岡山医学会雑誌
Online ISSN : 1882-4528
Print ISSN : 0030-1558
109 巻, 1-2 号
選択された号の論文の4件中1~4を表示しています
  • 真田 敏, 岡 〓次, 大田原 俊輔, 河原 道子, 栄 勝美, 平木 祥夫
    1997 年 109 巻 1-2 号 p. 1-6
    発行日: 1997/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    A clinical and neuroradiological study was carried out to clarify the relationship among cerebral dysgenesis, psychomotor retardation and neonatal epilepsy. Twenty-one cases with epilepsy developed within four weeks after birth were selected among 770 in-patients with childhood epilepsy. They consisted of one benign familial neonatal convulsion, nine of early myoclonic encephalopathy, four of Ohtahara syndrome, six of symptomatic localizationrelated epilepsy, and one of undetermined epilepsy. Seven cases with non specific types of epilepsies were investigated in detail. They developed into four of frontal lobe epilepsy, one of temporal lobe epilepsy and one severe epilepsy with multiple independent spike foci. Psychomotor retardation was observed in six of seven cases, and cerebral dysgenesis was considered to be important as an etiological factor. Proton MR spectroscopy revealed the decrease in the ratio of N-acetylaspartate/choline in the area with heterotopic gray matter and in the side of hemimegalencephaly, contrasted with a contralateral area without lesions. These findings can be inferred to reflect the decreased numbers of neuronal cell population or reduced metabolism in the lesions.
  • 藤川 えつこ
    1997 年 109 巻 1-2 号 p. 7-14
    発行日: 1997/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    The purpose of the present study is to clarify the changes of choroidal circulation developing in the selective injuries of the outer layer of the retina. One, 2, 3 weeks and 3 months after intravenous administration of Monoiodoacetic acid in the rabbits, choroidal vessels were observed using indocyanine green angiography (ICG). The diameter of retinal arterioles decreased significantly at 3 weeks and 3 months after the treatment and hypofluorescence in the background was observed at 3 months. Histological examination revealed significant decrease in choriocapillaris at 3 weeks, a thickening of the endothelial cytoplasma and a disappearance of fenestration in choriocapillaris after 3 months. These histological findings were considered to be a cause of hypofluorescence of background in ICG. The results suggest that the selective damage of the outer layer of the retina induce changes in the choroidal circulation.
  • 筒井 康子
    1997 年 109 巻 1-2 号 p. 15-24
    発行日: 1997/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    塩基性線維芽細胞増殖因子(basic fibroblast growth factor,以下bFGF)の存在下でニワトリ胚の網膜色素上皮細胞を浮遊培養して,その形態変化を観察した.孵化後7.5日胚の網膜色素上皮にトリプシン処理を施して細胞単位の懸濁液にしたものと,トリプシン処理を施さずピペッティングのみで細かくした網膜色素上皮小片とを,高濃度(10および200ng/ml)のbFGF存在下で培養すると小片は塊状になって増殖しタマネギ様の球形重層構造を形成したが,懸濁液にしたものはタマネギ様構造を形成しなかった.このタマネギ様構造の形成はbFGFの濃度に依存して形成され, bFGFの濃度が1ng/ml以下では形成されなかった.また,この部分は,免疫組織化学法にて抗クリスタリン抗体および抗bFGF受容体抗体に陽性であった.以上から,ニワトリ胚網膜色素上皮細胞から水晶体上皮細胞への分化転換には,網膜色素上皮細胞どうしの相互作用および一定濃度以上のbFGFの存在という2つの条件が揃うことが必要である.
  • 中心性漿液性脈絡網膜症と脈絡膜循環障害の関連について
    河西 葉子
    1997 年 109 巻 1-2 号 p. 25-33
    発行日: 1997/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    In order to know frequency of choroidal circulatory disturbance, 126 eyes with central serous chorioretinopathy followed-up between Jan. 1985 and Dec. 1990 were retrospectively investigated by fundus fluorescein angiography. Appearance of choroidal circulatory disturbance was divided into two types. The type 1 showed choroidal filling delay at late retinal venous phase. The type 2 showed mosaic pattern of choroidal background at late retinal venous phase. Among the 126 eyes, 3 eyes were type 1 (2.4%) and 57 eyes were type 2 (45.2%), totaling 60 eyes (47.6%). Sixty-three eyes with normal part of branch retinal vein occlusion matching in sex and age were selected as controls. In the controls, no eye was type 1 (0%) and 8 eyes were type 2 (12.7%), totaling 8 eyes (12.7%). Distinctly, proportion of the type 2 was higher in central serous chorioretinopathy than in branch retinal vein occlusion. In conclusion, the pathogenesis of central serous chorioretinopathy is related to choroidal circulatory disturbance and especially mosaic pattern (type 2) was found to be a new type of circulatory disturbance.
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