In order to investigate the metabolism of fatty acids in lung cancer patients, fatty acid composition was studied in the serum of 71 cases of lung cancer and 43 normal subjects or cases of other lung diseases, and in the autopsied lung tissue of 18 cases of lung cancer and 17 cases of cancer of other organs or other non-pulmonary diseases. The results obtained were as follows:
1. In fatty asids composition of serum, increase of C
16 and C
18=1, and decrease of C
18=2 and C
20=4 were observed in lung cancer compared with normal controls. However, no changes were seen according to age.
2. In lipid fractions of serum in lung cancer, increase of C
16 and decrease of C
18=2 in ChE, increase of C
18=1 and decrease of C
18 in FFA, and increase of C
16 and decrease of C
18=2 and C
20=4 in PL were observed compared with normal controls.
3. In lung tissue, fatty acid composition in cancer tissue showed a decrease of C
16 and an increase of C
18=1 and C
20=4 compared with normal tissues. The changes of C
16 and C
20=4 in cancer tissue were inversely proportional to those in serum.
4. In lipid fractions of lung tissue, decrease of C
16 and increase of C
18=1 and C
20=4 in ChE, and decrease of C
16 and increase of C
18=1 in PL were observed in cancer tissue compared with normal tissues. The changes of C
16 in ChE and PL in lung tissue were inversely proportional to those in serum.
5. Changes in C
16 and C
20=4 in serum were observed in subjects who had liver dysfunction, however, no changes were observed in lung tissue.
6. The effect of treatment on total lipids was observed in lung cancer, i. e., C
16 and C
18=2, and C
18=1 tended to normlize with FEM, FT-207,
60Co and BLM+
60Co, and
60Co and BLM+
60Co, respectively.
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