巻号一覧
94 巻 (1982)
- 11-12 号 p. 967-
- 9-10 号 p. 775-
- 7-8 号 p. 599-
- 5-6 号 p. 393-
- 3-4 号 p. 165-
- 1-2 号 p. 1-
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
94 巻, 11-12 号
選択された号の論文の16件中1～16を表示しています
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第III報 生体内投与における0-ジクロルベンゼンのラット肝に対する作用森 孝昭1982 年 94 巻 11-12 号 p. 967-972
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーo-Dichlorobenzene (o-DCB) was emulsified in a 2.5% gum arabic solution and given orally to rats for 60 and 120 days. The effects of o-DCB on rats were compared with control rats given water containing the same percent of gum arabic.
The following results were obtained:
1. The livers of rats administered o-DCB were slightly heavier than those of control rats.
2. Triglyceride levels of rats administered o-DCB were higher than those of control rats. The level of triglyceride in rats administered o-DCB tended to increase according to the duration of o-DCB administration.
3. The level of ATP in the liver of rats administered o-DCB was significantly lower than that in the liver of control rats.
4. The respiratory control of liver mitochondria of rats administered o-DCB decreased in state3 respiration, and increased in state4 respiration.
The respiratory control index of the liver mitochondria decreased after o-DCB was given orally to rats, and it was observed that the longer the period administration was, the lower the respiratory control index was.抄録全体を表示PDF形式でダウンロード (270K) -
第2報 尿中の微量蛋白質の採尿後即時定量法について田中 由紀子1982 年 94 巻 11-12 号 p. 973-983
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーThe total protein in urine from young boys before and after exercise was measured by spectrophotometry, using the TONEIN-TP reagent, and at the same time by naked-eye colorimetry.
Both methode were performed without delay after the urine was excreted. The latter method is simpler than the usual methods. In order to confirm the reliability of the naked-eye colorimetry, total protein in the urine of factory workers was also determined.
The following results were obtained:
1. The total protein in the urine of young boys before and after exercise was measured immediately after excretion in the field using a portable spectrophotometer. The young boys between the ages of 15-17 trained and rested together at a lodge during the summer of 1981. They belong to a basket ball or judo team.
2. It was confirmed that the increase in urine albumine was greater after exercisee than before by single radial immunodiffusion assay. The value of total protein and albumine in urine correlated well, especially in tests after exercise.
3. The author devised a simple method in which the TONEIN-TP reagent was added to the urine and coloration was determined with the naked eye instead of with a spectrophotometer. There was no statistical difference between the two methods.
4. The measurement of total protein in urine from workers was done by the TES-TAPE and the naked-eye methods. The latter method was more sensitive (5 mg/dl) than the TES-TAPE (30 mg/dl) method, so it is thought to be convenient when quick measurements are required. This method using the TONEIN-TP reagent was simple and sensitive. Moreover, the urine was used immediately after being excreted in the field, therefore, it was not necessary to worry about a chemical change occuring during preservation of the urine.抄録全体を表示PDF形式でダウンロード (619K) -
松本 緑郎1982 年 94 巻 11-12 号 p. 985-993
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリー11例の健常例, 18例の慢性膵炎例, 6例の急性膵炎例および5例の膵癌例においてPS試験の際得られた十二指腸液中のcyclic AMPを測定した. cyclic AMPは健常群においてはsecretinによる膵bicarbonate分泌の細胞内mediatorとして働いていると考えられるが,膵疾患時にはcyclic AMP-bicarbonate分泌機構が円滑に働かないと考えられ,量的にもcyclic AMP outputは低下していた.すべての群においてcyclic AMP outputはbicarbonateおよびamylase outputの上昇と同様にpancreozyminおよびsecretin刺激後にピークに達した. cyclic AMP outputは健常群に比し,膵疾患群では有意に低下した.一方, pancreozyminによるamylase分泌にはcyclic AMPは関与していないと考えられた.十二指腸液中のcyclic AMPはPS試験のparameter として応用できる可能性があると考えられた.しかしながら十二指腸液中のcyclic AMPの起源は膵のみでなく,膵,胆道系および十二指腸分泌の総合的な表現の可能性も考えられた.抄録全体を表示PDF形式でダウンロード (454K) -
永井 弘1982 年 94 巻 11-12 号 p. 995-1002
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーA simple silver stain for selective visualization of lysine-rich proteins in polyacrylamide gels was developed. The specificity of the stain was confirmed with a variety of protein mixtures. The staining procedure requires a relatively short time (2.53 hours) and has a sensitivity comparable to that of the conventional Coomassie blue stain (about 0.1μg per band for lysine-rich histones). Differences between the new staining procedure and other “highly sensitive non-specific silver stains” are discussed.抄録全体を表示PDF形式でダウンロード (1899K) -
緒方 正名, 水垣 順子, 泉 正樹, 武田 和久1982 年 94 巻 11-12 号 p. 1003-1008
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーErythrocyte catalase of a Japanese-type acatalasemia case and a normal control subject was separated by chromatofocusing with or without prior partial purification with DEAE cellulose and analyzed by polyacrylamide gradient gel electrophoresis.
Two bands of catalase activity were found in the partially purified preparations with molecular weights of 29×104 and 35×104 in the acatalasemia case and of 28×104 and 36×104 in the normal control. The molecular weight of normal catalase in untreated hemolysate was 25×104.
With normal catalase, chromatofocusing fractionation caused a shift toward higher molecular species in the alkaline range eluates from the untreated hemolysate and an opposite shift toward lower molecular weight species in the same pH range eluates from the partially purified preparation.
Normal catalase could be identified as protein bands on polyacrylamide gradient gel with hemolysate fractionated by chromatofocusing. Possible application of this technigne in the study of acatalasemia protein with a sensitive protein stain was suggested.抄録全体を表示PDF形式でダウンロード (793K) -
免疫賦活剤OK-432の術前腫瘍内投与および摘脾の併用効果鳩嵜 明一1982 年 94 巻 11-12 号 p. 1009-1022
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーThe acceleration of metastasis after excision of the main malignant tumor and the worsening of the prognosis are sometimes experienced. This phenomenon was simulated in model experiments using Lewis lung carcinoma (3LL) cells and BDF1 mice. The change of cell-mediated immunity was also studied using delayed type hypersensitivity (DTH) skin reaction. For the purpose of getting a better prognosis, preoperative intratumoral administration of large doses of the immunostimulant OK-432 and splenectomy were studied as possible adjuvant therapy to surgical treatment.
Pulmonary metastases and their growth were accelerated after excision of the main subcutaneous tumor, and as a result survival time was not extended. However, DTH increased after the operation. Splenectomy in the early stage was significantly effective on survival, increase of DTH and growthinhibition of the main tumor. The optimum dose of OK-432 in intratumoral administration was 10KE/mouse, and a significant effect was obtained on survival, increase of DTH and growth-inhibition of the main tumor with this dose. Preoperative intratumoral administration of OK-432 and splenectomy in the early stage were useful adjuvant therapy to surgical treatment. A significant effect was obtained on suppression of pulmonary metastases, increase of DTH and survival.抄録全体を表示PDF形式でダウンロード (809K) -
緒方 正名, 久保 善平1982 年 94 巻 11-12 号 p. 1023-1036
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーMortality due to cerebral vessel disease, malignant neoplasm, heart disease, pneumonia and bronchitis and accident was recorded from 1971 to 1975 in Okayama Prefecture and death rates adjusted to the Japanese population classified by age in 1950 were determined. The results obtained were as follows.
1) The incidence of cerbral vessel and heart disease was higher in the northern part of Okayama Prefecture than that of in the southern part. The incidence of neoplastic disease was high, and pneumonia and bronchitis was low in the southern area of Okayama Prefecture. Deaths by accident were relatively few in the South. The rate of longevity is higher in the North than the South.
2) The correlation coefficient among the five main causes of death and longevity rates was calculated, and a significant positive correlation was found between longevity rates of the various areas and between cerebral vessel diseases and accidents (P>0.1) significant negative correlation was found between the longevity rate and neoplasm at the 5% level.
3) Corrected death rates of the five main diseases in each district were classified in the 6 groups by cluster analysis.抄録全体を表示PDF形式でダウンロード (14920K) -
玉井 豊理, 田辺 正忠, 青野 要, 水川 帰一郎, 若林 寿生, 佐藤 功, 森本 節夫, 大川 元臣, 上者 郁夫, 児島 完治, 木 ...1982 年 94 巻 11-12 号 p. 1037-1044
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーDuring the 6 years from 1969 to 1974, 31 patients with esophageal cancer were treated by radiotherapy with focal doses above 4, 000 rad (40 Gy). Cobalt 60 gamma rays were employed for the irradiation with parallel-opposing portals.
Survival rates for these patients were 45.1% for 1 year, 12.9% for 2 years, 9.7% for 3 and 4 years, and 6.5% for 5 years; they mean survival time was 16.2 months. The results were tabulated according to the tumor types, lengths and sites and according to doses. Two of the 3 cases who survived more than 4 years were irradiated with 10, 000 rad (100 Gy) and more focal doses including reirradiation of local recurrences.抄録全体を表示PDF形式でダウンロード (375K) -
第2報 ラット肝ミトコンドリアのエネルギー転換系に対するハロゲン化炭化水素の作用荻野 泰夫1982 年 94 巻 11-12 号 p. 1045-1050
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーIn order to investigate the influence of various environmental pollutants on living organisms, the effects of hlogenated hydrocarbons on the mitochondrial membrane were examined. The results obtained were as follows:
1) Monohalogenated benzenes decrease state 3 respiration and increase state 4 respiration, resulting in a decrease in both respiratory control (RCI) and the ADP/O ratio.
2) The above activity is in the decreasing order of iodobenzene, bromobenzene, chlorobenzene and fluorobenzene. This order of activity is parallel to that of potassium releasing activity.
3) Similarly to the effect of monohalogenated benzenes, brominated hydrocarbons also decrease both RCI and the ADP/O ratio. The activity is in the decreasing order of tribromobenzene, dibromobenzene, boron carbide, monobromobenzene and bromoform, which parallels the potassium releasing activity.抄録全体を表示PDF形式でダウンロード (272K) -
上田 稔, 山田 信行, 内田 俊明, 庵谷 和夫, 斎藤 大治, 原岡 昭一, 西山 修, 喜多 利正, 種谷 節郎, 堺 裕, 榊原 宏1982 年 94 巻 11-12 号 p. 1051-1057
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーWe studied the echocardiograms of 243 school children who needed further examination of the heart beyond electrocardiography, auscultation, chest X-ray and/or medical history.
1. Thirty of them showed mitral valve prolapse including two with Marfan's syndrome, one with arrythmias exaggerated by physical exercise and a case with left ventricular volume overloading.
2. Five of eight patients who were suspected to suffer from a atrial septal defect by electrocardiography and auscultation showed right ventricular volume overload echocardiographically. In four of the five, an intracardiac shunt at the atrial level was confirmed by contrast echocardiography.
3. One case with right ventricular hypertrophy as determined by electrocardiography showed right ventricular pressure stress echocardiographically. He was diagnosed as having primary pulmonary hypertension by cardiac catheterization.
4. A ventricular septal defect and patent ductus arteriosus were diagnosed in six cases by auscultation or phonocardiography, but not so by echocardiogaraphy. Echocardiography as a secondary examination is not only diagnostic in itself but also is beneficial in determining whether or not further examination (cardiac catheterization) is needed.抄録全体を表示PDF形式でダウンロード (2041K) -
第1編 気管支喘息における喀痰中の好塩基球について斎藤 勝剛1982 年 94 巻 11-12 号 p. 1059-1066
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーA total of 103 samples of sputum from 20 patients with bronchial asthma were examined for appearance of basophils and eosinophils.
The results are as follows:
1) Basophilic leucocytes were found in the sputum of patients with bronchial asthma.
2) Basophils appeared in sputum during asthma attacks and disappeared during nonattack stages.
3) The number of basophils in sputum tended to increase at the end of attack stages.
4) High incidence of basophils in sputum was observed in asthmatic patients with low serum IgE levels.
5) Appearance of basophils in sputum was accompanied with that of eosinophils.
6) Appearance of basophils in sputum was related to the number of peripheral basophils, but not to the daily volume of sputum.
These results suggest that basophils migrate from the blood stream into bronchial tissues and appear in sputum during attack stages of bronchial asthma.抄録全体を表示PDF形式でダウンロード (421K) -
第2編 気管支喘息における皮膚および気管支の遅発型反応について斎藤 勝剛1982 年 94 巻 11-12 号 p. 1067-1075
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーLate skin and bronchial responses to house dust and Candida allergens were examined in 301 patients with bronchial asthma.
The results were as follows:
1) Late skin and bronchial responses to house dust extract were related to serum IgE levels, basophil reactivity to anti-IgE and RAST score of house dust,
2) Late skin and bronchial responses to Candida extract were related to precipitating antibodies to Candida, although these responses were not related to serum IgE levels and basophil reactivity to anti-human IgE.
These results suggest that the late response to house dust allergen was mainly elicited by IgE-mediated type I allergic reaction and that the late response to Candida allergen was in part elicited by precipitating antibody-mediated type III allergic reaction.抄録全体を表示PDF形式でダウンロード (476K) -
第1編 滑液中,及び末梢血中の凝固細溶能森本 忠一1982 年 94 巻 11-12 号 p. 1077-1086
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーCoagulation and fibrinolysis were examined in the synovial fluid and peripheral blood of rheumatoid arthritis (RA) patients. The results are summarized as follows:
1. In the peripheral blood of RA patients, coagulation and secondary fibrinolysis were higher than in healthy controls. These findings seemed to be compatible with chronic DIC.
2. Fibrinolysis was present in the synovial fluid of RA and OA patients. A positive correlation was found between the degree of inflammation and fibrinolysis in the synovial fluid of RA. However, antiplasmin activities were simultaneously elevated so that fibrinolysis was depressed and fibrin formation became dominent. Thus, local fibrin deposition may develop.抄録全体を表示PDF形式でダウンロード (511K) -
第2編 慢性関節リウマチの線維素溶解剤による治療の試み森本 忠一1982 年 94 巻 11-12 号 p. 1087-1093
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーCoagulation and fibrinolysis of RA patients were examined and Hypercoagulation and secondary fibrinolysis were found. On the basis of these findings, fibrinolytic treatment with 24, 000 ploug units of urokinase was performed. Urokinase treatment was effective in 5 out of 7 cases and seemed especially useful in alleviating symptoms of circulatory disturbances.抄録全体を表示PDF形式でダウンロード (321K) -
中島 晃1982 年 94 巻 11-12 号 p. 1095-1111
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーHistogenesis of experimental pancreatic carcinoma induced by DIPN in hamsters was studied morphologically and histologically. On the basis of carcinogenesis, two stages of changes in pancreatic tissue were seen: one being edematous which peaked at 8-10 weeks and the other being storomalfibrotic with acinous atrophy, resembling chronic pancreatitis. Hyperplastic changes (papillary hyperplasia and ductal proliferation) developed in the former stage, and atypical duct and adenomatous lesions (intraductal, tubular, papillary cystic and multilocular adenoma) were seen in the latter stage. In view of the histological resemblance of the stages, it was thought that hyperplastic changes develop into adenomatous lesions gradually. Pancreatic carcinomas, all of ductal origin, were seen at 16 weeks and after. Metastasis in regional lymph nodes and invasion of lymph and blood vessels were observed. According to the size of tumors and existence of infiltration, carcinomas were classified as infiltrated, minute and in situ carcinomas. Because of the similarity in the histological features, it was suggested that adenomas became infiltrated carcinomas, and intraductal adenomas or atypical ducts were the source of in situ carcinomas. However, minute carcinomas, in the absence of a precancerous lesion, were thought to be de novo in origin.抄録全体を表示PDF形式でダウンロード (3249K) -
古田 知久1982 年 94 巻 11-12 号 p. 1113-1125
発行日: 1982/12/30
公開日: 2009/08/24
ジャーナル フリーA flow cytometric analysis of DNA synthesis and a quantitative investigation of nervous system-specific S-100 protein were performed on cultured rat glioma (C-6) cells in the course of morphological differentiation induced by 1 mM dibutyryl cyclic AMP (dbc-AMP). The flow cytometric analysis revealed that a marked suppression of DNA synthesis was caused by dbc-AMP. The content of S-100 protein in dbc-AMP treated cells began to increase on the fourth day after the treatment with a subsequent increase to approximately 10-fold over the control cells at the stationary phase.
These results suggest that S-100 protein is a useful biochemical index for estimating the degree of differentiation of glioma cells.抄録全体を表示PDF形式でダウンロード (2337K)
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