巻号一覧
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
75 巻, 7-9 号
選択された号の論文の19件中1～19を表示しています
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第1編 制癌剤および制癌強化剤の抗腫瘍性効果,並びに担癌生体酵素代謝に及ぼす影響に就いて松浦 梅春1963 年 75 巻 7-9 号 p. 591-616
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーIn is known that cancer research has been concentrated to make a correlation between cancer and its bearing hosts. An attempt was made to study anticancer effect and enzyme metabolism under the administration of anticancer agents and their supporting substances in order to destruct cancer cells and increase biological resistance of its bearing mice. The results obtained are as follows:
1) Marked prolongation in survival period and inhibition of ascites were obtained in cancer bearing mice under mitomycin administration, but the administration of its large dosage in contrast, inhibited a prolongation of survival period and also made a loss of body weight. The combined administration of anticancer agents and their supporting substances manifested the most remarkable prolongation in survival period. Amongst three anticancer supporting substances, orotic acid made the greatest prolongation of survival period as well as marked inhibition of ascites. Glucuronic acid made the same results in less degree.
2) Mitomycin had a marked effect to inhibit the depression of catalase activity in liver and kidney of cancer bearing group, although mitomycin itself had a tendency to decrease catalase activity in liver and kidney of normal group.
3) Anticancer supporting substances, orotic acid and glucuronic acid markedly increased catalase of liver in normal group and inhibited the tendency of its decrement in cancer bearing group.
4) Anticancer agents showed the same tendency to saccinic dehydrogenase activity as to catalase.
5) S-GOT and S-GPT slightly increased in cancer bearing group. They were intensively improved under the combined administration of anticancer agents and their supporting substances.抄録全体を表示PDF形式でダウンロード (1848K) -
第2編 制癌剤および制癌強化剤の担癌生体核酸代謝に及ぼす影響,並びに癌細胞分裂像との相関に就いて松浦 梅春1963 年 75 巻 7-9 号 p. 617-632
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーNucleic acid metabolism of tumor itself and liver in cancer bearing mice, DNA matabolism of intraperitoneal free cancer cells were measured by microspectrophotometer (MSP) and their correlation with cancer cell proliferation were analyzed under administrations of anticancer agents and their supporting substances. The results obtained are as follows:
1) The ratio of RNA to DNA is approximately 2.6 in liver of normal mice. DNA was considerably increased in cancer bearing group, and was about 2.5 times greater than that of normal group.
2) Mitomycin inhibited DNA metabolism of tumor, also inhibited DNA assimilation in liver of tumor bearing mice. Anticancer supporting substances, especially orotic acid, in contrast, could hardly cause any change in DNA metabolism of tumor, but slightly increased RNA metabolism.
3) With regard to nucleic acid metabolism in cancer cells, DNA inhibited cell counts were increased and octoploid cell counts were decreased in case of mitomycin administration. On the other hand, three peak type of cellular arrangement was obtained in case of the administration of supporting substances, showing disturbance of DNA assimilation process.
4) Mitomycin caused disturbance of cell proliferation in early stage of administration course, and also abnormal proliferation and cell destruction. The supporting substances, on the other hand, did not cause any disturbance in process of normal proliferation but accelerated the original degeneration process of tumor eclls as if to drive t mor cells to the final stage of necrosis.抄録全体を表示PDF形式でダウンロード (15865K) -
第3編 制癌剤および制癌強化剤の担癌生体血清蛋白代謝に及ぼす影響,並びに血清電解質代謝との相関に就いて松浦 梅春1963 年 75 巻 7-9 号 p. 633-644
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーMetabolisms of serum protein and electrolytes in cancer bearing mice were studied to correlate with the effect of anticancer agents and their supporting substances administration. The results obtained are as follows:
1) Serum albumin was decreased in course of cancer progress, which was in negative correlation with ascites increment.
2) Serum Ca tended to decrease, K to increase and Na to fluctuate erratically.
3) The combined administration of anticancer agents and their supportiog substances improved more the liver function to accelerate the assimilation of serum protein and the anticancer resistance, and also improved more serum Ca metabolism than single administration of the anticancer agents in cancer bearing mice.抄録全体を表示PDF形式でダウンロード (8450K) -
松浦 梅春, 佐藤 実, 佐々木 澄治1963 年 75 巻 7-9 号 p. 645-648
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーIt has been known that there are numerous reports in Europe and America but few in Japan with regard to ulcerative colitis of which the first report was done by Wilks and Moxon in 1875, especially to segmental ulcerative colitis. This is the report of one case of our experience. The colitis was localized at right colon with typical pseudopolyposis and was undergone surgery resulting in a complete cure.
Segmental ulcerative colitis tends to originate at right colon and extend toward both oral and anal directions, and it is, therefore, mandatory to resect it surgically when it is localized at right colon, so-called at the stage of the right-sided colitis. In order to fulfill it with making the early diagnosis, the x-ray examination should be very carefully done at right colon in clinically suspected case of ulcerative colitis without any abnormal finding at romanoscopic examination.抄録全体を表示PDF形式でダウンロード (2202K) -
第1編 実験的てんかん焦点に対するアモバルビタールソーダ頸動脈注射の影響に関する研究八木 健1963 年 75 巻 7-9 号 p. 649-663
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーTwenty adult cats were utilized for this study under unanesthetized condition. Penicillin was locally given in various parts of cortex and subcortical nucleus or thalamus to elicit epileptogenic discharges and sodium amobarbital was intracarotidly injected to give arise transient functional depression of hemisphere. EEG was followed up in the course of this experiment.
1) Local application of penicillin into cortex or subcortical nucleus or thalamus considerably elicited epileptogenic discharges.
2) In case of focal cortical epileptogenic discharge, the first spike appearing at the neighbouring area of the focus was followed to be associated with the synchronous spike discharge at the opposite side and then the focal seizure discharge was built. The discharge was occaionally interrupted by the interictal state, building, in some of the cases, the final stage of generalized seizure discharge.
3) So was noted in its appearance and process in case of focal subcortical epileptogenic discharge. But there was a more tendency of transmission of its activity to the opposite side in comparison with the cortical epileptogenic discharge.
4) The epileptogenic discharge originated from unilateral cortical focus was abolished or inhibited by means of ipsilateral intracarotid injection of 5 to 10 mg sodium amobarbital, but was not affected by the contralateral administration. However, either side of the injection could not inhibit the discharge activity after it became a focal seigure discharge.
5) Subcortically elicited epileptogenic discharge, in contrast, could not be interfered by either side of the intracarotid administration.
6) In cases of both focal cortical and subcortical discharge, intracarotid injection of sodium amobarbital manifested a tendency of flattening and slowing of back ground activity at the injected side, but not at the opposide side.
7) The intracarotid administration could not activate the epileptogenic discharges either from cortex and subcortex.抄録全体を表示PDF形式でダウンロード (24262K) -
第2編 アモバルビタールソーダ頸動脈注射の脳波基礎律動に及ぼす影響に関する臨床的研究八木 健1963 年 75 巻 7-9 号 p. 665-673
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーAn attempt was made to analyze the changes of EEG secondary to the intracarotid injection of 50 to 100 mg of sodium amobarbital: 33 trials on 20 patients.
1) There appeared to be a marked change in all cases; limited or dominant ipsilaterally to the side of administration.
2) The latter was found in 22 out of 33 trials, and noted at the records of the frontal leads.
3) The change was composed of high amplitude and low frequency or of low amplitude and high frequency or of the mixed of both, occurring at 3 to 6 seconds after the onset of the injection and gradually disappearing to regain the normal state within 30 minutes.
4) These changes, especially the high amplitude and slow waves immediately after the injection at the same side were markedly noticed when the injection was in large dosage and in high speed.
5) There was no difference in such changes given arise by either side of administration in the same patient.
6) It is to be noted that there were no hazardous complications at the intracarotid injection of 10% sodium amobarbital under sufficient attention.抄録全体を表示PDF形式でダウンロード (10408K) -
第3編 1次的及び2次的両側同期性棘徐波複合の鑑別に関する臨床的研究八木 健1963 年 75 巻 7-9 号 p. 675-693
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーIntracarotid injection of 50 to 100 mg of 5 to 10% sodium amobarbital was given to 30 cases of epileptics, and change of the abnormal EEG was followed.
1) Unilateral focal cortical epileptogenic spikes were abolished by the ipsilateral administration, but not by the contralateral.
2) Amongst the cases of bilaterally synchronous spike and wave complex, two types of marked responses were obtained at the administration. One group manifested an abolishment of the complex from all leads of both hemispheres by administration on one side, but a transient inhibition of the spike component from the ipsilateral hemisphere by administration on the other side. This appears to indicate the complex originates from unilateral cortical focus which is located at the first side. This group may correspond with the secondary bilateral synchrony.
3) Another group manifested a transient inhibition of the spike component from ipsilateral hemisphere without abolishment of the complex at either side of administration. This may correspond with the primary bilateral synchrony, the so-called “centrencephalic origin”.
4) No activation of characteristic abnormal activities in epileptics was found at the intracarotid injection of sodium amobarbital.抄録全体を表示PDF形式でダウンロード (34122K) -
山本 道夫, 塩飽 健, 青野 要, 田辺 正忠, 勝俣 直躬, 羽田 良洋1963 年 75 巻 7-9 号 p. 695-702
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーFormerly cell toxin which is produced by irradiation disturbance was found by Yamamoto. Using one of the unsaturated fatty acid fraction from that toxin and testing it with He La cultured cells, the author knew that it inhibited the growth and destructed the cells.
This time, an experiment was done in order to observe the effect given upon Ehrlich's ascites tumor and Yoshida subcutaneous sarcoma. The result showed that this substance had effect to prolong the life span of the animal carrying Ehrlich's ascites tumor and Yoshida sarcoma. Also histologically in case of Yoshida sarcoma, destructive cell was recognized by means of intravenus injection. Especially the increase of degeneration and destruction of tumor cells at the border part between healthy and tumor tissues and also stromal reaction were admitted. The effect was remarkable.抄録全体を表示PDF形式でダウンロード (8994K) -
山本 道夫, 田辺 正忠, 山崎 進, 渡部 一秀, 宇佐美 政栄, 船田 基1963 年 75 巻 7-9 号 p. 703-710
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーLately we encountered a case considered as radiation lung fibrosis while treating post operative irradiation on cancer of the breast. Instead of using adrenal cortex hormon which had been used as far, Quiniron (chloroquine phosphate) was applied. The result showed remarkable recovery upon X-ray findings, lung function test, and general condition.抄録全体を表示PDF形式でダウンロード (5923K) -
第1編 正常胃粘膜の組織化学的研究北村 元男1963 年 75 巻 7-9 号 p. 711-720
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーA histochemical study of following five enzymes activities, i. e., diphosphopyridine nucleotide diaphorase (DPN-D), triphosphpyridine nucleotide diaphorase (TPN-D), succinic dehydrogenase (S-D), α-glycerophosphate dehydrogenase (α-GD), and phosphorylase (P-ase) has been carried out on 5 cases of human gastric mucosa which were obtained from surgically resected polyp stomach.
For the demonstration of DPN-D, TPN-D, S-D and α-GD, the modified method of Wattenberg was used and for P-ase the methode of Takeuchi.
The results were summarized as follows.
1) The surface epithelium showed a high activity of DPN-D and TPN-D, moderate activity of P-ase, and low activity of S-D and α-GD.
2) The mucous neck cells showed a modérate activity of DPN-D and TPN-D, low activity of S-D and α-GD, and no activity of P-ase.
3) The parietal cells showed higher activity of DPN-D and TPN-D, highest activity of S-D and α-GD, and no activity of P-ase.
4) The zymogenic cells showed a low activity of DPN-D and TPN-D, moderate activity of S-D and α-GD, and no activity of P-ase.抄録全体を表示PDF形式でダウンロード (4661K) -
第2編 胃癌の組織化学的研究北村 元男1963 年 75 巻 7-9 号 p. 721-738
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーA histochemical study of following five enzymes, diphospbopyridine nucleotide diaphorase (DPN-D), triphosphopyridine nucleotide diaphorase (TPN-D), succinic dehydrogenase (S-D), α-glyserophosphate dehydrogenase (α-GD), and phosphorylase (P-ase) has been carried out on fifty cases of surgically resected gastric cancer.
The histochemical demonstration of each enzymes was the same as that described in Part I.
The results were summerized as follows.
1) In general, gastric cancer cells showed a high activity of DPN-D and TPN-D, and both enzymes showed the similar staining pattern and localization DPN-D activity is slightly higher than that of the TPN-D. The poorly differentiated cancer cells showed a higher activity than well differeutiated ones.
The tumor cells at proliferating areas, such as at invading margine or isolated cell groups, showed an increased activity, while signet ring cells and cells at necrotic areas showed a weak activity.
2) S-D is parallel in its activity with α-GD, and S-D activity is slightly higher than that of α-GD. Generally, gastric cancer cells showed moderate activity of these enzymes, and the poorly differentiated cancer cells showed a lower activity than well differentiated ones. In the cases of scirrhus, some of them showed negative patterns. The cells of invading margine and isolated cell groups showed weak activity. The more, signet ring cells and necrotic part also showed no activity.
3) In general, P-ase activity was poor in the gastric cancer cells. Even though some of adenocarcinoma type of stomach cancer showed moderately increased activity, but carcinoma simplex and scirrhus type of stomach cancer hardly showed any activity.
4) It might therefore be well concluded that the characteristic reactions pattern of these enzymes in gastric cancer cells are high activity of DPN-D and TPN-D, and low activity of S-D, α-GD and P-ase.抄録全体を表示PDF形式でダウンロード (19868K) -
山本 道夫, 西下 創一, 青野 要, 田辺 正忠1963 年 75 巻 7-9 号 p. 739-742
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーThere are sometimes patients of oesophageal hiatus hernia who visit our clinic complaining gastrointestinal disturbances similiar to stomach cancer or gastric ulcer and symptoms of breast disease.
Recently we came upon three of these cases so as would like to report.抄録全体を表示PDF形式でダウンロード (1913K) -
塩飽 健, 荻野 敬一郎, 青野 要, 羽田 良洋1963 年 75 巻 7-9 号 p. 743-746
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーA case of primary reticulum cell sarcoma of the stomach was reported. The patient was a fifty-four year old housewife, with the chief complaints of epigastric pain and anorexia. The roentgen manifestations were consistent with gastric cancer, and total gastrectomy was performed. The lesion was localized in the stomach and histological examination revealed reticulum cell sarcoma.抄録全体を表示PDF形式でダウンロード (2516K) -
第1編 骨髄並びに脾組織培養加原 雅教1963 年 75 巻 7-9 号 p. 747-762
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーHematological and histological investigations were performed in mice with myelogenous type of leukemoid reaction induced by transplantation of MY sarcom. Thereafter, tissue culture of bone marrow and spleen were carried out. The following results were obtained.
1) Tissue culture of bone marrow. The growth patterns in bone marrow culture were always normal and did not display the leukemic type throughout the entire course of leukemoid reaction. The growth ratio of the pattern increased as leukemoid reaction progressed, while the cell density was fairly constant through the course of leukemoid reaction. Wandering velocity of the neutrophils was low in the early and intermediate stages and did not show difference from the controls iu the advanced stage. Cytological observations by phase contrast microscopy, vital staining and fluorescence microscopy did not revealed any difference from normal marrow cells, nor atypism which was usually seen in leukemic cells.
2) Tissue culture of spleen. The normal pattern was always observed as seen in bone marrow tissue culture through the entire course of leukemoid reaction. The growth ratio increased as the reaction progressed. However, the cell density did not show difference from the controls.
In leukemoid reaction, the lymphocytic cells were gradtally replaced by the neutrophilic cells. Therefore, 70 to 80 % of the cells in the growth zone of the splenic tissue culture were occupied by neutrophilic cells.
In fluorescence tissue culture, the growth zone seen in leukemoid reaction displayed diffuse reddish orange color as a result of a large number of neutrophilic cells present, while the zone observed in controls showed diffuse yellowish green color owing to abundant lymphocytes. These findings were very helpful for differentiation of the splenic tissue in leukemoid reaction from the controls.
The findings described above seemed to demonstrate the development of extramedullary hematopoiesis in the spleen.抄録全体を表示PDF形式でダウンロード (7061K) -
第2編 類白血病反応発現因子加原 雅教1963 年 75 巻 7-9 号 p. 763-769
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーLeukemoid-reaction inducing factor was searched in mice with myelogenous type of leukemoid reaction indnced by MY sarcom.
The following results were obtained.
1) Leukemoid reaction was not induced by subcutaneous injection of the extract of MY sarcom. Tissue culture of bone marrow of mice injected with the extract did not show difference from the controls. Therefore, it was presumable that the extract of MY sarcom did not contain leukemoid-reaction inducing factor.
2) Serum of mice with leukemoid reaction induced by MY sarcom was demonstrated to produce hyperplasia of the bone marrow of normal mice. This seemed to indicate that serum of the mice with leukemoid reaction contained leukemoid-reaction inducing factor.抄録全体を表示PDF形式でダウンロード (2774K) -
第3編 骨髄血管構造加原 雅教1963 年 75 巻 7-9 号 p. 771-780
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーThe detailed vascular structure of the bone marrow of MY sarcom transplanted strain D103 mice was studied by lndian ink infusion (Spalteholz's method).
1) In the normal controls, the distribution of both the arteries and veins were regular and the sinusoids which occupied the majority of the vascular system of the bone marrow, were hexagonal in shape, and connecting with each other, made up a complex network.
2) In the bone marrow of the mice at 4 days after transplantation of MY sarcom, alteration in shape, irregular arranggment of sinusoids and destruction of their walls were observed in part.
3) In the advanced stage of leukemoid reaction, the sinusoids became irregular in shape and narrowing of the sinusoids became prominent. The destruction of their wall was marked. In the well advanced case, almost all of the sinusoids showed destruction.抄録全体を表示PDF形式でダウンロード (7488K) -
1963 年 75 巻 7-9 号 p. 781-787
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (531K) -
1963 年 75 巻 7-9 号 p. 787-790
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (252K) -
1963 年 75 巻 7-9 号 p. 791-797
発行日: 1963/09/30
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (483K)
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