The purpose of the present study was to investigate the radiologic and histologic findings of bronchogenic carcinoma with asbestosis, in comparison to those of bronchogenic carcinoma without exposure to asbetos.
Sixteen cases were observed, 15 out of them being male, and their peak age group was 50-59, compared with 60-69, in the unexposed.
There was no relation between the duration of exposure, grade of asbestos lung and the association of malignancy. Even with a short sufficient exposure, pulmonary malignancy may follow many years later. The interval from initial exposure until the development of the neoplasm was about 32 years.
Peripheral type bronchogenic carcinoma associated with asbestosis numbered 14 out of the 16. Among them, 9 (64.3%) were in the lower lobes. However, 13 (37.3%) out of 35 bronchogenic carcinomas without exposure were in the lower lobes. Therefore, the ferquency of such tumors arising in the lower lobe was higher in the asbestos group.
Radiologic findings of peripheral bronchogenic carcinoma without exposure show some characteristic signs, such as, linear shadows through the tumor shadow, short radiating shadows surrounding the tumor shadow, notching or pleural indentation. But, in bronchogenic carcinoma associated with asbestosis, these characteristic signs were rare.
Resulting from the careful observation of histologic specimens of bronchogenic carcinoma associated with asbestosis, the frequency of epidermoid carcinoma, adenocarcinoma and large cell carcinoma were found to be similar. Furthermore, a mixed type was often observed. It is concluded that cell types of these carcinomas were rich in variety.
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