Major salivary glands, parotid, submandibular and sublingual glands, secrete serous and mucous saliva via the proper excretory ducts connecting between oral cavity and glandular bodies. Discovery of the salivary ducts in 17th century established the concept of exocrine secretion as well as salivary glands. In more recent investigations have revealed the endocrine functions of salivary glands by a variety of cell growth factors produced by granular ducts. In the present review describes the macroscopic findings of human major salivary glands and the microscopic differences of human and rodent salivary glands.
Various biomaterials, as well as autologous mucosal or skin grafts, have been applied to open wounds after partial glossectomy. We clinically evaluated postoperative pain and scar contracture in 37 patients who underwent partial glossectomy followed by covering with a polyglycolic acid （PGA） sheet and fibrin glue spray, as compared with 31 patients in whom an artificial dermis was used.
NSAIDs were administered for an average of 7.2 days postoperatively in the artificial dermis group and 5.9 days in the PGA sheet group. Scar contracture in patients with tongue cancer was milder in the PGA sheet group than in the artificial dermis group, although those with intraepithelial lesions showed minimal scar contracture in both groups.
These findings showed that the application of a PGA sheet and fibrin glue for open wounds of partial glossectomy was useful for promoting early oral feeding, rapid relief from postoperative pain, and prevention of scar contracture.
We report a rare case of spindle cell lipoma of the cheek. The patient was a 67-year-old man who visited our department because of a painless mass of the left cheek. A clinical examination revealed a mobile, painless mass of the left cheek, measuring 30 mm × 15 mm. Magnetic resonance imaging showed a well demarcated, internally homogeneous mass. The tumor was removed surgically under general anesthesia. Histopathological examination of the surgical specimen showed a spindle cell lipoma. There have been no signs of recurrence in the approximately 1 year since the operation.
Solitary fibrous tumors （SFTs） are rare lesions with a predilection for developing in the pleura. Recently, SFTs have been occasionally reported to occur in other regions, including the head and neck. Clinically and histologically, 13 ％ to 37 ％ of pleural SFTs show malignant behavior, but extrapleural SFTs are hardly ever malignant. However, extrapleural SFTs have been reported to recur or to become malignant in the oral cavity. We report on a 38-year-old Japanese woman who presented with a recurrent SFT of the mouth floor, which had been diagnosed as angioleiomyoma and resected 8 years previously. Histological and immunohistochemical re-examination of present and past specimens revealed that this was a case of recurrent SFT. Because recurrent SFT in the oral region has not been reported previously, its clinical behavior is poorly understood. Our case emphasizes that oral SFTs should be followed over the long term because of their intermediate malignant behavior.
Adenomatoid odontogenic tumor （AOT） is composed of odontogenic epithelium in a variety of histoarchitectural patterns. It often occurs around a maxillary canine tooth. Rarely, AOT extends into the nasal cavity and maxillary sinus. We describe a case of AOT that arose in the maxilla and extended into the maxillary sinus.
The patient was 33-year-old woman who went to a local dental clinic and was underwent panoramic X-ray examination. A radio-opacity was noted in the right maxillary sinus, and she consulted the department of dental surgery of a certain hospital. A biopsy was performed under local anesthesia, and the pathological diagnosis was AOT. She was then referred to our hospital for further evaluation and treatment.
Mild swelling was found in the right cheek. A bony hard gingival bulge was palpated on the labial side of the gingival mucosa, corresponding to the right maxillary first to third teeth. Computed tomography revealed a welldefined radiolucent image including an impacted tooth in the right maxillary sinus. The region contained small radiolucent calcifications. The tumor strongly compressed the bottom of the maxillary sinus and the nasal cavity. Tumor resection and impacted tooth extraction were performed under general anesthesia. Currently, the postoperative course is favorable at 24 months.
Pycnodysostosis is a rare autosomal recessive skeletal dysplasia characterized by short-limbed dwarfism, acroosteolysis, and a specific facial appearance associated with dysplasia of the jaw. We report the treatment of osteomyelitis of the mandible in a patient with pycnodysostosis that had not been diagnosed until 60 years of age. The patient visited our department because of buccal phlegmon arising from mandibular osteomyelitis. Pycnodysostosis was diagnosed on the basis of osteomyelitis of the jaw and other physical findings. He was treated under hospitalization. First, anti-inflammatory treatment of the right buccal phlegmon was performed. Subsequently, sequestrectomy was performed, and an external dental fistula was simultaneously constructed using the rhomboid-to-W technique. There has been no recurrence of acute inflammation, and the postoperative course has been favorable up to the present （2 years 10 months after operation）. However, the patient is being very closely followed up because the formation of a new sequestrum.
Perineurioma is a rare peripheral nerve sheath tumor of well-differentiated perineurial cells that presents as a soft tissue tumor and an intraneural tumor with distinctive clinicopathlogical features. We present a case of intraneural perineurioma that originated from perineurial cells of the alveolar nerve sheath.
The lesion appeared as a tip-of-thumb-sized radiolucency in the first molar region of the right mandibular body. The lesion was enucleated with the involved part of the inferior alveolar nerve. Histopathologically, tumor cells were arranged in pseudo-onion bulb structures, with scattered collagen bundles. Immunohistochemical staining was positive for epithelial membrane antigen （EMA）. The pathological diagnosis was intraneural perineurioma. There has been no evidence of recurrence for half a year after surgical extirpation.
Oblique facial cleft is a very rare congenital anomaly. Little has been published about the surgical treatment of facial and palatal clefts in such cases.
We encountered a patient with Tessier No. 4 and No. 5 oblique facial clefts accompanied by an atypical bilateral palatal cleft in Mexico during a charity medical campaign. This campaign is supported by Japan International Cooperation Agency (JICA), the mission of which is to bring surgical treatments to Mexican patients with clefts who have difficulties in receiving medical treatments because of economic reasons.
We repaired the facial clefts when the patient was 14 months old, and previously reported a summary of the treatment.
We now describe the details of palatoplasty applied to the atypical bilateral cleft palate of the patient. Because the palatal clefts were so wide and asymmetric’conventional push-back palatoplasty was not applicable. We used a modification of double opposite Z plasty, proposed by Furlow in 1972, for palate surgery. The patient’s age was 2 years 3 months. Since the patient had microphthalmia in the right eye, we also placed an ocular prosthesis in the right orbital cavity to retain the bone structure of the midface.