岡山医学会雑誌
Online ISSN : 1882-4528
Print ISSN : 0030-1558
67 巻, 2 号
選択された号の論文の12件中1~12を表示しています
  • 井出 愛邦
    1955 年 67 巻 2 号 p. 361-402
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    After the intravenous injection of various kinds of fluids, the free water and the connected water in brain were measured by Hatschek's method. The results were as follows:
    1) Normal cat:
    cerebral grey matter cerebral white matter brain stem cerebellum
    free water 71.6 57.7 63.4 70.9
    connected water 8.2 10.7 9.9 7.9
    total 79.8 68.4 73.3 78.8
    2) Trephined cat:
    cerebral grey matter cerebral white matter brain stem cerebellum
    free water 72.9 59.7 64.8 71.7
    connected water 8.3 11.7 10.5 8.4
    total 81.2 71.4 75.3 80.1
    3) Three hours after injection: Comparing with the normal cases, the free waterincreased, but the connected water had no change, when 0.9% NaCl solution, or Ringer's solution or 5% glucose solution was injected. In case of injecting Liq. Lans or 5% polytamin solution or plasma, however, no change was observed.
    4) Three hours after injection, the brain was exposed for 3 hours by trepanation:Comparing with the only trephined cases, the free water in the cerebral white matter increased, when 0.9% NaCl solution, or Ringer's solution or 5% glucose solution was injected. But no change was observed, when Liq. Lans, 5% polytamin solution or plasma was used.
    5) The brain was exposed for 3 hours and the injection was performed simultaneously: Comparing with the only trephined cases, 0.9% NaCl solution, or Ringer's solution or 5% glucose solution produced an increase of the free water in all parts of brain. But Liq. Lans or 5% polytamin solution produced the increase of the free water only in the cerebral white matter. On the contrary, the free water decreased by plasma-injection.
    6) The minimal increase of the fluid content of brain was seen when the plasma was injected. And then 5% polytamin solution and Liq. Lans came after.
    7) The increase of the water content of the brain was most remarkable in the cerebral white matter, followed by brain stem, cerebral grey matter and then cerebellum.
    8) The swelling of the brain by injection and trepanation was caused by the increase of the free water, but the connected water had no influence on it.
  • 坂井 邦典
    1955 年 67 巻 2 号 p. 403-428
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    The cow sera with phosphatid obtained from the cerebral gray matter, of cows were given in the ear vein of adult rabbits for 2cc per kg as antigen. As effective injection, 1cc per kg of diluted antigen, namely 4 and 6 times diluted solution of antigen was given every 4 days for 3-10 months in their ear vein.
    Thus the chronic local cerebral anaphylactic rabbits were made. And the motor area, frontal lobe, nucleus lenticularis, substantia nigra, Ammon's horn and pia mater were histologically researched. After repeated effective injections for a long time, the disappearance, disturbance of arrangement, atrophy, edematous degeneration, glial involvement and neuronophagia etc. of nerve cells, striking gliosis, disappearance and swelling of the sheath, hypertrophy of the wall of vessels, increase of wall cells, dilatation of lymphatic cavity surrounding the vessel adventitium, hypertrophy of pia mater and proliferation of connective tissue cells etc, were found.
    It would appear that, by repeating effective injections with diluted antigen for a longtime, the chronic local cerebral anaphylactic rabbits were made, and the histological findings of their brains were similar to those which were found in the brain of old idiopathic epilepsy.
  • 山谷 儔
    1955 年 67 巻 2 号 p. 429-457
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    The functional specialization and the regulation of the contraction in Musculus deltoideus, Musculus biceps brachii and Musculus extensor digitorum communis was studied electromyographically.
    The fibers of the muscles are devided in two neuromuscular units (NMU) functionally; the kinetic NMU and tonic NMU. The former is concerned with the pyramidal tract and the latter with extrapyramidal tract.
    By these both, the contraction is regulated, and each muscle has its own and fixed ratio of the content of these both NMU.
    Before the excision of area 6 of cerebral cortex in the epileptics, the regulation of contraction was almost similar in the normal side, but in the focal side, it was myographically rather insufficient. But the ratio of content of these both NMU had no remarkable difference from those of the normal. After the operation, the regulation of contraction became more insufficient and the tonic NMU became less. As time elapsed, they approached to the state before the operation and about 21 days after the operation the majority of them became almost as same as before the operation.
    In the patients who had a lesion in the area 6 of cerebral cortex, almost similar results to the epilepties were obtained, while in those who were not affected in the area 6. almost similar results to the normal were seen.
    But in all cases there was found no change of the content ratio of both NMU.
    Acetylcholine effected to disturb the regulation of contraction in normal skeletal muscles, but in abnormal muscles it did to correct the regulation of contraction, while it did not influence the content ratio of the both NMU. On the contrary, strychnine nitrate did not influence at all.
  • 第1編 各種麻醉法の脳含水量に及ぼす影響に関する実験的研究
    角南 敏孫
    1955 年 67 巻 2 号 p. 459-489
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    1) The ether inhalation, intramuscular injection of dial, rectal infusion of avertin, intravenous injection of ravonal, subcutaneous injection of narcopon and scopolamin and local injection of procaine chloride were performed in cats.
    From their clinical and electroencephalographic findings, the state of narcosis was classified into 6 phases and the dose was determined to keep the 4th phase of narcosis.
    2) Three hours after the narcosis of the 4th phase the amount of water in the brain was measured at the cortex, white substance, cerebellum and pons, dividing in free and bound water.
    3) The amount of bound water showed no change in all cases.
    4) The amount of free and total water was not influenced by narcosis with ravonal, dial and procaine, but increased by ether, avertin, and narcopon-scopolamin.
    5) The degree of increase was in the following order: white substance, cortex and cerebellum. The pons showed the least increase.
  • 第2編 手術操作の脳含水量に及ぼす影響に関する実験的研究
    角南 敏孫
    1955 年 67 巻 2 号 p. 491-504
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    1) Cats were anesthetized with dial. After craniotomy, such stimulations as rubbing, concussion and compression were performed. The amount of the water in the brain was measured on the affected and the intact side.
    2) The change of the bound water was not found.
    3) The slight rubbing, concussion and compression caused neither change of the free nor of the total water.
    4) After strong rubbing, concussion and compression an increase of the free and total water was found.
    5) It increased in the following order: cortex, white substance and cerebellum, but in the pons it showed no change.
    6) Compared with the intact side. it was more striking in the affected side.
  • 中西 格一
    1955 年 67 巻 2 号 p. 505-538
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    After removing the parts of each motor area of fore-limb, hind-limb, both areas of them and mixed area of both-limbs, the degeneration of the nerve fibres was pursued by Marchi staining. There were found not only the efferent fibres coming directly down, but also those taking roundabout way from these each of the fore- and hind-limb (all of the latter had been considered as associating fibres up to the present) and thus it was illustrated that they were intricating. These fibres included the pyramidal tract as well as the extrapyramidal tract. When the investigation was performed till the end of the spinal cord, it was found that the area for the hind-limb included a part of the fibres reaching the fore-limb.
  • 太田 亮介
    1955 年 67 巻 2 号 p. 539-559
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    The brain was fixed with formalin, washed by water, dehydrated with alcohol and etheralcohol, inbedded in celloidin and then stained by Nissl's method. The cells larger than 27.5 were to be considered as the Betz-cells. The area, where the Betzcells were found, were regarded as the motor area and the schemata of 70 cases of motor cortex were made.
    The fact was cleared from those schemata, that in the vicinity of th motor area those, which showed similar macroscopic findings, had similar extension of the motor area. The schemata of the macroscopic figure of the motor cortex were classified into 5 types and each type had its own shape of the motor area. There were a few exceptions among them, but they had also some close relation to the sulci. Among the 70 cases, those. in which the sulcus praecentralis superior was the anterior border, had the majority of 72.9%. In about 60% of all cases the motor area on one hemisphere was similar to the other side.
  • 第1編 血液ガスの所謂脳腫脹に及ぼす影響に関する実験的研究
    佐藤 治
    1955 年 67 巻 2 号 p. 561-578
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    The gas content in blood was changed by artificial pneumothorax in cats and measured by VAN SLYKE method. The water content in the cerebral motor cortex, white substance, cerebellum and brain stem was measured HATSCHEK's cobalt chloride method.
    The results were as follows;
    In normal cat brain the water content was different in each part; the most in the cerebral motor cortex, and became less in the order of cerebellum, brain stem and cerebral white substance.
    The water content increased rapidly when the ratio of O2 decrase in the arterial blood became more than 18-22% and when that of CO2 increase over8-10% And when the decrease of and O2the increase of CO2 became more, the water content accordingly showed a further increase, but almost constant.
    This increase of brain water content depended upon only the free water while the bound water was always constant. There was almost similar increase in each part above mentioned.
    By this study it was explained that, the increase of brain water content became rapid at the point of a certain decrease of O2 content and increase of CO2 in blood. This fact told us a suggestion of the genesis of brain edema and that the oxygen inhalation during and after the operation would prevent the so-called brain swelling.
  • 第2編 予備アルカリの所謂脳腫脹に及ぼす影響に関する実験的研究
    佐藤 治
    1955 年 67 巻 2 号 p. 579-590
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    The solutions of hydrochloric acid and natrium bicarbonicum were given to rabbits intravenously. The reserve alkali was measured by VAN SLYKE method, and the water content was measured by HATSCHEK' cobalt chloride method. The results were as follows;
    The brain water content increased rapidly at the point of 6-7% increase of the reserve alkali. It showed also considerable increase already at the point of 2.3% decreaae of it.
    It increased a little more by the further change of reserve alkali beyond these limits, but was almost fixed.
    This increase of brain water content depended on only the free water and the bound water was constant.
    By this study it was proved that, the increase of brain water content depended on not only the increase of blood caused by dilatation of brain vessels, but the increase of water conent in brain itself, and that the oxygen inhalation was very effective to prevent the so-called brain swelling during and after the operation.
  • 井上 広
    1955 年 67 巻 2 号 p. 591-602
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    The scar was made by mechanical and inflammatory way on the mesenterium in dog experimentally. In 22 cases of these 32 cases discahrgesat rest were found in the myogram of dorsal muscles from about 2 weeks after the operation. which ceased immediately by the lesion of the nerves of the mesenterium. Countless nerve fibres in the scar of the mesenterium were proved by Bielschowsky's sheath staining.
    As mentioned above, it is a viscerosensory reflex caused by abnormal stimulation of afferent nerve fibres passing through the scar.
  • 井上 広
    1955 年 67 巻 2 号 p. 603-613
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    The patients with mesenteritis cicatricans were investigated before and after the operation myographically in their dorsal muscles at rest. These discharges were seen in 18 of 20 cases with lumbago. and in 4 of 15 cases without it. After the resection of scar or Rankin-Reamonth's operation, there was seen disappearance or decrease of discharges, which corresponded with disapperance of lumbago and the objective findings.
    From the fact, that countless nerve fibres in the scar of the mesenterium were found by Bielschowsky's sheath staining and that no discharge was seen in those without mesenteric scar, it was concluded that the lumbago in this disease was to be a viscerosensory reflex caused by abnormal stimulation of afferent nerves, which passed through the scar.
  • 藤村 顕治
    1955 年 67 巻 2 号 p. 615-650
    発行日: 1955/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    The gliosis was investigated histologically at the motor cortex, nucleus lenticularis and Ammon's horn of the rabbits brain, which had chronic local cerebral anaphylaxis (CLCA) experimentally by repeating injection of diluted cow serum with phosphatide as antigen for a long time, or which had repeated convulsive seizures (RCS) by metrazol injection.
    The results were as follows:
    1) The increase of the glial cells was observed in all cases and in all parts above. mentioned. There was no significant difference of the increase at each part.
    2) The increase of the glial cells was the most at Ammon's horn, then at the motor cortex and the least at nucleus lenticularis.
    3) The increase of the glial cells was mostly due to that of the macroglia and the Hortega glia, and the increase of the oligodendroglia was slight.
    4) There was a striking increase of the macroglia and the Hortega glia in the brain with CLCA, and no significant difference of the increase between these two.
    5) There was a striking increase of the macroglia, especially the fibrous macrogliain the brain with RCS.
    6) The gliosis, especially the increase of the macroglia was more striking in the superficial cortex and the perivascular part. This tendency was more in the brains with RCS than that with CLCA.
    7) Circumscribed disappearance of nerve cells was observed in the brain with RCS, while it was never seen in that with CLCA.
    8) It was presumed that the increase of the macroglia was probably due to the convulsive seizures and that of the Hortega glia was the reaction to the stimulation.
    The author also investigated the state of gliosis in the human brains with old genuineepilepsy. The gliosis was mostly due to the increase of the macroglia, especially of the fibrous macroglia and there was no significant change of the number of the Hortega glia and the oligodendroglia.
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