Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 43 , Issue 10
Showing 1-18 articles out of 18 articles from the selected issue
  • Yukoh MURAKI, Chihiro YOSHIOKA, Jin-ichi FUKUDA, Tatsuji HANEJI
    1997 Volume 43 Issue 10 Pages 693-698
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Fas antigen is a cell surface glycoprotein that mediates apoptosis from the cell surface into the cytoplasm. A monospecific and high titer polyclonal antibody, designated as Fas D, raised against a synthetic polypeptide selected from part of the human Fas antigen (aa 104-114) was used to detect Fas antigen in human oral leukoplakia, lichen planus, and squamous cell carcinoma. Biopsy specimens obtained from patients with several lesions were prepared into paraffin sections and stained with Fas D antibody using an immunohistochemical method.
    Characteristic expression patterns of Fas antigen were obtained for each disease. For leukoplakia, intense staining was observed on the upper layer of the stratum spinosum. The Fas antigen appeared as granular structures around the cell membrane and cytoplasm. For lichen planus, intensive immunoreactivity of the Fas antigen was found in an extensive area from the spinous layer to the stratum granulosum. Staining of the Fas antigen was observed in the cytoplasm of the Fas-positive cells. In the well-differentiated squamous cell carcinomas (SCCs), almost all specimens showed Fas-positive staining. Intense staining was present on the cells of the nests. The Fas antigen was stained as granule-like structures around the cytoplasm of the Fas-positive cells.
    Although the number of specimens examined was limited (26 cases) in the present study, 88% of the well differentiated SCCs stained for Fas antigen. In moderately differentiated SCCs, only 36% of the SCCs (4 out of 11) showed Fas-positive staining. No Fas-positive cells were detected in poorly differentiated SCCs, although only three specimens were examined.
    These findings suggest that the expression of Fas antigen is related to the degree of tumor differentiation.
    Download PDF (6067K)
  • Hiroyuki WATANABE, Takafumi SATOMI, Hirotaka UENO, Masato WATANABE, Ta ...
    1997 Volume 43 Issue 10 Pages 699-704
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    In vitro fibronectin (FN) induces AP-1, which is a nuclear internal transcript factor that adjusts the gene expression of interleukin-2 (IL-2) via VLA-5 on T lymphocytes and enhances synthesis of IL-2 by jointly acting with signals via TCR/CD 3. Therefore, it is thought that activation and proliferation of T lymphocytes are induced by FN.
    To determine whether signals of IL-2 mRNA are enhanced by FN existing in cancer tissues, the signal intensity of IL-2 mRNA, the distribution of FN, and the number of T-cells infiltrating into cancer tissue were investigated by in situ hybridization, immunohistochemical staining, and an image analysis device in 30 cases of oral squamous cell carcinoma before treatment.
    Cases that were FN stain-positive in the cancer stroma (sFN stain-positive cases) showed more intense T-cells infiltration and stronger expressing of IL-2 mRNA than FN stainnegative cases and cases that were FN stain-positive in the cancer parenchyma (sFN stainnegative cases). These findings suggest that a biological effect of FN on activating T-cells was expressed in sFN stain-positive cases.
    As for sFN stain-nagative cases, sFN stain-negative cases apparently lacked sufficient local factors to activate T-cells, and this may be one of the reasons for the difficulty in forming immunity against cancer cells and the lower effectiveness of various types of immunotherapy against cancer.
    Download PDF (7879K)
  • Shigeru YAMABE, Akio MIZUNO, Shuichi FUJITA, Hiroshi TAKAHASHI, Haruo ...
    1997 Volume 43 Issue 10 Pages 705-711
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    In 30 cases of mucoepidermoid carcinoma of the salivary glands, the expressions of proliferating cell nuclear antigen (PCNA) and c-erbB-2 oncogene products were investigated immunohistochemically. A statistically significant difference was found between solid regions (12.26±9.95) and tubular regions (0.77±2.01) on the basis of the PCNA index. Three types of c-erbB-2 antibodies (NCL-PC11, CB11, and CBE 1) showed different patterns of expression. C-erbB-2 (PC11) was expressed on the cell membranes of solid regions in 17 cases (57%) and tubular regions in 7 cases (23%). C-erbB-2 (CB11) was expressed in the cytoplasm of solid regions in 20 cases (67%) and tubular regions in 7 cases (23%). Moreover, cerbB-2 (CBE 1) was expressed in tubular regions in only 2 cases (7%). In the present study, PCNA index was not related to the overexpression of c-erbB-2 in mucoepidermoid carcinoma.
    Download PDF (3718K)
  • Kazuhiko HIROYASU, Koichi SHIBASAKI, Akira YAMAGUCHI, Kohzo TSUCHIKAWA
    1997 Volume 43 Issue 10 Pages 712-719
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    In 1981, Rao et al. reported that urinary 6-hydroxymethylpterin (6-HMP), which is increased in patients with malignant tumors is useful as a tumor marker. In this study, we developed a new technique to measure urinary 6-HMP concentrations by high performance liquid chromatography (HPLC). Basic studies of 6-HMP were carried out in 32 patients with malignant tumors of the oral and maxillofacial region and 76 healthy volunteers to evaluate the usefulness of this marker. The results were as follows:
    1) The coefficient of variance (%) for reproducibility was 4.4% and 6.7%. The assay method was confirmed to have good reproducibility.
    2) Time-and temperature-related changes in urinary 6-HMP concentrations were investigated, and there were no changes for up to 24 hrs.
    3) In the daily profile of urinary 6-HMP concentrations, there were minimal changes, which did not influence the significance of measurement. It is therefore possible to use urine samples taken as needed.
    4) In a study of 76 samples of healthy human urine, the normal cutoff value for 6-HMP was 0.370μg/ml. There was no difference with respect to age or sex.
    5) In 32 cases of oral and maxillofacial malignant tumors, the mean and standard deviation was 0.669±0.370μg/ml.
    Our results indicate that the measurement of urinary 6 -HMP may be useful in the diagnosis of malignant tumors arising in the oral and maxillofacial region.
    Download PDF (907K)
  • Kouichiro NAGAMINE
    1997 Volume 43 Issue 10 Pages 720-728
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    This study was conducted to examine the effect of retinoic acid (RA) on the growth and gene expression of a human osteoblastic osteosarcoma cell line, Saos-2. RA inhibited in a dose-dependent fashion both cell growth and DNA synthesis of the cell line. RA also dose-dependently lowered the c-myc mRNA level in the cells, when the cells were treated for 24 hr with the reagent. Furthermore, production of c-jun mRNA was inhibited by treatment with RA at 10-7 and 10-6M. RA at 10-5M inhibited the c-jun mRNA level. It was lower than control at 6 h and returned to the control value by 12 h after the initiation of treatment. Indomethacin, a potent inhibitor of cyclooxygenase, eliminated the inhibitory effect of RA on c-myc and c-jun mRNA expression. On the other hand, RA also lowered, in a dose-dependent manner, the level of liver/bone/kidney alkaline phosphatase mRNA. Interestingly, however, RA stimulated transforming growth factor-beta mRNA exprssion in the cells.
    The present study suggests that RA functions as a negative regulator for expression of cmyc, c-jun, and liver/bone/kidney alkaline phosphatase genes and as a positive one for expression of the transforming growth factor-beta gene in human osteosarcoma Saos-2 cells.
    Download PDF (9476K)
  • Misao IKUZAWA, Ken MATSUMOTO, Yukako ATSUMI, Yasuko HAEUCHI, Hirohisa ...
    1997 Volume 43 Issue 10 Pages 729-732
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    We have reported on the surgical therapy of patients with chronic osteomyelitis of the mandible who were treated with polymethylmethacrylate (PMMA) beads impregnated with antibiotics. In this article, we report the long-term follow-up of 13 patients (3 men and 10 women) treated in our clinic from June 1988 throuth May 1994. The mean duration of postoperative follow-up was 46.6 months. A good outcome was obtained in 11 patients. Two patients had recurrence soon after operation and underwent mandibular hemisection. Preoperative X-ray examination showed evidence of diffuse osteosclerosis in 11 patients, sequestration in 2 patients, and osteolysis in 3 patients. In 3 of the 13 patients, the lesion was localized in the mandibular body, in 9 patients the lesion spread beyond the mandibular angle toward the mandibular ramus, and in 1 patient the lesion included the mandibular ramus and spread over the midline to the opposite side. Sequestration or osteolysis was not detected radiologically in any patient during follow-up; however, osteosclerosis remained in 7 of 11 cases despite a good clinical course. We used gentamicin to impregnate the beads, and no side effect of gentamicin was seen in any patient. This treatment method was considered very useful for chronic osteomyelitis of the mandible.
    Download PDF (511K)
  • Yoshioki HAMAMOTO, Naoki HAMAMOTO, Kenji IZUMI, Tadaharu KOBAYASHI, Ta ...
    1997 Volume 43 Issue 10 Pages 733-738
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    The relationship between recipient condition and the period required for periodontal healing of autotransplanted teeth was studied. The period for periodontal healing was evaluated on the basis of regeneration of the periodontal space and lamina dura on dental radiographs. Age, sex, site of transplantation, period after tooth extraction at the recipient site, and the timing of occlusal function were the recipient factors examined. The mean periods required for regeneration of the periodontal space and lamina dura were 3.7 months and 7.6 months, respectively. Regeneration of the periodontal space was not influenced by any recipient factor, whereas regeneration of lamina dura was associated with the period after tooth extraction, site of transplantation, and timing of occlusal function. It was suggested that regeneration of the lamina dura may not totally depend on that of the periodontal space.
    Download PDF (3484K)
  • Shigehito WADA, Isao FURUTA, Tadashi SADO, Masayuki IWAI, Shigeto ITOH ...
    1997 Volume 43 Issue 10 Pages 739-741
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    We report a case of buccal mucosal carcinoma with acute promyelocytic leukemia (APL) that remained in complete remission for a prolonged period.
    A 54-year-old man visited our clinic because of a mass in the right buccal mucosal region in July 1996. Because the oral mass was histopathologically confirmed to be squamous cell carcinoma and there was clinical evidence of metastasis to the cervical lymph nodes, we performed radical treatment for the oral cancer despite the presence of severe bone marrow suppression. During treatment, we prevented severe complications by the transfusion of platelet concentrate and administration of G-CSF.
    Download PDF (2809K)
  • Tomonori MASTUNO, Yasuhito OGINO, Yoko SAKUMA, Chikako KAMO, Minoru UC ...
    1997 Volume 43 Issue 10 Pages 742-744
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A case of a bilateral nasoalveolar cyst in a 66-year-old man is reported. Case reports of bilateral nasoalveolar cysts are very rare. He complained of gingival swelling on the right side of the maxilla. Computed tomographic examination showed bilateral cysts arising from the alveolar bone of the ala nasi. The lesions were completely excised under general anesthesia. The walls of the cyst partially adhered to the mucous membrane of the floor of the nose. Histopathologically, the right side of the cyst wall consisted of squamous epithelium, and the left side consisted of pseudostratified ciliated epithelium, with many goblet cells.
    Download PDF (2956K)
  • Akira HARA, Yukihiro MICHIWAKI, Toshiyuki SHIMIZU, Yoshizumi YAMAZAKI, ...
    1997 Volume 43 Issue 10 Pages 745-747
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A rare case of mucous retention cyst in the middle of the oral floor is reported. A 63-year-old woman was referred because of a painless swelling in the middle of the oral floor, which had persisted for 1 month. Resection was performed. The mass was located between the genioglossus muscle and geniohyoid muscle and was unrelated to the sublingual gland or Warthon's duct.
    The histopathological diagnosis was solitary mucous retention cyst. Differential diagnosis is also discussed.
    Download PDF (5034K)
  • Gaku YAMAMOTO, Keishi TAKIGAMI, Shin-ichi KAGAMI, Mitsunobu MORI, Yosh ...
    1997 Volume 43 Issue 10 Pages 748-750
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Recently, several studies have examined the biological activity of bone morphogenetic proteins (BMPs), which have been shown to promote the induction and regeneration of bone tissue within a short period of time. Autolyzed, antigen extracted, allogeneic (AAA) bone matrix, which is prepared from human cadaver bone by a chemical procedure that conserves the BMP content of bone tissue, not only has bone-induction capacity but also facilitates remodeling of newly forming bone.
    AAA bone matrix was implanted in bony defects after radicular cystectomy of the lower left molar region. In this patient, the postoperative course was good, and there were no complications.
    Opaque areas on X-ray film were noted whthin 10 weeks after the cystectomy. AAA bone matrix was considered to be a useful biological material for the surgical treatment of radicular cyst.
    Download PDF (6137K)
  • Jun-ichiro NUKATA, Masahiro MICHIZAWA, Yasuyuki KANO, Riki MATSUMOTO, ...
    1997 Volume 43 Issue 10 Pages 751-753
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    We performed a clinico-statistical study of 36 permanent teeth that were replanted after being avulsed by trauma. We found that the most frequently involved age group was 6 to 12 years old, and the average age was 13.8 years old. The most frequent causes were falling dropping, sports, and playing, and the maxillary central incisors were the most frequently avulsed teeth. Avulsed teeth were most often air-dried. The average period between avulsion and replantation was 4.9 hours.
    The most common type of splinting was a rigid wire fixation using an arch bar, and the average period of splinting was 54.4 days.
    As for the outcome of replantation, most root resorption occurred within 1 year after replantation and root resorption was closely related to the period between avulsion and replantation. The replanted teeth were functional after replantation and the 5-year survival rate was 63.6%. The 5-year rate of root resorption was 81.8%.
    The results suggest that every effort should be made to preserve avulsed teeth even when conditions are unfavorable for replantation.
    Download PDF (431K)
  • Yoshioki HAMAMOTO, Tamio NAKAJIMA, Tamaki MOHRI, Isao SAITO, Kooji HAN ...
    1997 Volume 43 Issue 10 Pages 754-756
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    We describe a patient who underwent autotransplantation of a tooth to the maxillary molar region, which lacked adequate bone thickness from the alveolar crest to antral floor. The patient was 34-year-old man with a missing left maxillary second molar. The right mandibular premolar, which had to be extracted because of orthodontic reasons, was transplanted to the region. The apical half of the root of the transplanted tooth projecting into the maxillary sinus was covered with the sinusmucoperiostium, which was carefully detached from the floor, to preserve blood-circulation to periodontal cells. The pocket-depth, mobility, and percussion-sound of the transplanted tooth were normal, and the periodontal space and newly formed bone were observed radiographically around the root 6 months after transplantation. The findings indicated that a tooth can be successfully autotransplanted to a maxillary-molar region that lacks adequate alveolarbony thickness withont the use of a bone graft.
    Download PDF (5951K)
  • Norio KUROYANAGI, Hiroyuki KINOSHITA, Toru NAGAO, Izumi MAKI, Ken-ichi ...
    1997 Volume 43 Issue 10 Pages 757-759
    Published: October 20, 1997
    Released: September 13, 2011
    JOURNALS FREE ACCESS
    A case of horizontal double impaction of the right mandibular first and second molars is described. A 21-year-old man with pain at the right mandibular region visited our hospital. Radiographic examination showed horizontal impaction, with the mandibular second molar lying over the first molar. These teeth were extracted under general anesthesia. The right half of the lower lip was paralysed after the operation, but symptoms disappeared subsequently. We attribute impaction in this patient to local causes because he had no noteworthy medical history and no abnormalities of the other teeth or jaw. Abnormal location of a tooth germ was therefore apparently involved.
    Download PDF (2998K)
  • Yoshinari MORIMOTO, Masaki FUJIMOTO, Wataru TAKIOKA, Tsutomu SUGIURA, ...
    1997 Volume 43 Issue 10 Pages 760-762
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A case of multiple sialolithiasis in the submandibular gland duct is reported. An 88-year-old man was referred to our clinic. He had no symptoms of the left submandibular area, but X-ray films showed the presence of small calcific densities in the left submandibular gland duct. Forty-seven stones were removed intraorally under local anesthesia. The progress of the patient has been good after the operation.
    This is a rare case with the largest number of salivary stones ever reported.
    Download PDF (3152K)
  • Masato KOBAYASHI, Nagato NATSUME, Teruyuki NIIMI, Motoo YOKOI, Mitsuku ...
    1997 Volume 43 Issue 10 Pages 763-765
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    Klinefelter syndrome is a sex chromosomal aberration characterized by conditions such as testicular atrophy, gynecomastia, and azoospermia. The incidence of this syndrome is about 0.1% of all male births.
    Because of its clinical characteristics, Klinefelter syndrome is usually diagnosed after puberty. Diagnosis depends on X-chromatin examination, and the karyotype is generally 47, XXY, or 48, XXXY. As the number of X increases, the level of disturbance increases. We report a case of Klinefelter syndrome with submucous cleft palate. This case was characterized by intellectual disturbance and 49, XXXXY.
    Download PDF (3085K)
  • Hiroki MIYATE, Yasuhiro DOIJIRI, Mitsumasa YOKOTA, Kiyoshi TAMURA, Yas ...
    1997 Volume 43 Issue 10 Pages 766-768
    Published: October 20, 1997
    Released: July 25, 2011
    JOURNALS FREE ACCESS
    A case of bilateral extremely elongated styloid processes that caused difficulty in swallowing is reported. The patient was a 44-year-old man who presented to the Department of Dentistry of Kawakubo Hospital because of spontaneous pain around the left mandibular angle and intensive swallowing pain. Radiographic examination bilaterally showed extremely elongated bony rods from the styloid process to the lesser horn of the hyoid bone. Both bony rods were shortened surgically via an extraoral approach. The length of the left excised process was 82 mm and its maximum thickness was 10 mm, while the length of the right one was 48 mm and its maximum thickness was 15mm.
    Download PDF (5847K)
  • Hiroyuki KINOSHITA, Kanji KOMAKI, Toru NAGAO, Hideo FUKANO, IZUMI MAKI ...
    1997 Volume 43 Issue 10 Pages 769-771
    Published: October 20, 1997
    Released: September 13, 2011
    JOURNALS FREE ACCESS
    We report a case of Quincke's edema. The patient was 48-year-old woman. She had no noteworthy medical history or family history. She became aware of sudden swelling of the upper and lower lips. The edematous swelling of her lips was severe. The patient also complained a pain at 7 and the submandibular region. Quincke's edema, periodontitis, and lymphadenitis were diagnosed. We administered hydrocortisone sodium succinate, tranexamic acid, d-chlorpheniramine maleate, and antibiotics. After 5 days, the lip edema almost disappeared. On laboratory examinations, the differential eosinophil count was 2 per cent and IgE was 149 IU/ml, ruling out a relation of I type allergy to this disease. In other laboratory examinations, C 1-inhibitor was within normal limits, which ruled out the possibility of angio-neurotic edema secondary to deficiency of C 1-inhibitor. We speculate that the odontogenic infection was one critical cause.
    Download PDF (2805K)
feedback
Top