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Volume 44, Issue 9
Displaying 1-18 of 18 articles from this issue
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Kazuya KANAI, Takafumi SATOMI, Hiroyuki WATANABE, Hirotaka UENO, Hiros ...1998 Volume 44 Issue 9 Pages 717-724
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThe detection and assay of urinary fibronectin fragment (uFN) was performed in a rabbit tongue cancer (VX2 graft) model using multiple anti-rabbit FN domain monoclonal antibodies and one-step sandwich EIA. Tumor volume, the presence of metastasis, and the amount of uFN were studied in four experimental groups: a normal group, a group 1 week after receiving a cancer graft, a group 2 weeks after receiving a cancer graft, and a group 3 weeks after receiving a cancer graft.
The results were as follows:
1. In VX2 tongue cancer rabbits, uFN was present as a small fragment (about 40 to 55 kDa), which corresponded to the fragmented (low molecular weight) FN domain II (gelatin affinity domain).
2. When the cut-off value for uFN concentration was set at 200, μg/mg·Cr, the positive rates were 0% in normal rabbits and 96% in cancer-bearing rabbits. There was a positive correlation between the concentration of uFN and tumor volume, with a correlation coefficient of 0.95.
3. The Metastasis group was compared with the non-metastasis group.
There was a significant difference in mean tumor volume between the two groups (1092.7±299.94 mm3 and 290.5±59.33 mm3 respectively)(p<0.05).
A significant difference was also observed in uFN concentration, being 981.6±331.53μg/mg·Cr and 458.5±173.31μg/mg·Cr, respectively (p<0.05).
These results suggest that uFN may become an excellent tumor marker.View full abstractDownload PDF (3522K) -
Effects of inhibition of intracellular signal transduction on cell motilityTakashi KAWANO, Toshiyuki SHIBATA, Hiroki NAGAYASU, Hiroyuki KITAJYO, ...1998 Volume 44 Issue 9 Pages 725-731
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSTo study the effects of epidermal growth factor (EGF) on invasion and metastasis of human oral squamous cell carcinoma, we examined the intracellular signal transduction of EGF-induced motility using an EGF sensitive s-1 clone cell line, obtained from Ca9-22 cell line. EGF (1, 10, 100ng/ml)- treated s-1 cells were affected by some blocking chemicals, and modulation of random motility was examined by phagokinetic track assay. When the cells ware treated with erbstatin analog; to inhibit tyrosine phosphorylation, or psi-tectorigenin to inhibit phosphatidyl-inositol turnover the motility enhanced by EGF was completely inhibited. When phorbol 12-myristate 13-acetate (PMA) was used, to stimulate protein kinase C (PKC), motility in the absence of EGF was enhanced similar to that of EGF stimulation. Calphostin C, an inhibitor of PKC activation, completely eliminated the EGF-induced enhancement of motility. Examination of the intracellular localization of PKC with a confocal laser microscope showed enhanced expression of PKC and translocation of PKC to membrane area after EGF stimulation. These results suggest that activation of phospholipase Cγ(PLCγ) caused by auto-phosphorylation of EGF receptor might play an important role in the signal transduction of EGF-induced motility.View full abstractDownload PDF (3548K) -
Goro KAWASAKI, Hideaki SAKAI, Yuzo KATO, Haruo OKABE, Akio MIZUNO1998 Volume 44 Issue 9 Pages 732-737
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSCathepsin D and E are the main aspartic proteinases, suggested to be involved in the invasion and progression of cancer cells. We immunohistochemically studied the localization of cathepsins in oral carcinoma. Specimens of SCC of the oral floor, obtained from 18 patients, were prepared. Part of the serial paraffin sections were stained with hematoxylin-eosin and classified according to Anneroth's classification. Immunohistochemical staining was performed by the labeled streptavidin-biotin method, using affinity-purified polyclonal antibodies against cathepsin D and E. The expression of cathepsin D was observed in the cancer cells and was significantly increased in the T 4 category and in clinical stage III and IV. No significant difference was observed in the expression of cathepsins among the malignancy groups classified by Anneroth's method; medium and high malignancy groups were associated with shorter survival. The expression of cathepsin E in cancer cells was very low, and there was no correlation with any clinical or histopathological factor.View full abstractDownload PDF (3347K) -
Cleft lip in only one twinFumihiko SATO, Akihiro YAMADA, Nagato NATSUME, Teruyuki NIIMI, Shigemi ...1998 Volume 44 Issue 9 Pages 738-746
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThe development of cleft lip and palate is known to involve genetic and environmental factors. The study of twins with cleft lip is useful in the evaluation of both factors. We investigated two sets of twins, in whom only one twin had clefting, with respect to body weight, height, features, dental arch, and cephalometric analysis to compare the growth gradient.
In conclusion,
1. The facial-growth pattern of the patients with cleft lip was various.
2. There were no maxillofacial characteristics specific to patients with unilateral incomplete type cleft lip.View full abstractDownload PDF (10772K) -
Takashi OGAWA, Hiromi HARAGUCHI, Hiroshige CHIBA1998 Volume 44 Issue 9 Pages 747-749
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA three-head SPECT camera (PRISM-3000) can complete full-circle scans (360° scan) within a short time, a definite advantage over the conventional one-head SPECT unit. In addition, the clinical utility of the three-dimensional (3D) imaging system is greatly enhanced by its high-speed data processing.
In the present study, we examined patients with osteomyelitis of the mandible and submandibular carcinoma that had spread to the mandible in order to determine the value of this system.
Our results showed that 3D images provide clearer information than that provided by conventional images, and the position of bone lesions can be observed easily.View full abstractDownload PDF (6557K) -
Tamaki ASAHINA, Hideki MIZUTANI, Yasuo SUGIMURA, Ryuji KANEKO, Katsuhi ...1998 Volume 44 Issue 9 Pages 750-752
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSRheumatoid arthritis (RA) is a chronic inflammatory disease with immunologic abnormalities. Although the temporomandibular joint (TMJ) can be involved, early changes of the TMJ affected by RA are unclear, and the treatment for temporomandibular disorders (TMD) in patients with RA is not established yet. Physiotherapy is effective for general joints with RA but its effect for RA of the TMJ is unknown. The clinical effects of physiotherapy for TMD in RA patients was investigated. Five patients with RA visited our department with complaints of the TMD. Physiotherapy, including exercises of TMJ movement and mastication training were stasted, bilaterally and simultaneously. Clinical findings showed an increase in maximal interincisal distance with no pain after therapy in 4 patients. No patient had anterior open bite or TMJ ankylosis in the follow-up period (2.5 to 5.3 years). These results suggest that physiotherapy is also effective for the TMD in RA patients.View full abstractDownload PDF (2813K) -
Jitsuo NISHIHARA, Minoru MIYAKE, Takaaki OGAWA, Yumiko OHBAYASHI, Akih ...1998 Volume 44 Issue 9 Pages 753-755
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA girl aged 11 years 2 months had atrophy of the right facial region extending from the cheek to the mental region since the age of 9 years. Facial hemiatrophy was diagnosed at our department, and she received stellate ganglion block treatment for dysfunction of the cervical sympathetic nerve. Although stellate ganglion block therapy was effective in arresting disease progression during treatment, symptoms recurred after the end of the treatment. A de-epithelialized free flap graft was used to repair her facial contour.
Over the past 3 years, the patient has shown a satisfactory postoperative outcome. The graft successfully restored her facial contours with no evidence of atrophy or resorption of the grafted flap.View full abstractDownload PDF (3094K) -
Nobuyuki TANAKA, Keiichi EDO, Yutaka KIMIJIMA, Itaru NAGAI, Akihiro MI ...1998 Volume 44 Issue 9 Pages 756-758
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSLentigo maligna, which often transforms into malignant melanoma, is rare in the oral cavity. A case of lentigo maligna in the oral mucosa is presented. A 50-year-old woman visited our clinic with a complaint of pigmented spots in the maxillary buccal gingiva and palate. Clinically, we suspected malignant melanoma; however, examination of a biopsy specimen revealed lentigo maligna. After radiotherapy and immunotherapy, the lesion was resected under general anesthesia. Histological examination showed that melanocytes with cellular atypia had proliferated in the basal layers and had scattered intraepithelially. Positive staining for S-100 and Dopa was observed, but no staining for HMB-45 was observed. Electron microscopic examination revealed many high-stage melanosomes. Two years two months have passed since initial presentation, and there has been no evidence of recurrence.View full abstractDownload PDF (3588K) -
Hidenori SAKAINO, Yumiko NAGAO, Naoko SEKI, Jingo KUSUKAWA, Tadamitsu ...1998 Volume 44 Issue 9 Pages 759-761
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSMyxoma of oral soft tissue is extremely rare. It occasionally occurs in the mouth floor. We describe a case of myxoma associated with multiple polypoid masses in a child. The patient was a 13-year-old Japanese boy who had already had a polypoid mass located at the right side of the floor of the mouth at birth. When he was 8 years old, three polypoid masses newly appeared. Because the masses showed no evidence of growth, they were not treated until the patient was referred to our hospital. All masses were smooth-surfaced, fresh red, elastic-soft, and unrelated to salivary gland ducts. The masses were excised under local anesthesia. Histopathological examination of the specimen revealed loosely arranged spindle or stellate cells in edematous connective tissue beneath the mucosal epithelium. The diagnosis was a myxoma of soft tissue. There has been no evidence of recurrence as of 3 years after operation.View full abstractDownload PDF (3315K) -
Toshihiko TAKENOBU, Yoshihiko FURUKI, Norio AYASAKA, Motohiro KIMURA, ...1998 Volume 44 Issue 9 Pages 762-764
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSOsteochondroma is frequently found near the end of long bones. Osteochondromas of the facial bones, especially at the coronoid process of the mandible, are rare.
A 56-year-old Japanese woman with an 18-year history of progressive limitation of mouth opening was referred to our hospital by her dentist. The maximum interincisal opening was 2mm. A radiographic examination showed an enlarged fungiform left coronoid process. A computed tomograph in the coronal plane clearly demonstrated the relationship between the coronoid process and the surrounding bony structures. A diagnosis of benign bony tumor of the left coronoid process was made. The patient was admitted to our hospital for tumor resection, performed with the patient under general anesthesia. The coronoid process was excised horizontally at its base. Pathologic examination confirmed a 35mm×39mm mushroom-shaped osteochondroma at the left coronoid process. After the operation, a maximum interincisal opening of 20mm was achieved. Three months after the operation, sagittal oblique MR imaging demonstrated bilateral anterior disk displacement without reduction of the temporomandibular joint (TMJ). The patient was followed up for 1 year while receiving treatment for TMJ disorder.View full abstractDownload PDF (5666K) -
Takashi KURODA, Toshitaka MURAJI, Shinjiro SUZUKI, Yutaka SHINODA, Mit ...1998 Volume 44 Issue 9 Pages 765-767
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA case of desmoplastic fibroma arising in the mandible of a 13-year-old boy is reported. Radiological examination revealed a well-defined unilocular radiolucency in the right side of the mandibular body. Surgical enucleation of the tumor with curettage of the surrounding bone was done under general anesthesia. The surgical specimen measured 23×23×15 mm. Histopathologically, the tumor was composed of small fibroblast-like cells and abundant collagenous fibers. There has been no evidence of local recurrence as of 2 years after operation.View full abstractDownload PDF (3165K) -
Masatoshi ISHII, Yoshimasa ISHII, Hitomi TODA, Takashi MORIYAMA, Shoji ...1998 Volume 44 Issue 9 Pages 768-770
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA very rare case of multinodular myofibromatosis involving a wide area of the mandible is presented. Myofibromatosis is a benign localized or generalized proliferation of fibroblastic tissue occurring exclusively in infants or children. Most lesions are recognized as dermal or subcutaneous nodules, but lesions rarely develop in the skeleton or internal organs. Our patient was a 15-year-old girl with buccal and submandibular swelling. Roentgenographic examination revealed a large well-demarcated radiolucent area. Segmental resection of the mandible was performed, and follow-up showed no evidence of recurrence. Microscopically, the tumor was multinodular and surrounded by a fibrous capsule. It was characterized by irregular fascicles of fibrous tissue alternating with a central hemangiopericytoma-like pattern.View full abstractDownload PDF (3302K) -
Nobuko ITO, Masashi HATORI, Toshiaki TAKEMI, Masato MANABE, Saburo KAK ...1998 Volume 44 Issue 9 Pages 771-773
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSA case of deep neck infection with severe dyspnea secondary to odontogenic infection is reported. The patient was a 55-year-old man with marked swelling in the left buccal, submental, and cervical regions. CT scanning revealed multiple areas of gas formation in the infected regions, resulting in severe stricture of the airways. The patient was successfully treated by emergency tracheotomy for dyspnea an extensive incision was made to promote pus discharge, and antibiotics were administered.View full abstractDownload PDF (2973K) -
Hajime MINAZAWA, Kohzo TSUCHIKAWA, Nobuhiko NINOMIYA, Kazuhiko HIROYAS ...1998 Volume 44 Issue 9 Pages 774-776
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSOsteochondritis dissecans is well known among orthopedic surgeons. It frequently affects the knee, ankle, elbow, and hip joints. However, there have been very few reports of osteochondritis dissecans of the temporomandibular joint (TMJ), because of its rarity.
This report describes a case of osteochondritis dissecans in the left TMJ of a 63-year-old woman who visited our clinic because of swelling, pain, and limitation of mouth opening. The presurgical diagnosis was established as synovial osteochondromatosis on the basis of clinical symptoms and radiological studies, including CT scan, MRI, nd bone scintigraphy. Surgical intervention into the affected TMJ was executed via a temporo-preauricular incicion. The mandibular head was enlarged, and pannus-like tissue was observed in the lower joint space, running from the anterior ligament of the disc into the anterior portion of the mandibular head. A bone chip was found in the pannus-like tissue. The histopathological findings confirmed the diagnosis of osteochondritis dissecans. The patient's postsurgical course was excellent, and maximal mouth opening increased from 28mm to 36mm without any discomfort.View full abstractDownload PDF (2909K) -
Takahiro MIYASAKA, Yohsuke IWASHIGE, Masatoshi ADACHI, Tazuko SATOH, M ...1998 Volume 44 Issue 9 Pages 777-779
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe describe a case of intravascular fasciitis. A 24-year-old Japanese man visited this hospital in November 1994 because of swelling of the upper lip. Ultrasound examination showed a hypoechoic mass, measuring 10 mm in diameter, with slightly illdefined margins in the upper lip. The mass was ellipsoid and flat, and its inner echo level was heterogerous. Under local anesthesia, the patient underwent resection of the mass. On the basis of these clinical and histopathological findings, we made a diagnosis of intravascular fasciitis of the upper lip. The patient made steady progress after the operation.View full abstractDownload PDF (3634K) -
Kiichiro SAITO, Hideaki SAKASHITA, Masaru MIYATA, Koichi OKABE, Motoi ...1998 Volume 44 Issue 9 Pages 780-782
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThyrogrossal duct cyst is a congenital anomaly resulting from retention of a thyroglossal duct during embryologic development. This cyst commonly occurs in children. Usually, these cysts are reported from departments of otorhinolaryngology or pediatric surgery. Reports of thyroglossal duct cyst are very rare in oral and maxillofacial surgery. In this report, a rare case of polycystic thyroglossal duct cyst in an elderly patient is described.View full abstractDownload PDF (6085K) -
Hiroyuki YAMADA, Kanichi SETO, Masaro MATSUURA, Makoto NAKAMURA, Susum ...1998 Volume 44 Issue 9 Pages 783-785
Published: September 20, 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe report on a 7-year-old boy in whom a wooden foreign body was found in the temporal region. A wooden foreign body was not suspected initially, because there was no past history of trauma according to the patient and his parents. A thumb-sized mass, suspected to be a malignant tumor, was found in the left temporal region of the head. Plain radiography, computed tomography, and magnetic resonance imaging revealed no evidence of a wooden foreign body. Diagnosis was difficult, and the wooden foreign body was detected on a second surgical exploration.View full abstractDownload PDF (2952K) -
1998 Volume 44 Issue 9 Pages e1
Published: 1998
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSDownload PDF (33K)
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