Tumors of the intestinal canal are not uncommon so far but tumors which grow in the small intestine and duodenum are said to be a rare case. Recently as we have found sarcomas growing in the jejunum and the descending portion of the duodenum, we have described about those X-ray findings and reported the differentiated findings with that of other diseases which appeared in the literature refirred.

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1) After the effect of OX substance upon the blood picture, liver function, change in body-weight and urine general test of a health rabbit was examined, it was compared with other antitumor agents which appeared in the literature referred.
2) It can be considered that our OX substance shows little effect on a health rabbit within the limits of the upper examination.

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This case is diagnosed by X-ray examination as armoured pericard which could be easily differentiated from calcification of mediastinal pleura, calcification of coronary blood vessels and calcified focus of the lung by means of oblique projection radiography, roentgen kymography, and tomography.

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The author investigated 125 lower limbs of 69 Japanese cadavers from his dissecting room, and obtained the following results.
1. Definition of the perforating arteries and the medial perforating branches.
As generally accepted, only those arteries, that perforate the adductors close to the linea aspera, are called perforating arteries. Such arteries, as those piercing the adductor maguns far from the femur, are provisionally called “medial perforating branches”.
The first perforating artery (I) appears backwards from between the adductor minimus and the main part of the adductor magnus.
The second perforating artery (II) perforates the main part of the adductor magnus above or at the proximal third of the origin of the short head of the biceps.
The third perforating arteries (III) perforate the adductor magnus at the height of the middle and the distal thirds of the biceps origin. In some cases, a twig whose course and distribution are the same as those of the third perforating arteries arises from the distal part of the femoral artery or from the popliteal artery. Such are also included in the third perforating arteries.
“Superior medial perforating branch” arises from the first perforating artery, the profunda femoris artery or the medial circumflex artery, pierces the adductor magnus and appears at the upper medial part of its posterior surface. Generally it occurs as one twig.
“Inferior medial perforating branches” arise from the muscular branches to the adductor magnus and appears backwards at the lower part of the muscle, as one to three twigs. (Table 9).
2. The total number of perforating arteries (Tables 1, 2 and 3).
They arise from the profunda femoris as 2-6 branches, in most of the cases as 3-5 (average 4.02). As they sometimes divide into 2 or 3 branches before they pass through the adductors, the number of branches, piercing the adductor magnus, is more than the former: 2-7, in most of the cases 4 or 5 (average 4.66). Furthermore, if the perforating arteries of the femoral and popliteal origins are included, the average number of the arteries, passing through the adductor magnus, is 4.85.
3. The number of each perforating artery (Tables 5 and 6).
I is generally single, rather rarely two (30 limbs, 24.0 %) or three (3 limbs, 2.4 %) in number. The supernumerary first perforating arteries are its ascending branches, that pierce the muscle separately. II also is generally single, rather rarely two or three (17.6 %). Whereas, III is generally two or three in number. In one case III was missing.
4. The origin and branching of the perforating arteries are presented in Fig. 2. In the majority of the cases, the first and the second branches become I and II respectively, and III are derived from the third branch and on (Type I, 72.0 %). Besides, the type II (15.2 %), in which the first branch divides into I and II, and type III (12.0 %), in which II are derived from the first and second branches, are not rarely found.
5. Generally, I and II pierce the adductor brevis and the adductor magnus, while III the latter muscle only. (Table 4).
6. Distribution of the perforating arteries and the “medial perforating branches”. (Table 7 and Fig. 4).
Generally the ascending branch of I is distributed to the lower part of the gluteus maximus and its neighbourhood, the descending branch (the main branch), as the principal source of the arterial supply of the hamstring muscles, supply the long head of the biceps, the semitendinosus, the semimembranosus and the sciatic nerve, and II and III supply the short head of the biceps and the vastus lateralis and intermedius.
The “superior medial perforating branch” enters the proximal part of the semimembranosus, and the “inferior medial perforating branches” supply chiefly the belly of the semimembranosus.

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The nutrient arteries to the shaft of the femur are dissected up to the nutrient foramina in 116 limbs of Japanese cadavers from our dissecting room. Results obtained are as follows:
1. The nutrient arteries are two in number in 56.1 % of the cases (Tables 1 and 2).
2. The nutrient foramina are situated generally in the upper third (64.9 %) of the shaft of the femur, less frequently in the middle third, rarely in the lower third (Table 3). Dividing the shaft in sections A, B and C as illustrated in Fig. 1, in the case of a single artery, it generally enters a foramen in B, with two arteries they enter most frequently foramina in A and B, and with three arteries mostly in A, B and C (Table 7). Thus, the height of the upper-most, second and third foramen varies widely according to the number of the nutrient arteries (Table 8).
3. The position of the nutrient foramina in relation to the linea aspera is presented in Table 9.
4. The origin of the nutrient arteries (Tables 10-14).
The nutrient arteries arise generally from the perforating arteries (Table 11). Arteries that enter the foramina in A originate most frequently from the Ist perforating artery or the IInd perforating artery branched out from the Ist perforating (a in Fig. 2 and Tables 12 and 13), less frequently from the intrinsic IInd perforating (c). Arteries to the foramina in B arise most frequently from the intrinsic IInd perforating, less frequently from the IIIrd perforating (e). Arteries to the foramina in C arise generally from the IIIrd perforating (Tables 10 and 13).
5. Conclusion: According to the origin of the arteries and the height of the foramina, the nutrient arteries to the shaft of the femur are distinguished into proximal, middle and distal groups. In the most typical pattern, the proximal nutrient artery arises from the Ist perforating and enters the foramen in A (Fig. 1), the middle nutrient arises from the IInd perforating and enters the foramen in B, and the distal nutrient arises from the IIIrd perforating and enters the foramen in C. Generally there occur two of these nutrient arteries, less frequently a single artery (especially the middle perforating) and sometimes all of the three (Tables 7 and 14). Though rarely, one of them occurs in double, by which various patterns give rise.

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Fibrinolysis as a factor of the hemorrhagic tendency is occasionally found in surgery, especially following open heart surgery with a pump-oxygenator. To clarify the cause of fibrinolysis and to find out the therapeutic measures, clinical and experimental investigations were performed and results obtained were as follows.
While in fifty seven patients subjected to major operations without a pump-oxygenator only three patients showed fibrinolysis in thrombelastography, fibrinolysis was found in seven patients of twenty nine patients undergone open heart surgery with the use of the heart-lung machine of Kay-Anderson type.
Results of the test by euglobulin lysis time in fifteen patients, which is more sensitive for detection of fibrinolytic activity than thrombelastography, showed activation of fibrinolytic activity in all cases immediately after administration of “polybrene”, which is a neutralizer of heparin. It was therefore obvious that polybrene enhanced fibrinolysis.
It was also proved in vitro that polybrene activated plasminogen proactivator by the method of fibrin plate.
Epsilon amino-n-caproic acid (EACA) was effective for the therapy of fibrinolysis in dogs produced by streptokinase, and an effective dose of EACA was 0.25-0.50 gram per kilogram of body weight. By the data mentioned above, about 0.25 gram of EACA per kilogram of body weight was administered into sixteen patients before administration of polybrene, which is an activator of plasminogen proactivator, for the prophylaxis of fibrinolysis and a remarkable decrease in postoperative blood loss through intrapleural drainage was found. Also no cases showed fibrinolysis in thrombelastography.

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The effects of fatty acids on swelling and contraction of mitochondria taken from rat liver and Ehrlich ascites tumor cells are studied and the following results were obtained.
1. The swelling of rat liver mitochondria is induced most effectively by myristic acid (14carbon chain compound) among the saturated fatty acids and by cis form unsaturated fatty acids more than trans form. These effects are proportional to the degree of stimulation on latent ATPase activity by fatty acids.
2. The degree of swelling of rat liver mitochondria is proportional to a concentration of oleic acid and is inhibited by anaerobiosis, cyanide, azide or antimycin A. These swollen mitochondria can be contracted reversibly by ATP, bovine serum albumin and magnesium ion.
3. The swelling action of oleic acid is stronger in the following order on mitochondria taken from mouse liver, liver of Ehrlich ascites tumor bearing mouse, Ehrlich ascites tumor cells and solid tumor. The degree of swelling parallel to respiratory activities in those mitochondria respectively.
4. The increase of respiration, decrease of ATP synthesis and inhibition of oxidative phosphorylation are observed in swollen mitochondria induced by oleic acid.
5. The amount of phosphoprotein and phospholipid in mitochondria decreases by oleic acid and the turnover of phosphate in bothe compounds also decreases.
6. The amount of pottasium in mitochondria increases slightly soon after adding of oleic acid but rather decreases later on.

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