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Volume 38, Issue 10
Displaying 1-20 of 20 articles from this issue
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Toshiyuki SHIBATA, Ituo CHIBA, Takanori MIZUKOSHI, Hirofumi MURASE, Ki ...1992 Volume 38 Issue 10 Pages 1489-1497
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe have previously reported that the 3-methylcolanthrene-induced rat fibrosarcoma KMT-17 cell line and its subclone A3 shed a tumor-associated antigen (TAA), termed CE7, from the cell surface and that this phenomenon might play a role in an immunological escape mechanism. We also reported that CE7-antigen shedding was inhibited by low dose (30 Gy) X-irradiation in vivo or in vitro, the antigen was expressed on the cell surface and the immunogenicity of CE7-antigen expressing cells was enhanced. The purpose of this study was to examine whether this CE7-antigen shedding is inhibited by the antitumor d rugs bleomycin (BLM), mitomycin C (MMC) and cyclophosphamide (4H-CY) and to clarify the mechanism of antigen shedding. We found that CE7-antigen shedding was inhibited following treatment with these antitumor drugs in vitro. When FCS concentration in media was changed, CE7-antigen expression was enhanced parallel to the extent of inhibiti on of cell growth (prolonged doubling time). We demonstrated CE7-antigen in A3 cells grown in 10% FCS medium by Western blotting. A large amount of CE7-antigen was localized in the cytoplasm of the cells. These results suggest that A3 cells in 10% FCS medium produce CE7-antigen, store it in the cytoplasm and shed it from the cell surface in vesicular form and that antitumor drug treatment inhibits vesicle production, enhancing CE7-antigen expression on the cell surface.View full abstractDownload PDF (2651K) -
Atsushi SATO1992 Volume 38 Issue 10 Pages 1498-1507
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThis study was undertaken to examine whether the production of active oxygen species by bleomycin (BLM) could be enhanced by various cytokines in human neutrophils.Peripheral blood neutrophils were obtained from normal volunteers, and the production of superoxide radical (O-2) and the generation of luminol dependent chemiluminescence (LDCL) were measured by the cytochrome C reduction method and an ATP photometer, respectively. IL-1α, IL-1β, IL-2, IL-6, IL-8, G-CSF, IFN-γ, and TNF-α were used as cytokincs, and neutrophils were treated with these cytokines for 10 minutes at 37°C. Phorbol myristate acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (FMLP) were used as stimulants of O-2 and LDCL production, respectively.
The results of these experiments revealed slight production of O-2 from neutrophils by BLM, and the production of O-2 by PMA was enhanced by BLM concentrations over 0.3 μg/ml. With a concentration of 2, 500 U/ml of IFN-γ, and at concentrations over l ng/ml of TNF-α, small amounts of O-2 wcre produced without the stimulants or BLM. Thc production of O-2 by BLM was enhanced by IL-1α, IL-1β, IL-8, G-CSF, IFN-γ and TNF-α, that produced by PMA was enhanced by IFN-γ or TNF-α, and O-2 produccd by BLM and PMA in combination was enhanced by IL-8, G-CSF, IFN-γ and TNF-α.
These results suggest that the production of active oxygen species by BLM in vivo may be enhanced by these cytokines, except for IL-2 and IL-6. Through this mechanism, cytokines might enhance the antitumor activity of BLM.View full abstractDownload PDF (1218K) -
Kuninori SASAOKA1992 Volume 38 Issue 10 Pages 1508-1523
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThe antigenicity of two products of hydroxyapatite (HAP), supplied by two Japanese manufacturers, and three products of tricalcium phosphate (β-TCP), supplied by two Japanese and one American manufacturers, was studied by means of delayed type skin reactions in guinea pigs.
Skin reactions were elicited by injection of the ceramic into the dorsal skin 13 or 14 days after being immunized by intradermal injection of HAP or β-TCP into the dorsal flanks or footpads of guinea pigs.
After 24 hours. skin reactions were assessed by measuring the diameter of erythema and the degree of hemorrhage and induration.
The results were as follows:
1. Antigenicity was not detected for the HAP obtained from Asahi Optical Co., Ltd. and LION Co., Ltd.(self setting α-TCP) by means of skin reactions.
2. Antigenicity was not detected for the β-TCP obtained from Asahi Optical Co., Ltd. and Kyocera Co., Ltd.
3. In contrast, β-TCP from MITER, INC, USA (Synthograft®) induced delayed type hypersensitivity (DTH) 24 hours after antigen elicitation. The reaction appeared to be based on tuberculin and Jones-Mote types of reactions.
4. In the present study, Arthus reaction was not seen in any group of animals, indicating that HAP and β-TCP did not induce antibody formation.View full abstractDownload PDF (9597K) -
Kiyoshi SEGAWA, Mitsuhiro ENDO, Eisuke NARA, Keigo KUDO, Yukio FUJIOKA ...1992 Volume 38 Issue 10 Pages 1524-1527
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe have studied a patient with osteolysis, considered to be the initial stage of massive osteolysis suggesting a mandibular cyst, is whom an iliac bone graft was performed.
The patient was a 33-year-old male referred to our hospital for spontaneous pain on the left side of the mandible. Radiographic examination revealed that the affected site of the mandible included a mandibular canal and exhibited an oval cyst-like radiolucent image with an unclear boundary. Surgery was performed under systemic anesthesia and included extirpation and curretting of the affected region as well as an iliac bone graft. Pathologically, cortical bone and bone marrow of the mandible were completely replaced by dense and irregular collagen fibers, and abundant iron pigment was deposited in fibrous tissues. The inferior alveolar nerve was normal, but the inferior alveolar artery was extremely narrow.
At present, 2 years and 4 months postoperatively the bone graft site shows almost complete osseous concrescence both clinically and radiologically.View full abstractDownload PDF (4430K) -
Pathological investigation of tumor-invaded skin lesionsKen-ichi NOTANI, Akira SATOH, Kanchu TEI, Hiroshi FUKUDA, Masanobu SHI ...1992 Volume 38 Issue 10 Pages 1528-1533
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSFourteen skin tumors derived from oral squamous cell carcinomas were studied clinicopathologically. All tumors underwent curative resection in our department and showed pathological evidence of skin invasion.
Skin invasion was typically situated in the regions of the face and neck adjoining the primary site. In all cases diffuse types of invasion (grade III and IV) predominated according to Willen's mode of invasion. However, there were no differences between recurrent and non-recurrent skin tumors in the mode of invasion or the WHO histological grade of the primary tumor. Histologically recurrent skin tumors were characterized by higher levels of invasion into capillaries, nerves, periosteum and bone, compared with non-recurrent skin tumors.
Cancerous nests of recurrent skin tumors were small and cord-like in shape. All cases with satellitosis were recurrent.
Evaluation of the histological effects of preoperative irradiation on the skin tumors by the Shimozato-Oboshi classification indicated low effectiveness in the majority of cases. There were no differences in histological effects between recurrent and non-recurrent skin tumors.
Lymph node metastases were found in 11 cases, the majority of which were recurrent.
Distant metastases were found in only 2 cases, both of which were reccurrent.
Based on these results, a safe surgical margin for the resection of skin tumors derived from oral squamous cell carcinomas was investigated.View full abstractDownload PDF (875K) -
Shin-ichiro HIRAKI, Masanobu OHNISHI, Michiya NAGANO, Naohiro HASHIKAW ...1992 Volume 38 Issue 10 Pages 1534-1541
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThe effect of sizofiran (SPG) on tumor-infiltrating lymphocytes was studied in 9 patients with oral cancer. Five patients were treated and 4 served as control.
SPG was administered intramuscularly 7 days before surgery and locally 3 days before surgery. Lymphocyte subpopulations were assayed by flow cytometry for peripheral blood. Lymphocytes infiltrating into tumor tissue and cervical lymph nodes were evaluated immunohistochemically by ABC staining technique. The monoclonal antibodies employed were Leu 2a, Leu 3a, Leu 7, Leu 11b, IL-2R and Leu M3.
In the peripheral blood, CD16-positive cells increased significantly after SPG treatment. In local tumor tissue, CD4-, CD8-, CD16-, CD57-, and CD14-positive cells increased. metastatic neck lymph nodes, CD4-, CD8-, and CD25-positive cells increased.
SPG apparently enhances the immunological response of oral cancer patients in the peripheral blood, tumor tissue and metastatic cervical lymph nodes, thereby resulting in antitumor effect.View full abstractDownload PDF (6080K) -
Quality of life (QOL) questionnaire designed for patients with oral cancer: Development and validitySusumu OMURA, Sonou KOBAYASHI, Ken ITO, Shinjiro AOKI, Satoshi UMINO, ...1992 Volume 38 Issue 10 Pages 1542-1549
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSWe studied the feasibility of using a questionnaire modified from the “Functional Living Index: Cancer” to measure the quality of life (QOL) in groups of patients with, oral cancer.
The questionnaire consisted of 20 questions based on a 5-grade scale for all questions. The overall QOL score was derived by summing the scores from all questions. The questionnaire was used to evaluate 62 patients. The criteria used were consistency of measurement, reliability, and suitability as measured against performance status and Lorish's face scale.
1. One-way analysis suggested that 4 of the 20 questions did not provide consistent data.
2. Cronbach's alpha index was greater than O.8, which indicates a high degree of reliability.
3. One-way analysis of variance and Kruskal-Wallis test showed that QOL score was significantly correlated (P<0.001) with the results for performance status and face scale, which suggests sufficient criterion-related validity.View full abstractDownload PDF (881K) -
Yasuhiro NAKAYAMA, Kohzo TAGAMI, Hajime URAOKA, Masahiro IWATA, Masayu ...1992 Volume 38 Issue 10 Pages 1550-1557
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSThirteen patients with oral squamous cell carcinomas, consisting of 11 previously untreated and 2 recurrent cases, were treated with cisplatin (CDDP 50-1, 000 mg/m2) on Day 1 followed by 96-or 120-hour continuous infusion of 5-fluorouracil (750-1, 000 mg/body/day) as one course of therapy. Each case received one or two courses. The 11 previouslyuntreated patients initially underwent this treatment regimen as preoperative chemotherapy. The effect of treatment and associated complications were as follows:
1. Complete response (CR) was achieved in 2 and partial response (PR) in 7 of the 13 cases. The overall response rate was 69.2%.
2. The 2 recurrent cases did not respond to treatment. The response rate in the 11 previously untreated cases was 81.8%.
3. The principal adverse reaction was gastrointestinal disturbances, but symptoms were able to be controlled. Signs of hematologic toxicity and renal disturbances were mild and did not preclude the continuance of therapy.
4. Eight of the 9 responders have not shown signs of recurrence 4-21 months after initiating therapy.
The results of this study indicated that combined chemotherapy with cisplatin and 5-FU was highly effective for the local control of oral squamous cell carcinomas.View full abstractDownload PDF (4458K) -
Toshio SUGAHARA, Yoshihide MORI, Tomoaki KAWAMOTO, Katsuhiro MINAMI, K ...1992 Volume 38 Issue 10 Pages 1558-1563
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSIn a series of 43 cases treated for mandibular prognathism by sagittal-split osteotomy, the change in mandibular position effected by surgery and the degree of relapse 6 months postoperatively were analyzed using lateral cephalograms. In addition, the post-surgical stability of the mandible was compared for prognathism with and without open bite.
Overall, the mean changes in vertical and horizontal skeletal parameters were generally small. Post-surgical vertical relapse of prognathism with open bite was larger than that without open bite. Multiple regression analysis did not reveal any association between preoperative morphological pattern and postoperative relapse. Based on these results, the etiology of relapse was discussed.View full abstractDownload PDF (780K) -
Shinichiro TERASAKI, Chihiro KOGA, Shisei TOYOFUKU, Tadamitsu KAMEYAMA ...1992 Volume 38 Issue 10 Pages 1564-1565
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
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Ikuhiro UCHIDA, Yoshiaki KOMIYA, Hideki KIZU1992 Volume 38 Issue 10 Pages 1566-1567
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
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Takashi OKUDA, Tadashi YASUOKA, Kazuo ABE, Tadashi OKUTOMI, Norichika ...1992 Volume 38 Issue 10 Pages 1568-1569
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
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using with PCNA immunohistochemical staining: a case reportYoshiyuki OHNISHI, Gaku YAMAMOTO, Shintaro SAWATARI, Shyu YAMAMOTO, Ta ...1992 Volume 38 Issue 10 Pages 1570-1571
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
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Carcinoma of the lower gingivaToshiaki KAWABATA, Tomio ISEKI, Kazuhiro MATSUMOTO, Moritaka SHIMA, Ry ...1992 Volume 38 Issue 10 Pages 1572-1573
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
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Takafumi OGURA, Suguru HAMADA, Hidekazu YAMADA, Kazuo TSUBAKI, Tokuzo ...1992 Volume 38 Issue 10 Pages 1574-1575
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
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Tomoyasu NAKAMURA, Susumu IIDA, Noriaki IKEDA, Toshihiko KAWAI, Tsuyos ...1992 Volume 38 Issue 10 Pages 1576-1577
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
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Mitsuhiro IWATA, Akira SASAKI, Yasuto YOSHIHAMA, Tomohiro MATSUMURA1992 Volume 38 Issue 10 Pages 1578-1579
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
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Hiroshi MASUDA, Kenji KAWANO, Rintaro MATSUSHIMA, Harumi MIZUKI, Shige ...1992 Volume 38 Issue 10 Pages 1580-1581
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
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Kazuhisa FUJIMOTO, Hiroyasu TAMAKI1992 Volume 38 Issue 10 Pages 1582-1583
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
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Masanori IWASA, Kaihei HAYASHI, Toshiyuki OGASAWARA, Naoto NISHIDE, Ma ...1992 Volume 38 Issue 10 Pages 1584-1585
Published: October 20, 1992
Released on J-STAGE: July 25, 2011
JOURNAL FREE ACCESSDownload PDF (2979K)
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