages 37-39
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    We describe a case of fibrous dysplasia (FD) with an aneurysmal bone cyst (ABC) of the maxilla and review similar cases arising in the oral and maxillofacial region.
    In May 1989, a 33-year-old woman visited the Department of Dentistry and Oral Surgery, Kawaguchi Municipal Medical Center because of a painless swelling in the left side of the maxilla, which had developed 5 years previously. At that time, a pathological diagnosis of FD was made, but she did not receive treatment because she was busy. In October 1994, she returned because the swelling of the left side of the maxilla had increased in size.
    Radiographically, the lesion showed a ground glass appearance mixed with a radiolucent area. The lesion was treated via an intraoral approach by maxillary partial resection within aesthetic limits. There was no severe bleeding during surgery.
    Microscopic examination showed a proliferation of mature non-neoplastic fibrous connective tissue. This tissue contained numerous areas of dysplastic bone. Some portions of the specimen had spaces containing blood. The final diagnosis was fibrous dysplasia with an aneurysmal bone cyst.
    Five years have passed since resection of the lesion, with no evidence of recurrence.
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  • Yasushi HIRATA, Teruo AMAGASA, Takafumi YAMADA, Narikazu UZAWA, Masats ...
    2001 Volume 47 Issue 1 Pages 40-42
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    We clinically and histopathologically analyzed 41 cemento-osseous dysplasias in 39 patients treated at the 1st Department of Oral and Maxillofcial Surgery, Tokyo Medical and Dental University between 1979 and 1998. Among the 39 patients, 9 were male and 30 female. The average age of the patients was 58.5 years. The tumor occurred most frequently in the mandible (37 cases, 90.2%), especially in the molar region. According to the new WHO classification (1992), there were 11 cases of periapical cemental dysplasia, 3 cases of florid cemento-osseous dysplasia, and 27 cases of other types of cemento-osseous dysplasia. There was no recurrence between 6 months and 15 years of any of the 41 lesions treated by sugery.
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  • Kayoko NODA, Jouji NOMURA, Yoshihiko MATSUMURA, Motoko SEKIDA, Kouyuu ...
    2001 Volume 47 Issue 1 Pages 43-45
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Enostosis of the jaw usually presents as an asymptomatic lesion; however, pain such as trigeminal neuralgia or numbness rarely occurs. We describe, a case of enostosis of the mandible in a 46-year-old woman with pain and numbness.
    To our knowledge, 7 cases of enostosis with pain, including ours, have been reported. Enostosis was located mainly around the root apex (type III according to the classification of Geist et al.) in 4 cases and just over the mandibular canal in 3 cases.
    The pain or numbness in our case, may have been caused extension of enostosis, increasing pressure on the mandibular canal.
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  • Shinya YURA, Kaori KURIHASHI, Tetsuya YOSHIKAWA, Ayako DEYAMA, Nobuo I ...
    2001 Volume 47 Issue 1 Pages 46-48
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A case of rheumatoid arthritis of the temporomandibular joint is presented. A 53-year-old woman had limited mouth opening and pain of the temporomandibular joint. She had suffered from generalized arthralgia due to rheumatoid arthritis for 23 years.
    An arthroscopic examination with a 0.8-mm rod-lens fiberscope revealed synovitis, deformity of the condyle, and fibrous adhesion in the lower joint cavity. Synovitis with capillary hyperemia, hypertropic soft-tissup-like synovial villi, exposure of subchondral bone of the eminence with pannus-like soft tissues, and fibrous adhesion were found in the upper cavity. After arthroscopic examination, arthrocentesis was performed.
    After arthrocentesis, difficulty in mouth opening and joint pain were improved moderately.
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  • Masashi ITO, Yoshihiko FURUKI, Toru FUJISAWA, Toshihiko TAKENOBU, Nori ...
    2001 Volume 47 Issue 1 Pages 49-51
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    We evaluated clinical response and changes in the temporomandibular joint (TMJ) by magnetic resonance imaging (MRI) in patients with internal derangement of TMJ who underwent intraoral vertical ramus osteotomy (IVRO).
    Twenty-two joints in 11 patients (1 male and 10 females) with internal derangement of the TMJ were studied. All patients underwent bilateral IVRO.
    The results were as follows:
    1. Maximum mouth opening without pain increased significantly after surgery.
    2. The disk repositioning rate in patients who had anterior disk displacement with reduction was 87.5%, and that in patients who had anterior disk displacement without reduction was 53.8%.
    IVRO was shown to be effective for patients with internal derangement of the TMJ.
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  • Atsushi SATO, Shinji YAMAZAKI, Taiki TOMOYOSE, Tai YAMAGUCHI
    2001 Volume 47 Issue 1 Pages 52-54
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    We report a case of secondary syphilis with various oral manifestations. A 26-year-old woman visited our hospital because of lingual pain. The patient had a red and soft verruca at the left angle of the mouth as well as three oval papules on the right side of the tongue. In addition, oral examination revealed marked swelling and redness of bilateral palatal tonsils along with opaline plaque over the palatoglossal arch and inferior surface of tongue. Moreover, multiple cervical lymphadenopathy, alopecia, and psoriasic exanthema on the planta were observed. There were no particular lesions of the vulva or inguinal lymphadenopathy. Serological examination showed the RPR test was×128, the TPHA test>2560, and the FTA-ABS test×1280. Since the Jarisch-Herxheimer reaction was induced after treatment with 1000mg/day of amoxicillin for 2 weeks, the patient was treated with 2000mg/day of erythromycin for 6 weeks. Oral lesions improved after 2 weeks of treatment, and the RPR test was×64 after 3 weeks of treatment. After 4 weeks of treatment, the oral lesions almost completely resolved.
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  • Namiko NARA, Tetsuro IKEBE, Shin-ichi KURAHARA, Yasuharu TAKENOSHITA, ...
    2001 Volume 47 Issue 1 Pages 55-57
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A case of pyostomatitis vegetans associated with ulcerative colitis is reported. A 57-year-old man with a history of ulcerative colitis was referred to our hospital because of pain in both sides of the buccal mucosa and malnutrition. A snail-track-shaped ulcer and miliary pustules with a cobblestone appearance were found in both sides of the buccal mucosa and soft palate. Treatment with topical corticosteroids had no effect on this lesion. The presence of abdominal pain and hematochezia led us to suspect a recurrence of ulcerative colitis. Immediately after the systemic administration of corticosteroids was started, the oral mucosal lesions resolved. This case suggests that treatment of ulcerative colitis with systemic corticosteroids is required to cure pyostomatitis vegetans.
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  • Asako HAMASAKI, Simon LEUNG, Yasunori NAKAMURA, Michiyo FURUKAWA, Hiro ...
    2001 Volume 47 Issue 1 Pages 58-60
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A 21-year-old man was referred to our department on February 10, 1997. because of swelling and pain of the third molar region. He had ischemic myocardiopathy due to Kawasaki disease, contracted at the age of 4 years. When his cardiac function became terminal stage, he was referred to the United States and underwent heart transplantation on May 13, 1995.
    The wisdom teeth were extracted on February 12, 1997. Flumarin® (flomoxef) was administered intravenously 1200mg per hour before operation and 800mg per hour during operation. The operation was interrupted for about 5 minutes because of nausea and hypotension, but he recovered soon by assuming the shock position. Flumarin® (flomoxef) was administered intravenously (4g per day) from February 12 to 14, and Cefzone® (cefdinir) was administered orally (300mg per day) from February 15 to 18.
    The postoperative course was uneventful, and these were no physical problems until 6 months after sur-gery.
    In Japan, few patients have undergone heart transplantation, but the number may increase in the near future. In this report we discus hemodynamics and the side effects of immunosuppressive agents in patients after heart transplantation
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  • Kei WATANUKI, Noriaki AOKI, Hiroki BUKAWA, Shinjiro AOKI, Ryoichi KAWA ...
    2001 Volume 47 Issue 1 Pages 61-63
    Published: January 20, 2001
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Gingival cyst is a developmental odontogenic cyst that rarely occurs in adults. Only two cases of gingival cyst arising from the mandible in adults have been described in the Japanese literature. We report on a 62-year-old woman with a gingival cyst arising in the maxilla. She was referred to our department on June 20, 1999 because of an asymptomatic swelling in the upper left incisal gingiva. Examination revealed a hemispheric, clearly bordered, light reddish cystic lesion measuring 7mm in diameter in the upper left incisal gingiva. We treated the patient by total excision under local anesthesia on July 11, 1999. Histopathologic examination showed a cyst lined with a thin layer of nonkeratinized squamous epithelium within the gingiva. The diagnosis was a gingival cyst in an adult. The postoperative course has been uneventful.
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