Alveolar-arterial O
2 tension difference (AaD
O2, ) and arterial-alveolar N
2 tension difference (aAD
N2) were measured on 434 subjects, comprising of 67 normal healthy and 367 chest patients. Attention was focused upon the subjects who demonstrated abnormally increased AaDs but who remained normal or only minimally abnormal by their ventilatory capacity.
AaD
C2 obtained on the 67 healthy subjects on supine position was 4.1±0.4 (mean±1S. E. E.) mmHg with 5% rejection upper limits of 9.8mmHg. aAD
N2 on the referred healthy subjects was 2.2±0.3mmHg with 5% rejection upper limlts of 5.5mmHg.
AaD
O2 for 243 bronchitis patients was 22.4±0.7mmHg, that for 22 asthmatics was 21.3±2.6mmHg, that for 25 emphysematous patients was 30.4±2.0mmHg and that for 30 pulmonary fibrotic patients was 32.8±2.6mmHg. aAD
N2 for each overmentioned group of subjects were 12.7±0.5mmHg, 8.7±1.6mmHg, 22.1±1.5mmHg and 16.4±1.9mmHg, respectively.
Among 243 bronchitic patients included were the patients demonstrated any detectable clinical evidence of small airway damage. These subjects revealed ventilatory capacity within normal limits or minimal ventilatory impairment. AaD
O2 and aAD
N2 obtained on these 175 patients were 25.7±0.8mmHg and 15.2±0.5mmHg, respectively.
In the present study the author established the normal diagnostic level both for AaD
O2 and aAD
N2 and, based on the results, he further discussed the impaired ventilation-perfusion ratio distribution in the lungs with regard to AaD
O2 and aAD
N2 on the patients with assumingly “so-called bronchiolitis syndrome”.
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