Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 37, Issue 7
Displaying 1-22 of 22 articles from this issue
  • Masafumi YABUMOTO
    1991 Volume 37 Issue 7 Pages 1209-1216
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Normal epithelial cell lines from mouse submandibular glands have been established in serum-free medium with EGF (M-SGβ1 cell line) or acidic-FGF (a-FGF)(MSGβ2 cell line).
    These cell lines were non-tumorigenic in athymic nude mice and showed some of the functional proteins, characteristic to the mouse submandibular gland, such as secretory component, amylase and mouse EGF. Furthermore, it has been revealed that EGF and a-FGF stimulate proliferation of M-SGβ1 and M-SGβ2 dose dependently and have the same function on the cells affecting growth.
    On the other hand, it has been found that the chromosome number of M-SGβ2 remained diploid, but that of M-SGβ1 shifted to triploid. Furthermore, culturing with EGF, chromosome number of the cells rapidly shifted from diploid to triploid. These results suggested that a-FGF but not EGF, has an important funciton of keeping the chromosome number diploid.
    M-SGβ2 which is a diploid epithelial cell line would be very useful for the study of growth factor expression and their receptors in the process of normal epithelial cell malignant transformation.
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  • Miho FURUE
    1991 Volume 37 Issue 7 Pages 1217-1233
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The author has isolated a cisplatin resistant subline designated HeLaDDP which showed about 4.3 fold stable resistance to cisplatin compared to HeLa cells. It was revealed that mechanisms of the resistance to cisplatin in HeLaDDP resulted in increased capacity to repair DNA damage and the decreased incorporation of cisplatin. Incorporation of cisplatin in HeLaDDP did not change in the presence or absence of glucose, amino acids, ouabain and NaN3. But, heat treatment facilitated incorporation of cisplatin. It is also revealed that the concentration of cisplatin in HeLaDDP cells at temperatures above 41°C increased more than that of HeLa cells at 41°C.
    Hyperthermia enhanced the cytotoxity of cisplatin on HeLa cells as well as HeLaDDP cells. This study has also demonstrated that head and neck squamous carcinoma (UEDA, NAKATA, KANETSUKI) and vulval squamous carcinoma (A 431) were naturally resistant to cisplatin compared to salivary gland adenoca cinoma (HSG, HSY) and cervical adenocarcinoma (HeLa). Furthermore, hyperthermia can enhance the cytotoxity of cisplatin on squamous carcinoma cells also. These results suggest that hyperthermia could circumvent the resistance to cisplatin, and could be used with cisplatin for clinical treatment of oral cancer.
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  • Yoshimasa MAEDA
    1991 Volume 37 Issue 7 Pages 1234-1248
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Epithelial linings of 170 post operative maxillary cysts (POMCs) were microscopically examined, and correlations between lining epithelia and clinical findings were investigated. Then, using 45 of 170 POMCs (including ciliated (38), squamous (4), and composite lining epithelia (3 cases)), 30 radicular cysts (composed of ciliated (2), non-keratinized squamous (25) and of these composite epithelia (2), and keratinized epithelium (1)), and also using 25 dentigerous cysts revealing keratinized or non-keratinized epithelia in 8 and 17 cases, respectively, lectin-bindings and keratin localization were histochemically examined.
    Ninety walls of the subjected POMCs were lined with ciliated columnar epithelium, and linings of cuboidal, squamous and their combinations were seen in 6, 19, and 20 cases, respectively. Many POMCs lined with squamous epithelium revealed infection during past history, and a correlation between squamous lining and the infection was noted. RKSE60 keratin (56. 5 KD) only existed in the keratinized layer of squamous linings, while RGE 53 keratin (45 KD) was detected not only in all columnar epithelia, but also in all POMCs lined with squamous epithelia and 4 cases of maxillary radicular cysts. Tissue culture study of rabbit respiratory ciliated epithelium revealed that squamous cells, seemingly derived from originally columnar epithelium, and some newly proliferated squamous cells, induced with prostaglandin E1, E2 and dibutyryl cyclic AMP, reacted with RGE53 antibody. RGE53 keratin was therefore considered to be continuously maintained even after squamous metaplasia. From these results, it seems certain that epithelial linings of maxillary radicular cysts are sometimes derived from the respiratory epithelium associated with squamous metaplasia, and that RGE53 keratin is a useful marker for identification of metaplastic squamous cells.
    Most squamous epithelia bound strongly with SBA, Con A and UEA-I, while columnar epithelia showed weak bindings. Only a few linings of the tested cysts bound with SVGA. Among these lectins tested, SBA bindings revealed the most contrastive dramatic difference between both epithelia. Con A bound most prominently to squamous linings, and binding of UEA-I and SBA followed in this order. RKSE60 keratin-positive (i.e. keratinized squamous) epithelia had no glycoconjugates with SBA on basal cells. Contrarily, basal cells negative for this keratin had some lectin-binding sugar residues in most cases. From the above findings and other previous reports regarding keratin localization and lectin-binding in reduced enamel epithelium and dental lamina, it seems likely that keratinized lining of some dentigerous cysts may be derived from the early stage of tooth germ development. Metaplastic squamous epithelia intensely bound with SBA, Con A and UEA-I throughout the whole layer, and ciliated epithelium coexisting with squamous cells had similar staining patterns to those of metaplastic squamous epithelium. Ciliated epithelia of radicular cysts were also positive for SBA, Con A and UEA-I. Additionally, cultured respiratory epithelium gradually increased SBA binding ability corresponding to the degree of metaplastic change. Taking these facts into consideration, it is therefore likely that lectin binding sugar residues are expressed in advance on squamous metaplasia-ready columnar cell surfaces.
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  • Yuzo TAKAHASHI, Yoshiyuki MORI, Miyuki AZUMA, Shuji MINATO, LING-DA Zh ...
    1991 Volume 37 Issue 7 Pages 1249-1263
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Successful adoptive immunotherapy of oral cancers with lymphokine-activated killer (LAK) cells presumably depend on their cytolytic potential and accumulation in sites of tumor. The aim of the present study is to investigate whether infused LAK cells labeled with 99mTc-HNIPAO can move to and localize in tumor sites using gamma camera imaging and histopathological examination.
    LAK cells (CD3·LAK) were generated in the culture of peripheral blood lymphocytes with solid phase immobilized anti-CD3 monoclonal antibody and recombinant interleukin-2, labeled with 99mTc-HMPAO, and then infused into cubital vein systemically of patients with upper jaw cancer (rT4N3M0), or directly into the tumor-feeding artery (superficial temporal artery) of patients with gingival cancer on the upper left jaw (T4N1140).
    LAK cells infused systemically and were distributed in the lungs, liver, and spleen within 30 minutes after infusion. Accumulation of LAK cells to the lungs immediately increased after injection, then cleared gradually, where as those in the liver and spleen tended to increase steadily. Localization of LAK cells in sites of tumor and metastatic lymphnodes was not clearly shown.
    Clear localization of LAK cells locally infused into the artery, was demonstrated in the area corresponding to the primary tumor, and this localization was seen within 24 hours.
    Distributing pattern of LAK cells to organs in the whole body had nearly the same pattern as that in the case of local infusion into the artery.
    Histopathological examinations indicated mononuclear infiltrations in fibrous connective tissues that arose due to prior radio-and chemotherapy, around tumors and intensive mononuclear infiltrations around degenerating minor salivary glands.
    These results indicated that local infusion of LAK cells via major tumor-feeding arteries would be an effective way to obtain selective localization of LAK cells in the primary oral cancer.
    Systemic intra-vcnous infusion of LAK cells would be useful in treating the metastatic lesions in lungs and/or liver.
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  • Takeshi KUZUHARA
    1991 Volume 37 Issue 7 Pages 1264-1278
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A study has been made to determine the long-term effect of collagen-immobilized porous polyethylene on living body tissues as a result of reaction between them, and to clarify the ultramicrostructure in the interface between such a material and the tissues. Experiments were made using 70 Wister rats. Collagen-immobilized porous polyethylene pieces, in which immobilization was attained through covalent bouding, and virgin porous polyethylene pieces were implanted subcutaneously in the backs of the rats. These polyethylene pieces were removed from the rats together with surrounding tissue from one week to one year after implantation, and were studied histologically using a light microscope, a scanning electron microscope (SEM) and transmission electron microscope (TEM). The results were as follows:
    1) Virgin Porous Polyethylene The rate of soft-tissue ingrowth into pores of these polyethylene pieces was very small, ranging from 13% to 18%, in all of the rats. The ingrown tissue was composed of granulation tissue having many inflammatory cells, and hyalinezation was observed in parts of the tissue. As far as SEM observation is concerned, it was found that the collagen fibers in the ingrowth tissue run in parallel to the surface of the pore in the polyethylene pieces, and irrespective of the differences of implanted period no contact between them was observed. One year after the implantation, tumorous growth was observed in nine (45%) of the 20 implanted virgin porous polyethylene pieces.
    2) Collagen-immobilized Porous Polyethylene The rate of tissue ingrowth into the porous polyethylene pieces stood at 23.2% one week after the subcutaneous implantation, 32.4% after two weeks, 60.2% after four weeks, 69.3% after six weeks, 81.6% after 12 weeks and higher than 90% 20 weeks after implantation.
    One year after implantation there was little change in the percentage, and by that time the ingrowth tissue and the porous polyethylene pieces had turned into biocomposite. The ingrowth formed loose connective tissue abounding in rete vasculosum containing a relatively low level of inflammatory cells. SEM observation found that the collagen fibers within the ingrown tissue were developing toward the pore surface of polyethylene material and coming in contact with the material surface. On the other hand, TEM observation of material-tissue interface found that one year after the implantation the living-body-originated collagen fibers were firmly anchored into the immobilized atero-collagen layer.
    One year after implantation, tumor formation was found in only one (5%) of the 20 polyethylene pieces removed from the rats representing virgin porous polyethylene use. These results suggest that covalent bonding immobilization of collagen onto surface of porous polyethylene material is useful in promoting the ingrowth of soft tissue, tissue-adhesion, and inhibition of tumorigenesis, making porous polyethylene material more suitable for introduction into the living body.
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  • Takeshi HARADA, Masanori SHINOHARA, Makoto SHIMADA, Seiji NAKAMURA, Ma ...
    1991 Volume 37 Issue 7 Pages 1279-1284
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We clinico-pathologically and immunobistochemically studied 80 cases of squamous cell carcinoma of the oral cavity. Of the 80 cases, primary cervical lymph node metastasis was observed in 20 cases and secondary cervical lymph node metastasis in 8 cases. Thc materials were obtained before the treatment, fixed in 10% formalin or 2% PLP, and embedded in paraffin. Immunostaining of S 100 protein was performed by the aviclin-biotin peroxidase complex (ABC) method with polyclonal anti-human S-100 protein antibodies. S-100 proteinpositive cells were graded as “very slight”: less than 2 positive cells, “slight”: 2-5 positive cells, “moderate”: 6-10 positive cells, “marked” more than 11 in the 200X field.
    Results showed that higher frequency of S-100 protein-positive cells in cases of welldifferentiated cancer region was observed than the peritumoral epithelia. In addition, the grade of S-100 protein-positive cells was related to the density of the lymphocytic infiltration in the primary tumor. Moreover, the number of S-100 protein-positive cells in the metastatic cancer tissues in the lymph nodes was more frequent than in the primary tumor region.
    Thus, these findings suggested that S-100 protein-positive cells play some immunological roles in squamous cell carcinoma of the oral cavity. However, the present study showed that the presence of cervical lymph node metastasis was not, atisfactorily predicted by the frequency of the 5-100 protein-positive cells.
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  • Ryuzo KATO, Shuichi KAWAJIRI, Shigehiro KUMAGAI, Etsuhide YAMAMOTO
    1991 Volume 37 Issue 7 Pages 1285-1290
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The growth incidence and the ultrastructure of the tongue carcinoma oral cancer (S. C. C.), type I and IV C, according to Yamamoto-Koharna classification were reported. In the cancer which was transplanted in nude mice, invasion was not observed but its histological structure was kept as in humans.
    The growth rate of type IV C cancer was about twice that of type III cancer. In type IV C cancer, loosing of the connective tissue was observed and then cytoplasmic process was increased.
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  • Takashi HARAKI
    1991 Volume 37 Issue 7 Pages 1291-1298
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Wc have succeeded in transplanting human osteogenic sarcoma of the mandible into nude mice. As the transplanted tumor shows features of calcified chondrosarcoma, this tumor is thought to be an excellent model for study of the process of endochondral calcification.
    Using this model, we studied relations between the expression of types II, and X collagen and chondrogenic differentiation of the transplanted tumor. Collagen distribution during the development and growth of the transplanted tumor was investigated by immunofluorescence with specific antibodies against type I, II, or X collagen.
    Type I collagen was localized in the peripheral region of the tumor, though it disappeared in the mineralizing region. Type II collagen was distributed in the premineralizing region where tumor cells showed chondrocytic or hypertrophic feature. Type X collagen was intensely stained in the mineralizing region. Tumor cells in this region were almost. hypertrophic.
    These results indicate that the type of collagen changes from type 11 to type x in the hypertrophic region and the appearance of type X collagen may be important in the onset of mineralization.
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  • Yukinobu TOMITA
    1991 Volume 37 Issue 7 Pages 1299-1312
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Speech intelligibility, salivary gland functions and gustation were examined in 74 patients who received chemo/radiotherapy and surgical excision of oral squarnous carcinoma. The results are surnmarized as follows.
    1. Among 52 patients who received glossoectorny, mild, moderate and severe impairment of single sound speech was found in 6, 5 and 2 cases, respectively. Sentence-reading tests revealed more restrictive impairment of speech intelligibility as class 11.(slightly difficult in understanding the spoken content) in 11 cases, class jll (understandable only when the speech content is already known) in 4 cases and class If impairment (hardly understandable) in one case.
    2. Speech impairment rarely resulted when the resection was limited to 1/3 of the tongue, and the impairment was greater in cases who received a glossoectorny over that limit. Speech intelligibility was related to tongue mobilit, and conservation of the tongue tip appeared important.
    3. Decrease in salivary flow rate (SFR) irreversibly occurred after treatment. SFR in the chemotherapy group decreased to 87% of the original value, and SFR in the cherno/radiotherapy group finally decreased to about 50% of the original. Viscosity increased grandually showing a reverse relation vi di SFR. Secretory IgA in saliva decreased during treatments, but an increase of s-IgA occurred 3 months after treatments.
    4. 99mTc uptake of the parotid and subrnandibular glands dec lined. Isotope activity in the submandibular glands decreased to about 70% of the initial value. Isotope elimination rate (IER) of the glands also decreased from an initial 26% to about 10% at one year after 60Co therapy. These results show that scintigraphy and SFR are useful for evaluation of salivary gland damage due to cancer therapies.
    5. Original taste thresholds in T1 and T2 cases did not significantly differ from healthy person values, but taste thresholds, especially for sugar were originally high in T3 and T4. Elevation of taste thresholds with chemotherapy was slight, but the chemo/radiotherapy group showed lemarkable threshold elevation. Recovery, to almost original levels, however, took place within a year.
    It was concluded from these results that taste impairment is temporary, while damage to the salivary glands is perrnanent, and that speech' impairment depends on excised tongue volume. Aggressive induction therapy made conservative surgery possible. Therefore, mini-mizing adverse effects to the salivary glands and tongue is essential for oral cancer treatments.
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  • primordial cyst and odontogenic keratocyst
    Munehisa ADACHI, Yoshinori HIGUCHI, Norifumi NAKAMURA, Hideo TASHIRO, ...
    1991 Volume 37 Issue 7 Pages 1313-1322
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Clinical and histopatliclogical analysis was made on 22 cysts of 18 cases of odontogenic keratocyst and primordial cyst.
    Solitary cyst was observed in 15 cases. Three cases had multiple cysts (7 cysts in all); of these, 2 cases were diagnosed as basal cell nevus syndrome.
    The most common sites were third molar region and ramus of the inaudible. The maxillary lesions were seen mainly in multiple cases.
    Radiologically, unilocular and well circumscribed cysts were observed commonly (17 cases): one of those showed as a lateral periodontal cyst, 5 cysts were found in association with an impacted tooth. Multi!ocular cysts were observed in 5 cases.
    Histopathological examination was performed in 19 cysts. They were classified into 17 odontogenic keratocysts and 2 nonkeratinizing primordial cysts. Microcystic change and budlike proliferation of the basal cells was seen in the epithelial layers in a few cases. Islands of odontogenic epithelium were seen in the subepithelial connective tissues in 8 cases. Daughter cysts were seen in 2 cases.
    Marsupialization of the large cysts as the initial therapy produced good results. Recurrence was observed in a case of large multilocular cyst on the mandibular ramus.
    Odontogenic keratocyst and primordial cyst were described as a synonym according to the WHO classification, although there has been controversy in regarding these two lesions as the same disease. In this study, clinical findings of two varieties of the lesions were almostly the same. But, further studies must be done to determine if both lesions are the same disease or separate entities.
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  • With special reference to the loss of premolar-molar support
    Yaeko WATANABE, Mamoru NAGASE, Masaki KOHNO, Susumu SHINGAKI, Tamio NA ...
    1991 Volume 37 Issue 7 Pages 1323-1327
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Bone change in the temporomandibular joint (TMJ) in 540 patients with TMJ disorders was studied radiographically in relation to the loss of premolar and/or molar support.
    The incidence of bone change (erosion or deformity) which was observed in 49. 404 of the patients was higher in female patients and showed a tendency to increase in older pati-ents. The bone change was noted in the symptomatic side in 72.3%, in the asymptcmatic side in 13.5% and bilaterally in 14.2% with an increase of bilateral involvement in older patients. The joint pain and the limited range of motion of the mandible were seen significantly higher in patients with bone change at the initial examination. The bone change was observed in 56.4% of patients with loss of premohr and/or molar support which was significantly higher than 40.4% of the patients without loss. The number of patients with loss of premolar and/or molar support and the incidence of bone change seen in these patients increased with age.
    The results indicate that the loss of premolar and/or molar support is one of the factors leading to bone change in TMJ
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  • Hideaki SAKASHITA, Masaru MIYATA, Hizuru MIYAMOTO, Nobuo UTSUMI
    1991 Volume 37 Issue 7 Pages 1328-1335
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The incidence of sialolithiasis in the parotid gland is usually lower than that of the submandibular salivary gland.
    Recently, we encountered a case of parotid sialolithiasis and examined the component elements of the calculus.
    The patient was a 65-year-old man who came to our department with the right parotid gland swelling. After clinical investigations, the calculus were removed and examined with X-ray microanalyzer and X-ray diffraction analyzer.
    The calculus were composed of Ca, P, S, Mg, I, Na, K and Cl, and had hydroxyapatite-like structure.
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  • Mikio KUSAMA, Norihisa IWAMOTO, Hiroyasu TSUKAHARA, Toyoko KISHI, Masa ...
    1991 Volume 37 Issue 7 Pages 1336-1347
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Twenty-five patients with oral squamous cell carcinomas were treated initially with methotrexate 75mg/body followed 1 hour later by 5-fluorouracil 500 mg/body twice a week. Treatments were repeated every 7 days for 2 weeks.
    1. Of 25 evaluable patients with squamous cell carcinoma, 17 (68%) achieved a partial (12) or complete (5) response, and 4 (16%) achieved minor response.
    2. Histopathological effect was found in 18 (72%) patients.
    3. Down-Stage rate was 72%.
    4. Clinical effect for cervical lymph nodes metastases was 75%, and in 2 out of 8 patients cervical lymph node metastases disappeared histopathologically.
    5. The recurrence rate of primary lesions was 12%, the metastasis rate of cervical lymph node was 8%, the distant metastasis rate was 4%, and the total recurrence and/or metastasis rate was 24%.
    6. Side effects were slight, and severe leukopenia, mucositis, and kidney disorders were not observed.
    7. The 5 year survival rate was 74.7%, and it was higher than that of surgery alone (58.4%) and that of preoperative radiotherapy-surgery (55.5%).
    This observation suggests that patients with oral squamous cell carcinoma were sensitive to initial MTX/5-FU therapy (MF therapy) and preoperative chemotherapy provide a good prognosis.
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  • Yasuyuki ODA, Seijiro OKUTSU, Yoshitaka NAKAJIMA, Mitsuhiro SATO, Osam ...
    1991 Volume 37 Issue 7 Pages 1348-1356
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    3 cases of vascular leiomyoma arising in the oral area were examined. The first case was a 72-year-old male showing slight swelling of the median palate. The second case was a 60-year-old male showing a red bean sized elastic hard mass in the right lower lip. The third case was a 57-year-old male with an appearance in the left nose vestibule.
    Histologically, all cases revealed that polygonal shaped smooth muscle like tumor cells proliferate perivascular area and formed small nodules with entangled muscle fibers. An immunohistochemical analysis showed that strong positive reaction for the VIIIth factor-related antigen in cord-like arranged tumor cells and in angioendothelial cells. The actin was positive for outer layer cells of the vesseles.
    Positive reaction for desmine was observed in fibroblastoid cells. The vimentin was positive for angioendothelial cells and most of the tumor cells.
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  • Hiroyuki IWATA, Manabu MIHARA, Kazuhisa TANGE, Masaru HATTORI
    1991 Volume 37 Issue 7 Pages 1357-1362
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Sialolithiasis is a fairly common disorder, associated with pain, swelling and discomfort. In many cases, surgical removal of the stone is required. The stone may grow to considerable size and, when located deep inside the submandibular gland, extirpation of the organ becomes necessary. Another organ in which formation of calculi may occur is the kidney. The serious problems and complications encountered in surgical removal of renal stones have led to intensive search for non-invasive treatment methods.
    Recently a novel, non-invasive method for renal lithtomy was successfully introduced into clinical practice. The method, extracorporal shock wave lithotripsy (ESWL), utilizes high-energy shock waves to disintegrate the renal stones. The enormous advantage of obviating surgery and long hospitalization has rapidly led to widespread use of this safe, nonsurgical method.
    We proposed disintegration of the salivary gland stone by shock wave. In vitro experiment, in which 4 sialoliths were subjected to shock waves produced by, SONOLITH 2000 B, demonstrated the destruction of the stones. Secondly, we examined the harm to the salivary gland caused by shock waves.
    The advantages of the method and the need for modification of the equipment is discused.
    We suggest that this method is non-invasive for salivary stone, and we should improve this equipment for facial use.
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  • Kiyomasa NAKAGAWA, Shigehiro KUMAGAI, Kiyoshi KOZIMA, Kazushi IMAI, Et ...
    1991 Volume 37 Issue 7 Pages 1363-1371
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Three cases of metastatic lung carcinoma in the oral cavity were presented.
    Case 1: A 57-year-old male had been treated with chemotherapy and radiotherapy for adenocarcinoma of the right upper lobe. The tumor was metastasized to the brain and the abdominal skin of the lateral side, so he was given secondary radiotherapy. Fourteen months after the finding of his lung tumor, a metastatic tumor appeared at the palate rniclline.
    Case 2: A 63-year-old male who was diagnosed as having adenocarcinoma. His left upper lobe has been resected at the Department of Surgery in this hospital. After twice extirpation of metastatic tumor to his brain, radiotherapy was applied. Thirteen months after finding this lung tumor, metastatic tumor appeared at the tooth extraction socket of the lower incisor.
    Case 3: A 70-year-old female whose resected left upper lobe was diagnosed anaplastic carcinoma in the Department of Surgery in this hospital. No sooner had the operation been done when a tumor appeared on the lower left molar gingiva. The biopsy of oral tumor revealed the final diagnosis of metastatic carcinoma from the lung. Patients 1 and 2 have died. Patient 3 is now in treatment. Accompanied with formerly reported 32 other oral carcinomas which were metastasized from lungs, these three cases were discussed while reviewing the literature.
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  • Masahisa TSUCHIDA, Kazuyoshi UEMURA, Masanori ITAHASHI, Hisashi YABUUC ...
    1991 Volume 37 Issue 7 Pages 1372-1379
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A case of traumatic carotid-cavernous sinus fistula (CCF) complicating fractures of the zygoma and mandible is reported. This fistula, characterized by pulsatile bruit, exophthalmons, chemosis, extraocular palsy and diplopia, is a very rare condition that may accompany maxillofacial fractures. Early diagnosis is important, as delay in treatment may cause irreversible neurological and ophthalmological damage.
    This lesion was treated by embolization of fistula using a detachable balloon catheter with good results.
    The necessity of total patient care, as well as, the importance of a team approach is emphasized.
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  • Masatsugu SHIMIZU, Harumi MIZUKI, Yoshiro FUKUYAMA, Yuushi MATSUMOTO, ...
    1991 Volume 37 Issue 7 Pages 1380-1384
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A case with fresh gunshot wound penetrating from the left lateral neck to the mouth angle, which was caused by pistol shooting during a conflict between gangs, was reported and discussed by us.
    The patient, a 41-year-old male, was shot probably with a 38-caliber revolver from behind. Its entrance was on the left rear of the neck, and the exit hole at the left mouth angle. The route through the body: the bullet passed inside of the mandible, where it caused a crashing fracture of the body in the molar region while breaking the lower prosthesis. But, he was very lucky that the important blood vessels and nerve bundles were not injured, although the route was very close to them. He was transported to our Dept. that same day and operated on under general anesthesia for removing foreign bodies, uniting and fixing the jaw fracture, and also for reconstructing the mouth angle, while we sanitized the wound and sutured the soft tissues at each place. At last, a tracheotomy was performed, to prevent suffocation from postoperative swelling. The progress after the operation was good, and he was discharged three weeks later. After 3 years he is now healthy and in prison.
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  • Munehiro HAMAGUCHI, Kazuo INOUE, Mikihiko KOGO, Yasunobu YASUI, Yasush ...
    1991 Volume 37 Issue 7 Pages 1385-1392
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Recently, for the deformity made by radical operation of head and neck cancer, early or simultaneous reconstruction is generally performed. But some patients may need repairs late. We reported 4 such eases, as follows:
    Case 1: We used the forehead flap to reconstruct the defect of the hard palate and anterior alveolus.
    Case 2: We also used the forehead flap to reconstruct a cheek defect from infection in the cheek after primary treatment.
    Case 3: We used the sternocleido-mastoid muscle flap and local lotation flap for a mandibular defect due to osteoradionecrosis.
    Case 4: We used the local rotation flap for a mandibular defect after a reoperation at the primary lesion.
    Postoperative conditions of all four flaps were excellent, so they were very useful for later repair as compared with D-P and PNTIVIC flaps.
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  • Kazuhiko SUGANO, Hiromitsu YAMANOI, Teruhiko ISHII, Tsubura SUZUKI, Ta ...
    1991 Volume 37 Issue 7 Pages 1393-1394
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
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  • Masashi SHIMAHARA, Katsumi ONO, Toshiyuki KONDA
    1991 Volume 37 Issue 7 Pages 1395-1396
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
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  • Yoshinori KANOH, Yuji KAMIYA, Tadashi YAMAMOTO, Hiroyuki MURO
    1991 Volume 37 Issue 7 Pages 1397-1398
    Published: July 20, 1991
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
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