巻号一覧
3 巻, 6 号
選択された号の論文の15件中1～15を表示しています
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工藤 武彦1974 年 3 巻 6 号 p. 383
発行日: 1974/12/15
公開日: 2011/10/07
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阿岸 鉄三, 太田 和夫1974 年 3 巻 6 号 p. 385-392
発行日: 1974/12/15
公開日: 2011/10/07
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―左心補助効果と長期間pumpingに関する検討高野 久輝, 高木 啓之, 阿久津 哲造1974 年 3 巻 6 号 p. 393-401
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーA peristaltic bypass type of left heart assist device, which diverts blood from the left atrium directly to the aorta, has been designed for human adults and large animals such as calves.
This device has two outstanding features. It has no valve in the conventional sense, but is in reality an avalvular pump in which the successive pumping of six pumping chambers simulates valve action. Also, when pumping during diastole of the natural heart, the device is pumping and simultaneously filling when blood is most readily available in the left atrium.
Acute calf experiments demonstrated marked changes in bypass flow, aortic root flow, left ventricular pressure, and left ventricular work during assist pumping. When all six chambers were used at 1:1 trigger ratio, complete atrialization of the left ventricle was achieved.
Continuous synchronous assisted circulation has been performed in calves up to three weeks. Bypass flow was 2.7l/min on an average and 3.8l/min in satisfactory cases. Our device was made all in one-piece out of Silastic, not including a conventional type of valve. No thrombus formation was noted on the pure Silastic surface inside the device when it was properly treated. Hematological studies showed hemolytic tendency caused by mechanical pumping, only for several day after surgery. Biochemical studies did not show any significant changes particularly related to the pumping fashion of the device used.抄録全体を表示PDF形式でダウンロード (12843K) -
榊原 欣作, 川村 光生, 小林 繁夫, 弥政 洋太郎, 高橋 英世, 小西 信一郎, 平山 れい子, 青木 利三郎, 若井 秀治, 渡辺 ...1974 年 3 巻 6 号 p. 402-408
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーTo improve many defects of the foremer model, a new type of pulsatile blood pump was developed which has very simplified mechanism and is also able to realize any type of pulse contour. As the pumping head, that of roller type blood pump was employed, but, as a driving power source, a specially designed pulse motor was introduced. The driving axis of this motor was designed to rotate 5° as one step, which corresponded with each input pulse, and through the control of pulse frequency, the disproportional movement of the axis can realize any type of pulsatile flow. Among many features of this pump, it does not require any valve mechanism in the blood stream, the control of this device is very simple and easy, and the driving condition is easily changeable as to modify the pulse contour freely. This blood pump can also be synchronized with ECG for the long-term assist circulation. The free choice of pulse contour is beneficial for the physiological analysis of the hemodynamics of artificial circulation, and is thought to be useful in determining the optimal driving condition of the total artificial heart.抄録全体を表示PDF形式でダウンロード (6350K) -
―前負荷・後負荷効果の測定と比較山越 憲一, 神谷 瞭, 戸川 達男, 島津 秀昭, 土屋 喜一1974 年 3 巻 6 号 p. 411-421
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーPhysiological and dynamic investigations were carried out to compare the parformances of natural and artificial heart as a blood pump from the preload and afterload effects on cardiac output. Pumping capacities for the circulation were analysed using the new designed flow limit type pressure regulator and the atrial pressure damper to control the load pressures of the ventricle and the artificial heart at desired levels.
The results of this analysis showed that at low contractile state of the ventricle the afterload effects, i. e., the decreases in cardiac output with increased arterial pressure, were much greater than those at normal or high contractile states within the physiological range of the atrial pressure. The output flow rate of the artificial heart also decreased with increasing the of terload pressures, but the most important result obtained from the experiments was that increased pump suction and driving pressure of the pump, increased modulus of elasticity of the ventricular wall material and increased inflow valve resistance caused a depressive effect on the cardiac output sensitivity of the artificial heart to venous pressure changes.
From these results the intrinsic regulation mechanism of the artificial heart was discussed from the points of the end systolic and diasotlic volume control.抄録全体を表示PDF形式でダウンロード (1527K) -
―濾過透析型人工腎臓および濾過吸着型人工腎臓―佐藤 公彦1974 年 3 巻 6 号 p. 422-429
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーIn order to improve the perfomance of the filtrationtype artificial kidney (Mark II), an attempt has been made to develop the filtration/dialysis-type artificial kidney (Mark III) and to examine the absorbing properties of numerous absorbants available as a fundamental basis to bring the filtration/absorption-type artificial kidney into practical use. Thromboresistance of the straight porous membrane was obtained by local heparinization of the virgin membrane after casting.
Removement of trivial pyrogens was successfully achieved by washing the membrane with distilled water at 50°C for 10 hour. Ultrafiltration and hemodialyis test of a newly-designed artificial kidney (Mark III) was performed in vitro and with dogs. Water-and bloodultrafiltration/dialysis rates of Mark III are about 190 and 80 times larger than those of a commercial kill type artificial kidney (with cuprophane), respectively. Amorphous carbon fiber proved useful for removing waste products, in particular BUN, from dialysate.抄録全体を表示PDF形式でダウンロード (2040K) -
小林 快三, 前田 憲志, 萬治 忠福, 川口 俊介, 野村 武彦, 筒井 修一, 酒井 宏, 高橋 広次郎, 岸 常規, 二村 弘一, 山 ...1974 年 3 巻 6 号 p. 430-437
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーWe have been working on the development of portable and handy artificial kidney which does not need a special room to install it. For this purpose, we tried to reduce the dialysate volume necessary for a dialysis by adding adsorbents into dialysate. Theoretically, substances with more than middle molecular weights can be removed by recirculating 30L of dialysate and adsorbents are necessary for the improvement of dialysis efficiency. We have examined some adsorbents suitable for the purpose and studied the bacterial growth expected during the recirculation of dialysate.
It can be concluded that our present system of 30L dialysate with 500g of activated charcoal and 200g of alumina is capable of short time dialysis without causing any disequilibrium syndrome.抄録全体を表示PDF形式でダウンロード (2737K) -
大島 宣雄, 出月 康夫, 東 順一, 堀 原一1974 年 3 巻 6 号 p. 438-442
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーA method for detecting thrombus formation on the artificial surfaces of the indwelling catheters was developed and its clinical feasibility was confirmed experimentally in the dogs.
The proposed method is based on the principle that the change in thermal conductivity of the blood due to thrombus formation can be detected thermometrically. A commercial peripheral blood flowmeter probe comprising of two sets of thermocouples, one for heating and another for detecting local temperature, was placed in the lumen of a catheter, which then was implanted in the vena cava of a dog. As the thrombus forms on the surface of implanted catheter, the heat transfer resistance of the thrombus layer increases and the temperature inside the catheter increases. The change of temperature was correlated to the thickness of the thrombus layer.
Antithrombogenicity of the indwelling catheters currently used as well as those of new materials and the effectiveness of anticoagulant (cytidine diphosphate choline) were tested by the above method. A continuous and long-term observation of thrombus formation in vivo up to serveral weeks was made possible by our method without sacrificing animals.抄録全体を表示PDF形式でダウンロード (776K) -
小島 幸一, 今井 庸二, 増原 英一1974 年 3 巻 6 号 p. 443-448
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーPoly (vinyl alcohol) (PVA)/methyl methacrylate, PVA/methyl acrylate and PVA/acrylonitrile graft copolymers were prepared by the ceric ion method to study the feasibility of these hydrophilic polymers as a biomedical material. These graft copolymers were evaluated from the viewpoint of tissue compatibility, biodeterioration or biodegradation, mechanical property and permeability characteristics.
These materials were implanted subcutaneously in dogs, removed after 1, 2, 3 months and 1 year, were subjected to a tensile strength testing and the surrounding tissue, to histopathological examination. They showed weak tissue reaction similar to that of Hydron, which is reported to be one of the most tissue compatible material and was used as a control one, and showed about twenty times greater tensile strength than that of Hydron. After implantation for one year little or no deterioration of tensile strength and elongation was noticed as compared with the control specimens which were stored in physiological saline solution at 37°C or in distilled water at room temperatures for one year.
Permeability and mechanical strength were varied with water content or graft copolymer composition. PVA/acrylonitrile graft having 1 to 1.5 ratio by weight and water content of 69% showed permeability and tensile strength superior to those of Cuprophane membrane.
These results suggest PVA graft copolymers will be useful in biomedical applications as a biocompatible, non-biodegradable, permeable and hydrophilic material.抄録全体を表示PDF形式でダウンロード (3818K) -
松岡 富男, 葛西 森夫1974 年 3 巻 6 号 p. 449-454
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーA new type of capillary membrane oxygenator is designed.
This oxygenator has triple lumen: inner sleeve consists of a thin silastic tube contained bundle of 120-140 silastic capillaries, and is sealed inside an outer cylindrical acryl or silastic housing. Inner tube has a side arm for blood inlet and outlet at the near of each end. Venous blood was flown into the inlet of inner tube, oxygenated between the capillary bundle and exits through outlet of inner tube. Outer cylindrical housing is added several devices, those which can be connected with pulse generator for air pulsation or water pulsation to blood.
This report describes the triple lumen-capillary membrane oxygenator used in animal experiments. Data on gas transfer and performance of this oxygenator with or without air and water pulsation are presented.抄録全体を表示PDF形式でダウンロード (829K) -
松岡 富男1974 年 3 巻 6 号 p. 455-460
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーThis experiment was submitted in the hope that the alginate cloth will be available to clinical trial for the arrest of capillary hemorrhage.
Alginate cloth used in the experiments, was woven with mixture consisted of 5 percent sodium alginate and 2 percent calcium alginate.
Bleeding wounds were made by brushing or cutting the surface of parenchymatous organs (liver, spleen and kidney) of dog or rabbit, and placed over tightly with this material. Hemostasis for the bleeding wounds was as quickly and easily controlled with this material as oxidized cellulose as control. Absorbability of this material in animal tissues and tissue reactions were investigated by packing the material into animal tissues as “sandwich” fashion. About 200 days later, this material was found to remained as the amorphous mass, capsulated with thin connective tissues. However, the surrounding area of the tissue showed seldom inflammatory reactions, and polymorphonuclear leucocytosis and foreign body giant cells could not be identified. While the control experiments used with oxidized cellulose or gelatin sponge showed more marked inflammatory reactions.抄録全体を表示PDF形式でダウンロード (13599K) -
和田 寿郎, 須田 義雄, 金子 正光, 安達 博昭, 金 有世, 浅井 康文1974 年 3 巻 6 号 p. 461-466
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーThe Travenol 0.75m2 membrane oxygenator (Modulung) were applied for open heart surgery of three cases of infants and children with mild hypothermia.
The membrane oxygenator provides safe, adequate exchange of oxygen and carbon dioxide, in spite of its limited capacity for gas exchange compared with the Sapporo ALL-IN-ONE bubble oxygenator.
Cardiopulmonary support was performed with no excessive blood damage, nor leakage from membrane defects, and the structural advantage of the membrane oxygenator made the rinsing procedure unnecessary, so that the membrane oxygenator was timesaving, and convenient in practical use.
We believe that Travenol membrane oxygenator is contributory to a successful open heart surgery, especially, for newborns and infants.抄録全体を表示PDF形式でダウンロード (6882K) -
木村 尚史, 大矢 晴彦, 鈴木 彰, 猪飼 康雄1974 年 3 巻 6 号 p. 467-470
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーTo reduce the volume of the dialysate used in a hemodialyser two methods are now considered to be possible. One is to purify the dialysate by adsorbing BUN, but presently no adsorbent is possible to adsorb urea selectively. The other is to recover water from the dialysate by the reverse osmosis process, which has been developed for purifying various kinds of waste water. In the latter process membranes made of cellulose acetate butyrate (CAB) is reported to reject urea effectively.
In this experiment the reverse osmosis module, made by De Danske Sukkerfabrikker (DDS) and equipped with CAB membranes made in our laboratory, is combined with a Lollow fiber dialyser and with a dialysate supplier. As a simulation experiment urea is removed using this system from aqueous urea solution or dialysate solution containing urea, which are used in place of blood.
Results shows that rejection of urea by CAB membranes is 80-90%, that of electrolytes is 99%, water recovery is 40-60%, and thus this system works good for the purpose. Further developments are necessary to improve CAB membrane to prevent degradation, and to increase water recovery, all of which are now under progress.抄録全体を表示PDF形式でダウンロード (550K) -
George J. PICHA, P. J. PARKS, Y. NOSE1974 年 3 巻 6 号 p. 471-478
発行日: 1974/12/15
公開日: 2011/10/07
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佐治 公明1974 年 3 巻 6 号 p. 490
発行日: 1974/12/15
公開日: 2011/10/07
ジャーナル フリーPDF形式でダウンロード (1863K)
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