巻号一覧
96 巻 (1984)
- 11-12 号 p. 1037-
- 9-10 号 p. 865-
- 7-8 号 p. 665-
- 5-6 号 p. 449-
- 3-4 号 p. 263-
- 1-2 号 p. 1-
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
96 巻, 9-10 号
選択された号の論文の15件中1～15を表示しています
- |<
- <
- 1
- >
- >|
-
第1編 肝の形態および血液生化学検査の検討曽我部 輝子1984 年 96 巻 9-10 号 p. 865-874
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーAfter administration of ethanol and pyrazole, a patient inhibitor of alcohol dehydrogenase, for 3 weeks to rats, histological changes, liver function tests and triglyceride contents of the liver were examined. Centrilobular zonal cell necrosis, remarkable eosinophilic degeneration, nuclear changes and fat deposition were found. Significant elevation of alkaline phosphatase was observed. Furthermore, there was retardation of growth. From these results, the marked liver damage produced by combination of ethanol and pyrazole can be atributed to the hormonal effect of a relatively high concentration of ethanol on liver cells and the combined effect of ethanol and pyrazole on liver cell microsomes.抄録全体を表示PDF形式でダウンロード (1668K) -
第2編 肝の糖質代謝律速酵素およびアルコール脱水素酵素に関する検討曽我部 輝子1984 年 96 巻 9-10 号 p. 875-881
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーAfter administration of ethanol and pyrazole, a potent inhibitor of alcohol dehydrogenase, for 3 weeks to rats, enzyme activities of key glycolytic enzymes of the liver (glucokinase, hexokinase, glucose-6-phosphate dehydrogenase, pyruvate kinase), a key gluconeogenic enzyme, (glucose-6-phosphatase), and alcohol dehydrogenase were invesgated. The resulting enzyme patterns are as follows: In rats treated with ethanol alone, glucose-6-phosphate dehydrogenase activity was decreased and glucose-6-phosphatase activity was increased. In the group treated with pyrazole, activities of hexokinase and glucose-6-phosphatase were decreased. In the group treated with pyrazole and ethanol, the activity of glucose-6-phosphate dehydrogenase was significantly increased, and those of pyruvate kinase and glucose-6-phosphatase were significantly decreased. The enzyme patterns appear to be different from those in liver injured by alcohol or hepatotoxins. This result suggests that liver damage caused by ethanol and pyrazole is due not only to high blood alcohol levels, but also to a combined effect of pyrazole and alcohol in regard to hepatic microsomes.抄録全体を表示PDF形式でダウンロード (299K) -
第1編 X線照射のマウス末梢血液細胞の回復に対するセファランチンの効果飯田 荘介1984 年 96 巻 9-10 号 p. 883-890
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーThe change in hemograms of mice was investigated after a whole-body bose of 300R of x-rays. Cepharanthin, a biscoclaurine alkaloid, was injected intraperitoneally 0.1, 0.2 and 0.4mg per mouse into mice from the first day to the fourteenth day following the irradiation. Cepharanthin (0.1mg) significantly accelerated the recovery of peripheral leukocytes compared with the control. However, cepharanthin injected at higher concentrations was less effective, thus the optimum dose was 0.1mg. In a differntial count of leukocytes, the relative percentage of granulocytes decreased in control irradiated mice, and increased in cepharanthin injected mice. The difference in the recovery of the actual number of lymphocytes was not statistically significant between the control and cephalanthin injected mice. This fact indicates that the marked recovery of leukocytes after irradiation followed by cepharanthin is due to the increased the recovery of actual number of granulocytes. The effect of cepharanthin was discussed in relation to radiation damage of hemopoietic function.抄録全体を表示PDF形式でダウンロード (436K) -
第2編 X線照射後のマウス造血組織に及ぼすセファランチンの効果飯田 荘介1984 年 96 巻 9-10 号 p. 891-899
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーAfter a whole-body irradiation at a single dose of 500R, mice were injected intraperitoneally with 0.1mg of cepharanthin (CR) every day for 20 days. Endogenous spleen colonies (CFU-S) were counted on Day 10, and the spleen and thymus weight was measured, peripheral leukocytes counted and hematocrit value determined for 30 days after the irradiation. The number of CFU-S increased remarkably in CR injected mice compared with control mice. Decreased spleen weight by irradiation recovered in excess by Day 30. In CR administered mice, the spleen weight increased transitorily along with the proliferation of CFU-S. After irradiation, the recovery of thymus weight was delayed compared with the spleen. Therefore, the effect of CR administration was not clear. Peripheral leukocytes decreased in number successively up to Day 10 and recovered linearly from Day 20 through Day 30, especially in CR injected mice. The hematocrit value was reduced to a minimum on Day 10 and almost recovered by Day 20 in irradiated mice. CR had no effect on the hematocrit value. The effect of cepharanthin was discussed in relation to radiation damage of hemopoietic tissue.抄録全体を表示PDF形式でダウンロード (455K) -
十川 秀夫1984 年 96 巻 9-10 号 p. 901-919
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーFrom 1975 to 1980, cementless total knee replacement (Mark-II, Okayama university type) has been performed in 66 patients, including 22 with rheumatoid arthritis and 8 with osteoarthritis. A radiographic follow-up study was made on 30 of these cases (45 knees). The average follow-up time was 5.4 years (from 3 to 8 years). The radiographic findings were compared with clinical assessment (Three Universities' Criteria).
There was no direct correlation between clinical assessment and radiographic findings, especially in the areas of pain relief and radiographic alignment. In the radiographic follow-up, bony sclerosis spreading into the medial condyle of the tibia was found in 11 cases (24 percent). Medial tilting of the tibial component and varus deformity was significantly greater in the medial sclerosing group than in the non-sclerosing group. The overall score, including pain and lateral instability, was less in the medial sclerosing group. It was indicated that medial tilting of the tibial component and varus deformity have an indirect correlation with the clinical results of total knee replacement.抄録全体を表示PDF形式でダウンロード (3108K) -
吉田 英紀, 庵谷 和夫, 長花 晴樹, 西原 正信, 今滝 健介, 木村 正司, 庵谷 文夫, 森近 豊, 大西 茂明, 藤井 章伸, 斉 ...1984 年 96 巻 9-10 号 p. 921-932
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーIt is often difficult to diagnose between cardiomegaly due to essential hypertension (EH) and that due to idiopathic cardiomyopathy (ICM). For the purpose of finding some useful clinical data for differentiating between cardiomegaly due to EH and that due to ICM, we examined the E. C. G., chest X-P and U. C. G. findings of 66 cases of EH and 46 cases of ICM. Body surface isopotential mappings (maps) were studied in 16 cases of EH and 18 cases of hypertrophic cardiomyopathy (HCM). Among those showing ASH or SH patterns in U. C. G., the ages of the EH group were greater than those of the ICM group. The thickness of the intraventricular septum (IVST) and the IVST/PWT ratio were greater and the left ventricular diastolic dimenaion (LVDd) was smaller in the ICM group than in the EH group. Among EH patients, the age and the systolic blood pressure were greater in those with abnormal U.C.G. findings. The septal activation time (SAT) obtained from maps correlated well with the IVST (r=0.55, p<0.005) and IVST/PWT ratio (r=0.61, p<0.005) obtained from U. C. G. In all of the HCM cases, the values os SAT were over 30 msec., the values of IVST over 25 mm and the IVST/PWT ratio over 2.0. These results suggest that these parameters should discriminate cardiomegaly due to EH from that due to ICM.抄録全体を表示PDF形式でダウンロード (3089K) -
第1編 各種膠原病における抗RNP, 抗Sm抗体の臨床的研究河本 紀一1984 年 96 巻 9-10 号 p. 933-943
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーThe antibodies to ribonucleoprotein (RNP) and Sm antigen were studied in patients with various connective tissue diseases including systemic lupus erythematosus (SLE) (150), scleroderma (28), polymyositis (25), rheumatoid arthritis (25), mixed connective tissue diseases (MCTD) (29), sclerodermatomysitis (8), sicca complex (70) and others (2).
One hundred fifty patients with SLE were divided into three groups: group 1 patients (37) had anti-RNP alone, group 2 patients (46) had anti-RNP and anti-Sm and group 3 patients (67) had neither anti-RNP nor anti-Sm. Raynaud's phenomenon and central nervovs disease were significantly more common in patients of groups 1 and 2 than group 3. Renal disease, elevated n-DNA binding and decreased CH50 were less common in patients of group 1 than group 3. LE cell phenomenon was less common in groups 1 and 2 than group 3. Renal disease was significantly less common in group 1 than group 2.
Scleroderma patients with anti-RNP had fever, elevated ESR and hypergammaglobulinemia more frequently than those without anti-RNP.
Twenty-nine patients with MCTD were divided into 2 groups: 16 patients with definite or probable collagen disease and 13 patients with probable collagen disease. The patients of the second group had swollen hands more frequently, and usually only had anti-RNP. The serological and clinical features of patients in the first group appeared to be more uniform and distinctive than those of patients in the second group.
Patients with sicca complex and anti-RNP showed a significantly higher frequency of fever, arthralgia, Raynaud's phenomenon, erythema and lower frequency of the rheumatoid factor than patients without anti-RNP.抄録全体を表示PDF形式でダウンロード (847K) -
第2編 全身性エリテマトーデスに認められる中枢神経症状の臨床免疫学的研究-抗RNP抗体との関連において-河本 紀一1984 年 96 巻 9-10 号 p. 945-952
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーForty of 150 (27%) patients with systemic lupus erythematosus (SLE) had central nervous system (CNS) disease including psychosis (24), seizure (10), coma (2), meningitis (3) and blindness (1). Raynaud's phenomenon (60%) and antibody to ribonucleoprotein (RNP) (78%) were significantly more common in the CNS SLE group than non-CNS SLE group. On the contrary, LE cell (40%) and clinical renal disease (43%) were less common in the CNS SLE group than the non-CNS SLE group. At the onset of CNS disease, the incidence of elevated n-DNA binding (35%) and decreased CH50 (35%) were significantly lower than in patients without CNS disease. Anti-RNP was present in 78% of the patients at the onset of CNS disease and 47% of the patients without CNS disease; this difference was significant (p<0.002).
Anti-RNP in CSF was demonstrated by the precipitin reaction in 7 patients at the onset of CNS disease. Anti-Sm in CSF was found in only one patient with CNS disease. Enrichment of anti-RNP in CSF over the serum level was demonstrated in 3 patients.
Seventy percent of the CNS episodes began within 8 weeks of the initiation or increase in dose of corticosteroids, including 9 patients within the 1st week, 9 during the 2nd week, 2 during the 3rd week, 5 during the 4th week and 3 during the 5th to 8th week.
These data suggest a high incidence of CNS episodes in patients with SLE and anti-RNP after increasing the corticosteroid dosage.抄録全体を表示PDF形式でダウンロード (747K) -
第1編 肺癌の早期発見に関する研究町田 健一1984 年 96 巻 9-10 号 p. 953-959
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーThe mass survey was carried out for the purpose of early lung cancer detection by annual chest roentogenography in Okayama Prefecture. For 9 years from 1973 to 1981, the total number of those examined was 2, 014, 098; seventy percent of them were aged 40 and older.
Four hundred twenty-eight cases of lung cancer (237 males and 191 females) were detected in this survey. The incidence was 21.25 per 100, 000 and 52.71 per 100, 000 in males aged 40 and older. More than half of them were older than 70 years old.
82.5 percent of lung cancer detected in this survey was peripheral type lung cancer. Most frequently the diameter of the tumor shadow was small; 32.5% was less than 2 cm and 29.1% from 2 to 3 cm.
Histologically, the lung cancer detected in this survey was diagnosed, 53% as adenocarcinoma, 31.4% as squamous cell carcinoma, 8.7% as small cell carcinoma, and 2.9% as large cell carcinoma. Most of the lung cancer detected in this survey was in the early stage; 79.3% was in stage I and II. Surgical resections were carried out on 61% of them.
The mass survey was very effective in detecting early peripheral type lung cancer. But it was not effective in detecting early hilar type. Cytological examination of sputum should be performed on smokers aged 40 and older to detect early hilar type lung cancer.抄録全体を表示PDF形式でダウンロード (1115K) -
第2編 進展期肺癌症例におけるCyclophosphamide, Vincristine, Methotrexate, Procarbazine併用療法に関する研究町田 健一1984 年 96 巻 9-10 号 p. 961-972
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーOne hundred and thirteen patients with advanced lung cancer were treated with a four-drug combination chemotherapy consisting of cyclophosphamide, vincristine, methotrexate and procarbazine. Of those, ninety three (80 men and 13 women) patients were evaluated.
Of 41 patients with small cell carcinoma, 10 (24%) achieved complete response (CR) and 18 (44%) achieved partial response (PR). The median duration of response was 5 months. The median survival time from initiation of chemotherapy was 11.3 months for patients with limited disease and 8 months for those with extensive disease. Responders lived significantly longer than non-responders; median survival time was 14 months for complete responders, 10.3 months for partial responders, and 6 months for non-responders.
Of 52 patients with non-small cell carcinoma, 2 achieved CR and 15 achieved PR: The overall response rate was 33%; with a response rate of 30% (8/27) for adenocarcinoma, 30% (6/20) for squamous cell carcinoma, and 60% (3/5) for large cell carcinoma. The median survival time was 13 months for patients with stage III, and 8 months for those with stage IV. Responders with non-small cell carcinoma displayed a tendency toward longer survival periods; the median survival time was 8.3 months for responders compared with 6 months for non-responders.
Myelosuppressive toxicity remained within acceptable limits, with 8.8% incidence of leucocytepenia (1, 000/cmm) and 6.7% incidence of thromobocytepenia (50, 000/cmm) in repeated courses. These resuts indicate that this regimen is useful for the treatment of advanced lung cancer.抄録全体を表示PDF形式でダウンロード (598K) -
木庭 茂治1984 年 96 巻 9-10 号 p. 973-989
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーThe influence of certain local anesthetics (LA) on immune responses was investigated in in vivo and in vitro systems. Since the stabilization of the cell membrane may play some role in the local anesthetic action of LA, the effect of LA on the cell membrane was also studied by measuring the fluidity of the membranes of lymphocytes and liposomes by steady-state fluorescence anisotropy.
Male babl/c mice were immunized with sheep red blood cells (SRBC), and LA was injected subcutaneously once a day for 5 consecutive days Thereafter, mice were killed by cervical dislocation, and spleen cells were isolated. LA significantly inhibited rosette forming cells and hemolytic plaque forming cells (HPFC). When sensitized-mouse spleen cells were treated with LA in vitro, significant inhibition of HPFC was observed. In another experiment, non-sensitized spleen cells were isolated from the mouse spleen and immunized with SRBC in the presence or absence of LA in a tissue culture plate for 4 days. Higher concentrations of LA inhibited the production of HPFC, but lower concentrations of LA increased the number of HPFC. LA decreased the fluidity of the plasma membrane of purified mice lymphocytes and the liquid crystalline state of liposomes made with dipalmitoylphosphatidylcholine. LA suppressed the histamine release from isolated rat mast cells due to compound 48/80 without affecting the content of c-AMP in mast cells. Inhibitory effects of LA on the responses elicited in lymphocytes and mast cells were considered to be bue to the membrane stabilizing effect.抄録全体を表示PDF形式でダウンロード (921K) -
林 政清1984 年 96 巻 9-10 号 p. 991-1001
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーThis experiment was undertaken to clarify the effect of fat emulsion administered immediately after an operation. Total parenteral nutrition (TPN) was supplied to rats after partial resection of the small intestine. Animals were divided in two groups according to the TPN regimen: TPN without fat (TPN-G) and TPN with 30% of the non-protein calories provided by fat emulsion (TPN-F).
TPN-F and TPN-G showed similar effects on body weight and nitrogen balance. The fat emulsion did not cause deleterious effects. Fat content of the liver was increased at 3 POD in both groups. The increase was attributable to triglycerides. Liver and muscle glycogen rose at 3 POD and returned to preoperative values at 5 POD. The results show that fat emulsion providing 30% of the non-protein calories is utilized as well as glucose in the immediate postoperative period.抄録全体を表示PDF形式でダウンロード (488K) -
明石 英夫1984 年 96 巻 9-10 号 p. 1003-1017
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーIntra-osseous fixation of transplanted flexor tendons has been used widely in clinical practice, but the anchoring process has not been elucidated well. In the present study, tendon fixation was observed histologically in chickens whose flexors are similar anatomically to human tendon. Right deep flexors of the third digits were cut at the insertion, and then reanchored to the distal phalanx by a pull-out method. Sixteen young chickens (2-3 months after hatcing) were used for the study and sacrificed 4 days to 12 weeks after the procedure. Histological changes at the re-anchored area were examined by light and scanning electron microscopy. A control study confirmed that deep flexor tendons of young chickens directly anchor to the bone tissue, where fine fibrils are dispersed in the bone matrix. Deep flexors re-anchored to the distal phalanx showed a healing process between the tendon and bone. Granulation tissue surrounding the tendon pulled through the anchor hole matured as newly formed connective tissue which connected the tendon and bone, and simultaneously ossification appeared from the bone marrow side. The point of insertion of the re-anchored tendon was made of three layers, consisting of tendon, fibrocartilage and bone, 8 weeks after the operation, similar to the normal anchorage. Ossification seemed to proceed with small granules, about 0.2 μ in size, which may correspond to matrix vesicles. It was indicated that firm fixation between tendon and bone is achieved at about 4 weeks when Sharpey's fibers appear histologically.抄録全体を表示PDF形式でダウンロード (4708K) -
その1 岡山大学泌尿器科における最近9年間の症例について公文 裕巳, 朝日 俊彦, 津川 昌也, 沖宗 正明, 宮田 和豊, 大森 弘之1984 年 96 巻 9-10 号 p. 1019-1027
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーDuring the 9-year period from 1972 to 1980, 1069 cases of urolithiasis were seen in the Department of Urology, Okayama University Hospital. The ratio of males to females was 2.1 to 1. The maximum incidence of urolithiasis occurred from the third to fifth decade. The overall recurrence rate was 26.7%, and most recurrence (62.1%) occurred 1-3 years following the removal of initial calculi. Concerning renal calculi, the incidence of residual calculi and postoperative recurrence was dependent on the shape and number of calculi rather than operative methods. Mixed calcium oxalate and phosphate calculi were found most frequently, and calculi containing struvite also were found frequently in females. The components of recurrent calculi were identical to those of initial calculi in most cases (72.8%).抄録全体を表示PDF形式でダウンロード (2457K) -
その2 尿路感染症との関連性について公文 裕巳, 朝日 俊彦, 津川 昌也, 古川 正隆, 赤沢 信幸, 大森 弘之1984 年 96 巻 9-10 号 p. 1029-1035
発行日: 1984/10/30
公開日: 2009/03/30
ジャーナル フリーThe relationship of urinary tract infection (UTI) to urolithiasis was studied in 1069 patients who were treated in the Department of Urology, Okayama University Hospital. Of 211 cases with known causative factors, 58 (27.5%) had UTI. The incidence of cloudy urine became higher with increasing age and was significantly higher in females with renal calculi than in males with renal calculi. The main organisms isolated from the urine were Pseudomonas, Staphylococcus, E. coli and Proteus. UTI, caluculi containing struvite, and proteus in the urine were fonud significantly more often in cases of stghorn caluculi than in cases of other renal calculi.抄録全体を表示PDF形式でダウンロード (2169K)
- |<
- <
- 1
- >
- >|