WHO classification is a worldwide accepted standard for histopathological diagnosis of tumors. Its classification of malignant tumors is related to the different biological behavior of the tumors. Therefore, the selection of treatment and the prediction of prognosis of the tumors mainly depend on the histopathological diagnosis. A good understanding of the recent WHO classification is required for clinicians as well as pathologists. Salivary gland tumors have the most complex histopathological features of any organs and, as a result, an exceptional breadth of different tumor types. The histological diversity of salivary gland tumors is caused by the participation of neoplastic myoepithelial cells/basal cell-like cells in addition to the variety of cell types present in normal salivary glands. Futhermore, they can show a striking range of morphological diversity within the same tumor type and share the similar morphological characteristics between the different tumor types. The third iteration of the histological classification of salivary gland tumors by the WHO （WHO・2005） provides comprehensive clinicopathological characteristics of each tumor type. The present review emphasizes the standard approach according to the concepts of WHO・2005 which leads to the precise diagnosis..
Although it is known that various oral diseases can lead to taste disorders, only a few studies have reported on the relation between oral candidiasis and taste disorders. We investigated the incidence and features of taste disorders caused by oral candidiasis. The subjects were 79 patients with taste disorders in whom fungal cultures were performed at our clinic over the past 2 years. Culture tests revealed that 27 patients （34％） were positive for Candida species, among whom 24 received antifungal agents and 15 showed improvement in symptoms of taste disorders. A second fungal culture test after antifungal treatment revealed negative conversion in 13 patients and significantly reduced amounts of Candida species in 2 patients. Accordingly, these 15 patients （15/79, 19％） were given a diagnosis of taste disorders caused by oral candidiasis. Bitter phantogeusia, hypogeusia, and xerostomia were frequently noted in these patients with taste disorders due to candidiasis. Because about half of the patients with taste disorders and candidiasis showed a normal appearance of the tongue, fungal examinations should be conducted to confirm infectious agents and to exclude psychological phantogeusia.
The primary development of small lymphocytic lymphoma in the oral cavity is very rare. A review of the literature revealed that no such case has been reported previously in Japan, and only a few cases have been reported overseas. We present a case of small lymphocytic lymphoma arising in the palate.
The patient was a 77-year old woman with an elastic, hard, painless mass with a smooth surface measuring 40 × 20 mm in the right palate. No particular abnormality was observed on blood tests or general examinations.
A biopsy was performed for a suspected diagnosis of a benign palatal tumor. A proliferation center, which is a characteristic of small lymphocytic lymphoma, was noted on hematoxylin-eosin staining. In addition, immunological staining revealed that CD5, CD10, and cyclin D1 were negative and CD20 and CD23 were positive. Therefore, the lesion was diagnosed to be a small lymphocytic lymphoma.
Three courses of R-THP-COP were administeret, and the tumor shrank immediately after the start of therapy. Complete remission with regard to both clinical and imaging findings was achieved by the end of treatment. No recurrence or metastasis has been noted for 1 year 6 months after therapy.
We report a rare case of a peripheral osteoma involving the inferior border of the mandible. The patient was a 59-year-old woman who presented to the hospital because of swelling of the left jaw and facial asymmetry. She had noticed the swelling 13 years earlier. A bone-like mass lesion measuring approximately 35 × 30 mm was observed in the subcutis at the inferior border of the left side of the mandible. Panoramic radiography showed a bone-like mass arising in the inferior border of the left side of the mandible. Computed tomography also showed a well-defined, lobular bone-like lesion with homogeneous density connected to the mandible. The clinical diagnosis was peripheral osteoma. Surgical resection of the lesion was performed extraorally with the patient under general anesthesia, and the histopathological diagnosis was peripheral compact osteoma. No recurrence has been detected postoperatively.