On 36 patients with diffuse lung diseases including idiopathic interstitial pneumonia, sarcoidosis, pneumoconiosis, rheumatoid arthritis and so-called disseminated eosinophilic collagen disease etc., forty transbronchial lung biopsies have been performed by means as previously described. Specimens were taken from two or three segments of one lung in most of the patients.
Twenty nine of 36 patients had definite roentgenologic evidence of diffuse pulmonary diseases, but in other 7 casses chest x-ray showed almost normal finding, though we could suspect of the presence of histopathological changes in their lungs because of their systemic involvement.
(1) The size of a specimen on an average was appoximately 1.0×2.0mm, and it was found that specimens were larger in the biopsy without bronchography than in the one with bronchography (Shibayama et al., 1970) as our experimental study (cf. part 1). So we performed the biopsy without bronchography later.
(2) Biopsies of 22 cases in 36 casses were useful for diagnostic and therapeutic purposes. We believe that diagnosis may be possible in many cases with the aid of all the clinical data.
(3) There were seven cases in which biopsy specimens disclosed pulmonary lesions histologically, though their chest x-rays were almost normal, showing that of the method may contribute to an early diagnosis.
(4) Only one complication, pneumothorax, was encountered among the 36 patients. Occasionaly and, transient bllody sputa were observed after biopsy, but they were minimal and negligible.
(5) Better biopsy forcep is hoped to be designed which is possible to penetrate the bronchus or bronchiole more easily and with greater certainty for obtaining pulmonary tissue.

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From 1970 through 1972, the symptom prevalence of chronic bronchitis was studied in people over 40 years of age living in 7 districts in Osaka by Osaka Prefecture and Sakai city. On the basis of the data obtained a statistic analysis was made of the symptom prevalence of chronic bronchitis in reference to air pollution in those districts with the following results:
1) The relations between the symptom prevalence of chronic bronchitis and sulfur dioxide level which was used as air pollution index led to
y=1.94α+2.87
where y: the symptom prevalence of chronic bronchitis in people over 40 years of age, in percent, and α: sulfur dioxide values measured by the PbO₂ method in mgSO₃/day/100cm².
2) The value from this formula was 2.2% higher than what was obtained previously from a 1962-1966 survey in Osaka city.
3) The relations between the symptom prevalence of chronic bronchitis and the nitrogen oxide level, instead of the sulfur dioxide level, were formulated as
y=0.88β+2.81
where β: nitrogen oxide values estimated on conjecture by the smoke diffusion equation in pphm.
4) A combined effect of sulfur dioxide and nitrogen oxide might be
y=1.0(α-1.0)+0.6β+2.7

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成人にいたってCO₂蓄積を伴う呼吸不全を呈するにいたった, 小顎症, 舌下垂の1例を報告した. 本症例での肺胞低換気の原因として, 上気道の閉塞と胸廓変形とが考慮されるべきであるが, 後者は軽度であったことから, 胸廓外上気道の閉塞が主役を演じ, 気道感染が病態の悪化のきっかけとなったものと考えたい.

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全身倦怠, 疲労感の訴えで発病. 胸部X線写真上, スリガラス様ないし粟粒様陰影が全肺野にみとめられ, 粟粒結核の疑いで, 結核化学療法が行われたが無効で, ステロイド剤の投与により, 自覚症状, 胸部X線所見ともに, 著明な改善が認められた. 肺生検を行い, conchoid body 封入体を含む類上皮細胞肉芽腫と肺組織中のベリリウム検出により, ベリリウム肺の慢性型と診断された.

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