岡山医学会雑誌

野外動物,住民の日本脳炎HI抗体および2-ME感受性抗体陽性率の推移(昭和44年度)

日本脳炎の疫学的研究, 第27報

緒方正名, 長尾寛, 渡辺真策, 人見硬, 実成文彦, 目黒忠道, 住田昭三, 安井茂夫, 木南富吉, 大隈義文, 杉 ...

1970 年 82 巻 1-2supplement 号 p. 1-7
発行日: 1970/02/28
公開日: 2009/03/30

DOIhttps://doi.org/10.4044/joma1947.82.1-2supplement_1

ジャーナルフリー

抄録を表示する抄録を非表示にする

The Japanese encephalitis patients of Okayama Prefecture in 1968 and 1969 were less, and the median date of epidemic time curve in 1968 and 1969 was later in coming than in 1965-1967. In order to clarify this fact, variation of the level of HI and 2-ME sensitive antibodies in the sera of swine, canine, and inhabitants were measured every week in summer of 1969, and the relationship between these seasonal variation of antibody level and the seasonal outbreak of patients were examined. By comparing these findings with those in 1965-1968, the following results were obtained.
1) In both norhtern and southern parts of Okayama Prefecture in 1969 year, the respective date showing 50 per cent positive HI reaction and 2-ME sensitive reaction (D, 50% pos. HI and D, 50% 2-ME in short) in swine was 10 days later than in 1965-1967 and 10 days earier than in 1968.
2) In inhabitants also, of both parts of the prefecture, D. 50% pos. 2-ME was more later in coming, and the positive rate of 2-ME sensitive reaction was also lower than in 1965-1967, that is, inhabitants received inapparent infection later and the rate of receiving inapparent infection was lower than in 1965-1967. And D. 50% pos. 2-ME was 10 days earier than that in 1968.
3) In the case of blood taken from the same out-patient successively, 2 out of 10 person shows 2-ME positive reaction in August in Kurashiki district and 2 out of 13 person in Tsuyama district.

抄録全体を表示

PDF形式でダウンロード (415K)
Adjuvant添加日本脳炎不活化vaccineによる予防接種の効果と自然感染の際の血清反応

日本脳炎の疫学的研究第28報

緒方正名, 長尾寛, 実成文彦, 北村直次, 岡崎時夫, 簡野正一郎, 藤原若彦, 芳谷尚, 田中欣一

1970 年 82 巻 1-2supplement 号 p. 9-18
発行日: 1970/02/28
公開日: 2009/03/30

DOIhttps://doi.org/10.4044/joma1947.82.1-2supplement_9

ジャーナルフリー

抄録を表示する抄録を非表示にする

We divised the vaccination with formalin inactivated virus of Japanese encephalitis mixed with complete adjuvant to the swine for inducing high titer of hemoagglutinin inhibition (HI in short) and neutralizing antibody which could prevent viremia, when swine were bitten by hazardous mosquitoes.
The results obtained were as follows.
1) The higher titer (1; 810) of HI antibody was induced by three times injections of 6 ml, 6 ml and 8 ml of inactivated Japanese encephalitis vaccine with complete adjuvant than that without adjuvant, and titer of HI antibody (1:400) showed itself 84 days after 1st injection with complete adjuvant.
2) The neutralizing antibodies obtained by the vaccination were almost proportional to HI antibodies.
3) HI antibodies of swine were increased by natural infection in 22nd of August. And it was recognized that 2-mercaptoethanol resistant antibodies were produced by vaccination with complete adjuvant as well as vaccination without complete adjuvant. However 2-mercaptoethanol sensitive antibodies were produced in swine of the non-vaccinated group by natural infection.
4) Viremia could be detected in 2 out of 4 swine in the non-vaccinated group, but could not be detected in the vaccinated group in Takahashi district.
5) In order to know that Japanese encephalitis viruses are spread or not through mosquitoes in a swinery where swine are vaccinated with the Japanese encephalitis virus mixed with the complete adjuvant, above vaccination was conducted.
And rabbits decoied for mosquitoes' attacks were set in a swinery of Yoshinaga district as well as of Wake district as a non-vaccinated control and the HI titer, in rabbit' blood was tested, and the next results were obtained.
a) The rabbits set in the swinery in Yoshinaga district where all eight swine received the vaccination of formalin inactivated virus mixed with the complete adjuvant, showed the negative HI reaction.
b) In Wake district where only six swine among forty ones received the above vaccination at the swinery, one out of three rabbits showed the positive HI reaction in the rabbit serum.
6) Piglets were born from 5 swines out of 10 received inactivated vaccine alone at Bisei Town situated in southern part in Okayama prefecture, and it is suggested that viremia was induced in swine innoculated with inactivated virus alone, by natural infection.

抄録全体を表示

PDF形式でダウンロード (1135K)
電子計算機による日本脳炎の流行時期の予測

日本脳炎の疫学的研究, 第29報

緒方正名, 大崎紘一

1970 年 82 巻 1-2supplement 号 p. 19-25
発行日: 1970/02/28
公開日: 2009/03/30

DOIhttps://doi.org/10.4044/joma1947.82.1-2supplement_19

ジャーナルフリー

抄録を表示する抄録を非表示にする

For the purpose of forecasting the date of prevalenc of Japanese encephalitis in Japan, we estimated the median date of this epidemic time curve of the prevalence from the regression equation of one variable and multiple regression equation from the above factors using an electronic computer. And the following results were obtained.
1) To estimate median date (y) and mode (z) of the epidemic curve of the prevalence, we can use the next equation:
The regression equation to estimate y or z from T. 6, 7 (x₁) is as follows.
y=3.75x₁+144.47 σ₀=12.4……(1)
z=-3.80x₁+157.26 σ₀=14.9 ……(1)'
The regression equation from D. pos. swine (x₂) is as follows.
y=0.68x₂+31, 82 σ₀=9.7 ……(2)
z=0.76x₂+40.71 σ₀=12.0……(2)'
The multiple regression equation from T 6, 7 and D. pos. swine is as follows.
y=1.07x₁+0.62x₂+59.37 σ₀=9.7……(3)
z=-0.79x₁+0.71x₂+61.02 σ₀=12.0……(3)'
The multiple regression equation from T 6, 7 D. pos. swine, latitude and longitude is as follows.
y=1.01x₁+0.58x₂-0.26x₃+0.37x₄+18.50 σ₀=9.8……(4)
z=-0.32x₁+0.52x₂+2.05x₃+0.54x₄-87.81 σ₀=11.8……(4)'
These factors (x₁, x₂)were obtained as the results from 1965 to 1967.
2) We got the estimated value of median and mode in 18 prefectures in 1968 and 14 prefecture, in 1969 in Kyushu, Chugoku, Shikoku, Kinki and Kanto provinces from (1) or (2) or (3) or (4) equation. Ten prefectures out of 17 prefectures by equation (1), 12 out of 18 by (2), 13 out of 18 by (3), and 13 out of 18 by (4) could be estimated with about 10 days (σ₀) error or less in 1968. And in 1969, 9 out of 14 by (3). 7 out of 13 by (4) could be estimated. In the case of mode, 10 out of 18 by equation(1)', 6 out of 17 by (2)', 8 out of 17 by (3)', 12 out of 18 by (4)' could be estimated with about 12 days (σ₀) error or less in 1968, and 9 out of 14 by equation (3)' and 9 out of 13 by equation (4)', in 1969.
3) For the estimation of median and mode of prevalence of Japanese encephalitis two new factors; the date when the numbers of caught mosquitoes (Q. t.) were found to be maximum, and the date when hazardous mosquitoes were found at first, were added to above four factors (T. 6, 7 and D. pos. swine, latitude and longitude) by the data on multiple regression equation. But accuracy of estimation did not increase significantly.

抄録全体を表示

PDF形式でダウンロード (415K)
日本脳炎の流行の規模(size)の予測及び周期について(特に岡山県を中心として)

日本脳炎の疫学的研究,第30報

緒方正名, 大崎紘一

1970 年 82 巻 1-2supplement 号 p. 27-35
発行日: 1970/02/28
公開日: 2009/03/30

DOIhttps://doi.org/10.4044/joma1947.82.1-2supplement_27

ジャーナルフリー

抄録を表示する抄録を非表示にする

For the purpose of forecasting cn the degree of prevalence of Japanese encephalitis in Okayama Prefecture, we estimated the incidence rate of the prevalence from the regression equation of one variable and multiple regression equation from the various factors using an electronic computer. And the following results were obtained.
1) On regression equation, estimation of incidence rate from the number of Cuiex tritaeniorhychus from May to July (C. t. 5-7 in short) is most correct. And the average atmospheric temperature from June to July (T. 6-7 in short) and vaccinated rate of inhabitants can also be useful for estimation.
2) On multiple regression equation, incidence rate can be estimated correctly in the descending order from (1) duration of sunshine in July, rainfall volume and Trit. 5-7, <(2) added vaccination rate of inhabitants to the above factors (1)<(3) added T. 6-7 and median date of epidemic time curve to the above factors (2).
3) In all Japan, presence of period of cycle, of 7 or 8 years, was recognized to be significant from 1954 to 1961. To each prefecture, period of cycles were detected to be various periods; 3 or 4 year's period to Nagasaki Prefecture, 6 or 7 year's to Okayama and Hyogo, 7 or 8 year's to Osaka, 5 year's to Kyoto, every second year's to Nagano by 1959, every year's by 1962 to Kanagawa, 2 or 3 year's from 1952 to Gunma and every second year's by 1958 to Ibaragi.

抄録全体を表示

PDF形式でダウンロード (497K)
1969年岡山県下における蚊の出現状態と日本脳炎発生状況について

稲臣成一, 板野一男, 村主節雄, 作本台五郎, 頓宮廉正, 木村道也, 山本友子

1970 年 82 巻 1-2supplement 号 p. 37-58
発行日: 1970/02/28
公開日: 2009/03/30

DOIhttps://doi.org/10.4044/joma1947.82.1-2supplement_37

ジャーナルフリー

抄録を表示する抄録を非表示にする

1. 1969年度岡山県下の蚊の出現数は昨年に比して,南部に於いて顕著に減少している.
2. 日本脳炎患者発生数も一般に減少の傾向を示し,蚊の出現数に平行していた.
3. 平均気温は比較的高く, 25℃を越えた7月13日を前後にC.t.のピークが表われている.

抄録全体を表示

PDF形式でダウンロード (833K)

J-STAGEへの登録はこちら（無料）