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Volume 42, Issue 3
Displaying 1-19 of 19 articles from this issue
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Reduction of cisplatin-induced renal toxicity by prostaglandin E1 in animal modelsNaoki NAKAMURA, Akira YAMAGUCHI, Koichi NISHIMURA1996 Volume 42 Issue 3 Pages 245-255
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe experimentally evaluated the usefulness of prostaglandin E1 (PGE1) in a model of cisplatin (CDDP)-induced nephrotoxicity. CDDP (6.5mg/kg) was intravenously injected in male Sprague-Dawley rats. PGE. was intravenously infused at different times and for different durations, and the following results were obtained:
1. Infusion of PGE. (0.1μg/kg/min) for 4 hours from 15 minutes before CDDP injection inhibited decreases in blood urea nitrogen, serum creatinine, fractional excretion of sodium, and creatinine clearance. The nephrotoxic effects of CDDP were thus reduced.
2. With PGE. infusion for 2 hours from 2 hours after CDDP administration, the effects was similar to those of PGE. infusion for 4 hours after CDDP injection. This suggested that PGE reduces the nephrotoxic effects of CDDP by inhibiting the renin-angiotensin system in the kidneys, there by maintaining renal hemodynamics. In addition, reabsorption and time factors in the pharmacokineties of CDDP seem to be involved.
3. PGE1 infusion for 4 hours before CDDP injection significantly reduced the fractional excretion of sodium, as compared with PGE1infusion for 4 hours after CDDP injection, and also reduced the renal platinum level. These findings suggest that PGE1 prevented renal tubular cell destruction by cytoprotection, resulting in the inhibition of platinum accumulation. These results suggest that PGE1 reduces CDDP-induced renal toxicity. In addition, PGE1 is a bioactive substance and has few side effects. When given in an appropriate dose and at an appropriate time, PGE. may be useful in the prevention of CDDP-induced renal toxicity.View full abstractDownload PDF (6527K) -
Part 2: Mechanisms of malignant phenotype acquisition by long-term EGF treatmentHiroki NAGAYASU, Toshiyuki SHIBATA, Makoto ARISUE, Takashi KAWANO, Mot ...1996 Volume 42 Issue 3 Pages 256-263
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe have previously reported that epidermal growth factor (EGF) enhanced the invasive and metastatic abilities of regressor ER-1 cells and that ER-1 cells might acquire stable malignant phenotypes after long-term EGF treatment. In this study, we studied the mechanisms of the malignant phenotype acquisition by long-term EGF treatment.
EGF enhanced the chemotactic response of ER-1 cells toward culture supernatant conditioned with rat lung endothelial cells in a dose-dependent fashion and also enhanced invasiveness into the reconstituted basement membrane (MatrigelTM) in a similar manner. Furthermore, when ER-1 cells were cultured in the presence of EGF for a month (1M EGF ER-1), they acquired stable invasiveness. In EGF binding assay using 125I-EGF, the numbers of EGF receptors were similar for ER-1 cells and 1 M EGF ER-1 cells, which expressed both highand low-affinity receptors. RT-PCR analysis demonstrated that mRNA expression of EGF receptors was similar for both ER-1 cells and 1M EGF ER-1 cells. Drug-resistance tests using c-SST-2 cells (parent cells of ER-1) revealed that colonies resistant to 6-thioguanine and ouabain appeared after long-term EGF treatment (one month).
These results suggest that long-term EGF treatment may affect the genomic alteration of ER-1 cells and that these may acquire stable malignant phenotypesView full abstractDownload PDF (2947K) -
Correlation of epithelial dysplasia with Ley antigen and P53 proteinMasako NAKAMURA, Keiko KANEMOTO, Kumie YUI, Ryutaro KAMIJO, Saburo KAK ...1996 Volume 42 Issue 3 Pages 264-269
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThe correlation of epithelial dysplasia with the expression of Lewisy (Ley) antigen and P53 protein was evaluated in oral leukoplakia. Changes in the expression of Ley antigen, P53 protein, and proliferating cell nuclear antigen (PCNA) were examined immunohistochemically in 30 cases of tongue leukoplakia with epithelial dysplasia (mild dysplasia: 11 cases, moderate dysplasia: 10 cases, and severe dysplasia: 9 cases). In addition, the expressions of these molecules in normal tongue epithelia and leukoplakia without epithelial dysplasia were also investigated.
The results revealed that Ley antigen was distributed throughout the epithelium except for the basal cell layer in normal epithelium, whereas in leukoplakia it was localized only in the superficial epithelium. P53 protein and PCNA appeared chiefly in the basal cell layer in normal epithelium, while they were more widely distributed in leukoplakia. The positive rate of Ley antigen decreased with the grade of epithelial dysplasia. In contrast, both P53 protein and PCNA positivity increased with the grade of epithelial dysplasia. Specifically, significant changes in the positivity of Ley antigen and P53 protein were observed in leukoplakia, when epithelial dysplasia progressed from mild to moderate dysplasia.
These results suggest that mutations of the p53 gene and alterations of cell surface carbohydrates may occur in the early stage at which epithelial dysplasia progress from mild to moderate.View full abstractDownload PDF (3546K) -
Cases in our department over the past 10 years with a review of the literature-Keiichirou OKAMOTO, Takeshi WADA, Toshihiro KAWASHIMA, Yasuhiro NAKANI ...1996 Volume 42 Issue 3 Pages 270-276
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSIn this report, 14 oral lipomas treated at our department between 1985 and 1995 were reviewed clinically and histopathologically, along with a discussion of oral lipomas reported in Japan.
The characteristics of our cases were as follows: 1) Eight patients were men and 6 were women. 2) Their age distribution ranged from 24 to 80 years. 3) The most common site of oral lipoma was the buccal mucosa (7 cases), followed by the lower lip (3 cases). 4) The duration of symptoms ranged from 1 month to 15 years. 5) The clinical diagnosis was lipoma in 8 cases, fibroma in 5 cases, and papilloma in 1 case. 6) Histologically, there were 6 simple lipomas, 7 fibrolipomas, and 1 angiomyolipoma.
Some reports state that oral lipomas are no longer a rare tumor. In our study, 14 oral lipomas were seen over 10 years. At 7 institutions in Japan, less than 2 cases were encountered per year per institution, indicating that the prevalence of oral lipoma is not high. We have to accumulate more cases and information on oral lipoma.View full abstractDownload PDF (8285K) -
Tetsu TAKAHASHI, Shoko KOCHI, Tomokazu SASAKI, Hirosi TAKANO, Hirokazu ...1996 Volume 42 Issue 3 Pages 277-286
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe used a mandibular kinegiograph (MKG) to evaluate mandibular movement in cleft lip and/or palate patients, especially those who received orthodontic treatment. A total of 25 patients with complete unilateral cleft lip and palate (UCLP group) who had completed orthodontic treatment at the Clinics for Maxillo-oral Disorders, Tohoku University School of Dentistry, and 25 non-cleft volunteers (control group) of similar age were studied.
Tracings of 10 variables of three major movements of the mandible (habitual opening and closing stroke, rapid opening and closing stroke, and rest position) were recorded and assessed by pattern analysis. Furthermore, the intensity of the mandibular movement disorder was classified and evaluated by scoring the 10 variables of mandibular movement on a scale of from 0 to 10 to derive the total mandibular kinetic score (TMK score). The results obtained were as follows:
1. In the individual pattern analysis of habitual opening and closing stroke, rapid opening and closing stroke and rest position, more aberrant movement patterns were seen in the UCLP group than in the control group.
2. In the TMK score evaluation, the mean TMK score in the UCLP group was 4.5 as compared with 1.8 in the control group, showing that the intensity of mandibular movement disorder was also higher in the UCLP group than in the control group.
3. Maxillomandibular asymmetry seems to affect the mandibular movement disorders in UCLP patients who undergo orthodontic treatment.
4. This study showed that the analysis of mandibular movement is important in the orthodontic care of cleft lip and/or palate patients. Further analyses of factors affecting mandibular movement are needed.View full abstractDownload PDF (1180K) -
Shunichi YOSHIDA, Yoshiaki KOMIYA, Ikuhiro UCHIDA, Syouhei IWAMOTO, Ka ...1996 Volume 42 Issue 3 Pages 287-289
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSForty-one patients with NO carcinoma of the tongue who received Ra needle interstitial brachytherapy between 1980 and 1994 at Metropolitan Komagome Hospital were studied. The patients included 12 cases of T 1, 27 cases of T 2, and 2 cases of T 3. The purpose of this study was to investigate local recurrence, secondary neck metastasis, and 5-year survival rate. There was no local recurrence, among T 1 cases, 2 local recurrences among T 2 cases, and 1 local recurrence among T 3 cases. Secondary neck metastasis occurred clinically in 4 T 1 cases, 10 T 2 cases, and 0 T 3 cases. The 5-year survival rate was 82% in T 1, 67% in T 2, and 50% in T3. The total cervical lymph node metastasic count, which was confirmed by pathological examination, was 26; 11 metastatic lymph nodes were found in the mid internal jugular nodes and 9 metastatic lymph nodes were found in the superior internal jugular nodes. These cases of secondary lymph node metastasis were found an average of 5.7 months after interstitial irradiation; 80% ocurred within one year. This period should therefore be carefully followed up.View full abstractDownload PDF (383K) -
Hirotaka UENO, Tadayoshi KANEKO, Jun ISHII, Hiroyuki WATANABE, Masato ...1996 Volume 42 Issue 3 Pages 290-292
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSAdenolymphoma is a benign epithelial tumor of the salivary gland that is rarely found at the lower end of the parotid gland. Here we report 2 cases of adenolymphoma complicated by tongue cancer.
Case 1 was a 71-year-old man who consulted our department for difficulty in ingesting food, caused by stomatitis after receiving radiation and chemotherapy at the department of oral surgery of another university. His diagnosis was tongue cancer with metastasis of the ipsilateral cervical lymph nodes.
Although the site of the primary cancer was unknown, pathological examination of tissue removed from the cervical region led to a diagnosis of adenolymphoma.
Case 2 was a 59-year-old man who consulted our department for tongue haphalgesia. The presence of a malignant tongue tumor as well as a parotid gland tumor was suspected and further evaluations were performed. The results of histopathological examinations led to a diagnosis of tongue cancer with adenolymphoma.
Both of the cases described above had tongue cancer with adenolymphoma on the same side. Such cases are considered extremely rare and none have been reported in the past.View full abstractDownload PDF (5257K) -
Observations by confocal laser scanning microscopyTetsunari NISHIKAWA, Masahiro WATO, Takeshi IIDA, Hakuro OKANO, Naochi ...1996 Volume 42 Issue 3 Pages 293-295
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA 67-year-old man with periodontitis underwent dental panoramic radiography at a dental clinic. A thumb-sized, punched-out radiolucency was observed in the mandibular left molar region, and the patient was referred to our hospital. Symptoms included mandibular swelling and tenderness. Histological examination of biopsy specimens revealed round or ovoid cells exhibiting abundant eosinophilic cytoplasm with eccentrically placed nuclei, as well as dense infiltration and proliferation of large cells with clear nuclei. Large, prominent nucleoli and signs of mitosis were also observed. Tumor cells were immunohistochemically positive for monoclonal IgA and A chain. A bone marrow smear indicated 31.5% plasma cells. Laboratory examination showed an increased blood IgA level (4, 960mg/dl), decreased IgG (673mg/dl) and IgM levels (42mg/dl), and the presence of urinary Bence-Jones protein. Confocal laser scanning microscopy disclosed enlargement of both the cytoplasm and nuclei of tumor cells with many sponge-like vacuoles, as compared with those of normal plasma cells. As sharply punched-out radiolucencies were also observed in the humerus and the skull, multiple myeloma was diagnosed.View full abstractDownload PDF (5419K) -
Katsuko HORII, Syosuke MORITA, Fumiya OGAWA, Takeshi IIDA, Hakuro OKAN ...1996 Volume 42 Issue 3 Pages 296-298
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSMetastatic carcinoma may involve the maxilla and the mandible. However, metastatic carcinoma of the jaw is quite rare. Three cases of thyroid carcinoma with metastatic osteolytic lesions in the jaws are presented.
Histologically, the metastatic lesions were the same as the primary tumors: an undifferentiated carcinoma and follicular carcinomas.
The undifferentiated carcinoma grew rapidly and tended to metastasize to the lung and other organs. The patient died of respiratory arrest 7 months later.
The prognosis of the follicular carcinoma was comparatively good due to its slow development. One of the follicular carcinomas has been controlled for 7.5 years with several operations for bone metastasis. The other case of follicular carcinoma died with multiple metastasis 7 years after the onset of metastasis.View full abstractDownload PDF (5124K) -
Yasuo MATSUNARI, Toshio SAKAKI, Keon-Sam KIM, Ryuichi KAJI, Kozo MUSHI ...1996 Volume 42 Issue 3 Pages 299-301
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe treated a case of neurilemoma of the cervical vagal nerve in a 25-year-old woman who complained of swelling in the left cervical region, with no other symptoms. The tumor was enucleated together with its capsule after careful abrasion from the vagal nerve. It was histopathologically diagnosed as a neurilemoma of Antoni type A and B. There were no postoperative complications.View full abstractDownload PDF (4627K) -
Hiroaki ISHII, Hisamichi GOHKE, Shinichi SASAKI, Yasuhiro MATSUMOTO, M ...1996 Volume 42 Issue 3 Pages 302-304
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe report a case of odontoameloblastoma arising in the mandibular molar region of a 26-year-old woman. The patient presented with a chief complaint of swelling at the molar region on the left side of the mandible. Radiographic examination showed an unilocular radiolucent area at the molar region of the left side of the mandible. Impacted teeth were found in this region. The tumor was enucleated in a single mass, along with the impacted teeth, under total anesthesia. The histopathological diagnosis was an odontoameloblastoma. As of six years after the operation, the patient's prognosis has been good.View full abstractDownload PDF (2393K) -
Yasutaka KUBOTA, Kihachiro ABE, Tetsuya MIHASHI, Shuro KUBO1996 Volume 42 Issue 3 Pages 305-307
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA rare case of Wegener's granulomatosis is reported. The patient was a 22-yearold woman who had multiple intractable ulcers of the oral mucosa, with purpura of the skin, arthralgia of the knees, abdominal pain, and hematuria. Pathological examination of the oral ulcer showed no distinct signs of vasculitis, but that of the purpura of the skin revealed vasculitis with the exudation of inflammatory cells and eosinocytes in all layers of the dermis. The patient responded to treatment with steroids and immunosuppressants. Longterm follow-up, however, is needed.View full abstractDownload PDF (4563K) -
Koichiro SUZUKI, Hideaki IWAMA, Hiroshi YOSHIDA, Kazue YAMAGUCHI, Hiro ...1996 Volume 42 Issue 3 Pages 308-310
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA case of a white sponge nevus involving the oral mucosa in a 20-year-old woman is presented. Physical examination revealed that the lesion was located only in the oral cavity. A biopsy showed hyperkeratosis and acanthosis with some vacuolation in the squamous epithelium. Based on these features, a white sponge nevus was diagnosed. Investigation of the patient's pedigree suggested that this case was sporadic, although the disease shows autosomal dominant inheritance.View full abstractDownload PDF (2972K) -
Tomoko OKADA, Ichiro SUZUKI, Tsutomu NOMURA, Masahiro YONEZAWA, Tamio ...1996 Volume 42 Issue 3 Pages 311-313
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA very rare case of teratoid cyst of the tongue is reported.
A 10-year-old girl presented with pain of the tongue. On palpation, there was a tumorous mass on the dorsal surface, which appeared as a hypoechoic lesion on ultrasonography. The lesion was surgically excised. There was no evidence of recurrence as of 9 months postoperatively. The excised specimen was a cyst with hair follicles, sebaceous glands, sweat glands, smooth muscle fibers, and cartilage tissue in the cyst wall. The histological diagnosis was teratoid cyst.View full abstractDownload PDF (4480K) -
Nobuyuki TANAKA, Yutaka KIMIJIMA, Miki SATO, Kenichi SHIONOYA, Teruo A ...1996 Volume 42 Issue 3 Pages 314-316
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe performed a clinicostatistical study of 102 maxillofacial fractures due to sports during the 17-year period between 1977 and 1993 at The First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University, Japan. Of all maxillofacial fractures, the rate of sports-related fractures was 10.5%. The patients had injuries resulting from 22 different sports, and the most common sport responsible for injury was rugby, followed by skiing, baseball, and soccer. The ratio of males to females was 6:1, and the majority of the patients were between 10 and 29 years old. Fractures of the mandible and the alveolar process were common. Conservative therapy, such as maxillomandibularfixation, was usually performed.View full abstractDownload PDF (277K) -
Hiroya ITOH, Takashi SEKIGUCHI, Shingo KAWAMURA, Kouji MUROTA, Ayumi M ...1996 Volume 42 Issue 3 Pages 317-319
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe clinicostatistically analyzed 135 cases of malar bone fractures treated at our clinic during the 18 years between April 1976 andMarch 1994. The results are as follows.
1) The ratio of males to females was 4.2.1, and the majority of cases were between 10 and 39 years old.
2) Medical doctors were responsible for referring 84.5% of the cases, whereas 2.0% were referred by dentists.
3) The majority of cases (83.6%) presented within two weeks after sustaining injury.
4) Road traffic accidents were the most common cause of malar bone fractures.
5) Trismus was the most frequent chief complaint.
6) According to the classification by Knight & North, 31.8%, 19.3%, 26.7%, 5.9%, 5.2%, and 11.1% of 135 malar bone fractures belonged to Group I, Group II, Group III, Group IV, Group V, and Group VI, respectively.
7) About one half of all cases were treated by antiinflammatory drugs only, and the others were usually treated by reduction without fixation or by fixation after reduction.View full abstractDownload PDF (398K) -
Takashi TACHIMURA, Hisanaga HARA, Takeshi WADA, Seiji IIDA, Mikihiko K ...1996 Volume 42 Issue 3 Pages 320-322
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSPharyngeal flap surgery is used in the prevention of hypernasality and the devel-opment of articulation disorders that are associated with velopharyngeal incompetence after primary palatal closure. However, surgery may result in failure when the level of the pharyngeal flap base is not determined properly with relation to that of velopharyngeal move-ment or when the flap shrinks because of scar contraction through prolonged exposure of its raw surface. This report describes one patient who had suffered from recurrence of velopharyngeal incompetence after pharyngeal flap surgery. Lateral cephalographic and nasopharyngeal fiberscopic examinations identified the cause of flap atrophy to be marked scar contraction, and the flap base was remarkably lower than the level of velopharyngeal closure in the patient. Unified velopharyngoplasty was newly performed on the basis of find-ings obtained from lateral cephalographic and nasopharyngeal fiberscopic examinations to correct the recurrence of velopharyngeal incompetence in the patient. One year postoperatively, complete closure of the velopharynx in coordination of the flap during speech was confirmed by nasopharyngeal fiberscopy.View full abstractDownload PDF (4994K) -
Shin-ichirou TERASAKI, Hiroshi FUJITA, Tomoko EGASHIRA, Tadamitsu KAME ...1996 Volume 42 Issue 3 Pages 323-325
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThe usefulness of cytodiagnosis and immunocytochemistry in the diagnosis of herpes infection of the oral and maxillofacial region was investigated. The subjects were 28 patients in whom HSV-1 was isolated and who underwent cytodiagnosis among patients who were examined at the Department of Oral Surgery, Kurume University School of Medicine during the 6 years from April 1989 to March 1994. They consisted of 21 patients with herpetic gingivostomatitis and 7 with recurrent herpes. Twelve patients who had positive findings on cytodiagnosis underwent immunocytochemical examination after depigmentation. The rate of positivity was low (43%), and there was no difference in the rate between patients with primary infection and those with recurrence. Immunocytochemistry was positive in 9 of the 12 patients. These findings suggest that sample collection should be improved and immunocytochemical examinations should be performed in fresh cases to increase the rate of positivity on cytodiagnosis.View full abstractDownload PDF (322K) -
Takao IMAI, Hitoshi KUNO, Yuji KAMIYA, Yasuo KINOSHITA, Hiroshi INAMOT ...1996 Volume 42 Issue 3 Pages 326-328
Published: March 20, 1996
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSIt is a serious and critical problem for medical practitioners to be infected with hepatitis B and C virus from patients. We therefore attempted to identify latent carriers of hepatitis B virus (HBV) and C virus (HCV) among patients who had consulted several departments of oral and maxillofacial surgery during the one year from April 1993 to March1994. Among 2167 patients, there were 17 (0.78%) and 86 (3.97%) positive carriers of HBV and HCV, respectively.View full abstractDownload PDF (377K)
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