Chondroid syringoma is a benign cutaneous tumor composed of epithelial and mesenchymal tissues and is considered to be a mixed tumor. It is difficult to diagnose the tumor on the basis of only clinical findings. Especially when the tumor is near the oral mucosa, differentiation from pleomorphic adenoma is needed. In this paper, we reported a 30-year-old man with chondroid syringoma of the lower lip. The mass was sphere-like, elastic, slightly hard, and mobile. On ultrasonic imaging, a mass 8 mm in diameter was seen in the lower lip. It showed slightly high signal intensity on magnetic resonance T1-weighted images and high signal intensity on T2-weighted images. Based on a diagnosis of benign tumor of the lower lip, the mass was surgically removed with the patient under local anesthesia. Intraoperatively, we recognized that the tumor existed between the skin and orbicularis oris muscle. Histopathological examination of the specimen demonstrated findings of an expanded branching luminal, chondroid, and myxoma-like structure. These findings were consistent with the diagnosis of chondroid syringoma. At the postoperative 2-year follow-up, there was no evidence of recurrence.
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