Clinical evaluations of cefmetazole in 75 cases (ages 20 to 70) of infectious diseases in the field of obstetrics and gynecology, including genital infections (such as intrauterine, intrapelvic and external genital infections), simple urinary tract infections and post-operative (genital carcinoma) complicated urinary tract infections, were collected and analyzed.
The routes of administration were: 48 cases of drip infusion, 22 cases of intravenous injection, 3 cases of intramuscular injection and a case each of combinations of drip infusion with intravenous injection or topical injection.
The daily doses were: 31 cases of 1.0 g, 27 cases of k2.0 g, 2 cases of 3.0 g, 7 cases of 4.0 g, 2 cases of 0.5 g and a case of 1.5 g, with 46 cases using the daily doses for 4 to 5 days, and the longesi period of administration was 14 days.
The effective rates by types of diseases were: 94.1% in genital infections, 92.5% in the cases of urinary tract infections, and the overall rate of efficacy in the field of obstetrics and gynecology was 93.3%.
The effective rates by isolated microorganisms were: 100% against gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus), 93.0% against gram-negative bacteria (E. coli, Klebsiella, Enterobacter, Proteus, GNR), 87.5% against a mixture of two types of bacteria, 66.7% against a mixture of 3 types of bacteria, and the overall effective rate was 91.7%.
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