Japanese Journal of Oral and Maxillofacial Surgery
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
Volume 34, Issue 1
Displaying 1-27 of 27 articles from this issue
  • (5) Radiosensitive effect of inunidazole compounds for human maxillary carcinoma
    Kazuo SAKAIZUMI, Shigeru SENUMA, Kazuhito SATO, Tetsuo NAGAI, Tsutomu ...
    1988 Volume 34 Issue 1 Pages 1-6
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The purpose of our investigation is to compare the radio-enhancement of three imidazole compounds to human oral malignant tumor transplanted on nude mice.
    Methods and evaluation: Battelle Columbus Laboratories Protocol.
    Tumor: PNC-1-JCK=human maxillary poorly differentiated squamous cell carcinoma.
    Subjects: Male CD-1 (ICR) nu/nu, BALBc nu/nu and conventional C 57 BL/6 N (age 10 weeks, 20-25g body weight).
    Imidazole compounds: Misonidazole (MISO) 20mg/mouse, dinitroimidazole ethanol (DNIE) 10mg/mouse and 5-methoxy carbonyl-2-methyl sulfinyl-l-methyl imidazole (KIH-3) 40mg/mouse.
    Tumors were transplanted to the subcutaneous region of the right thigh of CD-1 (ICR) nu/nu.
    Radiation: 60Co 15 Gy local radiation.
    These imidazole compounds were administrated into the abdomen of the CD-1 (ICR) nu/nu prior to 30 minutes of local irradiation.
    NK activity was compared among CD-1 (ICR) nu/nu, BALBc nu/nu and conventional
    C 57 BL/6 N.
    Results: Radiosensitive effect was evaluated for MISO 20mg+60Co 15 Gy group. DNIE 10mg+60Co 15 Gy and KIH-3 40mg+60Co 15 Gy groups were observed to show radioprotective effects rather than radiosensitivity.
    % NK activity was as follows:
    CD-1 (ICR) nu/nu, 4.9 in YAC-1 100:1; 7.0 in RL-male 100:1. BALBc nu/nu 24.6 in YAC-1 100:1; 15.9 in RL-male 100:1. C 57 BL/6 N 21.4 in YAC-1 100:1; 24.0 in RL-male 100:1.
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  • Shinobu MIYAUCHI, Takamasa MOROYAMA, Kazuaki TAKADA
    1988 Volume 34 Issue 1 Pages 7-14
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    The new cell line (Nakata-1) was established from squamous cell carcinoma of the buccal mucosa. IL-1 activity was found in its culture supernatants by thymocyte proliferation assay and fibroblast proliferation assay.
    This activity revealed the same behavior as that of human macrophage IL-1 in gel filtration chromatography. This activity, therefore, is thought to be attributed to the so-called “IL-1 like factor.”
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  • Takashi OHNO
    1988 Volume 34 Issue 1 Pages 15-23
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Effects of micro-electrical stimulation on osteoblasts were examined using osteogenic MC 3T3-E1 cells which have retained the capacity to differentiate into osteoblasts and form mineralized tissue in in vitro.
    The cells in 0.3% type I collagen gel at 2×106 cells/ml were cultured in α-MEM supplemented with 10% fetal bovine serum and 5mM β-glycerophosphate at 37°C in a fully humidified atmosphere of 5% CO2. Two platinum wire electrodes (0.3mm in diameter) were inserted into collagen gel at 10mm-intervals. The cells were stimulated by 1, 5, 10 or 20μA of constant direct currents via the electrodes for 6 days. At 5μA of current, their alkaline phosphatase (ALP) activities were maximum. Thus, they were stimulated by 5μA of current for a short or long term. ALP activity and 45Ca incorporation were significantly increased in long-term stimulated cultures. These results showed that long-term stimulation provided an optimal environment for MC 3T3-E1 cells to differentiate into osteoblasts. Next, the cells were stimulated by 5μA of current for a long term. ALP activity and 45Ca incorporation significantly increased in the stimulated cultures compared to the controls. Histological observations showed that the cells surrounding the cathode apparently differentiated into osteoblasts and synthesized abundant fibrous matrix. Moreover, many matrix vesicles containing needlelike crystals were observed on cathode at 9 days. On day 12, the stimulated cultures were positively stained with von Kossa.
    These results suggest that micro-electrical stimulation directly affects MC3T3-E1 cells and induces osteoblastic differentiation and calcification.
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  • Reiji SUZUKI
    1988 Volume 34 Issue 1 Pages 24-36
    Published: January 20, 1988
    Released on J-STAGE: September 13, 2011
    JOURNAL FREE ACCESS
    As pain is the subjective sensation itself, a number of difficulties exist in the objective and scientific study of this phenomenon. However, when pain evoked by various degrees of given stimulations is expressed quantitatively, there is a specific relationship observed between the stimulation intensity and the pain sensation magnitude.
    The author has attempted to quantitatively compare the changes that occur in pain sensation with changes in nitrous oxide concentration when electric dental stimulation is given under conditions of step-wise altering the pain threshold at specific time intervals in order to investigate the mechanism of nitrous oxide anesthesia via pain by determining pain electrophysiologically and objectively.
    Ten adult male volunteers were subjected to electric dental stimulation under various concentrations of nitrous oxide for measurement of somatosensory evoked potentials (SEP) to quantitatively determine the relationship between concentrations of nitrous oxide and pain sensation. The following results were obtained.
    (1) In SEP between 50 msec and 500 msec following stimulation, negative-positive-negativepositive-negative latencies were observed in all subjects, and the mean latencies were N 68, p98, N 148, p260 and N 360, respectively.
    (2) Upon comparison between nitrous oxide concentrations and the amplitude of SEP, the most significant amplitude decrease was observed at N 150-P260. As compared with the room air, graded reductions in the amplitude of SEP were noted at pre-15% and 30% nitrous oxide, particularly in the latter where the reduction was statistically significant (P>0.001). Furthermore, the amplitude of SEP began increasing with post-15% nitrous oxide, and the changes at N 150-P 260 correlated with the changes in nitrous oxide concentrations.
    (3) 30% nitrous oxide significantly delayed all elements of SEP latencies, while 15% nitrous oxide caused significant increases in the early components of N 70, p100 and N 150, and tended to increase other components.
    (4) 100% oxygen significantly increased SEP amplitude in N 70-P 100, and tended to increase other elements.
    (5) With 100% oxygen, SEP latencies were significantly faster at N 360 but three were no changes in the early components.
    (6) Values of pain scale either decreased or increased at intervals as in the SEP amplitude; however, there was no significant difference between these two parameters.
    The results as described above suggested the possibility of SEP as a useful index for determination of the optimum depth of nitrous oxide anesthesia.
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  • The 1st experiment: 1. Gross and microscopic observation, postulated the two range passway for the carcinoma
    Kohzo TSUCHIKAWA, Morio OZAKI, Kazuyoshi OZAWA, Masanori KONDO, Yasuyu ...
    1988 Volume 34 Issue 1 Pages 37-42
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    This chemically induced carcinogenesis experiment was performed for purposes of preliminary experimenting for further oral carcinoma studies. Painting 0.5% DMBA in liquid paraffin into six-week-old Golden Syrian Hamster's buccal pouches, threetimes a week for 14 weeks, the following results were elucidated.
    Within the first 4 weeks, inflammatory reactions of the mucosa, i. e., redness, formation of plaques, and bleeding were found. Thereafter, they naturaly disappeared from around the 5th to the 6 th experimental weeks. On the 8 th week, papillomatous tumors suddenly appeared which were growing gradually in size, number, and even in atypism. The surrounding epithelia showed changes comparable to epithelial dysplasia or carcinoma in situ. It was from the 12-week-painted group that well-differentiated squamous cell carcinomas were-first recognized.
    These tumors were rather exophytic growths and showed a minimal invasive trend. However, invasive tumors were formed as well in the 14-week-painted group. Therefore, two possible ways for carcinoma formation might be suggested. One is from papilloma through increased atypism, such as verrucous carcinoma, and the other from epithelial dysplasia or carcinoma in situ with downward growth of the rete-processes to the carcinoma.
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  • II. Effects of aspirin on experimental DIC induced by endotoxin in rabbits
    Hiroshi FUJITA, Masafumi SHIMAZU, Kaoru OHSAWA, Toshiya SHIBATA, Shin- ...
    1988 Volume 34 Issue 1 Pages 43-50
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    We have prcviously reported that an experimental model of disseminated intravascular coagulation (DIC) could be induced by continuous infusion of endotoxin (ET) at a dose of 3mg/kg duriy 3 hours in rabbits.Using this model, the effects of aspirin (ASA) against DIC were examined. Our studies were made in control rabbits and rabbits pretreated with ASA injection.The animals were divided into 4 groups as the followings;
    Group I (control group): ET (3mg/kg) infusion only.
    Group II (ASA pretreated group): Intravenous injection of ASA (100mg/kg) followed by ET (3mg/kg) infusion.
    Group III (ASA pretreated group): Intravenous injection of ASA (10mg/kg) followed by ET (3mg/kg) infusion.
    Group IV (ASA pretreatcd group): Intravenous injection of ASA (1mg/kg) followed by ET (3mg/kg) infusion.
    Tentative diagnostic criteria for experimental DIC were designed as DIC scoring system. DIC score was useful to determine the degree of DIC state (DIC score≥6 points) and evaluate the effects of ASA pretreatment against DIC. There sults of present study indicated that inhibition of development of DIC was neted in group III, IV. Group IV made the lowest score (2.2±1.6) in ASA pretreated groups.
    From these results, we may conclude that low dose of ASA could be effective for prevention of DIC.
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  • Masayoshi SAKUDA, Tetsuro SUMI, Yoshihide MORI, Masaaki TAKITA, Kayoko ...
    1988 Volume 34 Issue 1 Pages 51-55
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    General complications of 227 patients with head and neck cancer squamous cell carcinoma were analysed, and investigated in relation to the first choice of cancer treatment and prognosis of general complication after cancer treatment.
    The results were summarized as follows:
    (1) Cancer patients with general complications that included previous illnesses were 50.6%, and cancer patients with general complications of present illnesses were 23%.
    (2) 8 cases of cancer patients could not have operations for general complications.
    Control of present illness was necessary in 27 out of 54 cancer patients with present illness.
    (3) About 10% of cases developed present aggravated illness after the first choice of cancer treatment, and 5 cases (5/227, 2.2%) of these patients died of general complicatins. However, aggravation of these 5 patients was considered to have no direct relation to cancer treatment.
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  • Takamichi YANAGISAWA, Toshiaki ISHIKAWA, Kosuke HONDA, Yoshiko NATSUMI ...
    1988 Volume 34 Issue 1 Pages 56-61
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Neurilemmoma is not uncommon elsewhere in the body, but it is rare in the oral cavity. Here, we report a case of a neurilemmoma located in the lower lip, in a 23-year-old female. The patient complained of a painless swelling of the lower lip. During the course of the first medical examination, a circumscribed, elastic hard, movable, oval mass measuring 16×16mm was found in the lower right lip. The clinical diagnosis was a benign tumor of the lower lip. The lesion was totally excised under local anesthesia. From histopathological findings it was diagnosed as a neurilemmoma (Antoni Type A and B). There was no evidence of recurrence in the patient 4 months after the operation.
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  • Satoru OZEKI, Sadako KAI
    1988 Volume 34 Issue 1 Pages 62-67
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Total maxillectomy was performed with Fukuda's method which combined Worthington's surgical approach to the pterygoid region with Nasteff's immediate reconstruction of the orbital floor for recurrent advanced carcinoma of hard palate.
    The advantages of the present method include ready and safe access to the pterygoid region and adequate exposure for the separation of the maxilla from the pterygoid plates. In addition, postoperative face deformity is not so severe and the disturbance of eye movements is not seen owing to the immediate reconstruction of the orbital floor and the preservation of the zygomatic arch.
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  • Hiroomi CHO, Keigo KUDO, Hiroki MIYATE, Yukio FUJIOKA, Jun SASAKI, Yas ...
    1988 Volume 34 Issue 1 Pages 68-71
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Clinicopathological findings of a metachronous double cancer in the tongue and the esophagus are reported in this paper. A 42-year-old male with endophytic and welldifferentiated squamous cell carcinoma, which occurred in the right body of the tongue, was referred to the Dental Hospital of Iwate Medical University. The carcinoma disappeared clinicopathologically at 3 rd month after infusions of Bleomycin (60mg) and 5-FU (4, 800mg) with irradiations of 60Co (54 Gy) and radium needling (30 Gy). After 2 years, however, marked dysplasia of the epithelium in the left tongue margin appeared. It developed into an invasive carcinoma 2 years later, and then a partial resection of the tongue was performed.
    Poorly differentiated squamous cell carcinoma of the esophagus appeared after 8 years. Irradiation of 60Co (40 Gy) after surgery for the carcinoma was carried out. Aftenvords, his post-therapeutic course was uneventful.
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  • Hideaki SAKASHITA, Masaru MIYATA, Masako ARAKAWA, Morimoto HAYASHI
    1988 Volume 34 Issue 1 Pages 72-76
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A case of venous hemangioma in the premasseteric region of a 22-year-old man was reported. The chief complaint was a painless swelling in his right premasseteric region. His general condition was good. A thumb-tip-sized, elastic soft tumor, which fluctuated in size, was found at the premasseteric region. The first impression was hemangioma. CT-scan and ultrasonography revealed a soft tissue mass with several cystic spaces. Together with the findings of RI-angiography and blood pool imaging, a hemangioma was diagnosed. Under general anesthesia, the tumor was removed surgically by intra-oral approach. Histologically, it was diagnosed as a venous hemangioma.
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  • Ken-Ichiro MURAKAMI, Tadahiko IIZUKA, Masahiro NOSE, Kazuto KAMITANI, ...
    1988 Volume 34 Issue 1 Pages 77-87
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Long-term follow-up study was done on eight patients in child age with mandibular condylar fracture. A conservative treatment was done on five cases, and surgical reduction was carried out on three patients. The ages of patients at trauma were distributed from 6 to 14 years old, and the average follow up period was 7.5 years. The criteria for assesment of the posto-perative jaw function is classified into four groups: Excellent, fair, poor, and no good (Nakatomi, 1964). Four cases were evaluated “excellent”, two “fair” and two were assessed “poor”.
    Deviation-type fracture (MacLennan, 1952) in association with suspected pressured injury on the condylar surface seemed to have a closer relation to the poor result than the Dislocation type. Two chronic-case patients were included in the patients of Deviation type fractured group. Between the surgically-treated and conservatively cared patient groups, there is no obvious difference in the clinical course.
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  • Hiroshi KAWAMURA, Yoshio TAKAHASHI, Hiroshi NAGASAKA
    1988 Volume 34 Issue 1 Pages 88-97
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Experience of intraoral ramus osteotomy (IVRO) for correction of dentofacial deformities in 50 patients is reported.
    In comparing with sagital split ramus osteotomy (SSRO), IVRO shows some advantages. It has a lower incidence of hypoesthesia of the inferior alveolar nerve. It is an easier, faster procedure, and causes less rotational displacement of proximal segment in asymmetrical retrusion. IVRO compares quite well with SSRO.
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  • Hiroshi KAWAMURA, Yoshio TAKAHASHI, Hiroshi NAGASAKA, Masato MAEKAWA, ...
    1988 Volume 34 Issue 1 Pages 98-111
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Orthognathic surgery for maxillary deformities needs maxillary osteotomies. Le Fort I osteotomy is versatile and useful for correcting maxillary deformities.
    The safety of Le Fort I osteotomy has been examined fundamentally and clinically, and recently modified Le Fort I osteotomy has been introduced
    In this paper, two maxillary deformity cases operated by modified Le Fort I osteotomy have been presented.
    Modified Le Fort I osteotomy for many kinds of maxillary deformities indicates the best results for careful treatment planning of clinical, cephalometric and dental model analysis
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  • Yasushi KAWAMURA, Masahiko FUKAYA, Kazuki MORI, Hiroshi INAMOTO, Hatsu ...
    1988 Volume 34 Issue 1 Pages 112-115
    Published: January 20, 1988
    Released on J-STAGE: September 13, 2011
    JOURNAL FREE ACCESS
    Granular cell tumor is a relatively uncommon benign tumor which usually occurs in the oral cavity and the skin.
    In the oral cavity, the granular cell tumor most frequently occurs in the tongue and occasionally occurs in the buccal mucosa or lips.
    We experienced a case of granular cell tumor of the tongue in a 37 year-old male. Clinically a fibroma was suspected.
    The lesion was extirpated and diagnosed histopathologically as a granular cell tumor.
    There was no evidence of recurrence in the patient 1 year and 10 months after removal.
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  • Cementifying fibroma
    Yoshinori HIGUCHI, Norifumi NAKAMURA, Yasuo IDA, Hideo TASHIRO, Takesh ...
    1988 Volume 34 Issue 1 Pages 116-122
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Clinical and histopathological studies on 8 cases of cementifying fibroma of the jaws were reported.
    Seven female and one male patients had a mean age at first visit of 33.9 years. The condition had a predilection for molar region in the mandible and the maxilla.
    The lesions were treated by extirpation and curettage of surrounding bone in 7 cases and by hemimandibulectomy in one cases.
    Histologically, we found that the lesions produced various amounts of spherical cementums and they fused together into a large mass.
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  • Takanori OHYA, Yukio FUJIOKA, Sadahiko SHIBATA, Yoshiyasu NAGASAWA, Ya ...
    1988 Volume 34 Issue 1 Pages 123-130
    Published: January 20, 1988
    Released on J-STAGE: September 13, 2011
    JOURNAL FREE ACCESS
    The pathology of mandibular nerve tissue underlying mandibular diseases was investigated on the basis of operative findings and histopathological observation of raected specimens to clinically determine the surgical limitations topreservation of the inferior alveolar nerve. The study was performed on 14 patients with cyst, 28 with tumor (19 benign and 9 malignant tumors) and 8 with osteomyelitis. Benign tumors consisted of 11 cystic type ameloblastomas, 5 solid type ameloblastomas, 2 myxofibromas and 1 cementoma. Osteomyelites consisted of 5 chronic osteomyelites of the lower jaw and 3 radiation osteomyelites.
    In cystic diseases, though nerves were frequently compressed to the cystic wall, the inferior alveolar nerve was distinctly separated from the cyst without any histopathological abnormality of the nerve tissue, indicating that preservation of the inferior alveolar nerve was possible. In cystic type ameloblastomas, despite marked compression of the nerve tissue by severely developed tumors, the tumor and nerve tissue were clearly demarcated. Notwithstanding histopathological evidence of minor fibrosis around the epineurium, no abnormal pathology existed in the nerve tissue, indicating the possibilityof preservation. In solid type ameloblastomas, the nerve tissue was surrounded by the tumor with partial adhesion, which precluded preservation. In rnolignant tumors, severe fibrosis and hyalinization were histopathologically found to surround the nerve tissue. Preservation was impossible because of severe perineurial adhesion to the surrounding fibrous connective tissue, close contact with the tumor and tumor infiltration. In osteomyelites, macroscopical changes were demonstrable, and histopathological examination disclosed severe fibrosis around the nerve tissue and also severe hyalinization and degeneration along the perincurium. Preservation also proved to be impossible.
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  • Yutaka ENDO, Yoshimi ISHIKAWA, Seiichi HAYASHI, Susumu OHMURA, Genzabu ...
    1988 Volume 34 Issue 1 Pages 131-138
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A 33-year old woman with carcinoma in pleomorphic adenoma of the parotid gland was reported. Carcinoma in pleomorphic adenoma is relatively rare. Our case was treated with surgical resection, postoperative irradiation (50Gy) and 5-fluorouracil administration (2, 500mg).
    Facial palsy following this operation was treated with nerve repairing and acupuncture. Recovery was enough to retain face symmetry at rest. Postoperative course was uneventful during the past four and A half years
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  • Choichiro FUNAMOTO, Satoru SHIOTA, Toru YOSHIDA, Keiko TAKEDA, Kazuyos ...
    1988 Volume 34 Issue 1 Pages 139-143
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Recently, magnetic resonance (MR) imaging is capable of producting high-quality diagnosic images of medical fields. It is known that MR imaging provides much greater softtissue contrast than conventional X-ray based methods.
    With temporomandibular joint (TMJ) disorders, most X-ray based methods are useful for diagnosis of bony abnormalities, but their reduced soft-tissue contrast often make diagnostic evaluation difficult.
    This paper, reports on MR images of the TMJ. Materials and Methods: The subjects were 8 healthy persons (20-to 40-year males and/or females) with normal occlusion. No disorders were found in the TMJ and radiological findings were normal. MR imaging was performed on a 0.5 Tesla imaging system (MAGNETON, Siemens Co. made in Germany) using a surface coil (10 cm in diamter) for signal detection. Sagittal images in open (degrees of open: 1, 2, 3, 4cm) and closed mouth positions' were obtained of each subject.
    Results: The anatomy of the TMJ was well delineated on the MR images. Especially, important soft-tissue anatomy, including the articular disk with its anterior and posterior band, adjacent tissue, and its changes, etc., were readily appreciated: Namely low in signal (black) at the center of the articular disk, enhanced signal (dark gray) in its anterior and posterior edges and relatively hyperintense (bright) in the retrodiscal pad.
    We believe, therefore, that the region of the TMJ can now take advantage of the highresolution MR imaging, and these images permit the diagnostic evaluation of TMJ abnormalities.
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  • Immunohistocheinical investigations
    Hirotsugu YAMAMOTO, Kunio SUZUKI, Takamasa MATSUMOTO, Akira FUJII, Mit ...
    1988 Volume 34 Issue 1 Pages 144-147
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    An adenocarcinoma arising from the right soft palate of a 72-year-old male was examined by immunohistochemistry, and was reported.
    Review of the literature revealed that the incidence of adenoc arcinoma in salivary gland tumors ranged from 0% to 7.5%. It was 3.3% in all minor salivary gland tumors in our department. Thus, adenocarcinoma of the salivary gland is relatively rare. According to the subclassification of adenocarcinoma by Seifert, the present case belonged to solid type. Immunohistochemically, CEA was moderately-to-strongly positive in tumor cells and was found useful as a tumor maker for this tumor. Lactoferrin and EMA were also positive in tumor cells.
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  • Seiji SUZUKI, Kuniya FUJITA, Hisao SHIGEMATSU, Hitoshi SAOTOME, Nobuyu ...
    1988 Volume 34 Issue 1 Pages 148-156
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Necrotizing sialometaplasia is a disease of minor salivary glands that may be confused with, and misdiagnosed as, a malignancy. It was first reported by Abrams and associates in 1973. They described this entity as a lesion of the hard palate that did not recur after surgical excision.
    Most of the literatures suggest that an interruption of the blood supply may be the basic cause, but it also has been proposed that necrotizing sialometaplasia may be the ulcerative or terminal stage of leukokeratosis nicotini palati. However there are no previous reports that it is accompanied by any bone defect.
    Necrotizing sialometaplasia lesions are large, deeply excavated, and sharply demarcated from surrounding normal mucosa. They are usually located in the vicinity of the junction of the hard and soft palatal mucosa. Because the lesion is usually painless, patients often delay seeking treatment until 3 to 4 weeks after it appears.
    The cause of necrotizing sialometaplasia is unknown, but it is conjectured that minor trauma to the mucous membrane may be an initiating factor. Healing usually occurs within 6 to 8 weeks without treatment.
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  • Masanobu SATOH, Setsuko HATAKEYAMA, Mieko SASHIMA, Hiroaki MORITA
    1988 Volume 34 Issue 1 Pages 157-163
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A statistical survey of tongue cancer, collected from the annuals of pathological autopsy cases in Japan from 1977 to 1981, was done in order to examine the actual facts of tongue cancer.
    On the whole, the increase from year to year, of a total number of 404 autopsy cases (male: 293, female: 110, and unknown: 1) of tongue cancer, was revealed. The average age was 65.4±9.5 in male and 56. 8±14.9 years in female. The tongue cancer was found most frequently in the age group of 60-69 years, and the lateral borders (57.7%) were the most frequently affected sites in the tongue. The lung (44.1%) was the most common site of metastasis from the tongue, followed by cervical soft tissue (27. 3%), pharynx (14.9%), liver (14.7%), larynx (12.8%), and thyroid (14.1%). Concerning the metastasis from the tongue cancer into the lymph node, the cervical lymph nodes (32.5%) were most frequently invaded. Multiple primary cancers, affecting both the tongue and other organs, were found in 65 cases (double cancer: 58 cases, triple cancer: 5 casees, quadruplex cancer: 2 cases).
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  • Tatsuo TSUJI, Yasuyuki UENO, Atsuo HIROZANE, Kouji MATSUMURA, Michihik ...
    1988 Volume 34 Issue 1 Pages 164-166
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    This paper reports a familial occurence of hereditary gingival fibromatosis with some reference to literature. A 15-year-old male visited our hospital for the purpose of gingivectomy. The surgical procedure was performed in the gingiva of frontal teeth area. Histopathological examination confirmed the diagnosis of gingival fibramatosis. Five patients existed in this family within 3 generations.
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  • R eport of a case
    Tadao SUGIMOTO, Akihiro TANABE, Hideharu YOKOO, Kajin RIN, Kazutosi SU ...
    1988 Volume 34 Issue 1 Pages 167-174
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Lipoma, a benign neoplasm of adipose tissue, is a common tumor found almost anywhere on the body. In the oral cavity, lipoma commonly occurs in the cheek and the tongue. But rarely in the lower lip.
    We have experienced one case of lipoma in the left lower lip of a 53-year-old woman.
    The gross specimen consisted of a single piece of tissue measurig about 1.9×2.3×1.4cm. The cut surface revealed a well circumscribed, bright yellow, fatty lesion. Histopathologic examination showed a sharply demarcated prolife ration of adipose tissue with scant stroma.
    The prognosis is fairly good after surgical treatment and there is no recurrence after 8 months.
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  • Part 3: Epulis with hard tissue formation (peripheral ossifying/cementifying fibroma)
    Yohko FUKUTA, Morio TOTSUKA, Yasunori TAKEDA
    1988 Volume 34 Issue 1 Pages 175-181
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    Pathological analysis of 50 cases of the epulis with hard tissue formation was performed. The results were as follows:
    1. Females were affected more frequently than males; the ratio was 2.3:1 (female: 35 cases; male: 15 cases).
    2. The lesion was more common in the third and sixth decades of age, and the mean age was 37.3 years.
    3. No predilection was found for the location of the epulis, compared with other nonhard-tissue forming types of the epulis which frequently developed in the front tooth area.
    4. Size of the lesion was most often between 1 and 2 cm in diameter.
    5. The cases were classified hard tissues into histologically 4 types by i. e. 35 cases of bonelike tissue, 10 cases of mixture of bone-and cementum-like tissues, 2 cases of cementum-like tissue, and 3 cases of dystrophic calcification alone.
    6. Hard tissue of all male cases showed bone-like structure. On the other hand, cementumlike tissue was found in female cases only.
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  • Tadao SODA, Makoto NOGUCHI, Emiko YOKOO, Umeka TSUCHIYA, Tsutomu ISHIZ ...
    1988 Volume 34 Issue 1 Pages 182-187
    Published: January 20, 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
    A case of pleomorphic adenoma with cystic lesion developed on an area of the left cheek in a 65-year-old woman is reported.
    Clinical examination revealed a nontender, fluctuant swelling approximately 3-4cm in diameter in the left cheek, and approximately 9 ml of viscous fluid containing cholesterol crystals was aspirated. A contrastradiography and computed tomography of the maxillary area
    showed a well defined, uniloculated cystic lesion in the soft tissue around the left maxillary area. The provisional clinical diagnosis was a cyst of soft tissue in the cheek.
    The lesion was enucleated under local anesthesia.
    Histologic examination of the specimen revealed a cystic lesion lined with columnar or squamous epithelium and a neoplastic lesion in an area of th cyst wall which consisted of ductlike tubules of columnar and cuboidal epithelial cells, with some areas of solid proliferation of polygonal cells in a hyalinized connective tissue stroma.
    Histopathological diagnosis was pleomorphic adenoma with cystic lesion. In the large cystic formation in pleomorphic adenoma in this case it is assumed that degeneration of the tumor cells followed squamous metaplasia, or mucous retention resulted in obstruction of ducts by the tumor. No recurrence was evident during a follow-up period of three years.
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  • 1988 Volume 34 Issue 1 Pages 201
    Published: 1988
    Released on J-STAGE: July 25, 2011
    JOURNAL FREE ACCESS
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