巻号一覧
101 巻 (1989)
- 11-12 号 p. 977-
- 9-10 号 p. 863-
- 7-8 号 p. 687-
- 5-6 号 p. 423-
- 3-4 号 p. 285-
- 1-2 号 p. 1-
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
101 巻, 11-12 号
選択された号の論文の10件中1～10を表示しています
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特に脳内モノアミンにおよぼす影響渡辺 駿二1989 年 101 巻 11-12 号 p. 977-989
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーGuanidinoethanesulfonic acid (GES) is known to induce convulsive seizures when administered intracisternally into rabbits and cats. I examined the effects of GES on behavior, electroencephalogram and brain monoamine levels after intraventricular injection into mice. When GES was intraventricularly injected into mice, focal clonic movements of the face, vibrissae and ears, as well as twitchings of limbs were observed 0.5-1 min after injection. Hypersensitivity was observed until 7 min after the injection, after which the mice behaved in a normal way. It is also observed that GES induced sporadic spike discharges in the electroencephalogram. The latency and duration of the appearence of spike discharges showed considerable individual variation. The latency was from 0 to 5 min, and the duration was from 5 to 90 min. No spike discharge was observed in the saline injected animals. The 5-hydroxytryptamine (5-HT) level decreased in the hippocampus, diencephalon, pons-medulla oblongata and cerebellum 5 min after injection, and recovered to the control level 10 min after the injection. No change in the norepinephrine (NE) and dopamine (DA) levels was found after GES injection. 5-hydroxyindoleacetic acid increased in the striatum and cerebellum 5 min after injection. It is thought that the GES injection enhances the release of 5-HT in the striatum and cerebellum, although the mechanism of the decrease of 5-HT in the hippocampus, diencephalon and pons-medulla oblongata is unclear. These results indicate that the GES induced convulsive seizure is related to 5-HT neurons, not NE or DA neurons.抄録全体を表示PDF形式でダウンロード (1833K) -
第1編 フェニルヒドラジン投与時のアカタラセミアマウス血液カタラーゼ活性の熱安定性小柏 道子1989 年 101 巻 11-12 号 p. 991-997
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーIn order to investigate the heat stability of catalase in immature and mature erythrocytes of normal, acatalasemic and heterozygous hypocatalasemic mics, phenylhydrazine hydrochloride (PHZ) was administered to these mice at a dose of 40 μg/g of body weight subcutaneously daily for 3 days Anemic blood rich in reticulocytes was obtained 2 days after final injection. Thermostability of catalase in the non-anemic and anemic bloods was compared and the following results were obtained.
1. Specific catalase activity (catalase activity/amount of hemoglobin; PU/g Hb) in anemic blood from acatalasemic mice was significantly higher than that in non-anemic blood. Specific catalase activity in anemic blood from normal mice was a little higher than that in non-anemic blood from normal mice.
2. The residual catalase activity in the hemolysate after heat treatment was compared with that from before treatment in which hemolysate containing catalase was incubated at 42, 44, 46, 48 and 50 °C for 10 minutes in a water bath. At any temperature, catalase activity in immature red blood cells of normal and acatalasemic mice was more stable with heat than that inmature red blood cells.
3. In mormal mice, the T50 (the temperature at which 50 % of the catalase activity remained after heat treatment) in anemic normal blood was statistically higher than that in non-anemic blood. In the acatalasemic mice, the T12.5 (the temperature at which 12.5 % of the catalase activity remained after heat treatment) in anemic blood was statistically higher than that in non-anemic blood.抄録全体を表示PDF形式でダウンロード (351K) -
第2編 clofibrate投与時のアカタラセミアマウス肝臓カタラーゼ活性の熱安定性および血清酵素活性の変動小柏 道子1989 年 101 巻 11-12 号 p. 999-1007
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーNormal and acatalasemic mice were fed 0.5% clofibrate (CPIB) for 70 days and variations of catalase activity and thermal stability of liver catalase were investigated.
1. The specific catalase activity (catalase activity/g liver weight) in the liver of mice which received CPIB compared to that of controls was calculated. The specific catalase activity was in 2.2 normal mice and 1.2 in acatalasemic mice. A significant increase of activity was recognized in normal mice but not in acatalasemic mice.
2. The specific catalase activity in the blood of mice which received CPIB to that of control was determined. The specific catalase activity was 1.3 in normal mice and 1.1 in acatalasemic mice. A significant increase was not observed in either kind of mice.
3. The heat stability of catalase in the liver of normal or acatalasemic mice which received with CPIB was higher than that of normal or acatalasemic mice which did not received CPIB.
4. Increased levels of ALP and ChE activities and decreased levels of GOT activity and TG concentration were observed in the normal or acatalasemic mice which received CPIB, compared to control mice.
5. Isozyme of ALP were determined by electrophoresis. Increased ALP in the plasma of normal and acatalasemic mice was thought to be derived from liver ALP.抄録全体を表示PDF形式でダウンロード (1261K) -
林 肇輝, 白須賀 直樹, 小野 俊郎, 粟井 通泰1989 年 101 巻 11-12 号 p. 1009-1014
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリー内分泌腺細胞の分泌時間は瞬時とされていることから,一般的にその分泌像の形態的観察には,分泌を促進せしめる実験系が用いられている.又膵ラ氏島B細胞分泌の超微形態は,専ら浸漬固定標本で観察されている.今回,我々は分泌が遅延している動物で,高速還流した膵ラ氏島細胞について観察した.即ち,前報と同様のFe3+-NTA誘発糖尿病ラットの上行大動脈より2%グルタールアルデヒド150mlを15ml/minの速度で還流固定し,ラ氏島B細胞のβ顆粒分泌像に焦点を絞って観察した.その結果,前報の浸漬固定法では観察されなかった開口分泌像が多数観察され得た.対照の健常動物に比べ, Fe3+-NTA投与動物では,分泌直前から分泌後に至るいろいろな段階のβ顆粒の分泌過程が観察された.以上の結果から,開口分泌像の電顕的観察にはむしろ本実験系のように細胞分泌を障害ないし低下せしめ,高速還流固定法を用いることが必要であると結論した.抄録全体を表示PDF形式でダウンロード (1573K) -
第1編 遅発型気道反応におけるIgG抗体の関与について岡田 千春1989 年 101 巻 11-12 号 p. 1015-1025
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーThe similarities between the clinical characteristics of instractable asthma and attacks of late asthmatic response (LAR) have been noted. To clarify the pathogenesis of intractable asthma, the mechanism of LAR was studied using a technique of immuno-scaning electron microscopy to determine the density and distribution of immunoglobulins bound to the surface of peripheral blood basophils from bronchial asthma patients with asthmatic responses provoked by inhalation of house dust or Candida antigens. In a study of immunoglobulin density, the ratio of the number of IgG to IgE antibodies was higher in asthmatics with house dust-provoked LAR than in those with IAR, and the values were even higher in those with Candida-provoked LAR. In a study of the distribution of bound immunoglobulins, the overall rates of cap and patch formations, which seems to indicate an activation of cells, tended to be higher in asthmatics with house dust-provoked LAR than in those with IAR. The same tendency was also seen in those with Candida-provoked LAR. These results suggest that the IgG antibodies play an important role in LAR, although IgE antibodies are predominant in IAR. This trend is marked in asthmatics with Candida-induced LAR.抄録全体を表示PDF形式でダウンロード (2438K) -
第2編 遅発型気道反応におけるIgGサブクラスの役割について岡田 千春1989 年 101 巻 11-12 号 p. 1027-1036
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーThere are many problems in intractable asthmatics, such as corticosteroid dependency. The clinical course is different from atopic asthma. To clarify the differences between both type of asthma, we investigated the mechanism of LAR, which has similar features to the pathogenesis of intractable asthma. We have previously reported that IgG antibody was involved with the LAR. In this study, to clarify the role of IgG subclass, we observed the density and distribution of IgG1 and IgG4 antibodies bound to the peripheral blood basophils from bronchial asthmatics using a technique of immunoscaning electron microscopy. A study revealed a relative ratio of IgG1 to IgG4 antibodies on basophils of asthmatics with Candida-provoked LAR which was higher than that of asthmatics with house dust-provoked IAR and LAR. Furthermore, in the study of immunoglobulin distribution on the basophil surface, the proportion of cap and patch formation of IgG1 antibody was higher in bronchial asthmatics with Candida-provoked LAR than in those with house dust-provoked IAR and LAR. These data suggest that IgG1 antibody may play an important role in the pathogenesis of LAR, especially Candida-provoked asthmatic response.抄録全体を表示PDF形式でダウンロード (2228K) -
松浦 一彦1989 年 101 巻 11-12 号 p. 1037-1048
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーTo investigate the origin of liver epithelial-like cells derived from the normal rat, we examined ten liver epithelial-like cell clones. These cultured cells were isolated from clonogenically growing cells in the primary culture. Morphological, cytochemical and biochemical characteristics of these ten of clones showed the followings: (1) These cells consisted of dense, diffuse and intermediate types. (2) Analyses of serum-free conditioned culture media, using SDS-PAGE, demonstrated that the dense type had a certain profile in the group of secretory proteins, whereas the diffuse and intermediate types had varied profiles although the latter were somewhat similar in profile to the dense type. (3) The secretory protein groups were different from mesenchymal cell lines in their profiles. (4) Cytokeratin was present in all the ten of clones. (5) Cytokeratin was also present in the cholangiolar epithelia and cells localized in peripheral areas of normal hepatic lobules. (6) The function, as seen in mature-type hepatocytes and cholangiolar epithelia, was almost absent. (7) These ten clones were different from sinusoidal endothelia according to their morphologies and growth ability in the primary culture. In conclusion, the liver epithelial-like cell clones derived from normal rat can belong to a “stem-cell family” of liver tissue. These “stem cells” may be localized next to the hepatocytes and cholangiolar epithelia in vivo.抄録全体を表示PDF形式でダウンロード (3929K) -
温熱によるサル正常脳組織の組織学的変化松海 信彦1989 年 101 巻 11-12 号 p. 1049-1061
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーThe thermal damage threshold of brain tissue was estimated from the immediate and delayed histological changes caused by 2450 MHz microwave antenna and an antenna cooling system of a device used for interstitial hyperthermia treatment. An antenna within a cooling system was inserted through the small cranietomy under general anesthesia. The temperature at a reference point, 4 mm radially away from the surface of the cooling system, was maintained at 42 °C, 43 °C, 44 °C, 45 °C or 46 °C for 60 minutes. In a non-survival experiment, 18 animals were used and sacrificed immediately after the treatment. In a survival experiment, 9 animals were used and sacrificed seven days after the treatment. The histological changes were evaluated by microscopic examination with hematoxylin and eosin, Klüver-Barrera, or Bodian stainings. In the non-survival experiment, areas heated below 44 °C showed no obvious irreversible change. In the survival experiment, areas heated at 44 °C or above showed coagulative necrosis. Those histological findings indicate that the thermal damage occurs in normal brain tissue after heating at 44 °C or above for 60 minutes, and suggest that the safety limit for brain hyperthermia is 43 °C for 60 minutes.抄録全体を表示PDF形式でダウンロード (3627K) -
大村 勉1989 年 101 巻 11-12 号 p. 1063-1073
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーTo clarify the factors affecting pituitary prolactin (PRL) reserve during development, the serum PRL response to TRH and serum LH, FSH response to LH-RH were studied. The basal levels of serum estradiol (E2), testosterone (T) and dehydroepiandrosterone-sulfate (DHEA-S) were measured in 128 normal children and adolescents and 18 cases of Turner's syndrome.
In males, no correlation was found between E2, T, DHEA-S and the integrated secretion of PRL (∑PRL), while a positive correlation was found between the integrated secretion of FSH (∑FSH) and ∑PRL (p<0.05).
In females, positive correlations were found between E2 and ∑PRL (p<0.01), the integrated secretion of LH (∑LH) and ∑PRL (p<0.01) and DHEA-S and ∑PRL (p<0.01). E2 was selected as the explanatory variable of ∑PRL by means of multiple regression analysis.
In cases of Turner's syndrome, endocrinologically characterized by high gonadotropins and low E2, a positive correlation was found between ∑FSH and ∑PRL (p<0.05).
These findings suggest a stimulating effect of E2 on PRL reserve in females and the stimulating effect of endogenous LH-RH on PRL reserve in both sexes in children and adolescents.抄録全体を表示PDF形式でダウンロード (487K) -
黒田 昌宏, 田中 朗雄, 山本 淑雄, 清水 光春, 佐藤 伸夫, 上者 郁夫, 橋本 啓二, 平木 祥夫, 仲田 浩之, 木畑 正義1989 年 101 巻 11-12 号 p. 1075-1079
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーA 46-year-old female presented with lumbago. A plain X-ray examination did not indicate any distinctive changes, however a bone scintigram showed beautiful bone scan. A bone marrow biopsy certified metastatic adenocarcinoma and a primary gastric carcinoma was discovered subsequently. Beautiful bone scan can be seen in malignant metastasis, several bone metabolic diseases and other rare cases. A rare case of a gastric cancer exhibiting a beautiful bone scan, is described.抄録全体を表示PDF形式でダウンロード (1344K)
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